BDNF DNA methylation changes as a biomarker of psychiatric disorders: literature review and open access database analysis

Brain-derived neurotrophic factor (BDNF) plays an important role in nervous system development and function and it is well established that BDNF is involved in the pathogenesis of a wide range of psychiatric disorders. Recently, numerous studies have associated the DNA methylation level of BDNF promoters with certain psychiatric phenotypes. In this review, we summarize data from current literature as well as from our own analysis with respect to the correlation of BDNF methylation changes with psychiatric disorders and address questions about whether DNA methylation related to the BDNF can be useful as biomarker for specific neuropsychiatric disorders.

• Publication year

  2016

• Venue

  Behavioral and Brain Functions

• Publication date

  2016-06-06

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1186/s12993-016-0101-4PMID 27267954PMCID 4895990
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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