Natural killer cells in human autoimmune disorders

Natural killer (NK) cells are innate lymphocytes that play a critical role in early host defense against viruses. Through their cytolytic capacity and generation of cytokines and chemokines, NK cells modulate the activity of other components of the innate and adaptive immune systems and have been implicated in the initiation or maintenance of autoimmune responses. This review focuses on recent research elucidating a potential immunoregulatory role for NK cells in T-cell and B-cell-mediated autoimmune disorders in humans, with a particular focus on multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematous. A better understanding of the contributions of NK cells to the development of autoimmunity may lead to novel therapeutic targets in these diseases.

• Publication year

  2013

• Venue

  Arthritis Research & Therapy

• Publication date

  2013-07-11

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1186/ar4232PMID 23856014PMCID 3979027
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2013cited by this paper
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  2012influential reference
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  2011influential reference
• Unexpected Role for Granzyme K in CD56bright NK Cell-Mediated Immunoregulation of Multiple Sclerosis

  2011cited by this paper
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  2011cited by this paper
• Emerging role for NK cells in the pathogenesis of inflammatory arthropathies.

  2011cited by this paper
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  2011cited by this paper
• Natural Killer-22 Cells in the Synovial Fluid of Patients with Rheumatoid Arthritis Are an Innate Source of Interleukin 22 and Tumor Necrosis Factor-α

  2011cited by this paper
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  2011cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
• KIRs and their HLA ligands in remitting-relapsing multiple sclerosis.

  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2009cited by this paper
• Defective phosphorylation of interleukin-18 receptor beta causes impaired natural killer cell function in systemic-onset juvenile idiopathic arthritis.

  2009cited by this paper
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  2009cited by this paper
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  2009cited by this paper
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  2009cited by this paper
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  2009cited by this paper
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  2009cited by this paper
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  2009cited by this paper
• Pattern of DAP12 Expression in Leukocytes from Both Healthy and Systemic Lupus Erythematosus Patients

  2009cited by this paper
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  2009cited by this paper
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  2009cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2008influential reference
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  2008cited by this paper
• Macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis is associated with MUNC13-4 polymorphisms.

  2008cited by this paper
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  2008influential reference
• NKG2D-Mediated Cytotoxicity toward Oligodendrocytes Suggests a Mechanism for Tissue Injury in Multiple Sclerosis

  2007cited by this paper
• Chronic lymphocytosis of functionally immature natural killer cells.

  2007cited by this paper
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  2007influential reference
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  2007cited by this paper
• Increased natural cytotoxicity receptor expression and relevant IL‐10 production in NK cells from chronically infected viremic HCV patients

  2007cited by this paper
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  2007cited by this paper
• Reciprocal regulation of human natural killer cells and macrophages associated with distinct immune synapses.

  2007cited by this paper
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  2007cited by this paper
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• KIRs and autoimmune disease: studies in systemic lupus erythematosus and scleroderma.

  2007cited by this paper
• Altered Natural Killer Cells in Type 1 Diabetic Patients

  2007influential reference
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  2007cited by this paper
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  2007cited by this paper
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  2006cited by this paper
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  2006cited by this paper
• Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction.

  2006cited by this paper
• How do natural killer cells find self to achieve tolerance?

  2006cited by this paper
• Decidual NK cells regulate key developmental processes at the human fetal-maternal interface

  2006cited by this paper
• Regulatory CD56(bright) natural killer cells mediate immunomodulatory effects of IL-2Ralpha-targeted therapy (daclizumab) in multiple sclerosis.

  2006cited by this paper
• Licensing of natural killer cells by self‐major histocompatibility complex class I

  2006cited by this paper
• NK cells of human secondary lymphoid tissues enhance T cell polarization via IFN-gamma secretion.

  2006cited by this paper
• Human NK cell education by inhibitory receptors for MHC class I.

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• The killer immunoglobulin-like receptor gene cluster: tuning the genome for defense.

  2006cited by this paper
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  2005cited by this paper
• Differential Effects of IL-21 during Initiation and Progression of Autoimmunity against Neuroantigen1

  2005cited by this paper
• The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor

  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
• Expansion and enhanced survival of natural killer cells expressing the killer immunoglobulin-like receptor KIR3DL2 in spondylarthritis.

  2005cited by this paper
• Mechanism of natural killer (NK) cell regulatory role in experimental autoimmune encephalomyelitis.

  2005cited by this paper
• Abnormal killer inhibitory receptor expression on natural killer cells in patients with Behçet's disease

  2004cited by this paper
• Induced recruitment of NK cells to lymph nodes provides IFN-γ for TH1 priming

  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
• Association of killer cell immunoglobulin-like receptors with scleroderma.

  2004cited by this paper
• Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome

  2004cited by this paper
• The dynamic life of natural killer cells.

  2004cited by this paper
• Human T regulatory cells can use the perforin pathway to cause autologous target cell death.

  2004influential reference
• MHC Class I overexpression on muscles in early juvenile dermatomyositis.

  2004cited by this paper
• Clinicobiological, immunophenotypic, and molecular characteristics of monoclonal CD56-/+dim chronic natural killer cell large granular lymphocytosis.

  2004cited by this paper
• Natural killer cells activated by MHC class I(low) targets prime dendritic cells to induce protective CD8 T cell responses.

  2003cited by this paper
• Natural killer cell dysfunction in patients with systemic-onset juvenile rheumatoid arthritis and macrophage activation syndrome.

  2003cited by this paper
• KIR in type 1 diabetes: disparate distribution of activating and inhibitory natural killer cell receptors in patients versus HLA-matched control subjects.

  2003cited by this paper
• Analysis of circulating T gamma/delta lymphocytes and CD16/56 cell populations in children and adolescents with Graves' disease.

  2003cited by this paper
• Modifications of the immune responsiveness in patients with autoimmune thyroiditis: evidence for a systemic immune alteration.

  2003cited by this paper
• Natural killer cells and autoimmunity

  2003cited by this paper
• Reduced perforin expression in systemic juvenile idiopathic arthritis is restored by autologous stem-cell transplantation.

  2003cited by this paper
• Clinical features of large granular lymphocyte leukemia.

  2003cited by this paper
• CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity.

  2003cited by this paper
• Natural killer cells in the synovial fluid of rheumatoid arthritis patients exhibit a CD 56 bright , CD 94 bright , CD 158 negative phenotype

  2003cited by this paper
• Dendritic Cells Mediate NK Cell Help for Th1 and CTL Responses: Two-Signal Requirement for the Induction of NK Cell Helper Function 1

  2003cited by this paper
• Analysis of Circulating T γ/δ Lymphocytes and CD16/56 Cell Populations in Children and Adolescents with Graves' Disease

  2003cited by this paper
• Circulating natural killer cells in psoriasis

  2003cited by this paper
• Natural killer cells in the synovial fluid of rheumatoid arthritis patients exhibit a CD56bright,CD94bright,CD158negative phenotype.

  2003cited by this paper

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