Proglucagon products in plasma of noninsulin-dependent diabetics and nondiabetic controls in the fasting state and after oral glucose and intravenous arginine.

No abstract is available for this paper.

• Publication year

  1991

• Venue

  Journal of Clinical Investigation

• Publication date

  1991-02-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1172/JCI115012PMID 1991827PMCID PMC295092
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Complete sequences of glucagon-like peptide-1 from human and pig small intestine.

  1989cited by this paper
• Glucagonlike Peptide I (7–37) Actions on Endocrine Pancreas

  1989cited by this paper
• Effect of truncated glucagon-like peptide-1 [proglucagon-(78-107) amide] on endocrine secretion from pig pancreas, antrum, and nonantral stomach.

  1988cited by this paper
• Naturally occurring products of proglucagon 111-160 in the porcine and human small intestine.

  1988cited by this paper
• Truncated glucagon‐like peptide I, an insulin‐releasing hormone from the distal gut

  1987cited by this paper
• Pancreatic and intestinal processing of proglucagon in man

  1987cited by this paper
• Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas.

  1987cited by this paper
• Glucagon-like peptide-1 7-36: a physiological incretin in man.

  1987cited by this paper
• Radio-immunoassays for glucagon-like peptides 1 and 2 (GLP-1 and GLP-2).

  1987cited by this paper
• Glucagon-like peptides GLP-1 and GLP-2, predicted products of the glucagon gene, are secreted separately from pig small intestine but not pancreas.

  1986cited by this paper
• Molecular forms of glucagon‐like peptides in man

  1985cited by this paper
• Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus.

  1984cited by this paper
• Conversion of proglucagon in pancreatic alpha cells: the major endproducts are glucagon and a single peptide, the major proglucagon fragment, that contains two glucagon-like sequences.

  1984cited by this paper
• Exon duplication and divergence in the human preproglucagon gene

  1983cited by this paper
• Evidence that enteroglucagon (II) is identical with the C-terminal sequence (residues 33-69) of glicentin.

  1982cited by this paper
• The primary structure of porcine glicentin (proglucagon).

  1981cited by this paper
• Evidence that glicentin contains the entire sequence of glucagon.

  1980cited by this paper
• Immunoreactive glucagon and insulin C-peptide in man after resection of the pancreas and total pancreatectomy.

  1980cited by this paper
• A sensitive, precise radioimmunoassay of serum insulin relying on charcoal separation of bound and free hormone moieties.

  1972cited by this paper
• Radioimmunological determination of pancreatic and gut glucagon in plasma

  1971cited by this paper
• Studies of pancreatic alpha cell function in normal and diabetic subjects.

  1970cited by this paper

• Gut Peptide Alterations in Type 2 Diabetes and Obesity: A Narrative Review

  2026cites this paper
• Empagliflozin improves beta cell function independently of relief of glucotoxicity in patients with type 2 diabetes: results from a randomised cross-over study with insulin as comparator

  2025cites this paper
• Glucose-Dependent Effects of Exogenous Glucagon-Like Peptide-2 on Circulating Glucagon Levels in Healthy Men

  2025cites this paper
• Single incretin receptor knockout mice do not compensate by increasing glucose-stimulated secretion of the remaining incretin hormone.

  2025cites this paper
• Effect of a Meal on Invasive Hemodynamics and Plasma Incretin Levels in Patients With Heart Failure

  2025cites this paper
• Rare MTNR1B variants causing diminished MT2 signalling associate with elevated HbA1c levels but not with type 2 diabetes

  2025cites this paper
• Unravelling the heterogeneity of diabetes in chronic pancreatitis: Alpha and beta cell dysfunction and association with glycaemic control

  2025cites this paper
• Glycemic variability and entero-pancreatic hormones signatures after different bariatric surgery procedures: a cross-sectional study

  2025cites this paper
• The role of empagliflozin-induced metabolic changes for cardiac function in patients with type 2 diabetes. A randomized cross-over magnetic resonance imaging study with insulin as comparator

  2024cites this paper
• Human subjects with impaired beta-cell function and glucose tolerance have higher levels of intra-islet intact GLP-1.

  2024cites this paper
• Leveraging metabolism for better outcomes in heart failure

  2024cites this paper
• Metabolic and Hormonal Responses to Isomaltulose Ingestion Before or During Sustained Submaximal Exercise in Adults with Type 1 Diabetes Using Automated Insulin Delivery Systems

  2024cites this paper
• Regulation of proglucagon derived peptides by carbohydrate and protein ingestion in young healthy males-A randomized, double-blind, cross-over trial.

  2024cites this paper
• Determinants of plasma levels of proglucagon and the metabolic impact of glucagon receptor signalling: a UK Biobank study

  2024cites this paper
• Oral Glucose has Little or no Effect on Appetite and Satiety Sensations Despite a Significant Gastrointestinal Response.

  2023cites this paper
• Are SADI-S and BPD/DS bariatric procedures identical twins or distant relatives? - A case report.

  2023cites this paper
• Weight loss by calorie restriction does not alter appetite‐regulating gut hormone responses from perfused rat small intestine

  2023cites this paper
• No effect of the turmeric root phenol curcumin on prednisolone-induced glucometabolic perturbations in men with overweight or obesity

  2023cites this paper
• The relationship between dietary patterns and glycemic variability in people with impaired glucose tolerance.

  2023cites this paper
• Arginine-induced glucagon secretion and glucagon-induced enhancement of amino acid catabolism are not influenced by ambient glucose levels in mice.

  2022cites this paper
• GLP-1 receptor blockade reduces stimulated insulin secretion in fasted subjects with low circulating GLP-1.

  2022cites this paper
• LEAP2 reduces postprandial glucose excursions and ad libitum food intake in healthy men

  2022cites this paper
• Response of multiple hormones to glucose and arginine challenge in T2DM after gastric bypass

  2022cites this paper
• Glucagon and other proglucagon-derived peptides in the pathogenesis of obesity

  2022cites this paper
• Acute effects on glucose tolerance by neprilysin inhibition in patients with type 2 diabetes

  2022cites this paper
• A randomized, double‐blind, crossover study of the effect of the fluoroquinolone moxifloxacin on glucose levels and insulin sensitivity in young men and women

  2022cites this paper
• Comparable Effects of Sleeve Gastrectomy and Roux-en-Y Gastric Bypass on Basal Fuel Metabolism and Insulin Sensitivity in Individuals with Obesity and Type 2 Diabetes

  2022cites this paper
• Methods paper: Performance characteristics of novel assays for circulating levels of proglucagon-derived peptides and validation in a placebo controlled cross-over randomized clinical trial.

  2022cites this paper
• Circulating levels of five proglucagon-derived peptides in response to intravenous or oral glucose or lipids and to a mixed-meal in subjects with normal weight, overweight, and obesity.

  2022cites this paper
• Neprilysin Inhibition Increases Glucagon Levels in Humans and Mice With Potential Effects on Amino Acid Metabolism

  2021cites this paper
• GLP-1 Val8: A Biased GLP-1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats.

  2021cites this paper
• The effect of 6-day subcutaneous glucose-dependent insulinotropic polypeptide infusion on time in glycaemic range in patients with type 1 diabetes: a randomised, double-blind, placebo-controlled crossover trial

  2021cites this paper
• Glucagon Clearance is Preserved in Type 2 Diabetes.

  2021cites this paper
• Entero-pancreatic hormone secretion, gastric emptying and glucose absorption after frequently sampled meal tests.

  2021cites this paper
• Colonic lactulose fermentation has no impact on glucagon-like peptide-1 and peptide-YY secretion in healthy young men.

  2021cites this paper
• Glucagon's Metabolic Action in Health and Disease.

  2021cites this paper
• Antagonizing somatostatin receptor subtype 2 and 5 reduces blood glucose in a gut- and GLP-1R–dependent manner

  2021cites this paper
• Glucagon receptor signaling is not required for L-carbamoyl glutamate and L-citrulline induced ureagenesis in mice.

  2020cites this paper
• Modelling of dysregulated glucagon secretion in type 2 diabetes by considering mitochondrial alterations in pancreatic α-cells

  2020cites this paper
• Plasma glucagon levels measured by sandwich ELISA are correlated with impaired glucose tolerance in type 2 diabetes.

  2020cites this paper
• Secretin release after Roux-en-Y gastric bypass reveals a population of glucose-sensitive S cells in distal small intestine

  2020cites this paper
• Normal insulin sensitivity, glucose tolerance, gut incretin and pancreatic hormone responses in adults with atopic dermatitis

  2020cites this paper
• Counterregulatory responses to postprandial hypoglycemia after Roux-en-Y gastric bypass.

  2020cites this paper
• Alanine, arginine, cysteine, and proline but not glutamine are substrates for and acute mediators of the liver-alpha cell axis in female mice.

  2020cites this paper
• GIP and GLP-1 Potentiate Sulfonylurea-Induced Insulin Secretion in Hepatocyte Nuclear Factor 1α Mutation Carriers

  2020cites this paper
• A Potential Role for Endogenous Glucagon in Preventing Post-Bariatric Hypoglycemia

  2020cites this paper
• Glucagon-Like Peptide 2 Inhibits Postprandial Gallbladder Emptying in Man: A Randomized, Double-Blinded, Crossover Study

  2020cites this paper
• No direct effect of SGLT2 activity on glucagon secretion

  2020cites this paper
• Relationship between biochemical and symptomatic hypoglycemia after RYGB. Responses to a mixed meal test: a case-control study.

  2020cites this paper
• In the rat pancreas, somatostatin tonically inhibits glucagon secretion and is required for glucose‐induced inhibition of glucagon secretion

  2020cites this paper
• Gain-of-function mutation in the voltage-gated potassium channel gene KCNQ1 and glucose-stimulated hypoinsulinemia - case report

  2020cites this paper
• Paracrine regulation of somatostatin secretion by insulin and glucagon in mouse pancreatic islets

  2020cites this paper
• The effect of acute dual SGLT1/SGLT2 inhibition on incretin release and glucose metabolism after gastric bypass surgery.

  2020cites this paper
• Alanine, arginine, and proline but not glutamine are the feed-back regulators in the liver-alpha cell axis in mice

  2019cites this paper
• Neuromedin U Does Not Act as a Decretin in Rats.

  2019cites this paper
• Mechanism of Glucagon-Like Peptide 1 Improvements in Type 2 Diabetes Mellitus and Obesity

  2019cites this paper
• Fatty Liver Among Adolescent Offspring of Women With Type 1 Diabetes (the EPICOM Study)

  2019cites this paper
• Secretin release after Roux-en-Y Gastric Bypass reveals a population of glucose-sensitive S-cells in distal small intestine

  2019cites this paper
• Peptone‐mediated glucagon‐like peptide‐1 secretion depends on intestinal absorption and activation of basolaterally located Calcium‐Sensing Receptors

  2019cites this paper
• No direct effect of SGLT2 activity on glucagon secretion

  2019cites this paper
• Gluco-metabolic effects of oral and intravenous alcohol administration in men

  2019cites this paper
• Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents.

  2019cites this paper
• Short-chain fatty acids and regulation of pancreatic endocrine secretion in mice

  2019cites this paper
• Immunohistochemical distribution of glucagon‐like peptide 1 in the digestive system of different aquatic vertebrates

  2019cites this paper
• Physiology of the Incretin Hormones, GIP and GLP-1-Regulation of Release and Posttranslational Modifications.

  2019cites this paper
• Gut hormone release after gastric bypass depends on the length of the biliopancreatic limb

  2019cites this paper
• Efficacy of switching from dipeptidyl peptidase-4 inhibitors to dulaglutide in patients with type 2 diabetes

  2019cites this paper
• Effects of nicotinamide riboside on endocrine pancreatic function and incretin hormones in obese, non-diabetic men.

  2019cites this paper
• Acipimox Acutely Increases GLP-1 Concentrations in Overweight Subjects and Hypopituitary Patients.

  2019cites this paper
• Levels of Glucagon-like Peptide 1 are Decreased in Macrosomic Neonates from Non-Diabetic Mothers

  2018cites this paper
• Disruption of glucagon receptor signaling causes hyperaminoacidemia exposing a possible liver-alpha-cell axis.

  2018cites this paper
• Decreased serum glicentin concentration in patients with severe and morbid obesity

  2018cites this paper
• Insulin Secretion Depends on Intra-islet Glucagon Signaling.

  2018cites this paper
• Common variants in the hERG (KCNH2) voltage-gated potassium channel are associated with altered fasting and glucose-stimulated plasma incretin and glucagon responses

  2018cites this paper
• Patterns of Plasma Glucagon Dynamics Do Not Match Metabolic Phenotypes in Young Women

  2018cites this paper
• Starchy foods in the prevention of type 2 diabetes mellitus: Effects of food structure and composition on starch digestibility and the postprandial metabolic response

  2018influential citation
• Comparing olive oil and C4-dietary oil, a prodrug for the GPR119 agonist, 2-oleoyl glycerol, less energy intake of the latter is needed to stimulate incretin hormone secretion in overweight subjects with type 2 diabetes

  2018cites this paper
• Determinants of Fasting Hyperglucagonemia in Patients with Type 2 Diabetes and Nondiabetic Control Subjects

  2018cites this paper
• Acute administration of interleukin‐6 does not increase secretion of glucagon‐like peptide‐1 in mice

  2018cites this paper
• Biliopancreatic diversion with duodenal switch (BPD-DS) and single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) result in distinct post-prandial hormone profiles

  2018cites this paper
• Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas

  2018cites this paper
• Is glucagon‐like peptide‐1 fully protected by the dipeptidyl peptidase 4 inhibitor sitagliptin when administered to patients with type 2 diabetes?

  2018cites this paper
• Mixed Meal and Intravenous L-Arginine Tests Both Stimulate Incretin Release Across Glucose Tolerance in Man: Lack of Correlation with β Cell Function

  2018influential citation
• Patients with Long QT Syndrome Due to Impaired hERG-encoded Kv11.1 Potassium Channel Have Exaggerated Endocrine Pancreatic and Incretin Function Associated with Reactive Hypoglycemia

  2018cites this paper
• Effect of Alloxan-diabetes on the Immunoreactivity of Glicentin-producing L-cells in the Small Intestine of Sprague Dawley Rat

  2017cites this paper
• GIP(3–30)NH2 is a potent competitive antagonist of the GIP receptor and effectively inhibits GIP‐mediated insulin, glucagon, and somatostatin release

  2017cites this paper
• The New Biology and Pharmacology of Glucagon.

  2017cites this paper
• Glucagon and Amino Acids Are Linked in a Mutual Feedback Cycle: The Liver–α-Cell Axis

  2017cites this paper
• Patients with Long QT Syndrome Due to Impaired hERG-encoded Kv11.1 Potassium Channel Have Exaggerated Endocrine Pancreatic and Incretin Function Associated with Reactive Hypoglycemia

  2017cites this paper
• Glucagon-like peptide-1 levels and dipeptidyl peptidase-4 activity in type 2 diabetes.

  2017cites this paper
• Patients with Long QT Syndrome Due to Impaired hERG-encoded Kv11.1 Potassium Channel Have Exaggerated Endocrine Pancreatic and Incretin Function Associated with Reactive Hypoglycemia

  2017cites this paper
• Patients with Long QT Syndrome Due to Impaired hERG-encoded Kv11.1 Potassium Channel Have Exaggerated Endocrine Pancreatic and Incretin Function Associated with Reactive Hypoglycemia

  2017cites this paper
• Insights on glicentin, a promising peptide of the proglucagon family

  2017cites this paper
• Patients With Long-QT Syndrome Caused by Impaired hERG-Encoded Kv11.1 Potassium Channel Have Exaggerated Endocrine Pancreatic and Incretin Function Associated With Reactive Hypoglycemia

  2017cites this paper
• The role of somatostatin in GLP-1-induced inhibition of glucagon secretion in mice

  2017cites this paper
• Comparison of the mixed-meal stimulated gut hormone secretion profile after classical gastric bypass and the long biliopancreatic limb variant.

  2017cites this paper
• GIP(3-30)NH2 is a potent competitive antagonist of the GIP receptor and effectively inhibits GIP-mediated insulin, glucagon, and somatostatin release

  2017cites this paper
• Glucagon-like peptide-1 secreting cell function as well as production of inflammatory reactive oxygen species is differently regulated by glycated serum and high levels of glucose PUDDU

  2017cites this paper
• Postprandial Dyslipidemia: Pathophysiology and Cardiovascular Disease Risk Assessment

  2017cites this paper
• Liraglutide as adjunct to insulin treatment in type 1 diabetes does not interfere with glycaemic recovery or gastric emptying rate during hypoglycaemia: A randomized, placebo‐controlled, double‐blind, parallel‐group study

  2017cites this paper