The MAP1 family of microtubule-associated proteins

SummaryMAP1-family proteins are classical microtubule-associated proteins (MAPs) that bind along the microtubule lattice. The founding members, MAP1A and MAP1B, are predominantly expressed in neurons, where they are thought to be important in the formation and development of axons and dendrites. Mammalian genomes usually contain three family members, MAP1A, MAP1B and a shorter, more recently identified gene called MAP1S. By contrast, only one family member, Futsch, is found in Drosophila. After their initial expression, the MAP1A and MAP1B polypeptides are cleaved into light and heavy chains, which are then assembled into mature complexes together with the separately encoded light chain 3 subunit (LC3). Both MAP1A and MAP1B are well known for their microtubule-stabilizing activity, but MAP1 proteins can also interact with other cellular components, including filamentous actin and signaling proteins. Furthermore, the activity of MAP1A and MAP1B is controlled by upstream signaling mechanisms, including the MAP kinase and glycogen synthase kinase-3 β pathways.

• Publication year

  2006

• Venue

  Genome Biology

• Publication date

  2006-06-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1186/gb-2006-7-6-224PMID 16938900PMCID 1779536
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2005cited by this paper
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  2005influential reference
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  2005cited by this paper
• Glycogen synthase kinase-3β phosphorylation of MAP1B at Ser1260 and Thr1265 is spatially restricted to growing axons

  2005cited by this paper
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  2004cited by this paper
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  2004influential reference
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• Direct interaction between BKCa potassium channel and microtubule‐associated protein 1A

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• Microtubule-associated protein 1B

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• Microtubule-associated protein 1B

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  2000cited by this paper
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  1999cited by this paper
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• Novel Features of the Light Chain of Microtubule-associated Protein MAP1B: Microtubule Stabilization, Self Interaction, Actin Filament Binding, and Regulation by the Heavy Chain

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  1998cited by this paper
• Characterization of the Microtubule-binding Domain of Microtubule-associated Protein 1A and Its Effects on Microtubule Dynamics*

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• Localization of Postsynaptic Density-93 to Dendritic Microtubules and Interaction with Microtubule-Associated Protein 1A

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• Domains of Neuronal Microtubule-associated Proteins and Flexural Rigidity of Microtubules

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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1995cited by this paper
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  1994cited by this paper
• Molecular characterization of light chain 3. A microtubule binding subunit of MAP1A and MAP1B.

  1994cited by this paper
• Identification of two distinct microtubule binding domains on recombinant rat MAP 1B.

  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1991cited by this paper
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  1991cited by this paper
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  1990cited by this paper
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  1989cited by this paper
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  1989influential reference
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  1989cited by this paper
• Organization of microtubules in dendrites and axons is determined by a short hydrophobic zipper in microtubule-associated proteins MAP2 and tau

  1989cited by this paper
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