Epigenetic regulation of neural stem cell property from embryo to adult

Abstract Neural stem cells (NSCs) have the ability to self-renew and give rise to neurons and glial cells (astrocytes and oligodendrocytes) in the mammalian central nervous system. This multipotency is acquired by NSCs during development and is maintained throughout life. Proliferation, fate specification, and maturation of NSCs are regulated by both cell intrinsic and extrinsic factors. Epigenetic modification is a representative intrinsic factor, being involved in many biological aspects of central nervous system development and adult neurogenesis through the regulation of NSC dynamics. In this review, we summarize recent progress in the epigenetic regulation of NSC behavior in the embryonic and adult brain, with particular reference to DNA methylation, histone modification, and noncoding RNAs.

• Publication year

  2016

• Venue

  Neuroepigenetics

• Publication date

  2016-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.NEPIG.2016.01.001
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Genome-editing tools for stem cell biology

  2015cited by this paper
• Expression of DNMT1 in neural stem/precursor cells is critical for survival of newly generated neurons in the adult hippocampus.

  2015cited by this paper
• TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus

  2015cited by this paper
• Olig1 Function Is Required for Oligodendrocyte Differentiation in the Mouse Brain

  2015cited by this paper
• MicroRNA-153 Regulates the Acquisition of Gliogenic Competence by Neural Stem Cells

  2015cited by this paper
• Rett syndrome: a complex disorder with simple roots

  2015cited by this paper
• Tangential migration of neuronal precursors of glutamatergic neurons in the adult mammalian brain

  2015cited by this paper
• Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later.

  2015cited by this paper
• The long noncoding RNA Pnky regulates neuronal differentiation of embryonic and postnatal neural stem cells.

  2015cited by this paper
• Targeting Polycomb systems to regulate gene expression: modifications to a complex story

  2015cited by this paper
• Functional annotation of native enhancers with a Cas9 -histone demethylase fusion

  2015cited by this paper
• SOX2 primes the epigenetic landscape in neural precursors enabling proper gene activation during hippocampal neurogenesis

  2015cited by this paper
• Ngn1 inhibits astrogliogenesis through induction of miR-9 during neuronal fate specification

  2015cited by this paper
• Functions and dysfunctions of adult hippocampal neurogenesis.

  2014cited by this paper
• Activation of neuronal gene expression by the JMJD3 demethylase is required for postnatal and adult brain neurogenesis.

  2014cited by this paper
• The new frontier of genome engineering with CRISPR-Cas9

  2014cited by this paper
• Characterization of Np95 expression in mouse brain from embryo to adult: A novel marker for proliferating neural stem/precursor cells

  2014cited by this paper
• Development and applications of CRISPR-Cas9 for genome engineering.

  2014cited by this paper
• Transient accumulation of 5-carboxylcytosine indicates involvement of active demethylation in lineage specification of neural stem cells.

  2014cited by this paper
• Histone core modifications regulating nucleosome structure and dynamics

  2014cited by this paper
• The polycomb component Ring1B regulates the timed termination of subcerebral projection neuron production during mouse neocortical development

  2014cited by this paper
• The miR-17/106–p38 axis is a key regulator of the neurogenic-to-gliogenic transition in developing neural stem/progenitor cells

  2014cited by this paper
• Tet1 regulates adult hippocampal neurogenesis and cognition.

  2013cited by this paper
• Integration of genome-wide approaches identifies lncRNAs of adult neural stem cells and their progeny in vivo.

  2013cited by this paper
• Dynamics of 5-hydroxymethylcytosine and chromatin marks in Mammalian neurogenesis.

  2013cited by this paper
• Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons.

  2013cited by this paper
• TET enzymes, TDG and the dynamics of DNA demethylation

  2013cited by this paper
• Prenatal exposure to suberoylanilide hydroxamic acid perturbs corticogenesis.

  2013cited by this paper
• The long noncoding RNA RMST interacts with SOX2 to regulate neurogenesis.

  2013cited by this paper
• Molecular logic of neocortical projection neuron specification, development and diversity

  2013cited by this paper
• Locus-specific editing of histone modifications at endogenous enhancers using programmable TALE-LSD1 fusions

  2013cited by this paper
• TETonic shift: biological roles of TET proteins in DNA demethylation and transcription

  2013cited by this paper
• Mechanisms of astrocytogenesis in the mammalian brain.

  2013cited by this paper
• Crosstalk among Epigenetic Pathways Regulates Neurogenesis

  2012cited by this paper
• Adult neural stem cells bridge their niche.

  2012cited by this paper
• MicroRNA-146a: A Key Regulator of Astrocyte-Mediated Inflammatory Response

  2012cited by this paper
• Treatment of a Mouse Model of Spinal Cord Injury by Transplantation of Human Induced Pluripotent Stem Cell‐Derived Long‐Term Self‐Renewing Neuroepithelial‐Like Stem Cells

  2012cited by this paper
• Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA

  2012cited by this paper
• An Overview of Brain-Derived Neurotrophic Factor and Implications for Excitotoxic Vulnerability in the Hippocampus

  2011cited by this paper
• Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

  2011cited by this paper
• Epigenetic regulation of neurogenesis in the adult mammalian brain

  2011cited by this paper
• Human long non‐coding RNAs promote pluripotency and neuronal differentiation by association with chromatin modifiers and transcription factors

  2011cited by this paper
• Adult neurogenesis in the mammalian brain: significant answers and significant questions.

  2011cited by this paper
• Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells

  2011cited by this paper
• Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine

  2011cited by this paper
• miR-137 forms a regulatory loop with nuclear receptor TLX and LSD1 in neural stem cells.

  2011cited by this paper
• Functional integration of dopaminergic neurons directly converted from mouse fibroblasts.

  2011cited by this paper
• Dnmt3a-Dependent Nonpromoter DNA Methylation Facilitates Transcription of Neurogenic Genes

  2010cited by this paper
• Wnts Influence the Timing and Efficiency of Oligodendrocyte Precursor Cell Generation in the Telencephalon

  2010cited by this paper
• MicroRNA miR‐137 Regulates Neuronal Maturation by Targeting Ubiquitin Ligase Mind Bomb‐1

  2010cited by this paper
• Chromatin structure and the inheritance of epigenetic information

  2010cited by this paper
• Epigenetics, hippocampal neurogenesis, and neuropsychiatric disorders: unraveling the genome to understand the mind.

  2010cited by this paper
• Epigenetic regulation of miR-184 by MBD1 governs neural stem cell proliferation and differentiation.

  2010cited by this paper
• The specific role of histone deacetylase 2 in adult neurogenesis.

  2010cited by this paper
• Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex

  2010cited by this paper
• Cross talk between microRNA and epigenetic regulation in adult neurogenesis

  2010cited by this paper
• Active DNA demethylation: many roads lead to Rome

  2010cited by this paper
• Neurons derived from transplanted neural stem cells restore disrupted neuronal circuitry in a mouse model of spinal cord injury.

  2010cited by this paper
• Histone Demethylase LSD1 Regulates Neural Stem Cell Proliferation

  2010cited by this paper
• HDAC1 and HDAC2 Regulate Oligodendrocyte Differentiation By Disrupting β-Catenin-TCF Interaction

  2009cited by this paper
• The glial nature of embryonic and adult neural stem cells.

  2009cited by this paper
• Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition.

  2009cited by this paper
• miR-124 regulates adult neurogenesis in the SVZ stem cell niche

  2009cited by this paper
• Neuronal Activity–Induced Gadd45b Promotes Epigenetic DNA Demethylation and Adult Neurogenesis

  2009cited by this paper
• Committed neuronal precursors confer astrocytic potential on residual neural precursor cells.

  2009cited by this paper
• Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells

  2009cited by this paper
• Adult neural stem cells in the mammalian central nervous system

  2009cited by this paper
• TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment.

  2008cited by this paper
• Development of neural stem cell in the adult brain.

  2008cited by this paper
• From synapse to nucleus: calcium-dependent gene transcription in the control of synapse development and function.

  2008cited by this paper
• Epigenetic inheritance of cell differentiation status

  2008cited by this paper
• Epigenetic Regulation of the Stem Cell Mitogen Fgf-2 by Mbd1 in Adult Neural Stem/Progenitor Cells*

  2008cited by this paper
• EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency.

  2008cited by this paper
• Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation.

  2008cited by this paper
• Requirement for COUP-TFI and II in the temporal specification of neural stem cells in CNS development

  2008cited by this paper
• The mammalian epigenome.

  2007cited by this paper
• Neuronal subtype specification in the cerebral cortex

  2007cited by this paper
• Seizure-Associated, Aberrant Neurogenesis in Adult Rats Characterized with Retrovirus-Mediated Cell Labeling

  2007cited by this paper
• The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA

  2007cited by this paper
• SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron

  2007cited by this paper
• Epigenetic Modulation of Seizure-Induced Neurogenesis and Cognitive Decline

  2007cited by this paper
• Induction of oligodendrocyte differentiation by Olig2 and Sox10: evidence for reciprocal interactions and dosage-dependent mechanisms.

  2007cited by this paper
• Mecp2 deficiency leads to delayed maturation and altered gene expression in hippocampal neurons.

  2007cited by this paper
• The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development.

  2007cited by this paper
• The transcription factor Yin Yang 1 is essential for oligodendrocyte progenitor differentiation.

  2007cited by this paper
• Timing Is Everything: Making Neurons versus Glia in the Developing Cortex

  2007cited by this paper
• The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing.

  2007cited by this paper
• Multivalent engagement of chromatin modifications by linked binding modules

  2007cited by this paper
• Polycomb/Trithorax response elements and epigenetic memory of cell identity

  2007cited by this paper
• UHRF1 Plays a Role in Maintaining DNA Methylation in Mammalian Cells

  2007cited by this paper
• Chromatin modifications and their function.

  2007cited by this paper
• Adult neurogenesis and functional plasticity in neuronal circuits

  2006cited by this paper
• Neuronal production and precursor proliferation defects in the neocortex of mice with loss of function in the canonical Wnt signaling pathway.

  2006cited by this paper
• Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation.

  2006cited by this paper
• A positive autoregulatory loop of Jak-STAT signaling controls the onset of astrogliogenesis

  2005cited by this paper
• Jagged1 signals in the postnatal subventricular zone are required for neural stem cell self‐renewal

  2005cited by this paper
• Regulation of miRNA expression during neural cell specification

  2005cited by this paper
• Seizures induce proliferation and dispersion of doublecortin-positive hippocampal progenitor cells.

  2005cited by this paper
• Transplantation of human neural stem cells for spinal cord injury in primates

  2005cited by this paper
• Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex.

  2005cited by this paper

• Decoding the modulatory role of long non-coding RNAs in embryogenesis: a comprehensive review

  2026cites this paper
• Epigenetic changes and neurogenesis associated with socio-sexual behaviors.

  2025cites this paper
• EZH2 Upregulates Notch Signaling Pathway Genes and Increases Cell Migration in Gastric Cancers

  2024cites this paper
• The Derlin-1-Stat5b axis maintains homeostasis of adult hippocampal neurogenesis

  2024cites this paper
• The Epigenetic Regulation of Quiescent in Stem Cells

  2023cites this paper
• Homeostatic Regulation of Seizure Susceptibility and Cognitive Function by Derlin-1 through Maintenance of Adult Neurogenesis

  2023cites this paper
• The role of histone modifications: from neurodevelopment to neurodiseases

  2022cites this paper
• NXN Gene Epigenetic Changes in an Adult Neurogenesis Model of Alzheimer’s Disease

  2022cites this paper
• Embryonic Stem Cells Lacking DNA Methyltransferases Differentiate into Neural Stem Cells that Are Defective in Self-Renewal

  2022cites this paper
• Genome‐wide variation in DNA methylation linked to developmental stage and chromosomal suppression of recombination in white‐throated sparrows

  2021cites this paper
• The Strange Case of Jekyll and Hyde: Parallels Between Neural Stem Cells and Glioblastoma-Initiating Cells

  2021cites this paper
• Glia-Driven Brain Circuit Refinement Is Altered by Early-Life Adversity: Behavioral Outcomes

  2021cites this paper
• Oligodendroglial Epigenetics, from Lineage Specification to Activity-Dependent Myelination

  2021cites this paper
• Histone Lysine Demethylase JMJD2D/KDM4D and Family Members Mediate Effects of Chronic Social Defeat Stress on Mouse Hippocampal Neurogenesis and Mood Disorders

  2020cites this paper
• Genome-wide variation in DNA methylation linked to developmental stage and chromosomal suppression of recombination in white-throated sparrows

  2020cites this paper
• The Epigenetic Progenitor Origin of Cancer Reassessed: DNA Methylation Brings Balance to the Stem Force

  2020cites this paper
• Twin Loss in the Uterus: Neurodevelopmental Impairment and Reduced Resilience?

  2019cites this paper
• Transcriptional and epigenetic mechanisms underlying astrocyte identity

  2019cites this paper
• Decoding epigenetic cell signaling in neuronal differentiation.

  2019cites this paper
• Neural stem cells: origin, heterogeneity and regulation in the adult mammalian brain

  2019cites this paper
• Identification of the Molecular Events Involved in the Development of Prefrontal Cortex Through the Analysis of RNA-Seq Data From BrainSpan

  2019cites this paper
• Characterization of a Mouse Model of Börjeson-Forssman-Lehmann Syndrome

  2019cites this paper
• Exploring the Potential Role of Rosmarinic Acid in Neuronal Differentiation of Human Amnion Epithelial Cells by Microarray Gene Expression Profiling

  2019cites this paper
• Chronic Ethanol Exposure Alters DNA Methylation in Neural Stem Cells: Role of Mouse Strain and Sex

  2019cites this paper
• A review of epigenetics in human consciousness

  2019cites this paper
• Np95/Uhrf1 regulates tumor suppressor gene expression of neural stem/precursor cells, contributing to neurogenesis in the adult mouse brain.

  2019cites this paper
• Transcriptional and Epigenetic Control of Mammalian Olfactory Epithelium Development

  2018cites this paper
• Development and disease in a dish: the epigenetics of neurodevelopmental disorders.

  2018cites this paper
• NEUROEPIGENETICS IN METHODOLOGY AND TECHNOLOGICAL PLATFORM OF MENTAL MEDICINE

  2018cites this paper
• Assisted Reproductive Technology: Stress-Related Epigenetic and Neurodevelopmental Risk?

  2018cites this paper
• MicroRNAs Engage in Complex Circuits Regulating Adult Neurogenesis

  2018influential citation
• Nanopatterned Scaffolds for Neural Tissue Engineering and Regenerative Medicine.

  2018cites this paper
• Apolipoprotein E region molecular signatures of Alzheimer's disease

  2018cites this paper
• Neurodevelopmental alterations in a mouse model of maternal immune activation

  2018cites this paper
• The aPKC-CBP Pathway Regulates Post-stroke Neurovascular Remodeling and Functional Recovery

  2017cites this paper
• Role of the unfolded protein response in the development of central nervous system

  2017cites this paper
• Prenatal deletion of DNA methyltransferase 1 in neural stem cells impairs neurogenesis and causes anxiety-like behavior in adulthood

  2016cites this paper
• Régulation de la quiescence et de la prolifération des cellules souches neurales dans le cerveau adulte

  2016cites this paper
• DNA Methyltransferase 1 Is Indispensable for Development of the Hippocampal Dentate Gyrus

  2016cites this paper
• A mosaic world: puzzles revealed by adult neural stem cell heterogeneity

  2016cites this paper