The use of chromosomal translocations to study human immunoglobulin gene organization: mapping DH segments within 35 kb of the C mu gene and identification of a new DH locus.

No abstract is available for this paper.

• Publication year

  1988

• Venue

  EMBO Journal

• Publication date

  1988-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/j.1460-2075.1988.tb03039.xPMID 3138112PMCID PMC454475
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Complex rearrangements within the human J delta‐C delta/J alpha‐C alpha locus and aberrant recombination between J alpha segments.

  1988cited by this paper
• The mechanism of chromosome 14 inversion in a human T cell lymphoma.

  1987cited by this paper
• Lorist6, a cosmid vector with BamHI, NotI, ScaI and HindIII cloning sites and altered neomycin phosphotransferase gene expression.

  1987cited by this paper
• The t(8;14) chromosome translocation of the Burkitt lymphoma cell line Daudi occurred during immunoglobulin gene rearrangement and involved the heavy chain diversity region.

  1987cited by this paper
• Mechanism of the t(14;18) chromosomal translocation: structural analysis of both derivative 14 and 18 reciprocal partners.

  1987cited by this paper
• Physical linkage of three CD3 genes on human chromosome 11.

  1987cited by this paper
• Organization and evolution of variable region genes of the human immunoglobulin heavy chain.

  1986cited by this paper
• Toward a physical map of the genome of the nematode Caenorhabditis elegans.

  1986cited by this paper
• The t(8; 14) chromosomal translocation occurring in B-cell malignancies results from mistakes in V–D–J joining

  1986cited by this paper
• Diversity and rearrangement of the human T cell rearranging gamma genes: nine germ-line variable genes belonging to two subgroups.

  1986cited by this paper
• Clustering of extensive somatic mutations in the variable region of an immunoglobulin heavy chain gene from a human B cell lymphoma.

  1986cited by this paper
• The current status and portability of our sequence handling software

  1986cited by this paper
• Fusion of an immunoglobulin variable gene and a T cell receptor constant gene in the chromosome 14 inversion associated with T cell tumors.

  1985cited by this paper
• A cytochrome P‐450 gene family mapped to human chromosome 19

  1985cited by this paper
• Mapping muscle protein genes by in situ hybridization using biotin‐labeled probes.

  1985cited by this paper
• Human myosin heavy chain genes assigned to chromosome 17 using a human cDNA clone as probe

  1985cited by this paper
• A new selective phage cloning vector, lambda 2001, with sites for XbaI, BamHI, HindIII, EcoRI, SstI and XhoI.

  1984cited by this paper
• Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells

  1984cited by this paper
• Localization of the ribosomal genes in Caenorhabditis elegans chromosomes by in situ hybridization using biotin‐labeled probes.

  1984cited by this paper
• Effect of somatic mutation within translocated c-myc genes in Burkitt's lymphoma

  1984cited by this paper
• Translocation joins c-myc and immunoglobulin γ1 genes in a Burkitt lymphoma revealing a third exon in the c-myc oncogene

  1983cited by this paper
• A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

  1983cited by this paper
• The human immunoglobulin genes. The nineteenth Colworth medal lecture.

  1983cited by this paper
• Diversity and joining segments of mouse immunoglobulin heavy chain genes are closely linked and in the same orientation: implications for the joining mechanism.

  1983cited by this paper
• Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma.

  1983cited by this paper
• The sequence of a human immunoglobulin epsilon heavy chain constant region gene, and evidence for three non‐allelic genes.

  1982cited by this paper
• Chromosomal localization of human cellular homologues of two viral oncogenes

  1982cited by this paper
• Assignment of the structural gene for the third component of human complement to chromosome 19.

  1982cited by this paper
• Regulation of expression of liver‐specific enzymes

  1982cited by this paper
• Comparison of the hinge‐coding segments in human immunoglobulin gamma heavy chain genes and the linkage of the gamma 2 and gamma 4 subclass genes.

  1982cited by this paper
• The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers.

  1982cited by this paper
• Human immunoglobulin heavy chain genes: evolutionary comparisons of C mu, C delta and C gamma genes and associated switch sequences.

  1981cited by this paper
• Human immunoglobulin D segments encoded in tandem multigenic families

  1981cited by this paper
• Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region.

  1980cited by this paper
• Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing.

  1980cited by this paper
• Immunochemical analysis of the N-acetyl hexosaminidases in human-mouse hybrids made using a double selective system.

  1977cited by this paper
• Human gene mapping using an X/autosome translocation

  1976cited by this paper
• Detection of specific sequences among DNA fragments separated by gel electrophoresis.

  1975cited by this paper
• Genetic Analysis with Human—Mouse Somatic Cell Hybrids

  1969cited by this paper

• Immunoglobulins or Antibodies: IMGT® Bridging Genes, Structures and Functions

  2020cites this paper
• CD 34 selections from myeloma peripheral blood cell autografts contain residual tumour cells due to impurity , not to CD 34 + myeloma cells

  2017cites this paper
• Immunoglobulins and Laboratory Recognition of Monoclonal Proteins

  2013cites this paper
• Analysis of the Human V H Gene Repertoire Differential Effects of Selection and Somatic Hypermutation on Human Peripheral CD 5 1 / IgM 1 and CD 5 2 / IgM 1 B cells

  2013cites this paper
• Equivalentsthe Splenic Marginal Zone Heterogeneity of Tonsillar Subepithelial B

  2013cites this paper
• IGH (immunoglobulin heavy)

  2011cites this paper
• tissue- type B-cell lymphoma Somatic hypermutation in low-grade mucosa-associated lymphoid

  2011cites this paper
• Structural and functional characterization of a human IgG monoclonal antiphospholipid antibody.

  2011cites this paper
• Atlas of Genetics and Cytogenetics in Oncology and Haematology

  2011cites this paper
• Novel atypical nucleotide insertions specifically at VH-DH junction generate exceptionally long CDR3H in cattle antibodies.

  2010cites this paper
• Die B-Zell-Antwort im Synovialgewebe von Patienten mit Rheumatoider Arthritis

  2009cites this paper
• PDFlib PLOP: PDF Linearization, Optimization, Protection Page inserted by evaluation version

  2006cites this paper
• Molecular characterization of chronic lymphocytic leukemia with two distinct cell populations: Evidence for separate clonal origins.

  2006cites this paper
• Classification : Analysis by Direct DNA Sequencing in Non-Hodgkin ' s Lymphomas Typed According to the Kiel

  2006cites this paper
• Reconsidering the human immunoglobulin heavy-chain locus:

  2006cites this paper
• Major Breakpoint Regions in Non-Hodgkin ' s Lymphomas Typed According to the Kiel Classification : Analysis by Direct DNA Sequencing 1

  2006cites this paper
• Proteomics: A New Emerging Area of Biotechnology

  2005cites this paper
• Characterization of the Human Ig Heavy Chain Antigen Binding Complementarity Determining Region 3 Using a Newly Developed Software Algorithm, JOINSOLVER

  2004cites this paper
• JOINSOLVERDeveloped Software Algorithm, Determining Region 3 Using a Newly Chain Antigen Binding Complementarity Characterization of the Human Ig Heavy

  2004cites this paper
• Biallelic IgH rearrangements in patients with indolent lymphoproliferative disorders: Molecular and practical implications

  2004cites this paper
• Human Immunoglobulin Heavy Chain Locus

  2004cites this paper
• Recombinant monoclonal thyrotropin-stimulation blocking antibody (TSBAb) established from peripheral lymphocytes of a hypothyroid patient with primary myxedema

  2003cites this paper
• Genetic diversity of the human immunoglobulin heavy chain VH region

  2002cites this paper
• Comparative characteristics of μ chain and α chain transcripts expressed by individual tonsil plasma cells

  2001cites this paper
• Chromosomal localization, organization of the loci, and potential repertoire

  2001cites this paper
• Superantigens and Autoantigens May Be Involved in the Pathogenesis of Gastric Mucosa-Associated Lymphoid Tissue Lymphoma

  2001cites this paper
• Synthesis of the immunoglobulin chains

  2001cites this paper
• Nomenclature of the Human Immunoglobulin Heavy (IGH) Genes

  2001cites this paper
• Comparative characteristics of mu chain and alpha chain transcripts expressed by individual tonsil plasma cells.

  2001cites this paper
• Nomenclature of the Human Immunoglobulin Genes

  2000cites this paper
• Nucleotide variations amongst V(H)Genes of AMA-producing B cell clones in primary biliary cirrhosis.

  2000cites this paper
• Expression and Phylogenetic ImplicationsOrganization, the Channel Catfish: Structure, Heavy Chain Diversity Region Segments of

  2000cites this paper
• Heterogeneity of Tonsillar Subepithelial B Lymphocytes, the Splenic Marginal Zone Equivalents1

  2000cites this paper
• Heavy Chain Diversity Region Segments of the Channel Catfish: Structure, Organization, Expression and Phylogenetic Implications1 2

  2000cites this paper
• Detection of clonotypic IGH and TCR rearrangements in the neonatal blood spots of infants and children with B-cell precursor acute lymphoblastic leukemia.

  2000cites this paper
• Molecular analysis of the CDR3 encoding region of the immunoglobulin heavy chain locus in cerebrospinal fluid cells as a diagnostic tool in lymphomatous meningitis

  2000cites this paper
• The influence of CD40-CD154 interactions on the expressed human V(H) repertoire: analysis of V(H) genes expressed by individual B cells of a patient with X-linked hyper-IgM syndrome.

  2000cites this paper
• Equivalents Lymphocytes , the Splenic Marginal Zone Heterogeneity of Tonsillar Subepithelial

  2000influential citation
• Possible presence of enhancing antibodies in idiopathic thrombocytopenic purpura

  1999cites this paper
• The Human Immunoglobulin Heavy Diversity (IGHD) and Joining (IGHJ) Segments

  1999cites this paper
• Characterization of the CDR3 region of rearranged α heavy chain genes in human fetal liver

  1998cites this paper
• Clonal diversity of Ig and T-cell-receptor gene rearrangements identifies a subset of childhood B-precursor acute lymphoblastic leukemia with increased risk of relapse.

  1998cites this paper
• Clonally-related Immunoglobulin VH Domains and Nonrandom Use of DH Gene Segments in Rheumatoid Arthritis Synovium

  1998cites this paper
• Clonal Diversity of Ig and T-Cell-Receptor Gene Rearrangements Identifies a Subset of Childhood B-Precursor Acute Lymphoblastic Leukemia With Increased Risk of Relapse

  1998cites this paper
• Ig heavy chain third complementarity determining regions (H CDR3s) after stem cell transplantation do not resemble the developing human fetal H CDR3s in size distribution and Ig gene utilization.

  1998cites this paper
• Characterization of the CDR3 region of rearranged alpha heavy chain genes in human fetal liver.

  1998cites this paper
• Clonal expansion and somatic hypermutation of V(H) genes of B cells from cerebrospinal fluid in multiple sclerosis.

  1998cites this paper
• Chapter 1 - Antibody Specificity and Diversity: Part II: The Genes*

  1998cites this paper
• Immunological and molecular analysis of three monoclonal lupus anticoagulant antibodies from a patient with systemic lupus erythematosus.

  1998cites this paper
• Lack of intraclonal diversification in Ig heavy and light chain V region genes expressed by CD5+IgM+ chronic lymphocytic leukemia B cells: a multiple time point analysis.

  1998cites this paper
• Human anticardiolipin monoclonal autoantibodies cause placental necrosis and fetal loss in BALB/c mice.

  1998cites this paper
• Analysis of the human VH gene repertoire. Differential effects of selection and somatic hypermutation on human peripheral CD5(+)/IgM+ and CD5(-)/IgM+ B cells.

  1997cites this paper
• Rearrangement status of the malignant cell determines type of secondary IgH rearrangement (V-replacement or V to DJ joining) in childhood B precursor acute lymphoblastic leukemia

  1997cites this paper
• Molecular detection of minimal residual disease in adult and childhood acute lymphoblastic leukaemia reveals differences in treatment response

  1997cites this paper
• Human Ig heavy chain CDR3 regions in adult bone marrow pre-B cells display an adult phenotype of diversity: evidence for structural selection of DH amino acid sequences.

  1997cites this paper
• Differential Effects of Selection and Somatic Hypermutation on Human Peripheral CD5

  1997cites this paper
• A 37-kb restriction map of the human immunoglobulin lambda variable locus, VB cluster, harboring four functional genes and two non-coding V l sequences

  1997cites this paper
• Restricted use of cationic germline V(H) gene segments in human Rh(D) red cell antibodies.

  1997cites this paper
• VH Gene Use by HIV Type 1-Associated Lymphoproliferations

  1997cites this paper
• Immunoglobulin lambda light chain orphons on human chromosome 8q11.2

  1997cites this paper
• Analysis of rearranged immunoglobulin heavy chain variable region genes obtained from a bone marrow transplant (BMT) recipient

  1997cites this paper
• VHDJH gene sequences and antigen reactivity of monoclonal antibodies produced by human B-1 cells: evidence for somatic selection.

  1997cites this paper
• Preferential dissemination of B-cell gastric mucosa-associated lymphoid tissue (MALT) lymphoma to the splenic marginal zone.

  1997cites this paper
• Clonal instability preceding lymphoid blastic transformation of chronic myeloid leukemia

  1997cites this paper
• Intraclonal offspring expansion of gastric low-grade MALT-type lymphoma: evidence for the role of antigen-driven high-affinity mutation in lymphomagenesis.

  1997cites this paper
• Comparison of the immunoglobulin gene transcripts between immature B lineage acute lymphoblastic leukemia and the normal phenotypic counterparts in the bone marrow

  1997cites this paper
• Sequence of the human immunoglobulin diversity (D) segment locus: a systematic analysis provides no evidence for the use of DIR segments, inverted D segments, "minor" D segments or D-D recombination.

  1997cites this paper
• Immunoglobulin heavy chain junctional diversity in young and aged humans.

  1997cites this paper
• Analysis of VH genes rearranged by individual B cells in dermal infiltrates of patients with mycosis fungoides

  1997cites this paper
• Third complementarity-determining-region sequence analysis of lymphocytic interstitial pneumonia: most cases demonstrate a minor monoclonal population hidden among normal lymphocyte clones.

  1997cites this paper
• IgG rheumatoid factors isolated by the surface-displaying phage library technique

  1997cites this paper
• Analysis of immunoglobulin G kappa antithyroid peroxidase antibodies from different tissues in Hashimoto's thyroiditis.

  1997cites this paper
• Human thymic B cells largely overexpress the VH4 Ig gene family. A possible role in the control of tolerance in situ?

  1997cites this paper
• Human B cell biology.

  1997cites this paper
• Molecular analysis of ocular adnexal lymphoid proliferations. Characteristics of immunoglobulin VH, D and J segment usage.

  1996cites this paper
• Organization of the human immunoglobulin heavy-chain locus.

  1996cites this paper
• Intestinal dissemination of gastric mucosa-associated lymphoid tissue lymphoma.

  1996cites this paper
• Comparison of the immunoglobulin heavy‐chain complementarity determining region‐3 structure among the DNA sequences and the μ‐ and γ‐transcripts in human B‐lineage cells

  1996cites this paper
• Ordering of Human Bone Marrow B Lymphocyte Precursors by Single-Cell Polymerase Chain Reaction Analyses of the Rearrangement Status of the Immunoglobulin H and L Chain Gene Loci

  1996cites this paper
• Comparable gene structure of the immunoglobulin heavy chain variable region between multiple myeloma and normal bone marrow lymphocytes.

  1996cites this paper
• Quantification of t(14;18) in the lymphocytes of healthy adult humans as a possible biomarker for environmental exposures to carcinogens.

  1996cites this paper
• Organization of the Human Immunoglobulin Heavy-Chain Locus

  1996cites this paper
• Molecular analysis of stimulatory anti-thyrotropin receptor antibodies (TSAbs) involved in Graves' disease. Isolation and reconstruction of antibody genes, and production of monoclonal TSAbs.

  1996cites this paper
• Analysis of the complementary determining region III of the immunoglobulin heavy chain locus in acute lymphoblastic leukemia in Chilean children.

  1996cites this paper
• Antibody expression from the core region of the human IgH locus reconstructed in transgenic mice using bacteriophage P1 clones.

  1996cites this paper
• Third complementarity determining region sequence analysis of low-grade bronchus-associated lymphoid tissue lymphoma: genotypic analysis reveals heterogeneity in maturation.

  1996cites this paper
• MONOCLONALITY OF B‐CELL LINEAGE IN PRIMARY PULMONARY LYMPHOMA DEMONSTRATED BY IMMUNOGLOBULIN HEAVY CHAIN GENE SEQUENCE ANALYSIS OF HISTOLOGICALLY NON‐DEFINITIVE TRANSBRONCHIAL BIOPSY SPECIMENS

  1996cites this paper
• Molecular analysis of the leukaemic B cell in adult and childhood acute lymphoblastic leukaemia

  1996cites this paper
• The VDJ repertoire expressed in human preB cells reflects the selection of bona fide heavy chains

  1996cites this paper
• The use of IgH fingerprinting and ASO‐dependent PCR for the investigation of residual disease (MRD) in ALL

  1996cites this paper
• Ongoing mutation in MALT lymphoma immunoglobulin gene suggests that antigen stimulation plays a role in the clonal expansion.

  1996cites this paper
• CD34 selections from myeloma peripheral blood cell autografts contain residual tumour cells due to impurity, not to CD34+ myeloma cells

  1996cites this paper
• Clonal evolution of immunoglobulin heavy chain rearrangements in childhood B-precursor acute lymphoblastic leukemia after engraftment in SCID mice.

  1996cites this paper
• Evidence for oligoclonal diversification of the VH6-containing immunoglobulin repertoire during reconstitution after bone marrow transplantation.

  1996cites this paper
• Clonal analysis by polymerase chain reaction of B‐cell lymphoma with late relapse: A report of five cases

  1996cites this paper
• Organization of the human immunoglobulin lambda light-chain locus on chromosome 22q11.2.

  1995cites this paper
• Repertoire cloning of a human IgG inhibitor of αIIbβ3 function. The OG idiotype

  1995cites this paper
• VH3-21 B Cells Escape from a State of Tolerance in Rheumatoid Arthritis and Secrete Rheumatoid Factor

  1995cites this paper
• Repertoire cloning of a human IgG inhibitor of alpha IIB beta 3 function. The OG idiotype.

  1995cites this paper
• Detection of minimal residual disease in patients with childhood common acute lymphoblastic leukemia after autologous bone marrow transplantation with ex vivo purging and systemic IL-2 infusion: unsuccessful prediction of subsequent relapse.

  1995cites this paper