Molecular biology for formyl peptide receptors in human diseases

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Journal of molecular medicine

• Publication date

  2013-02-13

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00109-013-1005-5PMID 23404331
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cell surface receptor FPR2 promotes antitumor host defense by limiting M2 polarization of macrophages.

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• Infection Regulates Pro-Resolving Mediators that Lower Antibiotic Requirements

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• Formylpeptide receptors are critical for rapid neutrophil mobilization in host defense against Listeria monocytogenes

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• Pleiotropic regulation of macrophage polarization and tumorigenesis by formyl peptide receptor-2

  2011cited by this paper
• Pleiotropic regulation of macrophage polarization and tumorigenesis by formyl peptide receptor-2

  2011cited by this paper
• Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obese‐diabetic mice

  2011cited by this paper
• Annexin 1 released by necrotic human glioblastoma cells stimulates tumor cell growth through the formyl peptide receptor 1.

  2011cited by this paper
• Anti-Inflammatory Role of the Murine Formyl-Peptide Receptor 2: Ligand-Specific Effects on Leukocyte Responses and Experimental Inflammation

  2010cited by this paper
• The antimicrobial peptide human cationic antimicrobial protein‐18/cathelicidin LL‐37 as a putative growth factor for malignant melanoma

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• Cutting Edge: A Critical Role for the G Protein-Coupled Receptor mFPR2 in Airway Inflammation and Immune Responses

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  2010cited by this paper
• The Agonists of Formyl Peptide Receptors Prevent Development of Severe Sepsis after Microbial Infection

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• Transgenic Restoration of Long-Chain n-3 Fatty Acids in Insulin Target Tissues Improves Resolution Capacity and Alleviates Obesity-Linked Inflammation and Insulin Resistance in High-Fat–Fed Mice

  2010cited by this paper
• Cancer and Inflammation: Implications for Pharmacology and Therapeutics

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• Resolvin D1 binds human phagocytes with evidence for proresolving receptors

  2010cited by this paper
• FPR2/ALX receptor expression and internalization are critical for lipoxin A4 and annexin‐derived peptide‐stimulated phagocytosis

  2010cited by this paper
• Prions

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• Lipoxin A4 and Its Analogue Suppress the Tumor Growth of Transplanted H22 in Mice: The Role of Antiangiogenesis

  2010cited by this paper
• Norepinephrine Promotes Microglia to Uptake and Degrade Amyloid β Peptide through Upregulation of Mouse Formyl Peptide Receptor 2 and Induction of Insulin-Degrading Enzyme

  2010cited by this paper
• The pro-inflammatory peptide LL-37 promotes ovarian tumor progression through recruitment of multipotent mesenchymal stromal cells

  2009cited by this paper
• Effects of Lipoxin A4 on CoCl2-Induced Angiogenesis and Its Possible Mechanisms in Human Umbilical Vein Endothelial Cells

  2009cited by this paper
• Obesity‐induced insulin resistance and hepatic steatosis are alleviated by ω‐3 fatty acids: a role for resolvins and protectins

  2009cited by this paper
• International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the Formyl Peptide Receptor (FPR) Family

  2009cited by this paper
• Cancer-related inflammation

  2008cited by this paper
• Formyl-peptide receptor like 1: a potent mediator of the Ca2+ release-activated Ca2+ current ICRAC.

  2008cited by this paper
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  2007cited by this paper
• The Required Role of Endogenously Produced Lipoxin A4 and Annexin-1 for the Production of IL-10 and Inflammatory Hyporesponsiveness in Mice1

  2007cited by this paper
• Mechanism for Resolution of Inflammation A in Human Neutrophils : A Novel AmyloidApoptosis-Delaying Action of Serum Aspirin-Triggered Lipoxins Override the

  2007cited by this paper
• Resolvin D1 and Its Aspirin-triggered 17R Epimer

  2007cited by this paper
• Aspirin-Triggered Lipoxins Override the Apoptosis-Delaying Action of Serum Amyloid A in Human Neutrophils: A Novel Mechanism for Resolution of Inflammation1

  2007cited by this paper
• Transactivation of the epidermal growth factor receptor by formylpeptide receptor exacerbates the malignant behavior of human glioblastoma cells.

  2007cited by this paper
• Activation of Toll-like Receptor 2 on Microglia Promotes Cell Uptake of Alzheimer Disease-associated Amyloid β Peptide*

  2006influential reference
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  2006cited by this paper
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  2006cited by this paper
• Formylpeptide receptor FPR and the rapid growth of malignant human gliomas.

  2005cited by this paper
• Lipoxin A4 modifies platelet-derived growth factor-induced pro-fibrotic gene expression in human renal mesangial cells.

  2005cited by this paper
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  2005cited by this paper
• CpG‐containing oligodeoxynucleotide promotes microglial cell uptake of amyloid β 1–42 peptide by up‐regulating the expression of the G‐protein‐coupled receptor mFPR2

  2005influential reference
• Novel lipid mediator aspirin-triggered lipoxin A4 induces heme oxygenase-1 in endothelial cells.

  2005cited by this paper
• Lipoxin A4 inhibits TNF-alpha-induced production of interleukins and proliferation of rat mesangial cells.

  2005cited by this paper
• An Annexin 1 N-Terminal Peptide Activates Leukocytes by Triggering Different Members of the Formyl Peptide Receptor Family1

  2004cited by this paper
• N-Formylated humanin activates both formyl peptide receptor-like 1 and 2.

  2004cited by this paper
• Humanin, a Newly Identified Neuroprotective Factor, Uses the G Protein-Coupled Formylpeptide Receptor-Like-1 as a Functional Receptor1

  2004cited by this paper
• Obesity is associated with macrophage accumulation in adipose tissue.

  2003cited by this paper
• The annexin 1 receptor(s): is the plot unravelling?

  2003cited by this paper
• Formyl-peptide receptors revisited.

  2002cited by this paper
• Lipoxin-mediated inhibition of IL-12 production by DCs: a mechanism for regulation of microbial immunity

  2002cited by this paper
• Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A4

  2002cited by this paper
• Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor

  2002cited by this paper
• Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit peroxynitrite formation, NF-κB and AP-1 activation, and IL-8 gene expression in human leukocytes

  2002cited by this paper
• An overview of the determinants of CCR5 and CXCR4 co-receptor function.

  2001cited by this paper
• Lipoxin A4 and Aspirin-Triggered 15-Epi-Lipoxin A4 Antagonize TNF-α-Stimulated Neutrophil-Enterocyte Interactions In Vitro and Attenuate TNF-α-Induced Chemokine Release and Colonocyte Apoptosis in Human Intestinal Mucosa Ex Vivo1

  2001cited by this paper
• Beta amyloid peptide (Abeta42) is internalized via the G-protein-coupled receptor FPRL1 and forms fibrillar aggregates in macrophages.

  2001cited by this paper
• Differential Regulation of Formyl Peptide Receptor-Like 1 Expression During the Differentiation of Monocytes to Dendritic Cells and Macrophages1

  2001cited by this paper
• Detailed Characterization of Neuroprotection by a Rescue Factor Humanin against Various Alzheimer's Disease-Relevant Insults

  2001cited by this paper
• The neurotoxic prion peptide fragment PrP(106-126) is a chemotactic agonist for the G protein-coupled receptor formyl peptide receptor-like 1.

  2001cited by this paper
• The Synthetic Peptide Trp-Lys-Tyr-Met-Val-Met-NH2 Specifically Activates Neutrophils through FPRL1/Lipoxin A4 Receptors and Is an Agonist for the Orphan Monocyte-expressed Chemoattractant Receptor FPRL2*

  2001influential reference
• Cutting Edge: The Neurotoxic Prion Peptide Fragment PrP106–126 Is a Chemotactic Agonist for the G Protein-Coupled Receptor Formyl Peptide Receptor-Like 11 2

  2001cited by this paper
• A proinflammatory peptide from Helicobacter pylori activates monocytes to induce lymphocyte dysfunction and apoptosis.

  2001influential reference
• Ll-37, the Neutrophil Granule–And Epithelial Cell–Derived Cathelicidin, Utilizes Formyl Peptide Receptor–Like 1 (Fprl1) as a Receptor to Chemoattract Human Peripheral Blood Neutrophils, Monocytes, and T Cells

  2000cited by this paper
• Lipoxin A4 Inhibits IL-1β-Induced IL-6, IL-8, and Matrix Metalloproteinase-3 Production in Human Synovial Fibroblasts and Enhances Synthesis of Tissue Inhibitors of Metalloproteinases1

  2000cited by this paper
• Activation of the chemotactic peptide receptor FPRL1 in monocytes phosphorylates the chemokine receptor CCR5 and attenuates cell responses to selected chemokines.

  2000cited by this paper
• Inflammation and Alzheimer's disease.

  2000cited by this paper
• Down-regulation of the chemokine receptor CCR5 by activation of chemotactic formyl peptide receptor in human monocytes.

  2000influential reference
• Activation of Lipoxin a4 Receptors by Aspirin-Triggered Lipoxins and Select Peptides Evokes Ligand-Specific Responses in Inflammation

  2000cited by this paper
• Ibuprofen Suppresses Plaque Pathology and Inflammation in a Mouse Model for Alzheimer's Disease

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• Quantitative Analysis of Formyl Peptide Receptor Coupling to Giα1, Giα2, and Giα3 *

  1999cited by this paper
• Translating cell biology into therapeutic advances in Alzheimer's disease

  1999cited by this paper
• Impaired Antibacterial Host Defense in Mice Lacking the N-formylpeptide Receptor

  1999cited by this paper
• Regulation of tyrosine kinase cascades by G-protein-coupled receptors.

  1999cited by this paper
• Human formyl peptide receptor function role of conserved and nonconserved charged residues.

  1999cited by this paper
• Chemoattractant Receptor Cross-desensitization*

  1999cited by this paper
• Differential Phosphorylation Paradigms Dictate Desensitization and Internalization of the N-Formyl Peptide Receptor*

  1999cited by this paper
• Multiple activation steps of the N-formyl peptide receptor.

  1999cited by this paper
• Quantitative analysis of formyl peptide receptor coupling to g(i)alpha(1), g(i)alpha(2), and g(i)alpha(3).

  1999cited by this paper
• Association of β-Arrestin with G Protein-coupled Receptors during Clathrin-mediated Endocytosis Dictates the Profile of Receptor Resensitization*

  1999cited by this paper
• Aspirin-triggered 15-epi-lipoxin A4 and novel lipoxin B4 stable analogs inhibit neutrophil-mediated changes in vascular permeability.

  1999cited by this paper
• A synthetic peptide derived from human immunodeficiency virus type 1 gp120 downregulates the expression and function of chemokine receptors CCR5 and CXCR4 in monocytes by activating the 7-transmembrane G-protein-coupled receptor FPRL1/LXA4R.

  1999cited by this paper
• Human formyl peptide receptor function

  1999cited by this paper
• HIV-1 envelope gp120 inhibits the monocyte response to chemokines through CD4 signal-dependent chemokine receptor down-regulation.

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• Nobel Lecture: Prions

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• HIV-1 envelope gp41 is a potent inhibitor of chemoattractant receptor expression and function in monocytes.

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• Differential expression of members of the N-formylpeptide receptor gene cluster in human phagocytes.

  1994cited by this paper
• N-linked glycosylation of the receptor for murine ecotropic retroviruses is altered in virus-infected cells.

  1993cited by this paper
• Agonist-dependent phosphorylation of N-formylpeptide and activation peptide from the fifth component of C (C5a) chemoattractant receptors in differentiated HL60 cells.

  1993cited by this paper
• Differences in phosphorylation of formylpeptide and C5a chemoattractant receptors correlate with differences in desensitization.

  1993cited by this paper
• Species and subtype variants of the N-formyl peptide chemotactic receptor reveal multiple important functional domains.

  1993cited by this paper
• Formyl peptide receptor chimeras define domains involved in ligand binding.

  1993cited by this paper
• Multiple domains of the N-formyl peptide receptor are required for high-affinity ligand binding. Construction and analysis of chimeric N-formyl peptide receptors.

  1993cited by this paper
• Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor.

  1992cited by this paper
• Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19.

  1992cited by this paper

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• Mitochondrial DAMPs: Key Mediators in Neuroinflammation and Neurodegenerative Disease Pathogenesis.

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• FPR2-based anti-inflammatory and anti-lipogenesis activities of novel meroterpenoid dimers from Ganoderma.

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