Single-molecule imaging brings Rad51 nucleoprotein filaments into focus.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Trends in Cell Biology

• Publication date

  2010-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.tcb.2010.02.004PMID 20299221PMCID PMC2862779
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Visualizing protein-DNA interactions at the single-molecule level.

  2010cited by this paper
• Watching individual proteins acting on single molecules of DNA.

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• Visualizing the disassembly of S. cerevisiae Rad51 nucleoprotein filaments.

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• Dynamics of RecA filaments on single-stranded DNA

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• BRCA2: Shining light on the regulation of DNA-binding selectivity by RAD51

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• The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51.

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• Single Molecule Analysis of a Red Fluorescent RecA Protein Reveals a Defect in Nucleoprotein Filament Nucleation That Relates to Its Reduced Biological Functions*

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• Counting RAD51 proteins disassembling from nucleoprotein filaments under tension

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  2008cited by this paper
• Homology-driven chromatin remodeling by human RAD54

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• A DNA-translocating Snf2 molecular motor: Saccharomyces cerevisiae Rdh54 displays processive translocation and extrudes DNA loops.

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• Fluorescent human RAD51 reveals multiple nucleation sites and filament segments tightly associated along a single DNA molecule.

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• Recombination Mediator and Rad51 Targeting Activities of a Human BRCA2 Polypeptide*

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• Dissecting elastic heterogeneity along DNA molecules coated partly with Rad51 using concurrent fluorescence microscopy and optical tweezers.

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• Mechanism of RecA‐mediated homologous recombination revisited by single molecule nanomanipulation

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• Roles of ATP binding and ATP hydrolysis in human Rad51 recombinase function.

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• A Molecular Throttle : The Recombination Hotspot Controls DNA Translocation by the RecBCD Helicase 1993 )

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  2001cited by this paper
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• Some assembly required

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