Spheroid-based human endothelial cell microvessel formation in vivo

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Nature Protocols

• Publication date

  2009-07-01

• Fields of study

  Biology, Medicine, Engineering

• Identifiers
  DOI 10.1038/nprot.2009.96PMID 19644460
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Tumor angiogenesis

  2020cited by this paper
• VEGF-targeted therapy: mechanisms of anti-tumour activity

  2008cited by this paper
• Spheroid-based engineering of a human vasculature in mice

  2008cited by this paper
• The semaphorins: versatile regulators of tumour progression and tumour angiogenesis

  2008cited by this paper
• Tumor angiogenesis.

  2008cited by this paper
• Molecular regulation of angiogenesis and lymphangiogenesis

  2007cited by this paper
• In vivo models of angiogenesis

  2006cited by this paper
• Angiogenesis in life, disease and medicine

  2005cited by this paper
• Neural guidance molecules regulate vascular remodeling and vessel navigation.

  2005cited by this paper
• Methods in Endothelial Cell Biology

  2004cited by this paper
• Endothelial-pericyte interactions in angiogenesis

  2003cited by this paper
• Fibrin-based biomaterials to deliver human growth factors

  2003cited by this paper
• Thrombin signalling and protease-activated receptors

  2000cited by this paper
• Integration of Endothelial Cells in Multicellular Spheroids Prevents Apoptosis and Induces Differentiation

  1998cited by this paper
• Preparation of Gelled Substrates

  1998cited by this paper
• Mechanisms of angiogenesis

  1997cited by this paper
• Quantitative angiogenesis assays: Progress and problems

  1997cited by this paper
• A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor.

  1992cited by this paper
• Vascularization of normal and neoplastic tissues grafted to the chick chorioallantois. Role of host and preexisting graft blood vessels.

  1975cited by this paper
• Progress and problems

  1953cited by this paper

• MIL-53(Fe)-Glucose self-assembled complex for enhanced angiogenesis and endothelial tip cell activation

  2025cites this paper
• Differential Modulation of Endothelial Cell Functionality by LRP1 Expression in Fibroblasts and Cancer-Associated Fibroblasts via Paracrine signals and Matrix Remodeling.

  2025cites this paper
• Pre-cultured, cell-encapsulating fibrin microbeads for the vascularization of ischemic tissues.

  2023cites this paper
• Hypoxia‐induced tumor exosomes promote angiogenesis through miR‐1825/TSC2/mTOR axis in oral squamous cell carcinoma

  2023cites this paper
• The endothelial-enriched lncRNA LINC00607 mediates angiogenic function

  2023cites this paper
• Implantation of engineered human microvasculature to study human infectious diseases in mouse models

  2023cites this paper
• Hydrogels with tunable mechanical plasticity regulate endothelial cell outgrowth in vasculogenesis and angiogenesis

  2023cites this paper
• On-chip-angiogenesis based on a high-throughput biomimetic three-dimensional cell spheroid culture system.

  2023cites this paper
• Implications of Three-Dimensional Cell Culture in Cancer Therapeutic Research

  2022cites this paper
• SARS-CoV-2 Infects Human ACE2-Negative Endothelial Cells through an αvβ3 Integrin-Mediated Endocytosis Even in the Presence of Vaccine-Elicited Neutralizing Antibodies

  2022cites this paper
• Targeting angiogenic growth factors using therapeutic glycosaminoglycans on doppel-expressing endothelial cells for blocking angiogenic signaling in cancer.

  2022cites this paper
• Methods for vascularization and perfusion of tissue organoids

  2022cites this paper
• A Thromboxane A2 Receptor-Driven COX-2–Dependent Feedback Loop That Affects Endothelial Homeostasis and Angiogenesis

  2022cites this paper
• Electrochemical microwell sensor with Fe–N co-doped carbon catalyst to monitor nitric oxide release from endothelial cell spheroids

  2022cites this paper
• Nox4 promotes endothelial differentiation through chromatin remodeling

  2022cites this paper
• Active RhoA Exerts an Inhibitory Effect on the Homeostasis and Angiogenic Capacity of Human Endothelial Cells

  2022cites this paper
• The endothelial-specific LINC00607 mediates endothelial angiogenic function

  2022cites this paper
• Reciprocal Antagonism between MicroRNA-138 and SIRT1 and Its Implications for the Angiogenesis of Endothelial Cells

  2021cites this paper
• Avian Reovirus P17 Suppresses Angiogenesis by Promoting DPP4 Secretion

  2021cites this paper
• The CXCL2/IL8/CXCR2 Pathway Is Relevant for Brain Tumor Malignancy and Endothelial Cell Function

  2021cites this paper
• Angiogenic efficacy of ASC spheroids filtrated on porous nanosheets for the treatment of a diabetic skin ulcer.

  2021cites this paper
• SARS-CoV-2 Infection Remodels the Phenotype and Promotes Angiogenesis of Primary Human Lung Endothelial Cells

  2021cites this paper
• Impact of DICER1 and DROSHA on the Angiogenic Capacity of Human Endothelial Cells

  2021cites this paper
• In vitro 3D Systems to Model Tumor Angiogenesis and Interactions With Stromal Cells

  2020cites this paper
• Injectable pre-cultured tissue modules catalyze the formation of extensive functional microvasculature in vivo

  2020cites this paper
• Three-Dimensional Printed Stamps for the Fabrication of Patterned Microwells and High-Throughput Production of Homogeneous Cell Spheroids

  2020cites this paper
• Advanced biomedical applications based on emerging 3D cell culturing platforms.

  2020cites this paper
• 3D Print Technology for Cell Culturing

  2019cites this paper
• Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis

  2019cites this paper
• Scaffold-Free 3-D Cell Sheet Technique Bridges the Gap between 2-D Cell Culture and Animal Models

  2019cites this paper
• Fabrication of core-shell spheroids as building blocks for engineering 3D complex vascularized tissue.

  2019cites this paper
• In Vitro Spheroid Sprouting Assay of Angiogenesis.

  2019cites this paper
• Human adipose stromal-vascular fraction self-organizes to form vascularized adipose tissue in 3D cultures

  2019cites this paper
• Modulation of BDNF–TRKB Interactions on Schwann Cell-induced Oral Squamous Cell Carcinoma Dispersion In Vitro

  2019cites this paper
• Restoring Vasculogenic Potential of Endothelial Cells from Diabetic Patients Through Spheroid Formation

  2018cites this paper
• Goat tendon collagen-human fibrin hydrogel for comprehensive parametric evaluation of HUVEC microtissue-based angiogenesis.

  2018cites this paper
• Characterization of a drug-targetable allosteric site regulating vascular endothelial growth factor signaling

  2018cites this paper
• The Synergy of Scaffold-Based and Scaffold-Free Tissue Engineering Strategies.

  2018cites this paper
• Expansion of functional personalized cells with specific transgene combinations

  2018cites this paper
• Inhibin Is a Novel Paracrine Factor for Tumor Angiogenesis and Metastasis.

  2018cites this paper
• Ear Sponge Assay: A Method to Investigate Angiogenesis and Lymphangiogenesis in Mice.

  2018cites this paper
• CXCL5 Facilitates Melanoma Cell-Neutrophil Interaction and Lymph Node Metastasis.

  2018cites this paper
• Angiopoietin-4-dependent venous maturation and fluid drainage in the peripheral retina

  2018cites this paper
• 3D Imaging and Quantitative Analysis of Vascular Networks: A Comparison of Ultramicroscopy and Micro-Computed Tomography

  2018influential citation
• A Comprehensive Procedure to Evaluate the In Vitro Performance of the Putative Hemangioblastoma Neovascularization Using the Spheroid Sprouting Assay.

  2018cites this paper
• In vivo therapeutic applications of cell spheroids.

  2018cites this paper
• The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2

  2018cites this paper
• Modeling pre-metastatic lymphvascular niche in the mouse ear sponge assay

  2017cites this paper
• Digital biomanufacturing supporting vascularization in 3D bioprinting

  2017cites this paper
• Hepatoma cell functions modulated by NEK2 are associated with liver cancer progression

  2017cites this paper
• Spheroids as vascularization units: From angiogenesis research to tissue engineering applications.

  2017cites this paper
• Tumor cells and their crosstalk with endothelial cells in 3D spheroids

  2017cites this paper
• A heparin conjugate, LHbisD4, inhibits lymphangiogenesis and attenuates lymph node metastasis by blocking VEGF-C signaling pathway.

  2017cites this paper
• Stem Cell Spheroids and Ex Vivo Niche Modeling: Rationalization and Scaling-Up

  2017cites this paper
• RESULTS MANTIS Is a JARID 1 B-Suppressed lncRNA Downregulated in Human Idiopathic Pulmonary Arterial Hypertension

  2017cites this paper
• Azopolymer photopatterning for directional control of angiogenesis.

  2017cites this paper
• EphB4 forward signalling mediates angiogenesis caused by CCM3/PDCD10‐ablation

  2017cites this paper
• Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function

  2017cites this paper
• Pericyte-expressed Tie2 controls angiogenesis and vessel maturation

  2017cites this paper
• Ectopic vascularized bone formation by human mesenchymal stem cell microtissues in a biocomposite scaffold.

  2017cites this paper
• Multilayered Engineered Tissue Sheets for Vascularized Tissue Regeneration

  2017cites this paper
• Spheroid-Based In Vitro Angiogenesis Model.

  2016cites this paper
• 3D biomimetic model for cellular invasion in angiogenesis and cancer

  2016cites this paper
• Mini-pillar array for hydrogel-supported 3D culture and high-content histologic analysis of human tumor spheroids.

  2016cites this paper
• MMGZ01, an anti-DLL4 monoclonal antibody, promotes nonfunctional vessels and inhibits breast tumor growth.

  2016influential citation
• Studies on the Tumor Vasculature and Coagulant Microenvironment.

  2016cites this paper
• Human iPSC-derived endothelial cell sprouting assay in synthetic hydrogel arrays.

  2016cites this paper
• DOT1L promotes angiogenesis through cooperative regulation of VEGFR2 with ETS-1

  2016cites this paper
• Resistance to DNA Damaging Agents Produced Invasive Phenotype of Rat Glioma Cells—Characterization of a New in Vivo Model

  2016cites this paper
• Fibroblast recruitment as a tool for ovarian cancer detection and targeted therapy

  2016cites this paper
• Proliferation status defines functional properties of endothelial cells

  2016cites this paper
• Physiologically Low Oxygen Enhances Biomolecule Production and Stemness of Mesenchymal Stem Cell Spheroids

  2016cites this paper
• Filling the Gaps between the In Vivo and In Vitro Microenvironment: Engineering of Spheroids for Stem Cell Technology.

  2016cites this paper
• Targeting prion-like protein doppel selectively suppresses tumor angiogenesis.

  2016cites this paper
• Mechanical regulation of vascular network formation in engineered matrices.

  2016cites this paper
• Neutrophil Extracellular Traps Promote Angiogenesis: Evidence From Vascular Pathology in Pulmonary Hypertension

  2016cites this paper
• Polymeric nanofibrous substrates stimulate pluripotent stem cells to form three‐dimensional multilayered patty‐like spheroids in feeder‐free culture and maintain their pluripotency

  2015cites this paper
• LHT7, a chemically modified heparin, inhibits multiple stages of angiogenesis by blocking VEGF, FGF2 and PDGF-B signaling pathways.

  2015cites this paper
• Nonlinear 3D projection printing of concave hydrogel microstructures for long-term multicellular spheroid and embryoid body culture.

  2015cites this paper
• State-ofthe-Art Methods for Evaluation of Angiogenesis and Tissue Vascularization

  2015cites this paper
• Aha Scientific Statement 1. in Vitro Assays State-of-the-art Methods for Evaluation of Angiogenesis and Tissue Vascularization a Scientific Statement from the American Heart Association on Behalf of the American Heart Association Council on Basic Cardiovascular Sciences and Council on Cardiovascular

  2015cites this paper
• Cerebral Cavernous Malformation-1 Protein Controls DLL4-Notch3 Signaling Between the Endothelium and Pericytes

  2015cites this paper
• Semaphorin-3C signals through Neuropilin-1 and PlexinD1 receptors to inhibit pathological angiogenesis

  2015cites this paper
• Fibulin-3 is a Novel TGF-β pathway Inhibitor in the Breast Cancer Microenvironment

  2015cites this paper
• State-of-the-Art Methods for Evaluation of Angiogenesis and Tissue Vascularization: A Scientific Statement From the American Heart Association.

  2015cites this paper
• Common and specific effects of TIE2 mutations causing venous malformations.

  2015cites this paper
• Endothelial cell spheroids as a versatile tool to study angiogenesis in vitro

  2015cites this paper
• Transplantation of Heterospheroids of Islet Cells and Mesenchymal Stem Cells for Effective Angiogenesis and Antiapoptosis

  2015cites this paper
• Biofabrication of Vascular Networks

  2015cites this paper
• Stromal cells and stem cells in clinical bone regeneration

  2015cites this paper
• Correction: Mobilization of CD34+-Progenitor Cells in Patients with Severe Trauma

  2014cites this paper
• Oral delivery of a potent anti-angiogenic heparin conjugate by chemical conjugation and physical complexation using deoxycholic acid.

  2014cites this paper
• Ultrasound Molecular Imaging in a Human CD276 Expression–Modulated Murine Ovarian Cancer Model

  2014influential citation
• De novo hem- and lymphangiogenesis by endothelial progenitor and mesenchymal stem cells in immunocompetent mice

  2014cites this paper
• Assessment of Ovarian Cancer Spheroid Attachment and Invasion of Mesothelial Cells in Real Time

  2014cites this paper
• HIV-1 Matrix Protein p17 Promotes Lymphangiogenesis and Activates the Endothelin-1/Endothelin B Receptor Axis

  2014cites this paper
• Mobilization of CD34+-Progenitor Cells in Patients with Severe Trauma

  2014cites this paper
• Transfer, Imaging, and Analysis Plate for Facile Handling of 384 Hanging Drop 3D Tissue Spheroids

  2014cites this paper
• Antiangiogenic and proteolytic activities of prostate-specific antigen

  2014cites this paper
• Comprehensive analysis of HEK293 cells reveals a LEC-like phenotype

  2014influential citation