Pregnancy Enhances Sustained Ca2+ Bursts and Endothelial Nitric Oxide Synthase Activation in Ovine Uterine Artery Endothelial Cells Through Increased Connexin 43 Function1

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Biology of Reproduction

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1095/biolreprod.109.078253PMID 19741206PMCID PMC2802114
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Connexin43 phosphorylation: structural changes and biological effects.

  2009cited by this paper
• Gap junctional intercellular communication in bovine corneal endothelial cells.

  2006cited by this paper
• Dissociation of endothelial nitric oxide synthase phosphorylation and activity in uterine artery endothelial cells.

  2006influential reference
• Pregnancy-enhanced Ca2+ responses to ATP in uterine artery endothelial cells is due to greater capacitative Ca2+ entry rather than altered receptor coupling.

  2006cited by this paper
• Role of voltage-dependent modulation of store Ca2+ release in synchronization of Ca2+ oscillations.

  2006cited by this paper
• Pregnancy-enhanced store-operated Ca 2 C channel function in uterine artery endothelial cells is associated with enhanced agonist-specific transient receptor potential channel 3-inositol 1,4,5-trisphosphate receptor 2 interaction

  2006cited by this paper
• Pregnancy-enhanced endothelial nitric oxide synthase (eNOS) activation in uterine artery endothelial cells shows altered sensitivity to Ca2+, U0126, and wortmannin but not LY294002--evidence that pregnancy adaptation of eNOS activation occurs at multiple levels of cell signaling.

  2006cited by this paper
• Simultaneous imaging of [Ca2+]i and intracellular NO production in freshly isolated uterine artery endothelial cells: effects of ovarian cycle and pregnancy.

  2005cited by this paper
• Inhibition of gap junction-mediated intercellular communication by TNF-alpha in cultured human corneal fibroblasts.

  2005cited by this paper
• Connexin‐mimetic peptides dissociate electrotonic EDHF‐type signalling via myoendothelial and smooth muscle gap junctions in the rabbit iliac artery

  2005cited by this paper
• Gender, sex hormones, and vascular tone.

  2004cited by this paper
• Functional characterization of HUVEC-CS: Ca2+ signaling, ERK 1/2 activation, mitogenesis and vasodilator production.

  2004cited by this paper
• Pregnancy-specific changes in uterine artery endothelial cell signaling in vivo are both programmed and retained in primary culture.

  2003influential reference
• Possible mechanisms underlying pregnancy-induced changes in uterine artery endothelial function.

  2003cited by this paper
• Modelling of simple and complex calcium oscillations

  2002cited by this paper
• Gap junctions: structure and function (Review)

  2002influential reference
• Modelling of simple and complex calcium oscillations. From single-cell responses to intercellular signalling.

  2002cited by this paper
• VEGF transiently disrupts gap junctional communication in endothelial cells.

  2001cited by this paper
• Propagation of intercellular calcium waves in C6 glioma cells transfected with connexins 43 or 32

  2001cited by this paper
• Pregnancy-specific enhancement of agonist-stimulated ERK-1/2 signaling in uterine artery endothelial cells increases Ca(2+) sensitivity of endothelial nitric oxide synthase as well as cytosolic phospholipase A(2).

  2001cited by this paper
• Activity and expression of soluble and particulate guanylate cyclases in myometrium from nonpregnant and pregnant women: down-regulation of soluble guanylate cyclase at term.

  2001cited by this paper
• Connexin mimetic peptides: specific inhibitors of gap-junctional intercellular communication.

  2001cited by this paper
• Pregnancy-Specific Enhancement of Agonist-Stimulated ERK-1/2 Signaling in Uterine Artery Endothelial Cells Increases Ca2+ Sensitivity of Endothelial Nitric Oxide Synthase as well as Cytosolic Phospholipase A2.

  2001cited by this paper
• Sustained Endothelial Nitric-oxide Synthase Activation Requires Capacitative Ca2+ Entry*

  2000cited by this paper
• Pregnancy-dependent changes in cell signaling underlie changes in differential control of vasodilator production in uterine artery endothelial cells.

  2000influential reference
• The endothelial component of cannabinoid‐induced relaxation in rabbit mesenteric artery depends on gap junctional communication

  1999cited by this paper
• The responsiveness of isolated human hand vein endothelial cells in normal pregnancy and in pre‐eclampsia

  1998cited by this paper
• Nitric oxide and pregnancy.

  1997cited by this paper
• Nitric oxide contributes to estrogen-induced vasodilation of the ovine uterine circulation.

  1996cited by this paper
• Properties and regulation of gap junctional hemichannels in the plasma membranes of cultured cells

  1996cited by this paper
• Endothelial vasodilator production by uterine and systemic arteries. I. Effects of ANG II on PGI2 and NO in pregnancy.

  1996cited by this paper
• Perinatal and Pediatric Pathophysiology - A Clinical Perspective

  1994cited by this paper
• Physiological concentrations of purines and pyrimidines

  1994cited by this paper
• Scrape-loading and dye transfer. A rapid and simple technique to study gap junctional intercellular communication.

  1987cited by this paper
• Secretable storage pools in platelets.

  1979cited by this paper

• Aberrant Uteroplacental and Vascular Signaling and Remodeling by Matrix Metalloproteinases in Pregnancy-Related Hypertension and Preeclampsia

  2026cites this paper
• TNF but not VEGF induces secretion of multiple chemokines and cytokines by uterine artery endothelial cells - potential implications for preeclampsia.

  2025cites this paper
• Connexin 43 Affects Pulmonary Artery Reactivity via Changes in Nitric Oxide Production and Influences Proliferative and Migratory Responses in Mouse Pulmonary Artery Fibroblasts

  2025cites this paper
• Single cell analysis of uterine artery endothelial cells reveals cytokine induced emergence of specific immunomodulatory subtypes: implications for preeclampsia.

  2025cites this paper
• Ca2+ signals in human umbilical endothelial cells derived from pregnancy with fetal growth restriction associated with hypertensive disorder

  2024cites this paper
• Mononuclear Cells Negatively Regulate Endothelial Ca^2+ Signaling

  2023cites this paper
• The epidermal growth factor receptor in healthy pregnancy and preeclampsia.

  2022influential citation
• Uteroplacental Circulation in Normal Pregnancy and Preeclampsia: Functional Adaptation and Maladaptation

  2021cites this paper
• Differential Control of Uterine Artery Endothelial Monolayer Integrity by TNF and VEGF is Achieved Through Multiple Mechanisms Operating Inside and Outside the Cell - Relevance to Preeclampsia.

  2021cites this paper
• Cytokine concentrations direct endothelial function in pregnancy and preeclampsia.

  2020cites this paper
• Adenoviral transduction of EGFR into pregnancy-adapted uterine artery endothelial cells remaps growth factor induction of endothelial dysfunction.

  2020cites this paper
• Maternal disease and gasotransmitters.

  2020cites this paper
• Conjugated linoleic acid improves endothelial Ca2+ signaling by blocking growth factor and cytokine-mediated Cx43 phosphorylation.

  2020cites this paper
• Role of ROS/RNS in Preeclampsia: Are Connexins the Missing Piece?

  2020cites this paper
• TNF-alpha inhibits pregnancy-adapted Ca2+ signaling in uterine artery endothelial cells.

  2019cites this paper
• PM2.5 exposure during pregnancy induces hypermethylation of estrogen receptor promoter region in rat uterus and declines offspring birth weights.

  2018cites this paper
• Molecular and cellular underpinnings of normal and abnormal human placental blood flows.

  2018cites this paper
• Molecular determinants of microvascular dysfunction in hypertensive pregnancy and preeclampsia

  2018cites this paper
• Cyclic Nucleotides Differentially Regulate Cx43 Gap Junction Function in Uterine Artery Endothelial Cells From Pregnant Ewes

  2017cites this paper
• Matrix Metalloproteinases in Normal Pregnancy and Preeclampsia.

  2017cites this paper
• Mitochondrial connexin40 regulates mitochondrial calcium uptake in coronary endothelial cells.

  2017cites this paper
• Hyperandrogenemia reduces endothelium-derived hyperpolarizing factor-mediated relaxation in mesenteric artery of female rats†

  2017cites this paper
• Positive versus negative effects of VEGF165 on Ca2+ signaling and NO production in human endothelial cells.

  2017cites this paper
• Pregnancy‐adapted uterine artery endothelial cell Ca2+ signaling and its relationship with membrane potential

  2017cites this paper
• Online – only Data Supplement Cyclic Nucleotides Differentially Regulate Cx 43 Gap Junction Function in the Ovine Uterine Endothelium during Pregnancy

  2017cites this paper
• Transient receptor potential canonical type 3 channels: Interactions, role and relevance - A vascular focus.

  2017cites this paper
• Vascular adaptation in pregnancy and endothelial dysfunction in preeclampsia.

  2017cites this paper
• Mechanisms of Uterine Artery Dysfunction in Pregnancy Complications

  2017cites this paper
• Positive feedback role of TRPC3 in TNF-α-mediated vasogenic edema formation induced by status epilepticus independent of ETB receptor activation.

  2016cites this paper
• Mechanisms of Endothelial Dysfunction in Hypertensive Pregnancy and Preeclampsia.

  2016cites this paper
• Vascular Biology and Microcirculation Positive versus negative effects of VEGF 165 on Ca 2 (cid:2) signaling and NO production in human endothelial cells

  2016influential citation
• vasa vasorum endothelial cells artery signaling and proliferative responses in pulmonary 2+ P2Y1 and P2Y13 purinergic receptors mediate Ca

  2016cites this paper
• Domain-Specific Partitioning of Uterine Artery Endothelial Connexin43 and Caveolin-1

  2016influential citation
• Impairment of IKCa channels contributes to uteroplacental endothelial dysfunction in rat diabetic pregnancy.

  2015cites this paper
• Changes in Ca2+ Signaling and Nitric Oxide Output by Human Umbilical Vein Endothelium in Diabetic and Gestational Diabetic Pregnancies1

  2015cites this paper
• Phosphorylation of Ser-279/282 and Tyr-265 positions on Cx43 as possible mediators of VEGF-165 inhibition of pregnancy-adapted Ca2+ burst function in ovine uterine artery endothelial cells.

  2015cites this paper
• [Regulation of uterine blood flow. I. Functions of estrogen and estrogen receptor α/β in the uterine vascular endothelium during pregnancy].

  2014cites this paper
• Endothelial control of vasodilation: integration of myoendothelial microdomain signalling and modulation by epoxyeicosatrienoic acids

  2014cites this paper
• Local Effects of Pregnancy on Connexin Proteins That Mediate Ca2+-Associated Uterine Endothelial NO Synthesis

  2014influential citation
• Pregnancy programming and preeclampsia: identifying a human endothelial model to study pregnancy-adapted endothelial function and endothelial adaptive failure in preeclamptic subjects.

  2014cites this paper
• Activation of CB1 inhibits NGF-induced sensitization of TRPV1 in adult mouse afferent neurons.

  2014cites this paper
• Endothelial remodelling and intracellular calcium machinery.

  2014cites this paper
• Altered VEGF-stimulated Ca2+ signaling in part underlies pregnancy-adapted eNOS activity in UAEC.

  2014cites this paper
• Regulación del flujo sanguíneo uterino. I. Funciones de estrógeno y receptores estrogénicos α/β en el endotelio vascular uterino durante el embarazo

  2014cites this paper
• Violencia contra la mujer: rol del ginecólogo en el combate de un flagelo que impacta negativamente en la salud integral de la mujer

  2014cites this paper
• Gap junction regulation of vascular tone: implications of modulatory intercellular communication during gestation.

  2014influential citation
• Endothelial calcium dynamics, connexin channels and blood-brain barrier function.

  2013cites this paper
• Uteroplacental circulation and fetal vascular function and development.

  2013cites this paper
• Endothelial caveolar subcellular domain regulation of endothelial nitric oxide synthase

  2013cites this paper
• Regulation of myometrial circulation and uterine vascular tone by constitutive nitric oxide.

  2013cites this paper
• Pregnancy, programming and preeclampsia: gap junctions at the nexus of pregnancy-induced adaptation of endothelial function and endothelial adaptive failure in PE.

  2013cites this paper
• Endothelial Nitric Oxide Production in Preeclamptic Pregnancies

  2013cites this paper
• The loss of sustained Ca(2+) signaling underlies suppressed endothelial nitric oxide production in preeclamptic pregnancies: implications for new therapy.

  2013cites this paper
• The effects of oxidative stress on female reproduction: a review

  2012cites this paper
• Transient receptor potential canonical type 3 channels facilitate endothelium-derived hyperpolarization-mediated resistance artery vasodilator activity.

  2012cites this paper
• On the role of endothelial TRPC3 channels in endothelial dysfunction and cardiovascular disease.

  2012cites this paper
• Estrogen Receptor-α and Estrogen Receptor-β in the Uterine Vascular Endothelium during Pregnancy: Functional Implications for Regulating Uterine Blood Flow

  2012cites this paper
• eNOS activation and NO function: pregnancy adaptive programming of capacitative entry responses alters nitric oxide (NO) output in vascular endothelium--new insights into eNOS regulation through adaptive cell signaling.

  2011influential citation
• Misexpression of Wingless-Related MMTV Integration Site 5A in Mouse Mammary Gland Inhibits the Milk Ejection Response and Regulates Connexin43 Phosphorylation1

  2011cites this paper
• [Ca2+]i signaling vs. eNOS expression as determinants of NO output in uterine artery endothelium: relative roles in pregnancy adaptation and reversal by VEGF165.

  2011cites this paper
• P2Y1 and P2Y13 purinergic receptors mediate Ca2+ signaling and proliferative responses in pulmonary artery vasa vasorum endothelial cells

  2011cites this paper
• A key role of TRPC channels in the regulation of electromechanical activity of the developing heart.

  2011cites this paper
• eNOS activation and NO function: Pregnancy adaptive programming of capacitative entry responses alters nitric oxide (NO) output in vascular endothelium–new insights into eNOS regulation through adaptive cell signaling

  2011cites this paper
• Pregnancy Adaptive Programming of Capacitative Entry Responses

  2011cites this paper
• Artery Endothelium: Relative roles in pregnancy adaptation and reversal by

  2011cites this paper
• Regulation of cardiovascular TRP channel functions along the NO–cGMP–PKG axis

  2010cites this paper
• Pregnancy Induced Reprogramming of Endothelial Function in Response to ATP: Evidence for Post Receptor Ca2+ Signaling Plasticity

  2010cites this paper
• Estradiol-17&bgr; and Its Cytochrome P450- and Catechol-O-Methyltransferase–Derived Metabolites Stimulate Proliferation in Uterine Artery Endothelial Cells: Role of Estrogen Receptor-&agr; Versus Estrogen Receptor-&bgr;

  2010cites this paper
• Signaling vs eNOS Expression as Determinants of NO Output In Uterine 1 Artery Endothelium : Relative roles in pregnancy adaptation and reversal by 2 VEGF 165 . 3 4 5

  2010cites this paper