Adrenomedullin Infusion Attenuates Myocardial Ischemia/Reperfusion Injury Through the Phosphatidylinositol 3-Kinase/Akt-Dependent Pathway

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Circulation

• Publication date

  2004-01-20

• Fields of study

  Medicine

• Identifiers
  DOI 10.1161/01.CIR.0000109214.30211.7CPMID 14691041
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Ischemia-Reperfusion : The Roles of PI 3-Kinase , Akt , and Endothelial Nitric Oxide Nitric Oxide Mediates the Antiapoptotic Effect of Insulin in Myocardial

  2002cited by this paper
• Intravenous Adrenomedullin in Myocardial Function and Energy Metabolism in Patients After Myocardial Infarction

  2002cited by this paper
• Reperfusion-Activated Akt Kinase Prevents Apoptosis in Transgenic Mouse Hearts Overexpressing Insulin-Like Growth Factor-1

  2001cited by this paper
• Akt Activation Preserves Cardiac Function and Prevents Injury After Transient Cardiac Ischemia In Vivo

  2001cited by this paper
• Adrenomedullin Induces Endothelium-Dependent Vasorelaxation via the Phosphatidylinositol 3-Kinase/Akt-Dependent Pathway in Rat Aorta

  2001cited by this paper
• Cardiac adrenomedullin gene expression and peptide accumulation after acute myocardial infarction in rats.

  2000cited by this paper
• Action potential propagation in inhomogeneous cardiac tissue: safety factor considerations and ionic mechanism.

  2000cited by this paper
• Endogenous tumor necrosis factor protects the adult cardiac myocyte against ischemic-induced apoptosis in a murine model of acute myocardial infarction.

  2000cited by this paper
• Hemodynamic, renal, and hormonal effects of adrenomedullin infusion in patients with congestive heart failure.

  2000cited by this paper
• Adrenomedullin and nitric oxide inhibit human endothelial cell apoptosis via a cyclic GMP-independent mechanism.

  2000cited by this paper
• An autocrine or a paracrine role of adrenomedullin in modulating cardiac fibroblast growth.

  1999cited by this paper
• Quantitative assessment of cardiac myocyte apoptosis in tissue sections using the fluorescence-based tunel technique enhanced with counterstains.

  1999cited by this paper
• Cardiovascular and renal effects of adrenomedullin in rats with heart failure.

  1999cited by this paper
• Increased plasma adrenomedullin levels in patients with acute myocardial infarction in proportion to the clinical severity

  1998cited by this paper
• Cardiovascular and renal effects of adrenomedullin in rats with heart failure

  1998cited by this paper
• Adrenomedullin: a possible autocrine or paracrine inhibitor of hypertrophy of cardiomyocytes.

  1998cited by this paper
• Overexpression of human copper, zinc-superoxide dismutase (SOD1) prevents postischemic injury.

  1998cited by this paper
• Attenuation of ischemia/reperfusion injury in rats by a caspase inhibitor.

  1998cited by this paper
• Apoptosis in the heart.

  1997cited by this paper
• Adrenomedullin as an autocrine/paracrine apoptosis survival factor for rat endothelial cells.

  1997cited by this paper
• PI3K: downstream AKTion blocks apoptosis.

  1997cited by this paper
• Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53.

  1997cited by this paper
• Apoptosis in the heart.

  1996cited by this paper
• Distribution and characterization of immunoreactive rat adrenomedullin in tissue and plasma

  1994cited by this paper
• Distribution and characterization of immunoreactive adrenomedullin in human tissue and plasma

  1994cited by this paper
• Reperfusion injury induces apoptosis in rabbit cardiomyocytes.

  1994cited by this paper
• Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma.

  1993cited by this paper

• The PIWI-interacting RNA CRAPIR alleviates myocardial ischemia‒reperfusion injury by reducing p53-mediated apoptosis via binding to SRSF1

  2025cites this paper
• Cardiovascular Disease and COVID-19: Is There a Place for Mid-Regional Pro-Adrenomedullin? Preliminary Data from a Clinical Cohort

  2025cites this paper
• Mechanism of Danggui Buxue decoction in the treatment of myocardial infarction based on network pharmacology and experimental identification

  2024cites this paper
• Endothelial Dysfunction in Heart Failure: What Is Its Role?

  2024cites this paper
• MicroRNAs as the pivotal regulators of Temozolomide resistance in glioblastoma

  2024cites this paper
• Regulatory role of some protein kinases in signal transduction pathways in heart health and disease

  2023cites this paper
• The RISK pathway leading to mitochondria and cardioprotection: how everything started

  2023cites this paper
• Acute heart failure: mechanisms and pre-clinical models-a Scientific Statement of the ESC Working Group on Myocardial Function.

  2023cites this paper
• Mid-Regional Proadrenomedullin in COVID-19—May It Act as a Predictor of Prolonged Cardiovascular Complications?

  2023cites this paper
• miR-1297 sensitizes glioma cells to temozolomide (TMZ) treatment through targeting adrenomedullin (ADM)

  2022cites this paper
• Adrenomedullin ameliorates palmitic acid-induced insulin resistance through PI3K/Akt pathway in adipocytes

  2022cites this paper
• Adrenomedullin: Not Just Another Gastrointestinal Peptide

  2022cites this paper
• Comprehensive Analysis of N6-Methyladenosine RNA Methylation Regulators Expression Identify Distinct Molecular Subtypes of Myocardial Infarction

  2021cites this paper
• DRD4 Mitigates Myocardial Ischemia/Reperfusion Injury in Association With PI3K/AKT Mediated Glucose Metabolism

  2021cites this paper
• Momordica charantia silver nanoparticles modulate SOCS/JAK/STAT and P13K/Akt/PTEN signalling pathways in the kidney of streptozotocin-induced diabetic rats

  2021cites this paper
• Copeptin, pro-atrial natriuretic peptide and pro-adrenomedullin as markers of hypoxic stress in patients with obstructive sleep apnea—a prospective intervention study

  2021cites this paper
• Dissecting the Involvement of Ras GTPases in Kidney Fibrosis

  2021cites this paper
• Oestrogen Receptor β Activation Protects Against Myocardial Infarction via Notch1 Signalling

  2020cites this paper
• The Rationale for Angiotensin Receptor Neprilysin Inhibitors in a Multi-Targeted Therapeutic Approach to COVID-19

  2020cites this paper
• The Rationale of Neprilysin Inhibition in Prevention of Myocardial Ischemia-Reperfusion Injury during ST-Elevation Myocardial Infarction

  2020cites this paper
• Targeting Endothelial Dysfunction in Eight Extreme-Critically Ill Patients with COVID-19 Using the Anti-Adrenomedullin Antibody Adrecizumab (HAM8101)

  2020cites this paper
• NO66 overexpression rescues ethanol-induced cell apoptosis in human AC16 cardiomyocytes by suppressing PTEN and activating the PI3K/Akt signaling.

  2020cites this paper
• Adrenomedullin: Continuing to explore cardioprotection

  2019cites this paper
• 2,3,5,4′‐Tetrahydroxystilbene‐2‐O‐β‐d‐glucoside eliminates ischemia/reperfusion injury–induced H9c2 cardiomyocytes apoptosis involving in Bcl‐2, Bax, caspase‐3, and Akt activation

  2019cites this paper
• Cathelicidin-related antimicrobial peptide protects against myocardial ischemia/reperfusion injury

  2019cites this paper
• Natural and synthetic peptides in the cardiovascular diseases: An update on diagnostic and therapeutic potentials.

  2019cites this paper
• Adrenomedullin in heart failure: pathophysiology and therapeutic application

  2018cites this paper
• Adrenomedullin Receptor Antagonists as a Potential Therapeutic Target for Major Depressive Disorder

  2018cites this paper
• Physiologic, Pathologic, and Therapeutic Paracrine Modulation of Cardiac Excitation-Contraction Coupling

  2018cites this paper
• N-Methyl-d-Aspartate Receptor-Driven Calcium Influx Potentiates the Adverse Effects of Myocardial Ischemia-Reperfusion Injury Ex Vivo

  2017cites this paper
• Intramyocardial Injection of Recombinant Adeno-Associated Viral Vector Coexpressing PR39/Adrenomedullin Enhances Angiogenesis and Reduces Apoptosis in a Rat Myocardial Infarction Model

  2017cites this paper
• Protective roles of bioactive peptides during ischemia‐reperfusion injury: From bench to bedside

  2017cites this paper
• Chitosan hydrogel improves mesenchymal stem cell transplant survival and cardiac function following myocardial infarction in rats

  2017cites this paper
• The role of adrenomedullin in the pathogenesis of gastric cancer

  2017cites this paper
• The role of adrenomedullin in the pathogenesis of gastric cancer.

  2017cites this paper
• Adrenomedullin Stimulates Porcine Sinus Node Automaticity

  2017cites this paper
• Restoration of Circulating MFGE8 (Milk Fat Globule-EGF Factor 8) Attenuates Cardiac Hypertrophy Through Inhibition of Akt Pathway

  2017cites this paper
• Primary Graft Dysfunction and Mortality Following Lung Transplantation: A Role for Proadrenomedullin Plasma Levels

  2016cites this paper
• Secreted factors from adipose tissue-derived mesenchymal stem cells suppress oxygen/glucose deprivation-induced cardiomyocyte cell death via furin/PCSK-like enzyme activity

  2016cites this paper
• Cohort of estrogen-induced microRNAs regulate adrenomedullin expression.

  2016cites this paper
• Adrenomedullin regulates intestinal physiology and pathophysiology.

  2016cites this paper
• The endothelial adrenomedullin-RAMP2 system regulates vascular integrity and suppresses tumour metastasis.

  2016cites this paper
• Bench-to-bedside pharmacology of adrenomedullin.

  2015cites this paper
• Full Reviews Potential role of Akt signaling in chronic kidney disease

  2015cites this paper
• Analysis of the Secretome of Apoptotic Peripheral Blood Mononuclear Cells: Impact of Released Proteins and Exosomes for Tissue Regeneration

  2015cites this paper
• Potential role of Akt signaling in chronic kidney disease.

  2015cites this paper
• Mitochondrial DNA Oxidative Damage Contributes to Cardiomyocyte Ischemia/Reperfusion‐Injury in Rats: Cardioprotective Role of Lycopene

  2015cites this paper
• Effect of adrenomedullin over-expression in the cardiovascular system during development and disease

  2015cites this paper
• A New Therapeutic Modality for Acute Myocardial Infarction: Nanoparticle-Mediated Delivery of Pitavastatin Induces Cardioprotection from Ischemia-Reperfusion Injury via Activation of PI3K/Akt Pathway and Anti-Inflammation in a Rat Model

  2015cites this paper
• Ischemia and reperfusion related myocardial inflammation: A network of cells and mediators targeting the cardiomyocyte

  2015cites this paper
• Regulation and Neutralisation of Adrenomedullin in Cancer

  2014cites this paper
• Adrenomedullin and tumour microenvironment

  2014cites this paper
• Caracterización de un modelo de colitis en ratones knockout inducibles para adrenomedulina

  2014cites this paper
• Thyroid hormone and heart failure: from myocardial protection to systemic regulation

  2014cites this paper
• Adrenomedullin in cardiovascular disease: a useful biomarker, its pathological roles and therapeutic application.

  2013cites this paper
• Cardiac mTOR protects the heart against ischemia-reperfusion injury.

  2012cites this paper
• Adrenomedullin as a Growth and Cell Fate Regulatory Factor for Adult Neural Stem Cells

  2012cites this paper
• Neural Stem Cells in the Adult Brain: From Benchside to Clinic

  2012cites this paper
• Therapeutic Impact of Follistatin-Like 1 on Myocardial Ischemic Injury in Preclinical Models

  2012cites this paper
• Attenuation of Hyperoxia-induced Lung Injury in Rats by Adrenomedullin

  2012cites this paper
• The Protective Effect of Adrenomedullin on Renal Injury, in a Model of Abdominal Aorta Cross-Clamping

  2012cites this paper
• Adrenomedullin-epinephrine cotreatment enhances cardiac output and left ventricular function by energetically neutral mechanisms.

  2012cites this paper
• Adrenomedullin and cardiovascular diseases

  2012cites this paper
• Loss of receptor activity-modifying protein 3 exacerbates cardiac hypertrophy and transition to heart failure in a sex-dependent manner.

  2012cites this paper
• Role of adrenomedullin in the growth and differentiation of stem and progenitor cells.

  2012cites this paper
• Cytoprotective and Proangiogenic Activity of Ex-Vivo Netrin-1 Transgene Overexpression Protects the Heart Against Ischemia/Reperfusion Injury

  2012cites this paper
• Gender-related difference of sevoflurane postconditioning in isolated rat hearts: focus on phosphatidylinositol-3-kinase/Akt signaling.

  2011cites this paper
• Established and novel biomarkers in ST-elevation myocardial infarction.

  2011cites this paper
• Rôle de l'adrénomédulline dans la néoangiogenèse et l'invasion tumorale

  2011cites this paper
• Hypoxic Pulmonary Arterial Hypertension in the Chicken Model

  2011cites this paper
• Studies on bone marrow-derived stem cells in patients with acute myocardial infarction

  2011cites this paper
• Cell-based therapy for chronic ischemic heart disease--a clinical perspective.

  2011cites this paper
• Protein Kinases as Drug Development Targets for Heart Disease Therapy

  2010cites this paper
• The First Clinical Pilot Study of Intravenous Adrenomedullin Administration in Patients With Acute Myocardial Infarction

  2010cites this paper
• Nitric oxide/cGMP signalling mediates the cardioprotective action of adrenomedullin in reperfused myocardium

  2010cites this paper
• eNOS phosphorylation in health and disease.

  2010cites this paper
• Antioxidant and Anti-Inflammatory Action of Stem Cells in Cardiac Disease

  2010cites this paper
• Functional characterization of two human receptor activity-modifying protein 3 variants.

  2010cites this paper
• Avaliação da contribuição do receptor AT1 de angiotensina II e do papel da via de sinalização AKT/GSK-3/mTOR no processo de hipertrofia do cardiomiócito induzido pelo hormônio tiroideano

  2010cites this paper
• Vascular Actions of CGRP and Adrenomedullin: Mechanisms and Potential Contribution to Inflammation in the Cutaneous Microvasculature

  2010cites this paper
• Biomarkers in the diagnosis of aspiration syndromes

  2010cites this paper
• New aspects for the treatment of cardiac diseases based on the diversity of functional controls on cardiac muscles: mitochondrial ion channels and cardioprotection.

  2009cites this paper
• Non-receptor tyrosine kinase Src is required for ischemia-stimulated neuronal cell proliferation via Raf/ERK/CREB activation in the dentate gyrus

  2009cites this paper
• Increased Endothelial Nitric-Oxide Synthase Expression Reduces Hypertension and Hyperinsulinemia in Fructose-Treated Rats

  2009cites this paper
• DESIGN AND CHARACTERIZATION OF POLYSACCHARIDE-BASED NON-VIRAL CARRIERS AIMING AT GENE TRANSFECTION AND GENETIC ENGINEERING FOR CELL THERAPY

  2009cites this paper
• Acute myocardial infarction: the enduring challenge for cardiac protection and survival.

  2009cites this paper
• Adrenomedullin reduces intestinal epithelial permeability in vivo and in vitro.

  2009cites this paper
• Upregulated expression of intermedin and its receptor in the myocardium and aorta in spontaneously hypertensive rats.

  2009cites this paper
• Mast cells, peptides and cardioprotection - an unlikely marriage?

  2009cites this paper
• Angiotensin type 1 receptor mediates thyroid hormone-induced cardiomyocyte hypertrophy through the Akt/GSK-3β/mTOR signaling pathway

  2009cites this paper
• Adrenomedullin improves cardiac expression of heat-shock protein 72 and tolerance against ischemia/reperfusion injury in insulin-resistant rats.

  2009cites this paper
• Oxidative stress in cardiovascular disease.

  2009cites this paper
• Myocyte stress 1 plays an important role in cellular hypertrophy and protection against apoptosis

  2009cites this paper
• Paracrine action of HO‐1‐modified mesenchymal stem cells mediates cardiac protection and functional improvement

  2008cites this paper
• Genetic mouse models reveal key physiological functions of adrenomedullin signaling

  2008cites this paper
• Involvement of small Ras GTPases and their effectors in chronic renal disease

  2008cites this paper
• Adrenomedullin induces lymphangiogenesis and ameliorates secondary lymphoedema.

  2008cites this paper
• Adaptive or maladaptive response to adenoviral adrenomedullin gene transfer is context‐dependent in the heart

  2008cites this paper
• Effects of combined mesenchymal stem cells and heme oxygenase-1 therapy on cardiac performance.

  2008cites this paper
• Aortic cross-clamping-induced spinal cord oxidative stress in rabbits: the role of a novel antioxidant adrenomedullin.

  2008cites this paper