Regulation of T cell receptor activation by dynamic membrane binding of the CD3epsilon cytoplasmic tyrosine-based motif.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Cell

• Publication date

  2008-11-14

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.cell.2008.09.044PMID 19013279PMCID PMC2597348
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pillars article: antigen receptor tail clue. Nature. 1989. 338: 383-384.

  2014cited by this paper
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  2008cited by this paper
• Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling

  2008influential reference
• Surface-Anchored Monomeric Agonist pMHCs Alone Trigger TCR with High Sensitivity

  2008cited by this paper
• Structural basis for the inhibition of tyrosine kinase activity of ZAP-70.

  2007cited by this paper
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  2007cited by this paper
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  2006cited by this paper
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  2006cited by this paper
• Directed evolution of a monomeric, bright and photostable version of Clavularia cyan fluorescent protein: structural characterization and applications in fluorescence imaging.

  2006influential reference
• PI(3,4,5)P3 and PI(4,5)P2 Lipids Target Proteins with Polybasic Clusters to the Plasma Membrane

  2006cited by this paper
• Current applications of bicelles in NMR studies of membrane-associated amphiphiles and proteins.

  2006cited by this paper
• Lipid-binding activity of intrinsically unstructured cytoplasmic domains of multichain immune recognition receptor signaling subunits.

  2006cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2005cited by this paper
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  2003cited by this paper
• FRET Detection of Cellular a 4 -Integrin Conformational Activation

  2003cited by this paper
• The Xplor-NIH NMR molecular structure determination package.

  2003influential reference
• FRET detection of cellular alpha4-integrin conformational activation.

  2003cited by this paper
• The organizing principle in the formation of the T cell receptor-CD3 complex.

  2002cited by this paper
• Recruitment of Nck by CD 3 Reveals a Ligand-Induced Conformational Change Essential for T Cell Receptor Signaling and Synapse Formation

  2002cited by this paper
• Micelle-induced curvature in a water-insoluble HIV-1 Env peptide revealed by NMR dipolar coupling measurement in stretched polyacrylamide gel.

  2002cited by this paper
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  2002cited by this paper
• Mechanisms contributing to T cell receptor signaling and assembly revealed by the solution structure of an ectodomain fragment of the CD3 epsilon gamma heterodimer.

  2001cited by this paper
• Imaging protein-protein interactions using fluorescence resonance energy transfer microscopy.

  2001influential reference
• Structural evaluation of phospholipid bicelles for solution-state studies of membrane-associated biomolecules.

  2001influential reference
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  2001cited by this paper
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  2001cited by this paper
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  2000cited by this paper
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  1999cited by this paper
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  1998influential reference
• Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor

  1995influential reference
• Signal transduction by lymphocyte antigen receptors.

  1994influential reference
• Structure of a fluid dioleoylphosphatidylcholine bilayer determined by joint refinement of x-ray and neutron diffraction data. III. Complete structure.

  1992cited by this paper
• Static and dynamic lipid asymmetry in cell membranes.

  1991cited by this paper
• T-cell antigen receptors.

  1990cited by this paper
• Antigen receptor tail clue

  1989influential reference
• [T-cell antigen receptors].

  1989cited by this paper

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