Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference–based bone anabolic strategy

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Nature Medicine

• Publication date

  2015-02-09

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1038/nm.3791PMID 25665179PMCID PMC5508976
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Aptamers in Therapeutics.

  2016cited by this paper
• Use of bone morphogenetic proteins in mesenchymal stem cell stimulation of cartilage and bone repair.

  2016cited by this paper
• Skeletal changes through the lifespan—from growth to senescence

  2015cited by this paper
• Developing aptamer probes for acute myelogenous leukemia detection and surface protein biomarker discovery

  2014cited by this paper
• Preparation of aptamer-functionalized lipid nanoparticles (LNPs) encapsulating siRNAs

  2014cited by this paper
• Therapeutic RNA interference targeting CKIP-1 with a cross-species sequence to stimulate bone formation.

  2014cited by this paper
• Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation.

  2013cited by this paper
• Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles

  2013cited by this paper
• Advances in Lipid Nanoparticles for siRNA Delivery

  2013cited by this paper
• Delivery materials for siRNA therapeutics.

  2013cited by this paper
• Osteoblast isolation from murine calvaria and long bones.

  2012cited by this paper
• RNA therapeutics targeting osteoclast-mediated excessive bone resorption.

  2012cited by this paper
• Ovariectomy and 17β-estradiol replacement in rats and mice: a visual demonstration.

  2012cited by this paper
• A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy

  2012influential reference
• Capture-SELEX: Selection of DNA Aptamers for Aminoglycoside Antibiotics

  2012cited by this paper
• Aptamers and Their Biological Applications

  2012cited by this paper
• Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells

  2012cited by this paper
• miR-214 targets ATF4 to inhibit bone formation

  2012cited by this paper
• Generating Aptamers by Cell-SELEX for Applications in Molecular Medicine

  2012cited by this paper
• RNA Interference Technologies and Therapeutics

  2012cited by this paper
• Single-stranded DNA (ssDNA) production in DNA aptamer generation.

  2012cited by this paper
• Aging and bone loss: new insights for the clinician

  2012cited by this paper
• Macropinocytosis: an endocytic pathway for internalising large gulps

  2011cited by this paper
• Preparation of Single-Stranded DNA from PCR Products with Streptavidin Magnetic Beads

  2011cited by this paper
• Single‐dose, placebo‐controlled, randomized study of AMG 785, a sclerostin monoclonal antibody

  2011cited by this paper
• RNA Aptamer Evolution: Two Decades of SELEction

  2011cited by this paper
• Bone remodelling at a glance

  2011cited by this paper
• Rational Truncation of an RNA Aptamer to Prostate-Specific Membrane Antigen Using Computational Structural Modeling

  2011cited by this paper
• Modulation of Wnt signaling influences fracture repair

  2010cited by this paper
• The use of inhibitors to study endocytic pathways of gene carriers: optimization and pitfalls.

  2010cited by this paper
• Isolation and characterization of a novel peptide, osteoblast activating peptide (OBAP), associated with osteoblast differentiation and bone formation.

  2010cited by this paper
• Guidelines for assessment of bone microstructure in rodents using micro–computed tomography

  2010cited by this paper
• Development of DNA aptamers using Cell-SELEX

  2010cited by this paper
• Bisphosphonate-coated BSA nanoparticles lack bone targeting after systemic administration

  2010cited by this paper
• Efficient and targeted delivery of siRNA in vivo

  2010cited by this paper
• Aptamers as therapeutics

  2010cited by this paper
• Aptamers generated from cell-SELEX for molecular medicine: a chemical biology approach.

  2010cited by this paper
• Rational design of cationic lipids for siRNA delivery

  2010cited by this paper
• Stealth nanoparticles: high density but sheddable PEG is a key for tumor targeting.

  2010cited by this paper
• Prostate cancer cell death produced by the co-delivery of Bcl-xL shRNA and doxorubicin using an aptamer-conjugated polyplex.

  2010cited by this paper
• Combining use of a panel of ssDNA aptamers in the detection of Staphylococcus aureus

  2009cited by this paper
• Reversible cell-specific drug delivery with aptamer-functionalized liposomes.

  2009cited by this paper
• Development of lipidoid-siRNA formulations for systemic delivery to the liver.

  2009cited by this paper
• Upgrading SELEX Technology by Using Lambda Exonuclease Digestion for Single-Stranded DNA Generation

  2009cited by this paper
• Streptavidin-Coated Magnetic Beads for DNA Strand Separation Implicate a Multitude of Problems During Cell-SELEX

  2009cited by this paper
• Regulation of planar cell polarity by Smurf ubiquitin ligases.

  2009cited by this paper
• Pentosidine Effects on Human Osteoblastsin Vitro

  2008cited by this paper
• Pharmacokinetics and biodistribution of nanoparticles.

  2008cited by this paper
• Molecular recognition of acute myeloid leukemia using aptamers

  2008cited by this paper
• Building bone to reverse osteoporosis and repair fractures.

  2008cited by this paper
• Cancer cell targeting using multiple aptamers conjugated on nanorods.

  2008cited by this paper
• Induction of osteoclast-associated receptor, a key osteoclast costimulation molecule, in rheumatoid arthritis.

  2008cited by this paper
• Triggered release of siRNA from poly(ethylene glycol)-protected, pH-dependent liposomes.

  2008cited by this paper
• Molecular Recognition of Small‐Cell Lung Cancer Cells Using Aptamers

  2008cited by this paper
• Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1

  2008cited by this paper
• Dynamin 2 mediates fluid-phase micropinocytosis in epithelial cells

  2007cited by this paper
• Selection of aptamers for molecular recognition and characterization of cancer cells.

  2007cited by this paper
• Changes of microstructure and mineralized tissue in the middle and late phase of osteoporotic fracture healing in rats.

  2007cited by this paper
• Nonviral delivery of synthetic siRNAs in vivo.

  2007cited by this paper
• The PH domain containing protein CKIP-1 binds to IFP35 and Nmi and is involved in cytokine signaling.

  2007cited by this paper
• SELEX--a (r)evolutionary method to generate high-affinity nucleic acid ligands.

  2007cited by this paper
• First-in-Human Evaluation of Anti–von Willebrand Factor Therapeutic Aptamer ARC1779 in Healthy Volunteers

  2007cited by this paper
• Regulation of bone mass by Wnt signaling.

  2006cited by this paper
• Aptamer:toxin conjugates that specifically target prostate tumor cells.

  2006cited by this paper
• Formation

  2006cited by this paper
• Cell type–specific delivery of siRNAs with aptamer-siRNA chimeras

  2006cited by this paper
• Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

  2005cited by this paper
• Aptamers: an emerging class of therapeutics.

  2005cited by this paper
• Bone-targeting macromolecular therapeutics.

  2005cited by this paper
• Neutralizing Aptamers from Whole-Cell SELEX Inhibit the RET Receptor Tyrosine Kinase

  2005cited by this paper
• Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation.

  2005cited by this paper
• Liposomal, Nanoparticle, and Conjugated Formulations of Anticancer Agents

  2005cited by this paper
• Controllable self-assembly of nanoparticles for specific delivery of multiple therapeutic molecules to cancer cells using RNA nanotechnology.

  2005cited by this paper
• Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling*

  2005cited by this paper
• Compartmental Bone Morphometry in the Mouse Femur: Reproducibility and Resolution Dependence of Microtomographic Measurements

  2005cited by this paper
• Gene expression relevant to osteoclastogenesis in the synovium and bone marrow of mature rats with collagen-induced arthritis.

  2004cited by this paper
• Antidote-mediated control of an anticoagulant aptamer in vivo

  2004cited by this paper
• The RNAi revolution

  2004cited by this paper
• Signal transduction and biological functions of bone morphogenetic proteins.

  2004cited by this paper
• Involvement of FcRgamma in signal transduction of osteoclast-associated receptor (OSCAR).

  2004cited by this paper
• Secreted antagonists of the Wnt signalling pathway

  2003cited by this paper
• Burden of osteoporosis and fractures

  2003cited by this paper
• [Osteosarcoma in rats receiving long-term PTH injection].

  2003cited by this paper
• E3 Ubiquitin Ligase Smurf1 Mediates Core-binding Factor α1/Runx2 Degradation and Plays A Specific Role in Osteoblast Differentiation*

  2003cited by this paper
• In Vitro Selection of RNA Aptamers That Bind to Cell Adhesion Receptors of Trypanosoma cruzi and Inhibit Cell Invasion*

  2002cited by this paper
• Prevalence rate of osteoporosis in the mid - aged and elderly in selected parts of China.

  2002cited by this paper
• Generation of species cross-reactive aptamers using "toggle" SELEX.

  2001cited by this paper
• Tenascin-C Aptamers Are Generated Using Tumor Cells and Purified Protein*

  2001cited by this paper
• Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis.

  2001cited by this paper
• Preparation of single-stranded PCR products for electrospray ionization mass spectrometry using the DNA repair enzyme lambda exonuclease.

  2000cited by this paper
• Signal transduction by bone morphogenetic protein receptors: functional roles of Smad proteins.

  1999cited by this paper
• Randomised controlled study of effect of parathyroid hormone on vertebral-bone mass and fracture incidence among postmenopausal women on oestrogen with osteoporosis.

  1997cited by this paper
• PCR product with strands of unequal length.

  1995cited by this paper
• Direct sequencing by thermal asymmetric PCR.

  1991cited by this paper
• Regulation of alkaline phosphatase and alpha 2(I) procollagen synthesis during early intramembranous bone formation in the rat mandible.

  1990cited by this paper
• In vitro selection of RNA molecules that bind specific ligands

  1990cited by this paper
• Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase.

  1990cited by this paper
• Production of single-stranded DNA templates by exonuclease digestion following the polymerase chain reaction.

  1989cited by this paper
• Direct solid phase sequencing of genomic and plasmid DNA using magnetic beads as solid support.

  1989cited by this paper
• Generation of single-stranded DNA by the polymerase chain reaction and its application to direct sequencing of the HLA-DQA locus.

  1988cited by this paper

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  2026cites this paper
• RNA interference therapeutics for disease-associated proteins: from molecular design to clinical translation

  2026cites this paper
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  2026cites this paper
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  2026cites this paper
• Nanotechnology-driven heart targeting to fulfil the potential of cardiac microRNA therapies.

  2026cites this paper
• Targeted restoration of endothelial hypoxic response prevents angiogenic bone loss against liver fibrosis

  2025cites this paper
• Optimizing the targeting of lipid nanoparticles for gene therapy.

  2025cites this paper
• Immunomodulatory Biomaterials for Bone and Soft Tissue Chronic Inflammation Diseases

  2025cites this paper
• Engineered multi-domain lipid nanoparticles for targeted delivery.

  2025cites this paper
• Recent advancements in aptamers as promising nanotool for therapeutic and diagnostic applications.

  2025cites this paper
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  2025cites this paper
• Targeting tumor-infiltrating regulatory T cells: combining CD47 and PD-L1 inhibition via a novel aptamer-siRNA chimera

  2025cites this paper
• FNDC5/irisin-enriched sEVs conjugated with bone-targeting aptamer alleviate osteoporosis: a potential alternative to exercise

  2025cites this paper
• Enhanced Bone Targeting of Poly(l-glutamic acid)s through Cationic or Aromatic Substitution.

  2025cites this paper
• Framework nucleic acid-programmed aptamer-paclitaxel conjugates as targeted therapeutics for triple-negative breast cancer.

  2025cites this paper
• RNA‐Based Therapeutics: Cutting‐Edge Advances in Clinical Research

  2025cites this paper
• Nucleic acid aptamers in orthopedic diseases: promising therapeutic agents for bone disorders

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• Targeted delivery systems of siRNA based on ionizable lipid nanoparticles and cationic polymer vectors.

  2025cites this paper
• High-Resolution Characterization of Protein-Conjugated, mRNA-Loaded Lipid Nanoparticles by Analytical Ultracentrifugation.

  2025cites this paper
• Aptamer-functionalized biomaterials for bone-related diseases therapy

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  2024cites this paper
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  2024cites this paper
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  2023cites this paper
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  2023influential citation
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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