LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Neuron

• Publication date

  2012-09-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.neuron.2012.08.022PMID 22998870
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Synaptic vesicle trafficking and Parkinson's disease

  2012cited by this paper
• LRRK2 Controls Synaptic Vesicle Storage and Mobilization within the Recycling Pool

  2011cited by this paper
• Synaptic dysfunction in genetic models of Parkinson's disease: a role for autophagy?

  2011cited by this paper
• ELP3 controls active zone morphology by acetylating the ELKS family member Bruchpilot.

  2011cited by this paper
• Recruitment of endophilin to clathrin-coated pit necks is required for efficient vesicle uncoating after fission.

  2011influential reference
• The Structure and Function of Endophilin Proteins

  2011cited by this paper
• Characterization of a selective inhibitor of the Parkinson’s disease kinase LRRK2

  2011cited by this paper
• Loss of skywalker reveals synaptic endosomes as sorting stations for synaptic vesicle proteins.

  2011cited by this paper
• The Chaperone-Like Protein HYPK Acts Together with NatA in Cotranslational N-Terminal Acetylation and Prevention of Huntingtin Aggregation

  2010cited by this paper
• One SNARE complex is sufficient for membrane fusion

  2010cited by this paper
• A Mutational Analysis of the Endophilin-A N-BAR Domain Performed in Living Flies

  2010cited by this paper
• The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

  2010cited by this paper
• Worldwide frequency of G2019S LRRK2 mutation in Parkinson's disease: a systematic review.

  2010cited by this paper
• LRRK2 Kinase Regulates Synaptic Morphology through Distinct Substrates at the Presynaptic and Postsynaptic Compartments of the Drosophila Neuromuscular Junction

  2010cited by this paper
• Roles of Amphipathic Helices and the Bin/Amphiphysin/Rvs (BAR) Domain of Endophilin in Membrane Curvature Generation*

  2010cited by this paper
• Endophilin functions as a membrane-bending molecule and is delivered to endocytic zones by exocytosis.

  2010cited by this paper
• Correction: A Mutational Analysis of the Endophilin-A N-BAR Domain Performed in Living Flies

  2010cited by this paper
• LRRK2 G2019S Mutation Induces Dendrite Degeneration through Mislocalization and Phosphorylation of Tau by Recruiting Autoactivated GSK3β

  2010cited by this paper
• Leucine-rich repeat kinase 2 mutations and Parkinson’s disease: three questions

  2009cited by this paper
• In Vitro and in Vivo Protein-bound Tyrosine Nitration Characterized by Diagonal Chromatography*

  2009cited by this paper
• Discrimination between docking and fusion of liposomes reconstituted with neuronal SNARE-proteins using FCS

  2009cited by this paper
• Molecular Basis of the Potent Membrane-remodeling Activity of the Epsin 1 N-terminal Homology Domain*

  2009cited by this paper
• Bayesian Modeling of the Yeast SH3 Domain Interactome Predicts Spatiotemporal Dynamics of Endocytosis Proteins

  2009cited by this paper
• Regulated release of BDNF by cortical oligodendrocytes is mediated through metabotropic glutamate receptors and the PLC pathway

  2009cited by this paper
• Recombineering-mediated tagging of Drosophila genomic constructs for in vivo localization and acute protein inactivation

  2008cited by this paper
• LRRK2 regulates synaptic vesicle endocytosis.

  2008cited by this paper
• Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila.

  2007influential reference
• On the decrease in lateral mobility of phospholipids by sugars.

  2007cited by this paper
• Eps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development

  2007cited by this paper
• Role of the AP2 β-Appendage Hub in Recruiting Partners for Clathrin-Coated Vesicle Assembly

  2006cited by this paper
• Mechanism of endophilin N‐BAR domain‐mediated membrane curvature

  2006cited by this paper
• Endophilin BAR domain drives membrane curvature by two newly identified structure‐based mechanisms

  2006cited by this paper
• Crystal structure of the endophilin-A1 BAR domain.

  2005cited by this paper
• Postfusional control of quantal current shape.

  2004cited by this paper
• Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease.

  2004cited by this paper
• Determinants of liposome fusion mediated by synaptic SNARE proteins.

  2004cited by this paper
• Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology.

  2004cited by this paper
• Dap160/intersectin acts as a stabilizing scaffold required for synaptic development and vesicle endocytosis.

  2004cited by this paper
• Endophilin is required for synaptic vesicle endocytosis by localizing synaptojanin.

  2003cited by this paper
• Essential role of endophilin A in synaptic vesicle budding at the Drosophila neuromuscular junction

  2002influential reference
• Endophilin mutations block clathrin-mediated endocytosis but not neurotransmitter release.

  2002influential reference
• Generation of high curvature membranes mediated by direct endophilin bilayer interactions

  2001cited by this paper
• Fission and uncoating of synaptic clathrin-coated vesicles are perturbed by disruption of interactions with the SH3 domain of endophilin.

  2000cited by this paper
• The Stoned Proteins Regulate Synaptic Vesicle Recycling in the Presynaptic Terminal

  1999cited by this paper
• Synaptic vesicle size and number are regulated by a clathrin adaptor protein required for endocytosis.

  1998cited by this paper
• The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain.

  1997cited by this paper
• Role of Drosophila alpha-adaptin in presynaptic vesicle recycling.

  1997cited by this paper
• The Drosophila clathrin heavy chain gene: clathrin function is essential in a multicellular organism.

  1993cited by this paper

• LRRK2 regulates ArfGAP1 membrane localization, activity and neuronal toxicity via phosphorylation within its lipid-sensing ALPS2 motif

  2026cites this paper
• In vivo Proximity & Spatial Proteomics with CRISPR Screening Identify STXBP1 as a Protective Modifier of α-synuclein Toxicity in Dopamine Neurons

  2026cites this paper
• Targeting of Kinases to Treat Neurodegenerative Diseases

  2026cites this paper
• Protective or Pathogenic? Kinase activity and the neurodevelopmental origins of G2019S LRRK2-Associated Parkinson's disease.

  2025cites this paper
• Beyond Clathrin: Decoding the Mechanism of Ultrafast Endocytosis.

  2025cites this paper
• LRRK2 and the fragile synapse: a molecular prelude to Parkinson’s disease?

  2025cites this paper
• Bending the boundaries: the many facets of endophilin-As from membrane dynamics to disease

  2025cites this paper
• Synaptic deregulation of cholinergic projection neurons causes olfactory dysfunction across five fly Parkinsonism models

  2025cites this paper
• Lysosomal TPC2 channels disrupt Ca2+ entry and dopaminergic function in models of LRRK2-Parkinson’s disease

  2025cites this paper
• Recent advances in targeting LRRK2 for Parkinson’s disease treatment

  2025cites this paper
• LRRK2 in Drosophila Melanogaster Model: Insights into Cellular Dysfunction and Neuroinflammation in Parkinson’s Disease

  2025influential citation
• Roles in physiology and disease of the inositol phosphatase synaptojanin 1.

  2025cites this paper
• Role of LRRK2 in axonal transport and Parkinson’s disease

  2025cites this paper
• Soma-localized Rab39 inhibits synaptic autophagy by controlling trafficking of Atg9 vesicles

  2025cites this paper
• Parkinson’s Disease Associated with Mutations in the LRRK2 Gene: Approaches to Therapy

  2025cites this paper
• The senescent synapse: A look at autophagy, calcium handling, and mitochondrial bioenergetics at the synapse in ageing and Parkinson's disease

  2025cites this paper
• Macroautophagy at the service of synapses.

  2025cites this paper
• The LRRK2 P1446L mutation triggers dopaminergic neurodegeneration via DAPK1-mediated microglial neuroinflammation and neuronal apoptosis

  2025cites this paper
• Exploring LRRK2-dependent Mechanisms in Parkinson's Disease Therapy.

  2025cites this paper
• Low-frequency genetic variants in GAK enhance Golgi function and protect against Parkinson’s disease

  2025cites this paper
• Key genes and convergent pathogenic mechanisms in Parkinson disease

  2024influential citation
• Dysregulation of SNX1-retromer axis in pharmacogenetic models of Parkinson’s disease

  2024cites this paper
• Dysfunction of synaptic endocytic trafficking in Parkinson’s disease

  2024cites this paper
• Diverse Functions of Parkin in Midbrain Dopaminergic Neurons

  2024cites this paper
• Neuronal Autophagy: Regulations and Implications in Health and Disease

  2024cites this paper
• RAB3 phosphorylation by pathogenic LRRK2 impairs trafficking of synaptic vesicle precursors

  2024cites this paper
• Synaptic sabotage: How Tau and α-Synuclein undermine synaptic health.

  2024cites this paper
• Neurons Specialize in Presynaptic Autophagy: A Perspective to Ameliorate Neurodegeneration

  2024cites this paper
• LRRK2 in Parkinson's disease: upstream regulation and therapeutic targeting.

  2024cites this paper
• Biology of endophilin and it’s role in disease

  2023cites this paper
• Is Glial Dysfunction the Key Pathogenesis of LRRK2-Linked Parkinson’s Disease?

  2023cites this paper
• EndophilinA-dependent coupling between activity-induced calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutation

  2023cites this paper
• Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain

  2023cites this paper
• Disruption of Dopamine Homeostasis Associated with Alteration of Proteins in Synaptic Vesicles: A Putative Central Mechanism of Parkinson’s Disease Pathogenesis

  2023cites this paper
• Exploration of the Shared Molecular Mechanisms between COVID-19 and Neurodegenerative Diseases through Bioinformatic Analysis

  2023cites this paper
• Structural mechanisms of mitochondrial quality control mediated by PINK1 and parkin.

  2023cites this paper
• RAB3 phosphorylation by pathogenic LRRK2 impairs trafficking of synaptic vesicle precursors

  2023cites this paper
• Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto‐axonal target in late‐stage Parkinson's disease

  2023cites this paper
• The endo-lysosomal system in Parkinson's disease: expanding the horizon.

  2023cites this paper
• Role of ceramides and sphingolipidsin Parkinson's disease.

  2023cites this paper
• Leucine-rich repeat kinase 2 at a glance

  2023cites this paper
• Inhibition of the Exocyst Complex Attenuates the LRRK2 Pathological Effects

  2023cites this paper
• Parkinson's disease-linked parkin mutation disrupts recycling of synaptic vesicles in human dopaminergic neurons.

  2023cites this paper
• Novel variants in genes related to vesicle-mediated-transport modify Parkinson's disease risk.

  2023cites this paper
• The role of LRRK2 in intracellular organelle dynamics.

  2023cites this paper
• BAR Domain Proteins as Putative Regulators of the Protein Liquid Phase in Nerve Terminals in the Central Nervous System

  2023cites this paper
• LRRK2 and Lipid Pathways: Implications for Parkinson’s Disease

  2022cites this paper
• R1441C and G2019S LRRK2 knockin mice have distinct striatal molecular, physiological, and behavioral alterations

  2022cites this paper
• Long-term inhibition of mutant LRRK2 hyper-kinase activity reduced mouse brain α-synuclein oligomers without adverse effects

  2022cites this paper
• Genetics and Pathogenesis of Parkinson’s Syndrome

  2022cites this paper
• Clinical Manifestations and Molecular Backgrounds of Parkinson's Disease Regarding Genes Identified From Familial and Population Studies

  2022cites this paper
• Human Induced Pluripotent Stem Cell Phenotyping and Preclinical Modeling of Familial Parkinson’s Disease

  2022cites this paper
• Role of Bin‐Amphiphysin‐Rvs (BAR) domain proteins in mediating neuronal signaling and disease

  2022cites this paper
• Parkinson disease-associated Leucine-rich repeat kinase regulates UNC-104-dependent axonal transport of Arl8-positive vesicles in Drosophila

  2022influential citation
• LRRK2 and Proteostasis in Parkinson’s Disease

  2022cites this paper
• Endosomal recycling and dopamine neurotransmission: Exploring the links between the retromer and Parkinson's disease

  2022cites this paper
• EndophilinA-dependent coupling between activity-dependent calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutation

  2022cites this paper
• Parkinson's disease: From genetics to molecular dysfunction and targeted therapeutic approaches

  2022cites this paper
• The endophilin curvature-sensitive motif requires electrostatic guidance to recycle synaptic vesicles in vivo.

  2022cites this paper
• LRRK2 mutant knock-in mouse models: therapeutic relevance in Parkinson's disease

  2022cites this paper
• Long-term inhibition of mutant LRRK2 hyper-kinase activity reduced mouse brain α-synuclein oligomers without adverse effects

  2022cites this paper
• Altered autophagy on the path to Parkinson's disease

  2022cites this paper
• Modeling Parkinson's disease in LRRK2 mice: focus on synaptic dysfunction and the autophagy-lysosomal pathway.

  2022cites this paper
• Synaptic AP2 CCV life cycle regulation by the Eps15, ITSN1, Sgip1/AP2, synaptojanin1 interactome

  2021cites this paper
• Rab10 regulates the sorting of internalised TrkB for retrograde axonal transport

  2021cites this paper
• The Importance of Drosophila melanogaster Research to UnCover Cellular Pathways Underlying Parkinson’s Disease

  2021cites this paper
• In silico comparative analysis of LRRK2 interactomes from brain, kidney and lung

  2021cites this paper
• Current molecular approaches to investigate pre‐synaptic dysfunction

  2021cites this paper
• Non-Motor Symptoms of Parkinson’s Disease: The Neurobiology of Early Psychiatric and Cognitive Dysfunction

  2021cites this paper
• The cell biology of Parkinson’s disease

  2021cites this paper
• LRRK2; a dynamic regulator of cellular trafficking.

  2021cites this paper
• The Cell Biology of LRRK2 in Parkinson's Disease

  2021cites this paper
• Dysfunction of Synaptic Vesicle Endocytosis in Parkinson’s Disease

  2021cites this paper
• Drosophila as a model to study autophagy in neurodegenerative diseases and digestive tract

  2021cites this paper
• LRRK2 Modulates the Exocyst Complex Assembly by Interacting with Sec8

  2021cites this paper
• Conformation and Dynamics of the Kinase Domain Drive Subcellular Location and Activation of LRRK2.

  2021cites this paper
• Presynaptic Autophagy and the Connection With Neurotransmission

  2021cites this paper
• Endophilin-B regulates autophagy during synapse development and neurodegeneration.

  2021influential citation
• Neurodegenerative Disorders: Spotlight on Sphingolipids

  2021cites this paper
• Parkinson Disease: Translating Insights from Molecular Mechanisms to Neuroprotection

  2021cites this paper
• Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein

  2021cites this paper
• An Emerging Role for Phosphoinositides in the Pathophysiology of Parkinson’s Disease

  2021cites this paper
• Oligomerization of Lrrk controls actin severing and α-synuclein neurotoxicity in vivo

  2021cites this paper
• LRRK2 recruitment, activity, and function in organelles

  2021cites this paper
• Dysregulation of the AP2M1 phosphorylation cycle by LRRK2 impairs endocytosis and leads to dopaminergic neurodegeneration

  2021cites this paper
• Deletion of lrrk2 causes early developmental abnormalities and age-dependent increase of monoamine catabolism in the zebrafish brain

  2021cites this paper
• Aberrant Patterns of Sensory-Evoked Activity in the Olfactory Bulb of LRRK2 Knockout Mice

  2021cites this paper
• Asparagine endopeptidase cleaves synaptojanin 1 and triggers synaptic dysfunction in Parkinson's disease.

  2021cites this paper
• Synj1 Haploinsufficiency Causes Dopamine Neuron Vulnerability and alpha-synuclein Accumulation in Mice.

  2020cites this paper
• Alpha-Synuclein and LRRK2 in Synaptic Autophagy: Linking Early Dysfunction to Late-Stage Pathology in Parkinson’s Disease

  2020cites this paper
• Pathogenic LRRK2 R1441C mutation is associated with striatal alterations

  2020cites this paper
• Endosomal sorting pathways in the pathogenesis of Parkinson's disease.

  2020cites this paper
• Cdk5 and GSK3β inhibit fast endophilin-mediated endocytosis

  2020cites this paper
• Structural and functional alterations associated with the LRRK2 G2019S mutation revealed in structured human neural networks

  2020cites this paper
• CAV-2-Mediated GFP and LRRK2G2019S Expression in the Macaca fascicularis Brain

  2020cites this paper
• Origins of Parkinson’s Disease in Brain Development: Insights From Early and Persistent Effects of LRRK2-G2019S on Striatal Circuits

  2020cites this paper
• Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis

  2020cites this paper
• Absence of Sac2/INPP5F enhances the phenotype of a Parkinson’s disease mutation of synaptojanin 1

  2020cites this paper
• Neuronal functions of clathrin-associated endocytic sorting adaptors – from molecules to disease

  2020cites this paper
• Autophagy in Parkinson's disease.

  2020cites this paper