A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Neuron

• Publication date

  1998-05-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0896-6273(00)80471-7PMID 9620694
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• N-Shc and Sck, Two Neuronally Expressed Shc Adapter Homologs

  1998cited by this paper
• Src activation in the induction of long-term potentiation in CA1 hippocampal neurons.

  1998cited by this paper
• SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family.

  1998cited by this paper
• Synapse specificity and long-term information storage.

  1997cited by this paper
• Visualization of the Distribution of Autophosphorylated Calcium/Calmodulin-Dependent Protein Kinase II after Tetanic Stimulation in the CA1 Area of the Hippocampus

  1997cited by this paper
• A Requirement for the Mitogen-activated Protein Kinase Cascade in Hippocampal Long Term Potentiation

  1997cited by this paper
• Activity regulates the synaptic localization of the NMDA receptor in hippocampal neurons.

  1997cited by this paper
• Regulatory recruitment of signalling molecules to the cell membrane by pleckstrinhomology domains

  1997cited by this paper
• Binding of neuroligins to PSD-95.

  1997cited by this paper
• A Requirement for the Mitogen-activated Protein Kinase Cascade in Hippocampal Long Term Potentiation*

  1997cited by this paper
• Blockade of endogenous ligands of trkB inhibits formation of ocular dominance columns.

  1997cited by this paper
• The postsynaptic density at glutamatergic synapses.

  1997cited by this paper
• Regulatory recruitment of signalling molecules to the cell membrane by pleckstrinhomology domains.

  1997cited by this paper
• Disulfide-linked head-to-head multimerization in the mechanism of ion channel clustering by PSD-95.

  1997cited by this paper
• Opposing roles for endogenous BDNF and NT-3 in regulating cortical dendritic growth.

  1997cited by this paper
• Synaptotagmins: C2-domain proteins that regulate membrane traffic.

  1996cited by this paper
• Crystal structure of the GTPase-activating domain of human p120GAP and implications for the interaction with Ras

  1996cited by this paper
• Rapid and opposite effects of BDNF and NGF on the functional organization of the adult cortex in vivo

  1996cited by this paper
• Characterization of Densin-180, a New Brain-Specific Synaptic Protein of the O-Sialoglycoprotein Family

  1996cited by this paper
• Identification of a Phosphorylation Site for Calcium/Calmodulindependent Protein Kinase II in the NR2B Subunit of the N-Methyl-D-aspartate Receptor*

  1996cited by this paper
• Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases

  1996cited by this paper
• PDZs and receptor/channel clustering: rounding up the latest suspects.

  1996cited by this paper
• Calcium Influx via the NMDA Receptor Induces Immediate Early Gene Transcription by a MAP Kinase/ERK-Dependent Mechanism

  1996cited by this paper
• Ca(2+)-dependent routes to Ras: mechanisms for neuronal survival, differentiation, and plasticity?

  1996cited by this paper
• Activation of p42 Mitogen-activated Protein Kinase in Hippocampal Long Term Potentiation*

  1996cited by this paper
• Interaction of the N-Methyl—aspartate Receptor Complex with a Novel Synapse-associated Protein, SAP102*

  1996cited by this paper
• Intrinsic and GTPase-activating protein-stimulated Ras GTPase assays.

  1995cited by this paper
• How MAP Kinases Are Regulated (*)

  1995cited by this paper
• Modular binding domains in signal transduction proteins.

  1995cited by this paper
• Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF

  1995cited by this paper
• Calcium signaling in neurons: molecular mechanisms and cellular consequences.

  1995cited by this paper
• Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95.

  1995cited by this paper
• Refolding and purification of Ras proteins.

  1995cited by this paper
• Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus

  1995cited by this paper
• CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP.

  1995cited by this paper
• Improvement of an "In-Gel" digestion procedure for the micropreparation of internal protein fragments for amino acid sequencing.

  1995cited by this paper
• The major tyrosine-phosphorylated protein in the postsynaptic density fraction is N-methyl-D-aspartate receptor subunit 2B.

  1994cited by this paper
• A modified method for obtaining large amounts of high titer polyclonal ascites fluid.

  1993cited by this paper
• Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways.

  1993cited by this paper
• Optimized survival of hippocampal neurons in B27‐supplemented neurobasal™, a new serum‐free medium combination

  1993cited by this paper
• Long-term potentiation is associated with an increased activity of Ca2+/calmodulin-dependent protein kinase II.

  1993cited by this paper
• The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein.

  1992cited by this paper
• Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice.

  1992cited by this paper
• Activation of Ca2+/calmodulin-dependent protein kinase II and protein kinase C by glutamate in cultured rat hippocampal neurons.

  1992cited by this paper
• Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice.

  1992cited by this paper
• Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

  1992cited by this paper
• Stimulation of protein tyrosine phosphorylation by NMDA receptor activation

  1991cited by this paper
• Autophosphorylation of type II Ca2+/calmodulin-dependent protein kinase in cultures of postnatal rat hippocampal slices.

  1991cited by this paper
• Oncoproteins. GAPs in understanding Ras.

  1990cited by this paper
• Stimulation of p21ras upon T-cell activation

  1990cited by this paper
• GAPs in understanding Ras

  1990cited by this paper
• Molecular cloning of two types of GAP complementary DNA from human placenta.

  1988cited by this paper
• Cloning of bovine GAP and its interaction with oncogenic ras p21

  1988cited by this paper
• Purification of ras GTPase activating protein from bovine brain.

  1988cited by this paper
• Regional distribution of type II Ca2+/calmodulin-dependent protein kinase in rat brain

  1985cited by this paper
• Distinct forebrain and cerebellar isozymes of type II Ca2+/calmodulin-dependent protein kinase associate differently with the postsynaptic density fraction.

  1985cited by this paper
• Identification of protein phosphatase 1 in synaptic junctions: dephosphorylation of endogenous calmodulin-dependent kinase II and synapse-enriched phosphoproteins

  1985cited by this paper
• Evidence that the major postsynaptic density protein is a component of a Ca2+/calmodulin-dependent protein kinase.

  1984cited by this paper
• Biochemical and immunochemical evidence that the "major postsynaptic density protein" is a subunit of a calmodulin-dependent protein kinase.

  1983cited by this paper
• Isolation and characterization of postsynaptic densities from various brain regions: enrichment of different types of postsynaptic densities

  1980cited by this paper

• HDAC Inhibition Reshapes Splicing of Synaptic Plasticity-Related Genes and Neural Network Dynamics

  2026cites this paper
• Novel De Novo Intronic Variant of SYNGAP1 Associated With the Neurodevelopmental Disorders

  2025cites this paper
• AAV delivery of full-length SYNGAP1 rescues epileptic and behavioral phenotypes in a mouse model of SYNGAP1-related disorders

  2025cites this paper
• Epigenetic regulation of SYNGAP1 in alcohol use disorder in whole blood and saliva

  2025cites this paper
• Epigenetic modulation rescues neurodevelopmental deficits in Syngap1+/− mice

  2025cites this paper
• SYNGAP1-Related Intellectual Disability: Meaningful Clinical Outcomes and Development of a Disease Concept Model Draft.

  2025cites this paper
• NMDA‐Type Glutamate Receptor Activation Promotes Ischemic Arrhythmias by Targeting the AKT1–TBX3–Nav1.5 Axis

  2025cites this paper
• Roadmap to advance therapeutics for SYNGAP1-related disorder: a patient organization perspective from SynGAP Research Fund

  2025cites this paper
• Dissociation of SYNGAP1 Enzymatic and Structural Roles: Intrinsic Excitability and Seizure Susceptibility

  2025cites this paper
• Different Ras isoforms regulate synaptic plasticity in opposite directions

  2025influential citation
• Developmental and Epileptic Encephalopathy: Pathogenesis of Intellectual Disability Beyond Channelopathies

  2025cites this paper
• Missense mutations on SynGAP C2 domain impair membrane diffusion

  2025cites this paper
• CRISPR-mediated transcriptional activation as a mutation-independent therapeutic strategy for SYNGAP1-related intellectual disability

  2025cites this paper
• Use of polyadenosine tail mimetics to enhance mRNA expression from genes associated with haploinsufficiency disorders

  2025cites this paper
• Familial SYNGAP1 variants define the boundaries of a complex neurodevelopmental disorder with epilepsy

  2025cites this paper
• SYNGAP1 Syndrome and the Brain Gene Registry

  2025cites this paper
• Convergent depression of activity-dependent bulk endocytosis in rodent models of autism spectrum disorder

  2025cites this paper
• Loss of Necdin causes social deficit and aberrant synaptic function through destabilization of SynGAP

  2025cites this paper
• Syngap1 and the development of murine neocortical progenitor cells

  2025cites this paper
• Dissociation of SYNGAP1 enzymatic and structural roles: Intrinsic excitability and seizure susceptibility

  2025cites this paper
• SYNGAP-1 Mutation And Catatonia: A Case Series and Systematic Review

  2024cites this paper
• Decoding molecular mechanisms: brain aging and Alzheimer’s disease

  2024cites this paper
• Hematopoietic stem cell gene therapy for the treatment of SYNGAP1‐related non‐specific intellectual disability

  2024cites this paper
• Shifting rules in a brain disorder

  2024cites this paper
• Developmental outcome of electroencephalographic findings in SYNGAP1 encephalopathy

  2024cites this paper
• Haploinsufficiency of Syngap1 in Striatal Indirect Pathway Neurons Alters Motor and Goal-Directed Behaviors in Mice

  2024cites this paper
• Comprehensive phenotypes of patients with SYNGAP1‐related disorder reveals high rates of epilepsy and autism

  2024cites this paper
• Epigenetic Modulation to perturb the SYNGAP1 Intellectual Disability (ID) that ameliorates synaptic and behavioural deficits

  2024cites this paper
• Syngap1 and the development of murine neocortical progenitor cells

  2024cites this paper
• SynGAP regulates synaptic plasticity and cognition independently of its catalytic activity

  2024cites this paper
• Hyperexcitability and translational phenotypes in a preclinical mouse model of SYNGAP1-related intellectual disability

  2024cites this paper
• Hyperexcitability and translational phenotypes in a preclinical mouse model of SYNGAP1-Related Intellectual Disability

  2024cites this paper
• Key roles of C2/GAP domains in SYNGAP1-related pathophysiology.

  2024cites this paper
• Interactions between Ras and Rap signaling pathways during neurodevelopment in health and disease

  2024cites this paper
• Activity-dependent diffusion trapping of AMPA receptors as a key step for expression of early LTP

  2024cites this paper
• Neural Influences on Tumor Progression Within the Central Nervous System

  2024cites this paper
• Convergent depression of activity-dependent bulk endocytosis in rodent models of autism spectrum disorders

  2024cites this paper
• Context-dependent hyperactivity in syngap1a and syngap1b zebrafish models of SYNGAP1-related disorder

  2024cites this paper
• Excitation–transcription coupling, neuronal gene expression and synaptic plasticity

  2023cites this paper
• Hyperexcitability and translational phenotypes in a preclinical model of SYNGAP1 mutations

  2023cites this paper
• Impairments of Spatial Memory and N-methyl-d-aspartate Receptors and Their Postsynaptic Signaling Molecules in the Hippocampus of Developing Rats Induced by As, Pb, and Mn Mixture Exposure

  2023cites this paper
• Mouse models of SYNGAP1-related intellectual disability

  2023cites this paper
• Context-dependent hyperactivity in syngap1a and syngap1b zebrafish autism models

  2023cites this paper
• Emerging roles of O-glycosylation in regulating protein aggregation, phase separation, and functions.

  2023cites this paper
• Hyperexcitability and translational phenotypes in a preclinical model of SYNGAP1 mutations

  2023cites this paper
• SynGAP regulates synaptic plasticity and cognition independent of its catalytic activity

  2023cites this paper
• Interneuron-Targeted Disruption of SYNGAP1 Alters Sensory Representations in the Neocortex and Impairs Sensory Learning

  2023cites this paper
• Syngap1 Disruption Induced by Recombination between Inverted loxP Sites Is Associated with Hippocampal Interneuron Dysfunction

  2023cites this paper
• The autism-associated gene SYNGAP1 regulates human cortical neurogenesis

  2023cites this paper
• Mouse models of SYNGAP1-related intellectual disability

  2023cites this paper
• Non-synaptic function of the autism spectrum disorder-associated gene SYNGAP1 in cortical neurogenesis

  2023cites this paper
• Upregulation of SYNGAP1 expression in mice and human neurons by redirecting alternative splicing.

  2023cites this paper
• A perspective on molecular signalling dysfunction, its clinical relevance and therapeutics in autism spectrum disorder

  2022cites this paper
• Molecular mechanisms of synaptogenesis

  2022cites this paper
• O-GlcNAcylation modulates liquid–liquid phase separation of SynGAP/PSD-95

  2022cites this paper
• Rho–Rho-Kinase Regulates Ras-ERK Signaling Through SynGAP1 for Dendritic Spine Morphology

  2022cites this paper
• Reversibility and Therapeutic Development for Neurodevelopmental Disorders, Insights from Genetic Animal Models.

  2022cites this paper
• Interneuron-targeted disruption of SYNGAP1 alters sensory representations in neocortex and impairs sensory learning

  2022cites this paper
• Cyclin-dependent kinase 5 phosphorylates the N-terminal domain Cyclin-dependent kinase 5 phosphorylates the N-terminal domain of the postsynaptic density protein PSD-95 in neurons of the postsynaptic density protein PSD-95 in neurons

  2022cites this paper
• Editorial: The synaptic basis of neuropathology

  2022cites this paper
• CaMKII: a central molecular organizer of synaptic plasticity, learning and memory

  2022cites this paper
• Abnormal brain state distribution and network connectivity in a SYNGAP1 rat model

  2022cites this paper
• A Selective Review of the Excitatory-Inhibitory Imbalance in Schizophrenia: Underlying Biology, Genetics, Microcircuits, and Symptoms

  2021cites this paper
• A matter of space and time: Emerging roles of disease-associated proteins in neural development.

  2021cites this paper
• Nanoscale synapse organization and dysfunction in neurodevelopmental disorders.

  2021cites this paper
• SYNGAP1 and Its Related Epileptic Syndromes

  2021cites this paper
• Endogenous Syngap1 alpha splice forms promote cognitive function and seizure protection

  2021cites this paper
• Regulation of the Small GTPase Ras and Its Relevance to Human Disease.

  2021cites this paper
• Methylomic alteration in peripheral blood lymphocytes of prodromal stage and first-episode Chinese Han schizophrenia patients

  2021cites this paper
• Cyfip1 Regulates SynGAP1 at Hippocampal Synapses

  2021cites this paper
• Genetics in Epilepsy.

  2021cites this paper
• Dysfunction of NMDA receptors in neuronal models of an autism spectrum disorder patient with a DSCAM mutation and in Dscam-knockout mice

  2021cites this paper
• Synaptic Protein Phosphorylation Networks Are Associated With Electroacupuncture-Induced Circadian Control in the Suprachiasmatic Nucleus

  2021cites this paper
• Twenty Years of SynGAP Research: From Synapses to Cognition

  2020influential citation
• SynGAP splice variants display heterogeneous spatio‐temporal expression and subcellular distribution in the developing mammalian brain

  2020influential citation
• Phase separation at the synapse

  2020cites this paper
• Pressure Sensitivity of SynGAP/PSD‐95 Condensates as a Model for Postsynaptic Densities and Its Biophysical and Neurological Ramifications

  2020cites this paper
• SynGAP is expressed in the murine suprachiasmatic nucleus and regulates circadian‐gated locomotor activity and light‐entrainment capacity

  2020cites this paper
• Heterozygous deletion of SYNGAP enzymatic domains in rats causes selective learning, social and seizure phenotypes

  2020cites this paper
• Identification of an individual with a SYNGAP1 pathogenic mutation in India

  2020cites this paper
• Low-Dose Perampanel Rescues Cortical Gamma Dysregulation Associated With Parvalbumin Interneuron GluA2 Upregulation in Epileptic Syngap1+/- Mice.

  2020cites this paper
• Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases

  2020cites this paper
• SynGAP isoforms differentially regulate synaptic plasticity and dendritic development

  2020cites this paper
• Demystifying neuroscience laboratory techniques used to investigate single-gene disorders

  2020cites this paper
• Liquid-Liquid Phase Separation in Neuronal Development and Synaptic Signaling.

  2020cites this paper
• Splicing of the SynGAP Carboxyl-Terminus Enables Isoform-Specific Tuning of NMDA Receptor Signaling Linked to Cognitive Function

  2020cites this paper
• SynGAP splice isoforms differentially regulate synaptic plasticity and dendritic development

  2020cites this paper
• A sex difference in the response of the rodent postsynaptic density to synGAP haploinsufficiency

  2020cites this paper
• Multi-parametric analysis of 57 SYNGAP1 variants reveal impacts on GTPase signaling, localization, and protein stability.

  2020cites this paper
• Dysregulation of translational control signaling in autism spectrum disorders.

  2020cites this paper
• The Effects of Chronic Early-life Social Isolation on Hippocampal Cell Number and Hippocampal-Dependent Learning and Memory in Male and Female Rats

  2019cites this paper
• Tumor Suppression of Ras GTPase-Activating Protein RASA5 through Antagonizing Ras Signaling Perturbation in Carcinomas

  2019cites this paper
• The impact of two autism related genes on amygdala physiology

  2019influential citation
• Perampanel rescues cortical gamma dysregulation associated with parvalbumin interneuron GluA2 upregulation in epileptic Syngap1+/- mice

  2019cites this paper
• Syntenin: PDZ Protein Regulating Signaling Pathways and Cellular Functions

  2019cites this paper
• A sex difference in the composition of the rodent postsynaptic density

  2019cites this paper
• Generation of mouse models of neurodevelopmental disorders using the CRISPR/Cas9 system

  2019cites this paper
• Disruption of SynGAP–dopamine D1 receptor complexes alters actin and microtubule dynamics and impairs GABAergic interneuron migration

  2019cites this paper
• SynGAP Splice Variants Display Heterogeneous Spatio-Temporal Expression And Subcellular Distribution In The Developing Mammalian Brain

  2019influential citation
• Understanding intellectual disability and autism spectrum disorders from common mouse models: synapses to behaviour

  2019cites this paper