Effects of Resveratrol and Essential Oils on Growth Performance, Immunity, Digestibility and Fecal Microbial Shedding in Challenged Piglets

A study was conducted to evaluate the effects of resveratrol and essential oils from medicinal plants on the growth performance, immunity, digestibility, and fecal microbial shedding of weaned piglets. A total of 48 weaned piglets (8 kg initial weight, 28-d-old) were randomly allotted to four dietary treatments with 3 replications of 4 piglets each. The dietary treatments were NC (negative control; basal diet), PC (positive control; basal diet+0.002% apramycin), T1 (basal diet+0.2% resveratrol), and T2 (basal diet+0.0125% essential oil blend). All piglets were orally challenged with 5 ml culture fluid containing 2.3×108 cfu/ml of Escherichia coli KCTC 2571 and 5.9×108 cfu/ml Salmonella enterica serover Typhimurium. The PC group (p<0.05) showed the highest average daily gain (ADG) and average daily feed intake (ADFI) throughout the experimental period, although feed conversion ratio (FCR) was improved in the T1 group (p>0.05). Serum IgG level was increased in the T1 group, whereas TNF-α levels was reduced in the supplemented groups compared to control (p<0.05). The PC diet improved the dry matter (DM) digestibility, whereas PC and T2 diets improved nitrogen (N) digestibility compared to NC and T1 diets (p<0.05). Fecal Salmonella and E. coli counts were reduced in all treatment groups compared to control (p<0.05). Fecal Lactobacillus spp. count was increased in the T2 group compared to others (p<0.05). Dietary treatments had no significant effect on fecal Bacillus spp. count throughout the entire experimental period. Based on these results, resveratrol showed strong potential as antibiotic alternatives for reversing the adverse effects of weaning stress on growth performance, immunity and microbial environment in E. coli and Salmonella-challenged piglets.

• Publication year

  2013

• Venue

  Asian-Australasian Journal of Animal Sciences

• Publication date

  2013-05-01

• Fields of study

  Agricultural and Food Sciences, Medicine, Biology

• Identifiers
  DOI 10.5713/ajas.2012.12683PMID 25049839PMCID 4093338
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effects of dietary polyphenol-rich grape products on intestinal microflora and gut morphology in broiler chicks.

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  2010cited by this paper
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  2010cited by this paper
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  2010influential reference
• The investigation of intestinal microflora and growth response of young broilers given feed supplemented with different levels of peobiotic and prebiotic.

  2010cited by this paper
• Probiotics and prebiotics in animal feeding for safe food production.

  2010cited by this paper
• Effects of dietary protein supply, weaning age and experimental enterotoxigenic Escherichia coli infection on newly weaned pigs: health.

  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2007cited by this paper
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  2006cited by this paper
• The response of gastrointestinal microbiota to avilamycin, butyrate, and plant extracts in early-weaned pigs.

  2006influential reference
• Phytobiotics and Organic Acids As Potential Alternatives to the Use of Antibiotics in Nursery Pig Diets

  2006cited by this paper
• Effects of herbal extracts and antimicrobials on apparent digestibility , performance , organs morphometry and intestinal histology of weanling pigs

  2006cited by this paper
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  2006cited by this paper
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  2006influential reference
• Antimicrobial activity of essential oils and structurally related synthetic food additives towards selected pathogenic and beneficial gut bacteria

  2006cited by this paper
• Growth rate of broiler chickens given condensed tannins extracted from grape seed.

  2005cited by this paper
• Antibiotic susceptibility profiles of new probiotic Lactobacillus and Bifidobacterium strains.

  2005cited by this paper
• Effects of essential oils supplementation on growth performance, IgG concentration and fecal noxious gas concentration of weaned pigs

  2005cited by this paper
• Effect of plant extracts and formic acid on the intestinal equilibrium of early-weaned pigs.

  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2003cited by this paper
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  2000cited by this paper
• Bioavailability and Pharmacokinetics of Natural Volatile Terpenes in Animals and Humans

  2000cited by this paper
• 18 Antimicrobial and Promicrobial Agents

  2000cited by this paper
• Acute phase responses of pigs challenged orally with Salmonella typhimurium.

  2000cited by this paper
• Regulation of metabolism and growth during immune challenge: an overview of cytokine function.

  1997cited by this paper
• The effect of Chinese medicinal herb Zingiberis rhizoma extract on cytokine secretion by human peripheral blood mononuclear cells.

  1995cited by this paper
• Chapter 17 – Antimicrobial Agents

  1991cited by this paper
• Official methods of analysis

  1990cited by this paper
• Biology of interleukin 1

  1988cited by this paper
• Official Methods of Analysis

  1980cited by this paper
• Official Methods of Analysis of the Association of Official Analytical Chemists

  1971cited by this paper
• MULTIPLE RANGE AND MULTIPLE F TESTS

  1955cited by this paper

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