Cell-based therapies for the treatment of schizophrenia.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Brain Research

• Publication date

  2017-01-15

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/j.brainres.2016.08.010PMID 27544423PMCID PMC5474910
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Dopamine Receptors

  2018cited by this paper
• Stem cell derived interneuron transplants as a treatment for schizophrenia: preclinical validation in a rodent model

  2016cited by this paper
• Moving stem cells to the clinic: potential and limitations for brain repair.

  2015cited by this paper
• Duration of culture and sonic hedgehog signaling differentially specify PV versus SST cortical interneuron fates from embryonic stem cells

  2015cited by this paper
• Decrease in Reelin and Glutamic Acid Decarboxylase 67 (GAD 67 ) Expression in Schizophrenia and Bipolar Disorder

  2015cited by this paper
• Synaptic proteins in the hippocampus indicative of increased neuronal activity in CA3 in schizophrenia.

  2015cited by this paper
• Determinants of different aspects of everyday outcome in schizophrenia: The roles of negative symptoms, cognition, and functional capacity.

  2015cited by this paper
• Alterations in hippocampal connectivity across the psychosis dimension.

  2015cited by this paper
• INCREASING ENDOCANNABINOID LEVELS RESTORES ABERRANT DOPAMINE SYSTEM FUNCTION IN THE PCP MODEL OF SCHIZOPHRENIA

  2014cited by this paper
• Increasing Endocannabinoid Levels in the Ventral Pallidum Restore Aberrant Dopamine Neuron Activity in the Subchronic PCP Rodent Model of Schizophrenia

  2014cited by this paper
• Parvalbumin and GAD65 Interneuron Inhibition in the Ventral Hippocampus Induces Distinct Behavioral Deficits Relevant to Schizophrenia

  2014cited by this paper
• Unmet needs in the treatment of schizophrenia: new targets to help different symptom domains.

  2014cited by this paper
• The Role of Dopamine in Schizophrenia from a Neurobiological and Evolutionary Perspective: Old Fashioned, but Still in Vogue

  2014cited by this paper
• A fundamental role for hippocampal parvalbumin in the dopamine hyperfunction associated with schizophrenia.

  2014cited by this paper
• Interneuron precursor transplants in adult hippocampus reverse psychosis-relevant features in a mouse model of hippocampal disinhibition

  2014cited by this paper
• Inhibition of parvalbumin-expressing interneurons results in complex behavioral changes

  2014cited by this paper
• Magnetic resonance spectroscopy and tissue protein concentrations together suggest lower glutamate signaling in dentate gyrus in schizophrenia

  2014cited by this paper
• Functional organization of the hippocampal longitudinal axis

  2014cited by this paper
• Hippocampal interneuron transplants reverse aberrant dopamine system function and behavior in a rodent model of schizophrenia

  2013cited by this paper
• Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis.

  2013cited by this paper
• Imaging patients with psychosis and a mouse model establishes a spreading pattern of hippocampal dysfunction and implicates glutamate as a driver.

  2013cited by this paper
• Hippocampal deep brain stimulation reverses physiological and behavioural deficits in a rodent model of schizophrenia.

  2013cited by this paper
• Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells.

  2013cited by this paper
• Derivation and Isolation of NKX2.1-Positive Basal Forebrain Progenitors from Human Embryonic Stem Cells

  2013cited by this paper
• Spatial and temporal bias in the mitotic origins of somatostatin- and parvalbumin-expressing interneuron subgroups and the chandelier subtype in the medial ganglionic eminence.

  2012cited by this paper
• Generating GABAergic cerebral cortical interneurons from mouse and human embryonic stem cells.

  2012cited by this paper
• Glutamate dysfunction in hippocampus: relevance of dentate gyrus and CA3 signaling.

  2012cited by this paper
• Hippocampal dysregulation of dopamine system function and the pathophysiology of schizophrenia.

  2011cited by this paper
• Developmental pathology, dopamine, stress and schizophrenia

  2011cited by this paper
• Dopamine, But Not Serotonin, Regulates Reversal Learning in the Marmoset Caudate Nucleus

  2011cited by this paper
• GABAergic Precursor Transplantation into the Prefrontal Cortex Prevents Phencyclidine-Induced Cognitive Deficits

  2011cited by this paper
• Hippocampal interneurons are abnormal in schizophrenia.

  2011cited by this paper
• [Functional outcome in schizophrenia: relation to the MATRICS consensus cognitive battery].

  2011influential reference
• Neocortical excitation/inhibition balance in information processing and social dysfunction

  2011cited by this paper
• PAGES_DCNS 46_5.qxd:DCNS#45

  2010cited by this paper
• Prospective Isolation of Cortical Interneuron Precursors from Mouse Embryonic Stem Cells

  2010cited by this paper
• Sonic hedgehog signaling confers ventral telencephalic progenitors with distinct cortical interneuron fates.

  2010cited by this paper
• Serotonergic Neurons Mediate Dyskinesia Side Effects in Parkinson’s Patients with Neural Transplants

  2010cited by this paper
• Animal models of cognitive dysfunction and negative symptoms of schizophrenia: focus on NMDA receptor antagonism.

  2010cited by this paper
• Using the pharmacology of latent inhibition to model domains of pathology in schizophrenia and their treatment.

  2009cited by this paper
• Gestational methylazoxymethanol acetate administration: a developmental disruption model of schizophrenia.

  2009cited by this paper
• Differential targeting of the CA1 subfield of the hippocampal formation by schizophrenia and related psychotic disorders.

  2009cited by this paper
• A Loss of Parvalbumin-Containing Interneurons Is Associated with Diminished Oscillatory Activity in an Animal Model of Schizophrenia

  2009cited by this paper
• Anterior hippocampal and orbitofrontal cortical structural brain abnormalities in association with cognitive deficits in schizophrenia.

  2009cited by this paper
• Alterations in GABA-related transcriptome in the dorsolateral prefrontal cortex of subjects with schizophrenia

  2008cited by this paper
• A spatial bias for the origins of interneuron subgroups within the medial ganglionic eminence.

  2008cited by this paper
• The requirement of Nkx2-1 in the temporal specification of cortical interneuron subtypes.

  2008cited by this paper
• Allelic variation in GAD1 (GAD67) is associated with schizophrenia and influences cortical function and gene expression

  2007cited by this paper
• Phencyclidine animal models of schizophrenia: approaches from abnormality of glutamatergic neurotransmission and neurodevelopment.

  2007cited by this paper
• Decreased numerical density of CA3 hippocampal mossy fiber synapses in schizophrenia

  2007cited by this paper
• Aberrant Hippocampal Activity Underlies the Dopamine Dysregulation in an Animal Model of Schizophrenia

  2007cited by this paper
• The origin and specification of cortical interneurons

  2006cited by this paper
• Hippocampal and amygdala volumes according to psychosis stage and diagnosis: a magnetic resonance imaging study of chronic schizophrenia, first-episode psychosis, and ultra-high-risk individuals.

  2006cited by this paper
• The Hippocampus Modulates Dopamine Neuron Responsivity by Regulating the Intensity of Phasic Neuron Activation

  2006cited by this paper
• Neural stem cell proliferation is decreased in schizophrenia, but not in depression

  2006cited by this paper
• Cortical Inhibition Modified by Embryonic Neural Precursors Grafted into the Postnatal Brain

  2006cited by this paper
• Cognitive deficits and functional outcome in schizophrenia

  2006cited by this paper
• Brain volume in first-episode schizophrenia

  2006cited by this paper
• Sonic hedgehog maintains the identity of cortical interneuron progenitors in the ventral telencephalon

  2005cited by this paper
• Regionally specific disturbance of dorsolateral prefrontal-hippocampal functional connectivity in schizophrenia.

  2005cited by this paper
• Ultrastructural alterations in hippocampal mossy fiber synapses in schizophrenia: A postmortem morphometric study

  2005cited by this paper
• The temporal and spatial origins of cortical interneurons predict their physiological subtype.

  2005cited by this paper
• Duration of illness and treatment effects on hippocampal volume in male patients with schizophrenia

  2005cited by this paper
• Directed differentiation of telencephalic precursors from embryonic stem cells

  2005cited by this paper
• Directed differentiation of telencephalic precursors from embryonic stem cells

  2005cited by this paper
• Origins of Cortical Interneuron Subtypes

  2004cited by this paper
• Interneurons of the neocortical inhibitory system

  2004cited by this paper
• Pathology of layer V pyramidal neurons in the prefrontal cortex of patients with schizophrenia.

  2004cited by this paper
• Targeting the dopamine D1 receptor in schizophrenia: insights for cognitive dysfunction

  2004cited by this paper
• Disruption of Neurogenesis on Gestational Day 17 in the Rat Causes Behavioral Changes Relevant to Positive and Negative Schizophrenia Symptoms and Alters Amphetamine-Induced Dopamine Release in Nucleus Accumbens

  2004cited by this paper
• Smaller anterior hippocampal formation volume in antipsychotic-naive patients with first-episode schizophrenia.

  2003cited by this paper
• Complexity of prefrontal cortical dysfunction in schizophrenia: more than up or down.

  2003cited by this paper
• Layer Specification of Transplanted Interneurons in Developing Mouse Neocortex

  2003cited by this paper
• Impaired hippocampal recruitment during normal modulation of memory performance in schizophrenia.

  2003cited by this paper
• Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission

  2003influential reference
• Gene Expression Deficits in a Subclass of GABA Neurons in the Prefrontal Cortex of Subjects with Schizophrenia

  2003cited by this paper
• Evidence for a decrease in basilar dendrites of pyramidal cells in schizophrenic medial prefrontal cortex.

  2002cited by this paper
• Differential hippocampal expression of glutamic acid decarboxylase 65 and 67 messenger RNA in bipolar disorder and schizophrenia.

  2002cited by this paper
• A selective decrease in the relative density of parvalbumin-immunoreactive neurons in the hippocampus in schizophrenia.

  2002cited by this paper
• Neurophysiological Correlates of Delayed Visual Differentiation Tasks in Monkeys: the Effects of the Site of Intracortical Blockade of NMDA Receptors

  2001cited by this paper
• Distinct cortical migrations from the medial and lateral ganglionic eminences.

  2001cited by this paper
• Probing the human hippocampus using rCBF: Contrasts in schizophrenia

  2001cited by this paper
• In utero fate mapping reveals distinct migratory pathways and fates of neurons born in the mammalian basal forebrain.

  2001cited by this paper
• Glutamatergic Afferents from the Hippocampus to the Nucleus Accumbens Regulate Activity of Ventral Tegmental Area Dopamine Neurons

  2001cited by this paper
• Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the "right stuff"?

  2000cited by this paper
• Increased baseline occupancy of D2 receptors by dopamine in schizophrenia.

  2000cited by this paper
• Evidence for a compromised dorsolateral prefrontal cortical parallel circuit in schizophrenia.

  2000cited by this paper
• Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study.

  2000cited by this paper
• Decreased glutamic acid decarboxylase67 messenger RNA expression in a subset of prefrontal cortical gamma-aminobutyric acid neurons in subjects with schizophrenia.

  2000cited by this paper
• Reversal of antipsychotic-induced working memory deficits by short-term dopamine D1 receptor stimulation.

  2000cited by this paper
• Volumetric measure of the frontal and temporal lobe regions in schizophrenia: relationship to negative symptoms.

  2000cited by this paper
• Medial Frontal Cortex Mediates Perceptual Attentional Set Shifting in the Rat

  2000cited by this paper
• Injections of N‐methyl‐D‐aspartate into the ventral hippocampus increase extracellular dopamine in the ventral tegmental area and nucleus accumbens

  1999cited by this paper
• SPECT study of visual fixation in schizophrenia and comparison subjects.

  1999cited by this paper
• Impaired recruitment of the hippocampus during conscious recollection in schizophrenia

  1998cited by this paper
• A reduction of nonpyramidal cells in sector CA2 of schizophrenics and manic depressives.

  1998cited by this paper
• Reduced dendritic spine density on cerebral cortical pyramidal neurons in schizophrenia

  1998cited by this paper
• Hippocampal volume reduction in schizophrenia as assessed by magnetic resonance imaging: a meta-analytic study.

  1998cited by this paper
• The missing link: a failure of fronto-hippocampal integration in schizophrenia

  1998cited by this paper
• Stimulation of the Ventral Subiculum of the Hippocampus Evokes Glutamate Receptor‐mediated Changes in Dopamine Efflux in the Rat Nucleus Accumbens

  1997cited by this paper

• FOXO6: A Unique Transcription Factor in Disease Regulation and Therapeutic Potential.

  2025cites this paper
• Exploring hippocampal dysfunction in schizophrenia with pluripotent stem cell models.

  2025cites this paper
• Human umbilical cord blood mesenchymal stem cells mediate microglia activation and improve anxiety-like behavior in MIA-induced offspring of schizophrenic rats.

  2024cites this paper
• Prodromes and biological markers in schizophrenia: Importance for the dopamine, glutamate, and neurodevelopmental hypothesis

  2022cites this paper
• Journal of Stem Cell Research Stem Cells, Lithium and Neuropsychiatric Disorders

  2022influential citation
• Hippocampal α5-GABAA Receptors Modulate Dopamine Neuron Activity in the Rat Ventral Tegmental Area

  2022cites this paper
• Stem cell-based models and therapies: a key approach into schizophrenia treatment

  2021cites this paper
• Anti-anxiety and antidepressant-like effects of astragaloside IV and saponins extracted from Astragalus spinosus against the bisphenol A-induced motor and cognitive impairments in a postnatal rat model of schizophrenia

  2021cites this paper
• Buprenorphine Exposure Alters the Development and Migration of Interneurons in the Cortex

  2020cites this paper
• In Vitro and In Vivo Models for the Investigation of Potential Drugs Against Schizophrenia

  2020cites this paper
• Stem Cells for Improving the Treatment of Neurodevelopmental Disorders

  2020cites this paper
• Hyperactivity and Reduced Activation of Anterior Hippocampus in Early Psychosis.

  2019cites this paper
• Induced pluripotent stem cells in disease modelling and drug discovery

  2019cites this paper
• Adult stem cells in psychiatric disorders - New discoveries in peripheral blood.

  2018cites this paper
• Farmacogenética en psiquiatría: descripción de un caso clínico de depresión resistente y antecedente de múltiples efectos adversos

  2017cites this paper
• Understanding neurodevelopmental disorders using human pluripotent stem cell‐derived neurons

  2017cites this paper
• Forecasting Schizophrenia Incidence Frequencies Using Time Series Approach

  2017cites this paper
• Conceptualization and treatment of negative symptoms in schizophrenia.

  2015cites this paper
• Journal of Stem Cell Research

  year unknowncites this paper