The Extracellular Matrix Modulates the Metastatic Journey.

The extracellular matrix is perturbed in tumors. The tumor matrix promotes the growth, survival, and invasion of the cancer and modifies fibroblast and immune cell behavior to drive metastasis and impair treatment. Here, we discuss how the tumor matrix regulates metastasis by fostering tumor cell invasion into the stroma and migration toward the vasculature. We describe the role of the tumor matrix in cancer cell intravasation and vascular dissemination. We examine the impact of the matrix on disseminated tumor cell extravasation and on tumor dormancy and metastatic outgrowth. Finally, we discuss the clinical outcome of therapeutics that normalize tumor-matrix interactions.

• Publication year

  2019

• Venue

  Developmental Cell

• Publication date

  2019-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.devcel.2019.03.026PMID 31063753PMCID PMC6527347
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy

  2019cited by this paper
• Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix

  2018cited by this paper
• Dormant tumour cells, their niches and the influence of immunity

  2018cited by this paper
• Acute compressive stress activates RHO/ROCK-mediated cellular processes

  2018cited by this paper
• Mechanical signaling through the discoidin domain receptor 1 plays a central role in tissue fibrosis

  2018cited by this paper
• TGF-β attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

  2018cited by this paper
• Solid Stress Facilitates Fibroblasts Activation to Promote Pancreatic Cancer Cell Migration

  2018cited by this paper
• Cancer and platelet crosstalk: opportunities and challenges for aspirin and other antiplatelet agents.

  2018cited by this paper
• A tension-mediated glycocalyx–integrin feedback loop promotes mesenchymal-like glioblastoma

  2018cited by this paper
• Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms

  2018cited by this paper
• Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization

  2018cited by this paper
• Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases

  2018cited by this paper
• FAK inhibitors in Cancer, a patent review

  2018cited by this paper
• Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice

  2018cited by this paper
• Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix

  2017cited by this paper
• Intravascular Survival and Extravasation of Tumor Cells.

  2017cited by this paper
• Pirfenidone normalizes the tumor microenvironment to improve chemotherapy

  2017cited by this paper
• Platelets reduce anoikis and promote metastasis by activating YAP1 signaling

  2017cited by this paper
• A Phase II Randomized, Double‐Blind, Placebo‐Controlled Study of Simtuzumab or Placebo in Combination with Gemcitabine for the First‐Line Treatment of Pancreatic Adenocarcinoma

  2017cited by this paper
• A Phase II, Randomized, Double‐Blind, Placebo‐Controlled Study of Simtuzumab in Combination with FOLFIRI for the Second‐Line Treatment of Metastatic KRAS Mutant Colorectal Adenocarcinoma

  2017cited by this paper
• Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer

  2017cited by this paper
• α5β1-Integrin promotes tension-dependent mammary epithelial cell invasion by engaging the fibronectin synergy site

  2017cited by this paper
• A conduit to metastasis: circulating tumor cell biology

  2017cited by this paper
• Matrix Stiffness Enhances VEGFR-2 Internalization, Signaling, and Proliferation in Endothelial Cells.

  2017cited by this paper
• A bulky glycocalyx fosters metastasis formation by promoting G1 cell cycle progression

  2017cited by this paper
• Pre-metastatic niches: organ-specific homes for metastases

  2017cited by this paper
• Liver Metastasis Is Facilitated by the Adherence of Circulating Tumor Cells to Vascular Fibronectin Deposits.

  2017cited by this paper
• Lysyl Oxidase-like Protein LOXL2 Promotes Lung Metastasis of Breast Cancer.

  2017cited by this paper
• Tumor Cell Invadopodia: Invasive Protrusions that Orchestrate Metastasis.

  2017cited by this paper
• Syndecans – key regulators of cell signaling and biological functions

  2017cited by this paper
• Model driven optimization of antiangiogenics + cytotoxics combination: application to breast cancer mice treated with bevacizumab + paclitaxel doublet leads to reduced tumor growth and fewer metastasis

  2017cited by this paper
• Endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases

  2017cited by this paper
• ISDoT: in situ decellularization of tissues for high-resolution imaging and proteomic analysis of native extracellular matrix

  2017cited by this paper
• Circulating Tumor Cells: When a Solid Tumor Meets a Fluid Microenvironment.

  2016cited by this paper
• Expression/activation of α5β1 integrin is linked to the β-catenin signaling pathway to drive migration in glioma cells

  2016cited by this paper
• Pirfenidone: Clinical trials and clinical practice in patients with idiopathic pulmonary fibrosis.

  2016cited by this paper
• Tumor Cell-Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression.

  2016cited by this paper
• Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular-fibrosis and tumor progression

  2016cited by this paper
• Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease.

  2016cited by this paper
• Strain Stiffening of Fibrillar Collagen during Individual and Collective Cell Migration Identified by AFM Nanoindentation.

  2016cited by this paper
• Vessel co-option mediates resistance to anti-angiogenic therapy in liver metastases

  2016cited by this paper
• Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer

  2016cited by this paper
• Physical and Chemical Gradients in the Tumor Microenvironment Regulate Tumor Cell Invasion, Migration, and Metastasis.

  2016cited by this paper
• Simvastatin Ameliorates Matrix Stiffness-Mediated Endothelial Monolayer Disruption

  2016cited by this paper
• Periostin promotes immunosuppressive premetastatic niche formation to facilitate breast tumour metastasis

  2016cited by this paper
• Targeting Focal Adhesion Kinase Renders Pancreatic Cancers Responsive to Checkpoint Immunotherapy

  2016cited by this paper
• Matrix-bound nanovesicles within ECM bioscaffolds

  2016cited by this paper
• Phase Ib Study of PEGylated Recombinant Human Hyaluronidase and Gemcitabine in Patients with Advanced Pancreatic Cancer

  2016cited by this paper
• Oriented collagen fibers direct tumor cell intravasation

  2016cited by this paper
• Integrin-mediated mechanotransduction

  2016cited by this paper
• Matrix stiffening promotes a tumor vasculature phenotype

  2016cited by this paper
• Discoidin Domain Receptors: Potential Actors and Targets in Cancer

  2016cited by this paper
• Multi-organ Site Metastatic Reactivation Mediated by Non-canonical Discoidin Domain Receptor 1 Signaling.

  2016cited by this paper
• Matrix stiffness drives Epithelial-Mesenchymal Transition and tumour metastasis through a TWIST1-G3BP2 mechanotransduction pathway

  2015cited by this paper
• The Where, When, How, and Why of Hyaluronan Binding by Immune Cells

  2015cited by this paper
• Mechanical induction of the tumorigenic β-catenin pathway by tumour growth pressure

  2015cited by this paper
• Targeting the TGFβ pathway for cancer therapy.

  2015cited by this paper
• Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA.

  2015cited by this paper
• Tenascin-C: Exploitation and collateral damage in cancer management

  2015influential reference
• A 3D tension bioreactor platform to study the interplay between ECM stiffness and tumor phenotype.

  2015cited by this paper
• Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration.

  2015cited by this paper
• Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

  2015cited by this paper
• The αvβ1 integrin plays a critical in vivo role in tissue fibrosis

  2015cited by this paper
• Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy

  2015cited by this paper
• The role of mechanical forces in tumor growth and therapy.

  2014cited by this paper
• The cancer glycocalyx mechanically primes integrin-mediated growth and survival

  2014cited by this paper
• The extracellular matrix modulates the hallmarks of cancer

  2014cited by this paper
• Actomyosin-dependent formation of the mechanosensitive talin–vinculin complex reinforces actin anchoring

  2014cited by this paper
• Extracellular Matrix Modulates Angiogenesis in Physiological and Pathological Conditions

  2014cited by this paper
• Mechanisms of disseminated cancer cell dormancy: an awakening field

  2014cited by this paper
• Is there new hope for therapeutic matrix metalloproteinase inhibition?

  2014cited by this paper
• Extracellular matrix assembly: a multiscale deconstruction

  2014cited by this paper
• Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels

  2013cited by this paper
• The perivascular niche regulates breast tumor dormancy

  2013cited by this paper
• Procollagen Lysyl Hydroxylase 2 Is Essential for Hypoxia-Induced Breast Cancer Metastasis

  2013cited by this paper
• The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis

  2013cited by this paper
• Mammary epithelial cell interactions with fibronectin stimulate epithelial-mesenchymal transition

  2013cited by this paper
• Tuning three-dimensional collagen matrix stiffness independently of collagen concentration modulates endothelial cell behavior.

  2013cited by this paper
• Pancreatic stellate cells promote hapto-migration of cancer cells through collagen I-mediated signalling pathway

  2013cited by this paper
• Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force

  2013cited by this paper
• N-WASP-mediated invadopodium formation is involved in intravasation and lung metastasis of mammary tumors

  2012cited by this paper
• RNA sequencing of pancreatic circulating tumour cells implicates WNT signaling in metastasis

  2012cited by this paper
• Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma.

  2012cited by this paper
• Integrins as therapeutic targets.

  2012cited by this paper
• Molecular Pathways Molecular Pathways : Targeting the TGF-b Pathway for Cancer Therapy

  2012cited by this paper
• Vascular normalization as a therapeutic strategy for malignant and nonmalignant disease.

  2012cited by this paper
• TGF-β blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma

  2012cited by this paper
• Molecular Characterization of Circulating Tumor Cells in Human Metastatic Colorectal Cancer

  2012cited by this paper
• Matrix rigidity regulates a switch between TGF-β1–induced apoptosis and epithelial–mesenchymal transition

  2012cited by this paper
• Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials.

  2012cited by this paper
• Aligned collagen is a prognostic signature for survival in human breast carcinoma.

  2011cited by this paper
• From 3D cell culture to organs-on-chips.

  2011cited by this paper
• Abstract 423: Decipher the molecular mechanisms by which syndecan-1 in breast cancer stroma fibroblasts regulates extracellular matrix fiber organization and carcinoma cell motility

  2011cited by this paper
• Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors

  2011cited by this paper
• Integrin Signaling, Cell Survival, and Anoikis: Distinctions, Differences, and Differentiation

  2011cited by this paper
• Mechanical compression drives cancer cells toward invasive phenotype

  2011cited by this paper
• Plasma fibronectin promotes lung metastasis by contributions to fibrin clots and tumor cell invasion.

  2010cited by this paper
• LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling

  2010cited by this paper
• Promising human brain tumors therapy with interference RNA intervention (iRNAi)

  2010cited by this paper
• Dynamic interplay between the collagen scaffold and tumor evolution.

  2010cited by this paper

• Combining Spatial Transcriptomics and Machine Learning Unravels Fibroblast-Related Biomarkers in Ulcerative Colitis

  2026cites this paper
• FGF-23 facilitates osteosarcoma metastasis by modulating the miR-4463/LOXL2 axis expression via the ERK, p38, and JNK signaling pathway

  2026cites this paper
• Tumor-Associated Neutrophils and Desmoplastic Reaction in Breast Cancer Microenvironment: Association with Tumor Grade and Clinicopathological Features

  2026influential citation
• Targeting Lipid Metabolism in CAFs: A Therapeutic Opportunity in Solid Tumors.

  2026cites this paper
• Identification of Basement Membrane-Related Biomarkers in the Progression of Cutaneous Squamous Cell Carcinoma

  2026cites this paper
• m6A epitranscriptomic regulation of KRAS by METTL3 promotes EMT and stromal remodeling through TGF-β/SMAD signaling in cervical cancer

  2026cites this paper
• RNA-Seq analysis reveals regulatory networks driven by EpCAM overexpression in esophageal adenocarcinoma cells.

  2026cites this paper
• Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

  2026cites this paper
• Dysregulation of Extracellular Matrix Genes Identifies Neuroblastoma Patients at High Risk of Recurrence and Poor Outcome.

  2026cites this paper
• Microenvironment plays a critical role in modulating tumor cell dormancy: Current perspectives and potential treatment options

  2026cites this paper
• Design of hierarchical micro/nanofibrous silk bioscaffold for regulating stem cell differentiation

  2026cites this paper
• Src promotes tumor cell invasion by hijacking the translation machineries.

  2026cites this paper
• Effect of mechanical relaxation of 3D-printed collagen-based extracellular matrix on behavior of neural cell.

  2026cites this paper
• From mechanosensing to immune regulation: mechanisms of acupuncture signal initiation and amplification mediated by macrophages.

  2026cites this paper
• Cellulose microfiber-mediated mesoscale architecture promotes the expansion of patient-derived lung cancer organoids while preserving their malignant characteristics.

  2025cites this paper
• Tumor secretome shapes the immune landscape during cancer progression

  2025cites this paper
• Macromolecular Crowding for Reparative Medicine and Drug Discovery Applications.

  2025cites this paper
• Integrins as Key Mediators of Metastasis

  2025cites this paper
• Timp2 loss-of-function mutation and TIMP2 treatment in a murine model of NSCLC: Modulation of immunosuppression and oncogenic signaling

  2025cites this paper
• Seryl‐tRNA synthetase inhibits Wnt signaling and breast cancer progression and metastasis

  2025cites this paper
• In Silico and In Vitro Evaluation of δ-cadinene from Decatropis bicolor as a Selective Inhibitor of Human Cell Adhesion and Invasion Proteins

  2025cites this paper
• Quantitative Histopathology Analysis Based on Label-free Multiphoton Imaging for Breast Cancer Diagnosis and Neoadjuvant Immunotherapy Response Assessment

  2025cites this paper
• A fetal oncogene NUAK2 is an emerging therapeutic target in glioblastoma

  2025cites this paper
• A stumbling block in pancreatic cancer treatment: drug resistance signaling networks

  2025cites this paper
• The underlying difference of metastatic and non-metastatic breast cancer cells in configuring type I collagen fibres to promote migration by cell mechanics

  2025cites this paper
• The effects of autophagy-modifying drugs chloroquine and lithium on the skin melanoma microenvironment.

  2025cites this paper
• Therapeutic potential of inhibitors of gelatinases MMP-2 and MMP-9 for the treatment of breast cancer.

  2025cites this paper
• RUNX1 promotes pathological retinal angiogenesis through von Willebrand factor.

  2025cites this paper
• Matrix deformation and mechanotransduction as markers of breast cancer cell phenotype alteration at matrix interfaces.

  2025cites this paper
• Statins as Secondary Preventive Agent to Limit Breast Cancer Metastatic Outgrowth

  2025cites this paper
• Hedyotis diffusa Willd. inhibits pulmonary metastasis of cancer through suppression of Src/FAK signaling.

  2025cites this paper
• Extracellular matrix and immune dysfunction: An overlooked relationship in idiopathic pulmonary fibrosis

  2025cites this paper
• Sequentially unlockable prodrug nanoparticles enable spatiotemporal coordination of chemotherapy and tumor microenvironment regulation for metastasis prevention in breast cancer.

  2025cites this paper
• ALCAM-CD6 axis suppression: a key determinant of immune-mediated metastasis recurrence in stage III non-small cell lung cancer

  2025cites this paper
• Collagenase-mediated extracellular matrix targeting for enhanced drug penetration and therapeutic efficacy in nanoscale delivery systems for cancer therapy

  2025cites this paper
• Exosomes are specialized vehicles to induce fibronectin assembly

  2025cites this paper
• Metastatic breast cancer cells adapt to a soft environment with limited involvement of mechanotransduction.

  2025cites this paper
• Cancer progression through the lens of age-induced metabolic reprogramming

  2025cites this paper
• Extracellular matrix reorganization during endometrial decidualization

  2025cites this paper
• Sp1 mechanotransduction regulates breast cancer cell invasion in engineered viscoelastic extracellular matrices.

  2025cites this paper
• In-depth proteomic profiling of the extracellular matrix of pancreatic ductal adenocarcinomas identifies signatures correlating with lymphocyte infiltration

  2025cites this paper
• Extracellular matrix dysregulation in aging, calcification, and cancer diseases: insights into cellular senescence, inflammation, and novel therapeutic strategies

  2025cites this paper
• Modeling the metastatic tumor microenvironment: a co-culture platform of lung cancer and blood vessel organoids for drug evaluation

  2025cites this paper
• Organotropic metastasis in colorectal cancer: integrating molecular pathways with therapeutic opportunities

  2025cites this paper
• Fibrotic Fortresses and Therapeutic Frontiers: Pancreatic Stellate Cells and the Extracellular Matrix in Pancreatic Cancer

  2025cites this paper
• Mechanoimmunological Control of Metastatic Site Selection

  2025cites this paper
• Jagged1 regulates extracellular matrix deposition and remodeling in triple-negative breast cancer

  2025cites this paper
• A Review of Talin- and Integrin-Dependent Molecular Mechanisms in Cancer Invasion and Metastasis

  2025cites this paper
• Identification of CENPM as a key gene driving adrenocortical carcinoma metastasis via physical interaction with immune checkpoint ligand FGL1

  2025cites this paper
• Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition

  2025cites this paper
• Mollusk Shell-Derived Chitin-Enhanced Hydrogel Scaffolds with Dual-Cross-Linking Biomimetic Networks for Phenotype-Stable Cartilage Regeneration

  2025cites this paper
• Combining spatial transcriptomics and ECM imaging in 3D for mapping cellular interactions in the tumor microenvironment.

  2025cites this paper
• Integrin-TGFβ axis induces partial EMT in basal-like cells to lead collective invasion

  2025cites this paper
• Electrochemical Immunosensing of The Neo‐Antigen Collagen Type I α 1 to Assist in the Personalized Management of Advanced Colorectal Cancer

  2025cites this paper
• dia-PASEF Proteomics of Tumor and Stroma LMD Enriched from Archived HNSCC Samples

  2025cites this paper
• Focal adhesion in the tumour metastasis: from molecular mechanisms to therapeutic targets

  2025cites this paper
• Molecular Resonance Quantification and Label‐Free Interactome Characterization of Total Proteome of Tumor Specimens Decipher Responder and Success Predictors in Colorectal Cancer Patients Treated With Panitumumab

  2025cites this paper
• The molecular and immune microenvironmental landscape of brain metastases: Implications for novel treatment options

  2025cites this paper
• The extracellular matrix protein type I collagen and fibronectin are regulated by β-arrestin-1/endothelin axis in human ovarian fibroblasts

  2025cites this paper
• Dynamic cell patterning and photopolymerization with electric field modulation for constructing hierarchical tumor microenvironments.

  2025cites this paper
• Risk factors and management of lung cancer in idiopathic pulmonary fibrosis: A comprehensive review

  2025influential citation
• Strain-stiffening universality in composite hydrogels and soft tissues

  2025cites this paper
• Emerging strategies and translational advancements of DDR1 in oncology

  2025cites this paper
• Tissue mechanics in tumor heterogeneity and aggression

  2025cites this paper
• Asporin increases the extracellular matrix cross-links and inhibits the cancer cell migration

  2025cites this paper
• Tissue-Informed Biomaterial Innovations Advance Pulmonary Regenerative Engineering.

  2025cites this paper
• 3D vascularized microtumors unveil aberrant ccRCC vasculature and differential sensitivity to targeted treatments

  2025cites this paper
• Extracellular Fibronectin and Hyaluronic Acid Effects on Tumorigenic Functions of Triple-Negative Breast Cancer Cells.

  2025cites this paper
• Optical Phenotyping Using Label-Free Microscopy and Deep Learning

  2025cites this paper
• The impact of compression and confinement in tumor growth and progression: emerging concepts in cancer mechanobiology

  2025cites this paper
• Renal oncocytoma with liver metastasis: a case report with genetic analysis and literature review

  2025cites this paper
• In vitro 3D modeling of colorectal cancer: the pivotal role of the extracellular matrix, stroma and immune modulation

  2025cites this paper
• Alternative Splicing of FBLN2 Generates a Prometastatic Extracellular Matrix in Gastrointestinal Cancers by Determining N‐Glycosylation of Fibulin 2

  2025cites this paper
• Interactions between microbiota and innate immunity in tumor microenvironment: Novel insights into cancer progression and immunotherapy

  2025cites this paper
• Lymphatic Metastasis of Esophageal Squamous Cell Carcinoma: The Role of NRF2 and Therapeutic Strategies

  2025cites this paper
• Spatiotemporal dynamics of the pre-metastatic niche: remodeling of lung microenvironment before breast cancer metastasis and targeted intervention strategies.

  2025cites this paper
• Acquired resistance to immunotherapy by physical barriers with cancer cell–expressing collagens in non–small cell lung cancer

  2025cites this paper
• Tuning collagen nonlinear mechanics with interpenetrating networks drives adaptive cellular phenotypes in three dimensions

  2025cites this paper
• Challenges and opportunities for new intraoperative optical techniques in the surgical treatment of pituitary adenomas: a review

  2025cites this paper
• Tuning non-linear mechanics in collagen hydrogels modulates cellular morphotypes in three dimensions

  2024cites this paper
• Mapping functional to morphological variation reveals the basis of regional extracellular matrix subversion and nerve invasion in pancreatic cancer.

  2024cites this paper
• Unravelling the CXCL12/CXCR4 Axis in breast cancer: Insights into metastasis, microenvironment interactions, and therapeutic opportunities

  2024cites this paper
• Histoplasty Modification of the Tumor Microenvironment in a Murine Preclinical Model of Breast Cancer.

  2024cites this paper
• MCOLN1/TRPML1 in the lysosome: a promising target for autophagy modulation in diverse diseases

  2024cites this paper
• Cross-talk between disulfidptosis and immune check point genes defines the tumor microenvironment for the prediction of prognosis and immunotherapies in glioblastoma

  2024cites this paper
• Proteomic profiling of tumour tissue‐derived extracellular vesicles in colon cancer

  2024cites this paper
• The role of liver cancer stem cells in hepatocellular carcinoma metastasis

  2024cites this paper
• Forces at play: exploring factors affecting the cancer metastasis

  2024cites this paper
• Understanding the glioblastoma tumor microenvironment: leveraging the extracellular matrix to increase immunotherapy efficacy

  2024cites this paper
• Breast Tumor Metastasis and Its Microenvironment: It Takes Both Seed and Soil to Grow a Tumor and Target It for Treatment

  2024cites this paper
• M2-Type Macrophages and Cancer-Associated Fibroblasts Combine to Promote Colorectal Cancer Liver Metastases

  2024cites this paper
• Adhesion, metastasis, and inhibition of cancer cells: a comprehensive review

  2024influential citation
• Angiogenesis is promoted by hypoxic cervical carcinoma-derived extracellular vesicles depending on the endothelial cell environment.

  2024cites this paper
• Unexpected softening of a fibrous matrix by contracting inclusions.

  2024cites this paper
• Hydrophobic surface induced pro-metastatic cancer cells for in vitro extravasation models

  2024cites this paper
• Integrinβ-1 in disorders and cancers: molecular mechanisms and therapeutic targets

  2024cites this paper
• Basement membranes in lung metastasis growth and progression.

  2024cites this paper
• Hypoxia‐induced translation of collagen‐modifying enzymes PLOD2 and P4HA1 is dependent on RBM4 and eIF4E2 in human colon cancer HCT116 cells

  2024cites this paper
• High levels of fibrotic tumor components are associated with recurrence and intratumoral immune status in advanced colorectal cancer patients

  2024cites this paper
• Biophysical and biochemical aspects of immune cell–tumor microenvironment interactions

  2024cites this paper