More Is Not Always Better: Increased Fractional Anisotropy of Superior Longitudinal Fasciculus Associated with Poor Visuospatial Abilities in Williams Syndrome

We used diffusion tensor imaging to examine white matter integrity in the dorsal and ventral streams among individuals with Williams syndrome (WS) compared with two control groups (typically developing and developmentally delayed) and using three separate analysis methods (whole brain, region of interest, and fiber tractography). All analysis methods consistently showed that fractional anisotropy (FA; a measure of microstructural integrity) was higher in the right superior longitudinal fasciculus (SLF) in WS compared with both control groups. There was a significant association with deficits in visuospatial construction and higher FA in WS individuals. Comparable increases in FA across analytic methods were not observed in the left SLF or the bilateral inferior longitudinal fasciculus in WS subjects. Together, these findings suggest a specific role of right SLF abnormality in visuospatial construction deficits in WS.

• Publication year

  2007

• Venue

  Journal of Neuroscience

• Publication date

  2007-10-31

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1523/JNEUROSCI.3591-07.2007PMID 17978036PMCID PMC6673356
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Fronto‐striatal dysfunction and potential compensatory mechanisms in male adolescents with fragile X syndrome

  2007cited by this paper
• Diffusion tensor imaging segmentation of white matter structures using a Reproducible Objective Quantification Scheme (ROQS)

  2007cited by this paper
• Risk factors for the emergence of psychotic disorders in adolescents with 22q11.2 deletion syndrome.

  2007cited by this paper
• Frontostriatal dysfunction during response inhibition in Williams syndrome.

  2007cited by this paper
• Abnormal cortical activation during response inhibition in 22q11.2 deletion syndrome

  2007cited by this paper
• Fiber Pathways of the Brain

  2006influential reference
• Williams Syndrome: A Neurogenetic Model of Human Behavior

  2006cited by this paper
• Neural mechanisms in Williams syndrome: a unique window to genetic influences on cognition and behaviour

  2006influential reference
• The neurobiology of Williams syndrome: Cascading influences of visual system impairment?

  2006influential reference
• Neuro-functional differences associated with arithmetic processing in Turner syndrome.

  2006cited by this paper
• Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data

  2006influential reference
• Increased local gyrification mapped in Williams syndrome

  2006cited by this paper
• Selective Alterations of White Matter Associated with Visuospatial and Sensorimotor Dysfunction in Turner Syndrome

  2006cited by this paper
• To modulate or not to modulate: Differing results in uniquely shaped Williams syndrome brains

  2006influential reference
• DtiStudio: Resource program for diffusion tensor computation and fiber bundle tracking

  2006influential reference
• Anomalous sylvian fissure morphology in Williams syndrome

  2006influential reference
• Segmentation of subcomponents within the superior longitudinal fascicle in humans: a quantitative, in vivo, DT-MRI study.

  2005cited by this paper
• Choice reaction time performance correlates with diffusion anisotropy in white matter pathways supporting visuospatial attention.

  2005cited by this paper
• Relative sparing of primary auditory cortex in Williams Syndrome.

  2005cited by this paper
• Evidence for superior parietal impairment in Williams syndrome

  2005cited by this paper
• Abnormal Cortical Complexity and Thickness Profiles Mapped in Williams Syndrome

  2005influential reference
• COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome

  2005cited by this paper
• Fiber tract-based atlas of human white matter anatomy.

  2004influential reference
• Anomalous brain activation during face and gaze processing in Williams syndrome

  2004influential reference
• Frontostriatal deficits in fragile X syndrome: relation to FMR1 gene expression.

  2004cited by this paper
• Advances in functional and structural MR image analysis and implementation as FSL.

  2004cited by this paper
• Maturation of White Matter is Associated with the Development of Cognitive Functions during Childhood

  2004cited by this paper
• Neural Correlates of Auditory Perception in Williams Syndrome: An fMRI Study

  2003cited by this paper
• Nonparametric Permutation Tests for Functional Neuroimaging

  2003influential reference
• The DNA sequence of human chromosome 7

  2003cited by this paper
• The basis of anisotropic water diffusion in the nervous system – a technical review

  2002cited by this paper
• Imaging cortical association tracts in the human brain using diffusion‐tensor‐based axonal tracking

  2002influential reference
• Increased gyrification in Williams syndrome: evidence using 3D MRI methods.

  2002cited by this paper
• Dorsal forebrain anomaly in Williams syndrome.

  2001cited by this paper
• Analysis of cerebral shape in Williams syndrome.

  2001cited by this paper
• Linking Cognitive Neuroscience and Molecular Genetics : New Perspectives from Williams Syndrome

  2001cited by this paper
• Corpus callosum morphology of Williams syndrome: relation to genetics and behavior

  2001cited by this paper
• American Academy of Pediatrics: Health care supervision for children with Williams syndrome.

  2001cited by this paper
• Enlarged cerebellar vermis in Williams syndrome.

  2001cited by this paper
• Corpus callosum morphology of Williams syndrome: relation to genetics and behavior.

  2001cited by this paper
• Letter from the Special Issue Editor

  2000cited by this paper
• IV. Neuroanatomy of Williams Syndrome: A High-Resolution MRI Study

  2000cited by this paper
• Imaging Cognition II: An Empirical Review of 275 PET and fMRI Studies

  2000cited by this paper
• Three‐dimensional tracking of axonal projections in the brain by magnetic resonance imaging

  1999cited by this paper
• Tracking neuronal fiber pathways in the living human brain.

  1999cited by this paper
• The DNA sequence of human chromosome 22

  1999cited by this paper
• Nonrigid registration using free-form deformations: application to breast MR images

  1999cited by this paper
• Bridging cognition, the brain and molecular genetics: evidence from Williams syndrome.

  1999cited by this paper
• Automated image registration: I. General methods and intrasubject, intramodality validation.

  1998cited by this paper
• MR diffusion tensor spectroscopy and imaging.

  1994cited by this paper
• Hemizygosity at the elastin locus in a developmental disorder, Williams syndrome

  1993cited by this paper
• Automated image registration

  1993cited by this paper
• SCL-90-R, Administration, Scoring, and Procedures Manual-II for the R(evised) Version and Other Instruments of the Psychopathology Rating Scale Series

  1983cited by this paper

• Reduction of systematic errors in diffusion tensor imaging of the human brain as a prospect for increasing the precision of planning neurosurgical operations with particular emphasis on fiber tracking

  2025cites this paper
• Radiologic evaluation of the uncinate fasciculus using diffusion tensor imaging and tractography: review of technical considerations and clinical implications

  2025cites this paper
• Brain lateralization for perceiving direction of motion is reversed in Williams syndrome and related to BUD23

  2025cites this paper
• Effects of trace element dysregulation on brain structure and function in spinocerebellar Ataxia type 3.

  2025cites this paper
• White matter tract correlations with spoken language in cerebrovascular disease

  2025cites this paper
• Associations between mathematical skills and white matter microstructure in children born preterm

  2025cites this paper
• Adolescent Brain Development Following Early Life Stress: A Systematic Review of White Matter Alterations from Diffusion Tensor Imaging Studies

  2025cites this paper
• Assessment of auditory pathway microstructure in vestibular schwannoma patients: a quantitative diffusion tensor tractography study.

  2025cites this paper
• Mediation of symptom severity in the relationship between white matter alterations and functional impairment in attention deficit-hyperactivity disorder children: an AFQ and TBSS study.

  2025cites this paper
• Assessing changes in whole-brain structural connectivity in the unilateral 6-hydroxydopamine rat model of Parkinson’s disease using diffusion imaging and tractography

  2024cites this paper
• The Multifaceted Role of Oxytocinergic System and OXTR Gene

  2024cites this paper
• A systematic review of neuroimaging studies of clozapine-resistant schizophrenia

  2023cites this paper
• Frontoparietal function and underlying structure reflect capacity for motor skill acquisition during healthy aging.

  2023cites this paper
• Classification of multiple sclerosis women with voiding dysfunction using machine learning: Is functional connectivity or structural connectivity a better predictor?

  2023cites this paper
• Quantitative Relaxometry Assessment of Brain Microstructural Abnormality of Preschool Children With Autism Spectrum Disorder With Synthetic Magnetic Resonance Imaging

  2023cites this paper
• Sex-dependent gut microbiota-brain-cognition associations: a multimodal MRI study

  2023cites this paper
• Neuroimaging Research in Williams Syndrome: Beginning to Bridge the Gap with Clinical Care.

  2023cites this paper
• Robust associations between white matter microstructure and general intelligence.

  2023cites this paper
• Diffusion tensor MR imaging evaluation in children with developmental delay

  2023cites this paper
• The long-term effects of adolescent Δ9-tetrahydrocannabinol on brain structure and function assessed through neuroimaging techniques in male and female rats.

  2023cites this paper
• Neuroanatomical differences in Latinx children from rural farmworker families and urban non-farmworker families and related associations with pesticide exposure

  2023cites this paper
• Structural Connectivity and Emotion Recognition Impairment in Children and Adolescents with Chromosome 22q11.2 Deletion Syndrome

  2022cites this paper
• Robust associations between white matter microstructure and general intelligence

  2022cites this paper
• A diffusion MRI study of brain white matter microstructure in adolescents and adults with a Fontan circulation: Investigating associations with resting and peak exercise oxygen saturations and cognition

  2022cites this paper
• Neuroimaging Findings in Neurodevelopmental Copy Number Variants: Identifying Molecular Pathways to Convergent Phenotypes.

  2022cites this paper
• Using whole-brain diffusion tensor analysis to evaluate white matter structural correlates of delayed visuospatial memory and one-week motor skill retention in nondemented older adults: A preliminary study

  2022cites this paper
• Deep brain stimulation in Parkinson's disease: analysis of brain fractional anisotropy differences in operated patients.

  2022cites this paper
• Asymmetry Matters: Diffusion Tensor Tractography of the Uncinate Fasciculus in Children with Verbal Memory Deficits

  2022cites this paper
• Journal Pre-proofs A diffusion MRI study of brain white matter microstructure in adolescents and adults with a Fontan circulation: Investigating associations with resting and peak exercise oxygen saturations and cognition

  2022cites this paper
• Brain Substrates of Episodic Memory for Identity, Location, and Action Information: A Lesion-Behavior Mapping Study

  2022cites this paper
• Visual and social differences in dyslexia: deep phenotyping of four cases with spared phonology

  2022cites this paper
• Structural connectivity and its association with social connectedness in early adolescence.

  2022cites this paper
• Socioeconomic factors, stress, hair cortisol, and white matter microstructure in children.

  2021cites this paper
• Correlation between Cranial Nerve Microstructural Characteristics and Vestibular Schwannoma Tumor Volume

  2021cites this paper
• Race, Socioeconomic Status, and Cerebellum Cortex Fractional Anisotropy in Pre-Adolescents.

  2021cites this paper
• Mechanisms of Network Changes in Cognitive Impairment in Multiple Sclerosis

  2021cites this paper
• White Matter Correlates of Hostility and Aggression in the Visuospatial Function Network in Patients With Schizophrenia

  2021cites this paper
• Cortical connectivity in the face of congenital structural changes—A case of homozygous LAMC3 mutation

  2021cites this paper
• A preliminary study to evaluate white matter structural correlates of delayed visuospatial memory and one-week motor skill retention in nondemented older adults

  2021cites this paper
• Opposing white matter microstructure abnormalities in 22q11.2 deletion and duplication carriers

  2021cites this paper
• Age dependency and lateralization in the three branches of the human superior longitudinal fasciculus

  2021cites this paper
• Altered White Matter Tracts in the Somatosensory, Salience, Motor, and Default Mode Networks in 7-Year-Old Children Living with Human Immunodeficiency Virus: A Tractographic Analysis

  2021cites this paper
• Left and Right Arcuate Fasciculi Are Uniquely Related to Word Reading Skills in Chinese-English Bilingual Children

  2021influential citation
• Elevated Circulating Microparticle Subpopulations in Incidental Cerebral White Matter Hyperintensities: A Multimodal Study

  2021cites this paper
• Global fractional anisotropy predicts transition to psychosis after 12 months in individuals at ultra‐high risk for psychosis

  2021cites this paper
• Cerebral White Matter Myelination and Relations to Age, Gender, and Cognition: A Selective Review

  2021cites this paper
• Abnormalities of Cerebral White Matter Microstructure in Children With New-Onset, Untreated Idiopathic-Generalized Epilepsy

  2021cites this paper
• Whole brain atlas-based diffusion kurtosis imaging parameters for evaluation of minimal hepatic encephalopathy

  2021cites this paper
• Delayed development of aphasia related to degeneration of the arcuate fasciculus in the dominant hemisphere nine years after the onset in a patient with intracerebral hemorrhage: a case report

  2021cites this paper
• Impaired cerebro-cerebellar white matter connectivity and its associations with cognitive function in patients with schizophrenia

  2021cites this paper
• Aberrant structural network of comorbid attention deficit/hyperactivity disorder is associated with addiction severity in internet gaming disorder

  2020cites this paper
• Double Dissociation of Auditory Attention Span and Visual Attention in Long-Term Survivors of Childhood Cerebellar Tumor: A Deterministic Tractography Study of the Cerebellar-Frontal and the Superior Longitudinal Fasciculus Pathways

  2020cites this paper
• The development of visuospatial processing

  2020cites this paper
• Investigation of structure-function correlation among the young offspring of patients with bipolar disorder.

  2020cites this paper
• Thalamic Volume Is Related to Increased Anterior Thalamic Radiations in Children with Reactive Attachment Disorder.

  2020cites this paper
• Prediction of memory impairment in epilepsy surgery by white matter diffusion.

  2020cites this paper
• White Matter Integrity Involvement in the Preclinical Stage of Familial Creutzfeldt–Jakob Disease: A Diffusion Tensor Imaging Study

  2020cites this paper
• White matter alterations in Williams syndrome related to behavioral and motor impairments

  2020cites this paper
• Concomitant modulation of BOLD responses in white matter pathways and cortex

  2020cites this paper
• Identifying neurodevelopmental anomalies of white matter microstructure associated with high risk for psychosis in 22q11.2DS

  2020cites this paper
• Relating Response Inhibition, Brain Connectivity, and Freezing of Gait in People with Parkinson’s Disease

  2020cites this paper
• Evidence for associations between Rey-Osterrieth Complex Figure test and motor skill learning in older adults

  2020cites this paper
• Association between the superior longitudinal fasciculus and perceptual organization and working memory: a diffusion tensor imaging study.

  2020cites this paper
• Abnormal white matter tracts of insula in smokers

  2020cites this paper
• Impaired integrity of commissural and association fibers in essential tremor patients:Evidence from a diffusion tensor imaging study

  2020cites this paper
• White Matter Microstructure and the General Psychopathology Factor in Children.

  2020cites this paper
• Cerebro-cerebellar white matter connectivity in bipolar disorder and associated polarity subphenotypes.

  2020cites this paper
• Juntendo Medical Journal

  2020cites this paper
• Concurrent anatomical, physiological and network changes in cognitively impaired multiple sclerosis patients

  2020cites this paper
• Alterations in the Structural and Functional Connectivity of the Visuomotor Network of Children With Periventricular Leukomalacia.

  2019cites this paper
• Reciprocal White Matter Changes Associated With Copy Number Variation at 15q11.2 BP1-BP2: A Diffusion Tensor Imaging Study

  2019cites this paper
• Neuronal deletion of Gtf2i, associated with Williams syndrome, causes behavioral and myelin alterations rescuable by a remyelinating drug

  2019cites this paper
• Williams syndrome hemideletion and LIMK1 variation both affect dorsal stream functional connectivity.

  2019cites this paper
• Genetics of brain networks and connectivity

  2019cites this paper
• Differences in attentional control and white matter microstructure in adolescents with attentional, affective, and behavioral disorders

  2019cites this paper
• Crystallized and fluid intelligence are predicted by microstructure of specific white‐matter tracts

  2019cites this paper
• DTI-based tractographic analysis of white matter alterations in HIV infected children

  2019cites this paper
• General Psychopathology in Children : Epidemiological Studies of Biological Mechanisms

  2019cites this paper
• Widespread higher fractional anisotropy associates to better cognitive functions in individuals at ultra‐high risk for psychosis

  2019cites this paper
• Exploring the relationship between visuospatial function and age-related deficits in motor skill transfer

  2019cites this paper
• Cortico-limbic connectivity as a possible biomarker for bipolar disorder: where are we now?

  2019cites this paper
• Cognitive Control of Saccadic Selection and Inhibition from within the Core Cortical Saccadic Network

  2019cites this paper
• Altered working memory-related brain responses and white matter microstructure in extremely preterm-born children at school age.

  2019cites this paper
• Neuroimaging depression and anxiety in essential tremor: A diffusion tensor imaging study.

  2019cites this paper
• Altered Relationship between Working Memory and Brain Microstructure after Mild Traumatic Brain Injury

  2019cites this paper
• White matter microstructure among perinatally HIV-infected youth: a diffusion tensor imaging study

  2019cites this paper
• Improving Cognition to Increase Treatment Efficacy in Schizophrenia: Effects of Metabolic Syndrome on Cognitive Remediation's Outcome

  2018cites this paper
• Brain Morphometry

  2018influential citation
• Neural mechanisms of social-emotional dysfunction in autism spectrum disorder and conduct disorder

  2018cites this paper
• Reduced white matter connectivity associated with auditory verbal hallucinations in first-episode and chronic schizophrenia: A diffusion tensor imaging study.

  2018cites this paper
• Brief Computer‐Based Information Processing Measures are Linked to White Matter Integrity in Pediatric‐Onset Multiple Sclerosis

  2018cites this paper
• Investigating Sex-Specific Characteristics of Nicotine Addiction Using Metabolic and Structural Magnetic Resonance Imaging

  2018cites this paper
• Probing the neuroanatomy of the cerebellum using tractography.

  2018cites this paper
• Diffusion Tensor Tract Analysis of Patients with Traumatic Brain Injury: Stratification by Susceptibility Weighted Imaging

  2018cites this paper
• A Different Brain: Anomalies of Functional and Structural Connections in Williams Syndrome

  2018cites this paper
• Complex spatial and temporally defined myelin and axonal degeneration in Huntington disease

  2018cites this paper
• The 7q11.23 Protein DNAJC30 Interacts with ATP Synthase and Links Mitochondria to Brain Development.

  2018cites this paper
• Morphological brain alterations in patients with obsessive–Compulsive disorder

  2018cites this paper
• Abnormal brain white matter network in young smokers: a graph theory analysis study

  2018cites this paper
• Gut microbiome populations are associated with structure-specific changes in white matter architecture

  2018cites this paper