Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Nature Neuroscience

• Publication date

  2010-05-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1038/nn.2519PMID 20348917PMCID PMC2947358
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Deficits of mesolimbic dopamine neurotransmission in rat dietary obesity.

  2009cited by this paper
• Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV)

  2009cited by this paper
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  2008cited by this paper
• Diagnostic and Statistical Manual of Mental Disorders

  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
• Gastric distention activates satiety circuitry in the human brain

  2008cited by this paper
• Brain reward systems and compulsive drug use.

  2007cited by this paper
• PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans

  2007cited by this paper
• Decreases in dietary preference produce increased emotionality and risk for dietary relapse.

  2007cited by this paper
• Leptin Regulates Striatal Regions and Human Eating Behavior

  2007cited by this paper
• Eating for pleasure or calories.

  2007cited by this paper
• Genetically Determined Differences in Learning from Errors

  2007cited by this paper
• Weight stigmatization and bias reduction: perspectives of overweight and obese adults.

  2007cited by this paper
• Issues for DSM-V: should obesity be included as a brain disorder?

  2007cited by this paper
• Inactivation of dorsolateral striatum enhances sensitivity to changes in the action-outcome contingency in instrumental conditioning.

  2006cited by this paper
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  2006cited by this paper
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  2006cited by this paper
• Leptin receptor signaling in midbrain dopamine neurons regulates feeding.

  2006cited by this paper
• Leptin regulation of the mesoaccumbens dopamine pathway.

  2006cited by this paper
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  2005cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
• Differential Glycosylation and Intracellular Trafficking for the Long and Short Isoforms of the D2 Dopamine Receptor (*)

  1995cited by this paper
• Synthesis and processing of D2 dopamine receptors.

  1993cited by this paper
• Construct validity of a self-stimulation threshold paradigm: effects of reward and performance manipulations.

  1992cited by this paper
• Postcocaine anhedonia. An animal model of cocaine withdrawal.

  1991cited by this paper
• Persistent obesity in rats following a period of consumption of a mixed, high energy diet.

  1980cited by this paper
• A Stereotaxic Atlas of the Rat Brain

  1980cited by this paper
• FEEDING AND SELF‐STIMULATION *

  1969cited by this paper
• Aversion to lateral hypothalamic stimulation caused by intragastric feeding or obesity.

  1969cited by this paper
• Relative Effects of Nutritional Deficit and Deprivation Period on Rate of Electrical Self-stimulation of Lateral Hypothalamus

  1968cited by this paper
• Lateral hypothalamic reward decreased by intragastric feeding: Self-determined “threshold” technique

  1967cited by this paper
• Self-stimulation of the lateral hypothalamus modified by insulin and glucagon ☆

  1967cited by this paper
• Modification of intracranial self-stimulation by hunger satiety.

  1962cited by this paper
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  1962cited by this paper
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  year unknowncited by this paper

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