[3H]nisoxetine--a radioligand for noradrenaline reuptake sites: correlation with inhibition of [3H]noradrenaline uptake and effect of DSP-4 lesioning and antidepressant treatments.

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Neuropharmacology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1016/0028-3908(95)00134-4PMID 8684598
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Repeated electroconvulsive shock increases the number of [3H]desipramine binding sites in rat cerebral cortex

  2004cited by this paper
• [3H]paroxetine binding in rat frontal cortex strongly correlates with [3H]5-HT uptake: effect of administration of various antidepressant treatments.

  1993cited by this paper
• Blockade by newly-developed antidepressants of biogenic amine uptake into rat brain synaptosomes.

  1993cited by this paper
• Effects of repeated administration of desipramine or electroconvulsive shock on norepinephrine uptake sites measured by [3H]nisoxetine autoradiography.

  1992cited by this paper
• Comparative pharmacology of dothiepin, its metabolites, and other antidepressant drugs

  1992cited by this paper
• [3H]nisoxetine: a radioligand for quantitation of norepinephrine uptake sites by autoradiography or by homogenate binding.

  1992cited by this paper
• Regional Distribution of Imipramine, Desipramine and Specific [3H]Desipramine Binding Sites in the Rat Brain after Acute and Chronic Treatment with Imipramine

  1991cited by this paper
• [3H]nisoxetine: a new radioligand for norepinephrine uptake sites in brain.

  1990cited by this paper
• High- and low-affinity [3H]desipramine-binding sites in human postmortem brain tissue.

  1990cited by this paper
• The interaction of the beta-haloethyl benzylamines, xylamine, and DSP-4 with catecholaminergic neurons.

  1990cited by this paper
• Antidepressant treatments, including sibutramine hydrochloride and electroconvulsive shock, decrease beta 1- but not beta 2-adrenoceptors in rat cortex.

  1989cited by this paper
• [3H]Desipramine Binding to Rat Brain Tissue: Binding to Both Noradrenaline Uptake Sites and Sites Not Related to Noradrenaline Neurons

  1989cited by this paper
• Antidepressant Treatments, Including Sibutramine Hydrochloride and Electroconvulsive Shock, Decrease β1 but Not β2‐Adrenoceptors in Rat Cortex

  1989cited by this paper
• The contribution of metabolites to the rapid and potent down-regulation of rat cortical beta-adrenoceptors by the putative antidepressant sibutramine hydrochloride.

  1989cited by this paper
• Effect of Chronic Desipramine Treatment on Dihydroalprenolol, Imipramine, and Desipramine Binding Sites: A Quantitative Autoradiographic Study in the Rat Brain

  1986cited by this paper
• A note on Shirley's nonparametric test for comparing several dose levels with a zero-dose control.

  1986cited by this paper
• A note on Shirley's nonparametric test for comparing several dose levels with a zero-dose control

  1986cited by this paper
• Differential visualization of dopamine and norepinephrine uptake sites in rat brain using [3H]mazindol autoradiography

  1985cited by this paper
• [3H]mazindol binding associated with neuronal dopamine and norepinephrine uptake sites.

  1984cited by this paper
• Pharmacological modifications of the neurotoxic action of the noradrenaline neurotoxin DSP4 on central noradrenaline neurons.

  1984cited by this paper
• Antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitro.

  1984cited by this paper
• Blockade by antidepressants and related compounds of biogenic amine uptake into rat brain synaptosomes: most antidepressants selectively block norepinephrine uptake.

  1984cited by this paper
• A practical computer-based approach to the analysis of radioligand binding experiments.

  1983cited by this paper
• Temporal sequence of changes in central noradrenergic system of rat after prolonged antidepressant treatment: receptor desensitization and neurotransmitter interactions.

  1983cited by this paper
• A new inhibitor of norepinephrine uptake devoid of affinity for receptors in rat brain.

  1982cited by this paper
• Characterization of [3H]desipramine binding associated with neuronal norepinephrine uptake sites in rat brain membranes

  1982cited by this paper
• High‐Affinity Binding of [3H]Desipramine to Rat Brain: A Presynaptic Marker for Noradrenergic Uptake Sites

  1982cited by this paper
• Norepinephrine neuronal uptake binding sites in rat brain membranes labeled with [3H]desipramine.

  1981cited by this paper
• DSP4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine)--a useful denervation tool for central and peripheral noradrenaline neurons.

  1981cited by this paper
• 'High affinity' binding of [3H]desipramine to rat cerebral cortex: relationship to tricyclic antidepressant-induced inhibition of norepinephrine uptake.

  1981cited by this paper
• High-affinity [3H] DMI binding is associated with neuronal noradrenaline uptake in the periphery and the central nervous system.

  1981cited by this paper
• Long-term antidepressant treatment decreases spiroperidol-labeled serotonin receptor binding.

  1980cited by this paper
• Ligand: a versatile computerized approach for characterization of ligand-binding systems.

  1980cited by this paper
• A non-parametric equivalent of Williams' test for contrasting increasing dose levels of a treatment.

  1977cited by this paper
• Effect of nisoxetine on uptake of catecholamines in synaptosomes isolated from discrete regions of rat brain.

  1976cited by this paper
• Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction.

  1973cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• NMDA receptor antagonism requires serotonin and noradrenaline to induce antidepressant-like effects in a treatment-resistant depression rat model.

  2026cites this paper
• Noradrenaline transporter PET reflects neurotoxin-induced noradrenaline level decrease in the rat hippocampus

  2023cites this paper
• New Drugs to Treat ADHD: Opportunities and Challenges in Research and Development.

  2022cites this paper
• Pharmacological characterization of 3,4-methylenedioxamphetamine (MDA) analogs and two amphetamine-based compounds: N,α-DEPEA and DPIA.

  2022cites this paper
• EVALUATION OF WEIGHT REDUCTION EFFICACY AND SAFETY OF SIBUTRAMIN-CONTAINING DRUGS IN PATIENTS WITH ALIMENTARY OBESITY

  2022cites this paper
• The contribution of the locus coeruleus-norepinephrine system in the emergence of defeat-induced inflammatory priming.

  2019cites this paper
• Sexually Dimorphic Effects of Prenatally Applied Fluoxetine ( Prozac ) on Behavior and Cognition in Rats

  2019cites this paper
• Effects of monoamine uptake inhibitors on pain-related depression of nesting in mice.

  2019cites this paper
• The Neurotoxin DSP-4 Induces Hyperalgesia in Rats that is Accompanied by Spinal Oxidative Stress and Cytokine Production.

  2018cites this paper
• Dopamine and μ-opioid receptor dysregulation in the brains of binge-eating female rats – possible relevance in the psychopathology and treatment of binge-eating disorder

  2017cites this paper
• Erratum to: Effects of atomoxetine on attention in Wistar rats treated with the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4)

  2017cites this paper
• Pharmacological profile of methylphenidate-based designer drugs.

  2017cites this paper
• Effects of methylphenidate on attention in Wistar rats treated with the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4)

  2017cites this paper
• Effects of atomoxetine on attention in Wistar rats treated with the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4)

  2017cites this paper
• Effects of vagus nerve stimulation on cognitive functioning in rats with cerebral ischemia reperfusion

  2016cites this paper
• MS Binding Assays for the Three Monoamine Transporters Using the Triple Reuptake Inhibitor (1R,3S)‐Indatraline as Native Marker

  2015cites this paper
• Monoamine Reuptake Inhibitors in Parkinson's Disease

  2015cites this paper
• Comparison of dopamine kinetics in the larval Drosophila ventral nerve cord and protocerebrum with improved optogenetic stimulation

  2015cites this paper
• Binge-Like Eating Attenuates Nisoxetine Feeding Suppression, Stress Activation, and Brain Norepinephrine Activity

  2014cites this paper
• The Effect of Sibutramine, a Serotonin-Norepinephrine Reuptake Inhibitor, on Platelets and Fibrin Networks of Male Sprague-Dawley Rats: A Descriptive Study

  2014cites this paper
• Predominant role of plasma membrane monoamine transporters in monoamine transport in 1321N1, a human astrocytoma‐derived cell line

  2014cites this paper
• The Role of the Noradrenergic System and Its Receptors in Levodopa-Induced Dyskinesia

  2014cites this paper
• DSP4, a Selective Neurotoxin for the Locus Coeruleus Noradrenergic System. A Review of Its Mode of Action

  2014cites this paper
• Dopamine reuptake transporter (DAT) "inverse agonism"--a novel hypothesis to explain the enigmatic pharmacology of cocaine.

  2014cites this paper
• An in vivo and in ovo evaluation of the toxicity of Sibutramine

  2014cites this paper
• Effects of desipramine treatment on stress-induced up-regulation of norepinephrine transporter expression in rat brains

  2014cites this paper
• Norepinephrine transporter occupancy by nortriptyline in patients with depression: a positron emission tomography study with (S,S)-[¹⁸F]FMeNER-D₂.

  2014cites this paper
• Development and validation of an LC-ESI-MS/MS method for the triple reuptake inhibitor indatraline enabling its quantification in MS Binding Assays

  2014cites this paper
• Effects of monoamine reuptake inhibitors in assays of acute pain-stimulated and pain-depressed behavior in rats.

  2013cites this paper
• Pharmacologically Active Drug Metabolites: Impact on Drug Discovery and Pharmacotherapy

  2013cites this paper
• High-Fat Diet-Induced Alterations in the Feeding Suppression of Low-Dose Nisoxetine, a Selective Norepinephrine Reuptake Inhibitor

  2013cites this paper
• A review of the abuse potential assessment of atomoxetine: a nonstimulant medication for attention-deficit/hyperactivity disorder

  2013cites this paper
• Studies on the chemoenzymatic synthesis of (R)- and (S)-methyl 3-aryl-3-hydroxypropionates: the influence of toluene-pretreatment of lipase preparations on enantioselective transesterifications

  2013cites this paper
• Investigação da participação de adrenoceptores α1 no efeito antinociceptivo da amitriptilina em um modelo de dor neuropática

  2012cites this paper
• The β2-Adrenoceptor Agonist Formoterol Stimulates Mitochondrial Biogenesis

  2012cites this paper
• Norepinephrine Transporter Imaging in the Brain of a Rat Model of Depression Using Radioiodinated (2S, αS)-2-(α-(2-iodophenoxy)benzyl)morpholine

  2012cites this paper
• The effects of the neurotoxin DSP4 on spatial learning and memory in Wistar rats

  2012cites this paper
• Lesioning noradrenergic neurons of the locus coeruleus in C57Bl/6 mice with unilateral 6-hydroxydopamine injection, to assess molecular, electrophysiological and biochemical changes in noradrenergic signaling.

  2012influential citation
• Characterization, stability, and pharmacokinetics of sibutramine/β-cyclodextrin inclusion complex

  2012cites this paper
• The Noradrenergic System is a Major Component in Parkinson’s Disease

  2011cites this paper
• Effects of DSP4 and methylphenidate on spatial memory performance in rats

  2011cites this paper
• Development of novel radiotracers as tools for imaging the human brain

  2011cites this paper
• The effect of denervation of the locus coeruleus projections with N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) on cocaine-induced locomotion and place preference in rats.

  2011cites this paper
• Changes in postnatal norepinephrine alter alpha-2 adrenergic receptor development.

  2011cites this paper
• Distinct adrenergic system changes and neuroinflammation in response to induced locus ceruleus degeneration in APP/PS1 transgenic mice.

  2011cites this paper
• Development of Pharmaceutical Dosage Form with New Sibutramine Salt

  2010cites this paper
• Development of BioEquiv, a Computer Program for the Analysis of Bioequivalence

  2010cites this paper
• Vieillissement olfactif chez la souris normale et chez la souris APP/PS1, modèle de la maladie d'Alzheimer : implications de la neurogenèse et du système noradrénergique

  2010cites this paper
• Enhanced solubility and bioavailability of sibutramine base by solid dispersion system with aqueous medium.

  2010cites this paper
• Induced LC degeneration in APP/PS1 transgenic mice accelerates early cerebral amyloidosis and cognitive deficits.

  2010cites this paper
• (R)-N-Methyl-3-(3'-[F]fluoropropyl)phenoxy)-3-phenylpropanamine (F-MFP3) as a potential PET imaging agent for norepinephrine transporter.

  2010cites this paper
• Synthesis, fluorine-18 radiolabeling, and biological evaluation of N-((E)-4-fluorobut-2-en-1-yl)-2beta-carbomethoxy-3beta-(4'-halophenyl)nortropanes: candidate radioligands for in vivo imaging of the brain dopamine transporter with positron emission tomography.

  2010cites this paper
• A comprehensive analysis of the effect of DSP4 on the locus coeruleus noradrenergic system in the rat.

  2010cites this paper
• Nicotinic Acetylcholine Receptors in the Mesolimbic Pathway: Primary Role of Ventral Tegmental Area α6β2* Receptors in Mediating Systemic Nicotine Effects on Dopamine Release, Locomotion, and Reinforcement

  2010influential citation
• Fluorine-18 Radiolabeled PET Tracers for Imaging Monoamine Transporters: Dopamine, Serotonin, and Norepinephrine.

  2009cites this paper
• Interference of the noradrenergic neurotoxin DSP4 with neuronal and nonneuronal monoamine transporters

  2009cites this paper
• 5‐HT1A Activation Counteracts Cardiovascular But Not Hypophagic Effects of Sibutramine in Rats

  2009cites this paper
• Down-regulation of norepinephrine transporter expression on membrane surface induced by chronic administration of desipramine and the antagonism by co-administration of local anesthetics in mice.

  2008cites this paper
• Synthesis, radiosynthesis, and biological evaluation of fluorine-18-labeled 2beta-carbo(fluoroalkoxy)-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography.

  2008cites this paper
• Determination of the active metabolites of sibutramine in rat serum using column-switching HPLC.

  2008cites this paper
• Sibutramine: current status as an anti-obesity drug and its future perspectives

  2008cites this paper
• Pharmacologic Treatment of Obesity: Pitfalls and New Promises

  2008cites this paper
• Tratamiento farmacológico de la obesidad: presente, pasado y futuro

  2007cites this paper
• Inhibition of Dopamine and Norepinephrine Reuptake Produces Additive Effects on Energy Balance in Lean and Obese Mice

  2007cites this paper
• Effects of the noradrenergic neurotoxin DSP4 on spatial memory in the rat

  2007influential citation
• Pharmacological properties of the active metabolites of the antidepressants desipramine and citalopram.

  2007cites this paper
• Neurokinin 1 receptor antagonism requires norepinephrine to increase serotonin function.

  2007cites this paper
• Synthesis and PET evaluation of (R)‐[S‐methyl‐11C]thionisoxetine, a candidate radioligand for imaging brain norepinephrine transporters

  2006cites this paper
• Down-regulation of norepinephrine transporter function induced by chronic administration of desipramine linking to the alteration of sensitivity of local-anesthetics-induced convulsions and the counteraction by co-administration with local anesthetics.

  2006cites this paper
• Indirect Modulation by α7 Nicotinic Acetylcholine Receptors of Noradrenaline Release in Rat Hippocampal Slices: Interaction with Glutamate and GABA Systems and Effect of Nicotine Withdrawal

  2006influential citation
• Synthesis and evaluation of radioiodinated (S,S)-2-(alpha-(2-iodophenoxy)benzyl)morpholine for imaging brain norepinephrine transporter.

  2006cites this paper
• Synthesis and evaluation of radioiodinated (S,S)-2-(α-(2-iodophenoxy)benzyl)morpholine for imaging brain norepinephrine transporter

  2006cites this paper
• Post-mortem human brain autoradiography of the norepinephrine transporter using (S,S)-[18F]FMeNER-D2.

  2005cites this paper
• Pharmacological profile of radioligand binding to the norepinephrine transporter: instances of poor indication of functional activity.

  2005cites this paper
• Short communication Post-mortem human brain autoradiography of the norepinephrine transporter using (S,S)-( 18 F)FMeNER-D 2

  2005cites this paper
• Autonome, kardiovaskuläre und metabolische Wirkungen kombinierter pharmakologischer Noradrenalin- und Serotonin-Wiederaufnahme-Hemmung

  2004cites this paper
• Acute Cardiovascular Effects of Sibutramine in Conscious Rats

  2004cites this paper
• Relative bioavailability and pharmacokinetics of a new sibutramine formulation in healthy male subjects: a randomized, open-label, two-period, comparative crossover study.

  2004cites this paper
• Electrophysiological Evidence for the Tonic Activation of 5-HT1A Autoreceptors in the Rat Dorsal Raphe Nucleus

  2004cites this paper
• Evaluation of radioiodinated (R)-N-methyl-3-(2-iodophenoxy)-3-phenylpropanamine as a ligand for brain norepinephrine transporter imaging.

  2004cites this paper
• Regulation of the norepinephrine transporter by chronic administration of antidepressants.

  2004cites this paper
• [11C]‐DASB, a tool for in vivo measurement of SSRI‐induced occupancy of the serotonin transporter: PET characterization and evaluation in cats

  2003cites this paper
• Documento de consenso: obesidad y riesgo cardiovascular

  2003cites this paper
• Synthesis and in vivo evaluation of novel radiotracers for the in vivo imaging of the norepinephrine transporter.

  2003cites this paper
• Comparison of the thermogenic and hypophagic effects of sibutramine's metabolite 2 and other monoamine reuptake inhibitors.

  2002cites this paper
• The discovery and status of sibutramine as an anti-obesity drug.

  2002cites this paper
• Interaction of stress and noradrenergic drugs in the control of picrotoxin-induced seizures.

  2002cites this paper
• Mechanism of the thermogenic effect of Metabolite 2 (BTS 54 505), a major pharmacologically active metabolite of the novel anti-obesity drug, sibutramine

  2002cites this paper
• Effects of sibutramine on the central dopaminergic system in rodents

  2001cites this paper
• Modification of norepinephrine and serotonin, but not dopamine, neuron firing by sustained bupropion treatment

  2001cites this paper
• Effects of central noradrenaline depletion by the selective neurotoxin DSP-4 on the behaviour of the isolated rat in the elevated plus maze and water maze

  2001influential citation
• Effects of N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4) on alpha2-adrenoceptors which regulate the synthesis and release of noradrenaline in the rat brain.

  2001cites this paper
• Studies on the interaction of local anaesthetic agents with the norepinephrine transporter

  2001cites this paper
• Sibutramine does not decrease the number of 5-HT re-uptake sites in rat brain and, like fluoxetine, protects against the deficits produced by dexfenfluramine.

  2000cites this paper
• Effects of noradrenaline depletion in the brain on response to novelty in isolation-reared rats

  2000cites this paper
• An assessment of the safety and efficacy of sibutramine, an anti‐obesity drug with a novel mechanism of action

  2000cites this paper
• Norepinephrine uptake sites in the locus coeruleus of rat lines selectively bred for high and low alcohol preference: a quantitative autoradiographic binding study using [3H]-tomoxetine.

  2000cites this paper
• Strain-dependent neurochemical and neuroendocrine effects of desipramine, but not fluoxetine or imipramine, in spontaneously hypertensive and Wistar-Kyoto rats.

  2000cites this paper
• Comparison of changes in the extracellular concentration of noradrenaline in rat frontal cortex induced by sibutramine or d‐amphetamine: modulation by α2‐adrenoceptors

  1999cites this paper
• Pharmacological treatment of obesity: therapeutic strategies.

  1999cites this paper