LIN-12/Notch signaling in C. elegans.

Receptors of the LIN-12/Notch family mediate cell-cell interactions during animal development, and aberrations in LIN-12/Notch signaling have been implicated in human disease. Studies in C. elegans have been instrumental in defining the basic features of the LIN-12/Notch pathway, the role of LIN-12/Notch proteins as receptors for intercellular signals, the mechanism of signal transduction, and the regulation of LIN-12/Notch signaling during cell fate decisions. This chapter is focused on detailing how the "awesome power of C. elegans genetics" has identified many core components and modulators of LIN-12/Notch activity.

• Publication year

  2005

• Venue

  WormBook

• Publication date

  2005-08-08

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1895/WORMBOOK.1.10.1PMID 18050403PMCID PMC4781465
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• lin-12 Notch functions in the adult nervous system of C. elegans

  2005cited by this paper
• Evidence for functional redundancy between C. elegans ADAM proteins SUP-17/Kuzbanian and ADM-4/TACE.

  2005influential reference
• The lateral signal for LIN-12/Notch in C. elegans vulval development comprises redundant secreted and transmembrane DSL proteins.

  2004influential reference
• sel-7, a Positive Regulator of lin-12 Activity, Encodes a Novel Nuclear Protein in Caenorhabditis elegans

  2004cited by this paper
• ATX-2, the C. elegans ortholog of ataxin 2, functions in translational regulation in the germline

  2004influential reference
• Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA

  2004cited by this paper
• Crosstalk Between the EGFR and LIN-12/Notch Pathways in C. elegans Vulval Development

  2004cited by this paper
• Notch signaling in development and disease.

  2004cited by this paper
• The Maternal Genes apx 4 and glp 7 and Establishment of Dorsal-Ventral Polarity in the Early C . elegans Embryo

  2003influential reference
• Post-transcriptional regulation of the E/Daughterless ortholog HLH-2, negative feedback, and birth order bias during the AC/VU decision in C. elegans.

  2003cited by this paper
• Notch signaling in development and disease

  2003cited by this paper
• Genetic analysis of Caenorhabditis elegans glp-1 mutants suggests receptor interaction or competition.

  2003cited by this paper
• Two suppressors of sel-12 encode C2H2 zinc-finger proteins that regulate presenilin transcription in Caenorhabditis elegans

  2003cited by this paper
• Notch signaling and inherited disease syndromes.

  2003cited by this paper
• Loss of spr‐5 bypasses the requirement for the C.elegans presenilin sel‐12 by derepressing hop‐1

  2002cited by this paper
• A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response

  2002cited by this paper
• Endocytosis-mediated downregulation of LIN-12/Notch upon Ras activation in Caenorhabditis elegans

  2002cited by this paper
• aph-1 and pen-2 Are Required for Notch Pathway Signaling, γ-Secretase Cleavage of βAPP, and Presenilin Protein Accumulation

  2002cited by this paper
• Suppressors of the egg-laying defective phenotype of sel-12 presenilin mutants implicate the CoREST corepressor complex in LIN-12/Notch signaling in C. elegans.

  2002cited by this paper
• aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation.

  2002cited by this paper
• APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

  2002cited by this paper
• The Caenorhabditis elegans presenilin sel-12 is required for mesodermal patterning and muscle function.

  2002cited by this paper
• Notch Inhibition of RAS Signaling Through MAP Kinase Phosphatase LIP-1 During C. elegans Vulval Development

  2001cited by this paper
• The Notch Intracellular Domain Is Ubiquitinated and Negatively Regulated by the Mammalian Sel-10 Homolog*

  2001cited by this paper
• SEL-10 Is an Inhibitor of Notch Signaling That Targets Notch for Ubiquitin-Mediated Protein Degradation

  2001cited by this paper
• Bt Toxin Resistance from Loss of a Putative Carbohydrate-Modifying Enzyme

  2001cited by this paper
• Functional Interaction between SEL-10, an F-box Protein, and the Nuclear Form of Activated Notch1 Receptor*

  2001cited by this paper
• The SEL-12 presenilin mediates induction of the Caenorhabditis elegans uterine pi cell fate.

  2001cited by this paper
• A Human Protein with Sequence Similarity to DrosophilaMastermind Coordinates the Nuclear Form of Notch and a CSL Protein To Build a Transcriptional Activator Complex on Target Promoters

  2001cited by this paper
• spr-2, a suppressor of the egg-laying defect caused by loss of sel-12 presenilin in Caenorhabditis elegans, is a member of the SET protein subfamily.

  2000cited by this paper
• Article

  2000cited by this paper
• EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans.

  2000influential reference
• A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE.

  2000influential reference
• Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing

  2000cited by this paper
• Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

  2000cited by this paper
• LAG-3 is a putative transcriptional activator in the C. elegans Notch pathway

  2000cited by this paper
• Mastermind is a putative activator for Notch.

  2000cited by this paper
• Left-right asymmetry in C. elegans intestine organogenesis involves a LIN-12/Notch signaling pathway.

  2000cited by this paper
• SEL-8, a nuclear protein required for LIN-12 and GLP-1 signaling in Caenorhabditis elegans.

  2000cited by this paper
• A common enzyme connects notch signaling and Alzheimer's disease.

  2000influential reference
• MAML1, a human homologue of Drosophila Mastermind, is a transcriptional co-activator for NOTCH receptors

  2000influential reference
• Repression by suppressor of hairless and activation by Notch are required to define a single row of single-minded expressing cells in the Drosophila embryo.

  2000cited by this paper
• aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling.

  2000cited by this paper
• p24 Proteins and Quality Control of LIN-12 and GLP-1 Trafficking in Caenorhabditis elegans

  1999cited by this paper
• SEL-5, a serine/threonine kinase that facilitates lin-12 activity in Caenorhabditis elegans.

  1999cited by this paper
• Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling.

  1999cited by this paper
• Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin.

  1998cited by this paper
• Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

  1998influential reference
• Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins.

  1998influential reference
• Nuclear access and action of notch in vivo.

  1998influential reference
• SUP-17, a Caenorhabditis elegans ADAM protein related to Drosophila KUZBANIAN, and its role in LIN-12/NOTCH signalling.

  1997cited by this paper
• HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling.

  1997influential reference
• The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginal discs.

  1997cited by this paper
• sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins.

  1997cited by this paper
• Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis.

  1997cited by this paper
• Identification and characterization of genes that interact with lin-12 in Caenorhabditis elegans.

  1997influential reference
• Structure, function, and expression of SEL-1, a negative regulator of LIN-12 and GLP-1 in C. elegans.

  1997cited by this paper
• The Caenorhabditis elegans sel-1 gene, a negative regulator of lin-12 and glp-1, encodes a predicted extracellular protein.

  1996cited by this paper
• lag-1, a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su(H).

  1996influential reference
• KUZ, a Conserved Metalloprotease-Disintegrin Protein with Two Roles in Drosophila Neurogenesis

  1996cited by this paper
• Assessment of normal and mutant human presenilin function in Caenorhabditis elegans.

  1996cited by this paper
• Roles of the RAM and ANK domains in signaling by the C. elegans GLP‐1 receptor.

  1996influential reference
• Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2

  1996cited by this paper
• Time-dependent responses to glp-1-mediated inductions in early C. elegans embryos.

  1996cited by this paper
• An inductive interaction in 4-cell stage C. elegans embryos involves APX-1 expression in the signalling cell.

  1996cited by this paper
• Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo.

  1996influential reference
• Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-Jκ/Su(H)

  1995cited by this paper
• Signalling downstream of activated mammalian Notch

  1995cited by this paper
• The Caenorhabditis elegans lin-12 gene mediates induction of ventral uterine specialization by the anchor cell.

  1995cited by this paper
• Enhancers of glp-1, a gene required for cell-signaling in Caenorhabditis elegans, define a set of genes required for germline development.

  1995influential reference
• Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

  1995cited by this paper
• Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

  1995cited by this paper
• Reciprocal changes in expression of the receptor lin-12 and its ligand lag-2 prior to commitment in a C. elegans cell fate decision.

  1994cited by this paper
• lag-2 may encode a signaling ligand for the GLP-1 and LIN-12 receptors of C. elegans.

  1994cited by this paper
• GLP-1 is localized to the mitotic region of the C. elegans germ line.

  1994cited by this paper
• Cell-Cell Interactions: Receiving signals in the nematode embryo

  1994cited by this paper
• glp-1 and inductions establishing embryonic axes in C. elegans.

  1994cited by this paper
• Two maternal genes, apx-1 and pie-1, are required to distinguish the fates of equivalent blastomeres in the early Caenorhabditis elegans embryo.

  1994influential reference
• Combinatorial specification of blastomere identity by glp-1-dependent cellular interactions in the nematode Caenorhabditis elegans.

  1994cited by this paper
• glp-1 can substitute for lin-12 in specifying cell fate decisions in Caenorhabditis elegans.

  1993cited by this paper
• Suppressors of glp-1, a gene required for cell communication during development in Caenorhabditis elegans, define a set of interacting genes.

  1993influential reference
• Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo.

  1993cited by this paper
• Suppressors of a lin-12 hypomorph define genes that interact with both lin-12 and glp-1 in Caenorhabditis elegans.

  1993cited by this paper
• Two homologous regulatory genes, lin-12 and glp-1, have overlapping functions.

  1991influential reference
• Cell autonomy of lin-12 function in a cell fate decision in C. elegans.

  1989cited by this paper
• glp-1 and lin-12, genes implicated in distinct cell-cell interactions in C. elegans, encode similar transmembrane proteins.

  1989cited by this paper
• The Caenorhabditis elegans lin-12 gene encodes a transmembrane protein with overall similarity to Drosophila Notch

  1988cited by this paper
• The glp-1 locus and cellular interactions in early C. elegans embryos.

  1987cited by this paper
• glp-1 is required in the germ line for regulation of the decision between mitosis and meiosis in C. elegans.

  1987cited by this paper
• Sequence of the notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors

  1986cited by this paper
• Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats.

  1985cited by this paper
• Identification and characterization of 22 genes that affect the vulval cell lineages of the nematode Caenorhabditis elegans.

  1985cited by this paper
• lin-12, a nematode homeotic gene, is homologous to a set of mammalian proteins that includes epidermal growth factor.

  1985cited by this paper
• A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes

  1984cited by this paper
• Sequence of a Drosophila segmentation gene: protein structure homology with DNA-binding proteins

  1984cited by this paper
• The lin-12 locus specifies cell fates in Caenorhabditis elegans.

  1983influential reference

• Anticancer bioactive phytochemicals screening from medicinal-edible homologous materials in Caenorhabditis elegans.

  2025cites this paper
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  2024cites this paper
• C. elegans Germline as Three Distinct Tumor Models

  2024cites this paper
• The Intricate Notch Signaling Dynamics in Therapeutic Realms of Cancer.

  2023cites this paper
• Genetic and Chemical Controls of Sperm Fate and Spermatocyte Dedifferentiation via PUF-8 and MPK-1 in Caenorhabditis elegans

  2023cites this paper
• Identifying the Caenorhabditis elegans vulval transcriptome

  2022cites this paper
• A new toolkit to visualize and perturb endogenous LIN-12/Notch signaling in C. elegans

  2022cites this paper
• Tissue-specific inhibition of protein sumoylation uncovers diverse SUMO functions during C. elegans vulval development

  2022cites this paper
• Identifying the C. elegans vulval transcriptome

  2022cites this paper
• Programmed cell fusion in development and homeostasis.

  2021cites this paper
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• Tissue-specific inhibition of protein sumoylation uncovers diverse SUMO functions during C. elegans vulval development

  2021cites this paper
• Early C. elegans embryos modulate cell division timing to compensate for, and survive, the discordant conditions of a severe temperature gradient

  2020cites this paper
• A toolkit of tagged glp-1 alleles reveals strong glp-1 expression in the germline, embryo, and spermatheca

  2020cites this paper
• Comparative genomics of 10 new Caenorhabditis species

  2019cites this paper
• The Drosophila CPEB Protein Orb Specifies Oocyte Fate by a 3′UTR-Dependent Autoregulatory Loop

  2019cites this paper
• The Signaling Network Controlling C. elegans Vulval Cell Fate Patterning

  2018cites this paper
• NOTCH1 regulates the viability of cholangiocarcinoma cells via 14-3-3 theta

  2018cites this paper
• PRP-19, a conserved pre-mRNA processing factor and E3 ubiquitin ligase, inhibits the nuclear accumulation of GLP-1/Notch intracellular domain

  2018cites this paper
• Small GTPases.

  2018cites this paper
• The E3 ubiquitin ligase MIB-1 is necessary to form the nuclear halo in C. elegans sperm

  2018cites this paper
• The E3 Ubiquitin Ligase MIB-1 Is Necessary To Form the Nuclear Halo in Caenorhabditis elegans Sperm

  2018cites this paper
• Polycomb and Notch signaling regulate cell proliferation potential during Caenorhabditis elegans life cycle

  2018cites this paper
• An Efficient FLP-Based Toolkit for Spatiotemporal Control of Gene Expression in Caenorhabditis elegans

  2017cites this paper
• β-Integrin de-phosphorylation by the Density-Enhanced Phosphatase DEP-1 attenuates EGFR signaling in C. elegans

  2017cites this paper
• Do as I say, Not(ch) as I do: Lateral control of cell fate.

  2017cites this paper
• Breaching and Opening Basement Membrane Barriers: The Anchor Cell Leads the Way

  2017cites this paper
• Invading, Leading and Navigating Cells in Caenorhabditis elegans: Insights into Cell Movement in Vivo

  2017cites this paper
• Partial frataxin suppression in Caenorhabditis elegans reduces tumor formation by dampening the RAS/MAPk signaling

  2017influential citation
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  2016cites this paper
• MOLECULAR GENETIC STUDY OF REPRODUCTIVE SYSTEM DEVELOPMENT IN THE NEMATODE CAENORHABDITIS BRIGGSAE

  2016influential citation
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  2016cites this paper
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• Estudio del papel del factor de transcripción LAG-1 en el proceso de diferenciación terminal de las neuronas serotonérgicas ADF en C. elegans.

  2016cites this paper
• Antagonistic roles of Polycomb repression and Notch signaling in the maintenance of somatic cell fate in C. elegans.

  2016cites this paper
• Behavioural investigation of normal and mutant human presenilin functions in caenorhabditis elegans

  2015cites this paper
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  2014cites this paper
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  2014cites this paper
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  2013cites this paper
• The Characterization of Nemadipine and Migrazole as Small Molecule Tools for Use in the Nematode Caenorhabditis elegans

  2013cites this paper
• Sending the right signal: Notch and stem cells.

  2013cites this paper
• The NM23-H1/H2 homolog NDK-1 is required for full activation of Ras signaling in C. elegans

  2013cites this paper
• Canonical RTK-Ras-ERK signaling and related alternative pathways

  2013cites this paper
• Caenorhabditis elegans Histone Deacetylase hda-1 Is Required for Morphogenesis of the Vulva and LIN-12/Notch-Mediated Specification of Uterine Cell Fates

  2013cites this paper
• Notch signaling: genetics and structure.

  2013influential citation
• Identification of novel cis-regulatory regions from the Notch receptor genes lin-12 and glp-1 of Caenorhabditis elegans.

  2013cites this paper
• A network model for the specification of vulval precursor cells and cell fusion control in Caenorhabditis elegans

  2013cites this paper
• LIN-12/Notch signaling instructs postsynaptic muscle arm development by regulating UNC-40/DCC and MADD-2 in Caenorhabditis elegans

  2013cites this paper
• LIN-12/notch regulates lag-1 and lin-12 expression during anchor cell/ventral uterine precursor cell fate specification

  2013cites this paper
• The transcription factor VAB-23 links vulval cell fate specification and morphogenesis

  2012cites this paper
• Genetic Control of Vulval Development in Caenorhabditis briggsae

  2012cites this paper
• The Notch signalling system: recent insights into the complexity of a conserved pathway

  2012cites this paper
• Notch signaling and cardiac repair.

  2012cites this paper
• Notch signaling inhibits axon regeneration.

  2012influential citation
• Dynamic changes of the Caenorhabditis elegans proteome during ontogenesis assessed by quantitative analysis with 15N metabolic labeling.

  2012cites this paper
• Cell-cycle regulation of NOTCH signaling during C. elegans vulval development

  2012cites this paper
• Coordinated lumen contraction and expansion during vulval tube morphogenesis in Caenorhabditis elegans.

  2012cites this paper
• Notch Signaling Is Antagonized by SAO-1, a Novel GYF-Domain Protein That Interacts with the E3 Ubiquitin Ligase SEL-10 in Caenorhabditis elegans

  2012cites this paper
• Morphogenesis of the vulva and the vulval-uterine connection.

  2012cites this paper
• Notch-dependent induction of left/right asymmetry in C. elegans interneurons and motoneurons.

  2011cites this paper
• Ras effector switching promotes divergent cell fates in C. elegans vulval patterning.

  2011influential citation
• LIN-39 and the EGFR/RAS/MAPK pathway regulate C. elegans vulval morphogenesis via the VAB-23 zinc finger protein

  2011cites this paper
• Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo

  2011cites this paper
• OrthoList: A Compendium of C. elegans Genes with Human Orthologs

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• Ras effector switching as a developmental strategy

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• Hybrid Modeling of Cell Signaling and Transcriptional Reprogramming and Its Application in C. elegans Development

  2011cites this paper
• Signalogs: Orthology-Based Identification of Novel Signaling Pathway Components in Three Metazoans

  2011cites this paper
• Notch-independent functions of CSL.

  2011cites this paper
• Acquisition of renogenic competence in the early mouse embryo and embryonic stem cells

  2011cites this paper
• Evolution of Developmental Control Mechanism Conserved mechanism of Wnt signaling function in the specification of vulval precursor fates in C. elegans and C. briggsae

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  2010influential citation
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• Movers and shakers or anchored: Caenorhabditis elegans nuclei achieve it with KASH/SUN

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• LIN-14 inhibition of LIN-12 contributes to precision and timing of C. elegans vulval fate patterning.

  2010cites this paper
• The C. elegans sex determination protein MOG-3 functions in meiosis and binds to the CSL co-repressor CIR-1.

  2010influential citation
• Understanding the molecular basis of Alzheimer’s disease using a Caenorhabditis elegans model system

  2010influential citation
• A conserved tetraspanin subfamily promotes Notch signaling in Caenorhabditis elegans and in human cells

  2010cites this paper
• sel-11 and cdc-42, Two Negative Modulators of LIN-12/Notch Activity in C. elegans

  2010cites this paper
• The caenorhabditis elegans CDT-2 ubiquitin ligase is required for attenuation of EGFR signalling in vulva precursor cells

  2010cites this paper
• Cancer models in Caenorhabditis elegans

  2010cites this paper
• The temporally regulated transcription factor sel-7 controls developmental timing in C. elegans.

  2009cites this paper
• TRA-1/GLI controls the expression of the Hox gene lin-39 during C. elegans vulval development.

  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
• The CSL transcription factor LAG-1 directly represses hlh-6 expression in C. elegans.

  2008cites this paper
• Notch signaling and morphogenesis of single-cell tubes in the C. elegans digestive tract.

  2008cites this paper
• Non-redundant roles of E(spl) proteins during Drosophila neurogenesis

  2008cites this paper
• Dorsoventral patterning of the C. elegans postembryonic mesoderm requires both LIN-12/Notch and TGFbeta signaling.

  2008cites this paper
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  2007cites this paper
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  2007cites this paper
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  2007cites this paper