Cholesterol metabolism and homeostasis in the brain

Cholesterol is an essential component for neuronal physiology not only during development stage but also in the adult life. Cholesterol metabolism in brain is independent from that in peripheral tissues due to blood-brain barrier. The content of cholesterol in brain must be accurately maintained in order to keep brain function well. Defects in brain cholesterol metabolism has been shown to be implicated in neurodegenerative diseases, such as Alzheimer’s disease (AD), Huntington’s disease (HD), Parkinson’s disease (PD), and some cognitive deficits typical of the old age. The brain contains large amount of cholesterol, but the cholesterol metabolism and its complex homeostasis regulation are currently poorly understood. This review will seek to integrate current knowledge about the brain cholesterol metabolism with molecular mechanisms.

• Publication year

  2015

• Venue

  Protein & Cell

• Publication date

  2015-02-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s13238-014-0131-3PMID 25682154PMCID 4383754
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• 24(S)‐hydroxycholesterol is actively eliminated from neuronal cells by ABCA1

  2013cited by this paper
• High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease

  2012cited by this paper
• Cholesterol metabolism in neurons and astrocytes.

  2011cited by this paper
• Linking lipids to Alzheimer's disease: cholesterol and beyond

  2011cited by this paper
• Statins: multiple neuroprotective mechanisms in neurodegenerative diseases.

  2011cited by this paper
• Linking lipids to Alzheimer's disease: cholesterol and beyond

  2011cited by this paper
• Local cholesterol increase triggers amyloid precursor protein‐Bacel clustering in lipid rafts and rapid endocytosis

  2011cited by this paper
• Anatomically Defined Neuron-Based Rescue of Neurodegenerative Niemann–Pick Type C Disorder

  2011cited by this paper
• ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD

  2010cited by this paper
• Neuronal LRP1 Knockout in Adult Mice Leads to Impaired Brain Lipid Metabolism and Progressive, Age-Dependent Synapse Loss and Neurodegeneration

  2010cited by this paper
• Conditional Niemann-Pick C mice demonstrate cell autonomous Purkinje cell neurodegeneration.

  2010cited by this paper
• Altered cholesterol and fatty acid metabolism in Huntington disease.

  2010cited by this paper
• BDNF function and intracellular signaling in neurons.

  2010cited by this paper
• Cholesterol reduction impairs exocytosis of synaptic vesicles

  2010cited by this paper
• Niemann–Pick type C pathogenesis and treatment: from statins to sugars

  2010cited by this paper
• Cholesterol homeostasis markers are localized to mouse hippocampal pyramidal and granule layers

  2010cited by this paper
• Cholesterol‐promoted synaptogenesis requires the conversion of cholesterol to estradiol in the hippocampus

  2009cited by this paper
• Transcriptional profiles of receptors and transporters involved in brain cholesterol homeostasis at the blood-brain barrier: use of an in vitro model.

  2009cited by this paper
• Niemann-Pick C2 (NPC2) and intracellular cholesterol trafficking.

  2009cited by this paper
• Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1−/− mouse

  2009cited by this paper
• Absence of ApoE Upregulates Murine Brain ApoD and ABCA1 Levels, But Does Not Affect Brain Sterol Levels, While Human ApoE3 and Human ApoE4 Upregulate Brain Cholesterol Precursor Levels

  2009cited by this paper
• Plasma membrane expansion: a neuron's Herculean task

  2009cited by this paper
• Apolipoprotein E receptors in the nervous system

  2009cited by this paper
• Mechanism underlying apolipoprotein E (ApoE) isoform‐dependent lipid efflux from neural cells in culture

  2009cited by this paper
• Marked differences in cholesterol synthesis between neurons and glial cells from postnatal rats

  2009cited by this paper
• Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis

  2009cited by this paper
• Cholesterol retention in Alzheimer's brain is responsible for high β-and γ-secretase activities and Aβ production

  2008cited by this paper
• Cellular cholesterol trafficking and compartmentalization

  2008cited by this paper
• Cholesterol efflux pathways and other potential mechanisms involved in the athero‐protective effect of high density lipoproteins

  2008cited by this paper
• A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function

  2008cited by this paper
• Neuronal expression and subcellular localization of cholesterol 24‐hydroxylase in the mouse brain

  2008cited by this paper
• Role of ATP‐binding cassette transporters in brain lipid transport and neurological disease

  2008cited by this paper
• Cholesterol retention in Alzheimer's brain is responsible for high beta- and gamma-secretase activities and Abeta production.

  2008cited by this paper
• Lipid rafts, cholesterol, and the brain.

  2008cited by this paper
• ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2 Published, JLR Papers in Press, October 4, 2007.

  2008cited by this paper
• Polyunsaturation in lipid membranes: dynamic properties and lateral pressure profiles.

  2007cited by this paper
• Apolipoprotein E as a target for developing new therapeutics for Alzheimer’s disease based on studies from protein, RNA, and regulatory region of the gene

  2007influential reference
• Survival of adult neurons lacking cholesterol synthesis in vivo

  2007cited by this paper
• Cholesterol efflux as a critical component of Alzheimer’s disease pathogenesis

  2007cited by this paper
• Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Oxysterols block transport by binding to Insig

  2007cited by this paper
• ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL Published, JLR Papers in Press, August 10, 2006.

  2006cited by this paper
• The 3‐hydroxy‐3‐methylglutaryl co‐enzyme A reductase inhibitor pravastatin enhances neurite outgrowth in hippocampal neurons

  2006cited by this paper
• Oxysterols and Alzheimer's disease

  2006cited by this paper
• Cholesterol synthesis rate in human hippocampus declines with aging.

  2006cited by this paper
• Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain

  2006cited by this paper
• Seeking long‐term relationship: axon and target communicate to organize synaptic differentiation

  2006cited by this paper
• Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease.

  2006cited by this paper
• Molecular anatomy of a trafficking organelle.

  2006cited by this paper
• Expression of ABCG1, but Not ABCA1, Correlates with Cholesterol Release by Cerebellar Astroglia*

  2006cited by this paper
• Multiple mechanisms mediate cholesterol-induced synaptogenesis in a CNS neuron.

  2005cited by this paper
• ABCA1 and ABCG1 Synergize to Mediate Cholesterol Export to ApoA-I

  2005cited by this paper
• Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis.

  2005cited by this paper
• Regulation of hippocampal cholesterol metabolism by apoE and environmental stimulation

  2005cited by this paper
• High cholesterol level is essential for myelin membrane growth

  2005cited by this paper
• Distinct spatio‐temporal expression of ABCA and ABCG transporters in the developing and adult mouse brain

  2005cited by this paper
• ATP-binding cassette transporter A1: a cell cholesterol exporter that protects against cardiovascular disease.

  2005cited by this paper
• The Absence of ABCA1 Decreases Soluble ApoE Levels but Does Not Diminish Amyloid Deposition in Two Murine Models of Alzheimer Disease*

  2005cited by this paper
• Cholesterol-mediated Neurite Outgrowth Is Differently Regulated between Cortical and Hippocampal Neurons*

  2005cited by this paper
• Direct Observation of Rapid Internalization and Intracellular Transport of Sterol by Macrophage Foam Cells

  2005cited by this paper
• Deficiency of ABCA1 Impairs Apolipoprotein E Metabolism in Brain*

  2004cited by this paper
• The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease.

  2004cited by this paper
• ABCA1 Is Required for Normal Central Nervous System ApoE Levels and for Lipidation of Astrocyte-secreted apoE*

  2004cited by this paper
• Brain Cholesterol: Long Secret Life Behind a Barrier

  2004cited by this paper
• Intracellular Cholesterol Transport

  2004cited by this paper
• Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease

  2004cited by this paper
• A novel cholesterol stain reveals early neuronal cholesterol accumulation in the Niemann-Pick type C1 mouse brain Published, JLR Papers in Press, January 1, 2004. DOI 10.1194/jlr.D300032-JLR200

  2004cited by this paper
• A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes

  2004cited by this paper
• Neuronal localization and association of Niemann Pick C2 protein (HE1/NPC2) with the postsynaptic density.

  2004cited by this paper
• Thematic review series: Brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal Published, JLR Papers in Press, May 16, 2004. DOI 10.1194/jlr.R400004-JLR200

  2004cited by this paper
• Postnatal development of inflammation in a murine model of Niemann-Pick type C disease: immunohistochemical observations of microglia and astroglia.

  2003cited by this paper
• Novel Role for Apolipoprotein E in the Central Nervous System

  2003cited by this paper
• Genetic association of acyl-coenzyme A: cholesterol acyltransferase with cerebrospinal fluid cholesterol levels, brain amyloid load, and risk for Alzheimer's disease

  2003influential reference
• Alzheimer's disease: the cholesterol connection

  2003cited by this paper
• Knockout of the Cholesterol 24-Hydroxylase Gene in Mice Reveals a Brain-specific Mechanism of Cholesterol Turnover*

  2003cited by this paper
• Ontogenesis and regulation of cholesterol metabolism in the central nervous system of the mouse.

  2003cited by this paper
• ABCA1 modulates CSF cholesterol levels and influences the age at onset of Alzheimer's disease.

  2003influential reference
• 22R-Hydroxycholesterol and 9-cis-Retinoic Acid Induce ATP-binding Cassette Transporter A1 Expression and Cholesterol Efflux in Brain Cells and Decrease Amyloid β Secretion*

  2003cited by this paper
• ABCA1 mRNA and Protein Distribution Patterns Predict Multiple Different Roles and Levels of Regulation

  2002cited by this paper
• Neurodegeneration in the Niemann-Pick C mouse: glial involvement.

  2002cited by this paper
• On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation: critical importance of the position of the oxygen function.

  2002cited by this paper
• Induction of the Cholesterol Transporter ABCA1 in Central Nervous System Cells by Liver X Receptor Agonists Increases Secreted Aβ Levels*

  2002cited by this paper
• The Complex Regulation of Cholesterol Biosynthesis Takes Place at Several Levels

  2002cited by this paper
• ABCA1 and Scavenger Receptor Class B, Type I, Are Modulators of Reverse Sterol Transport at an in Vitro Blood-Brain Barrier Constituted of Porcine Brain Capillary Endothelial Cells*

  2002cited by this paper
• Cholinergic and GABAergic pathways in fly motion vision

  2001cited by this paper
• Characterization of four lipoprotein classes in human cerebrospinal fluid.

  2001influential reference
• CNS synaptogenesis promoted by glia-derived cholesterol.

  2001cited by this paper
• The human ATP-binding cassette (ABC) transporter superfamily.

  2001cited by this paper
• Differential Functions of Members of the Low Density Lipoprotein Receptor Family Suggested by Their Distinct Endocytosis Rates*

  2001cited by this paper
• Control of synapse number by glia.

  2001cited by this paper
• Effect of the Structure of Natural Sterols and Sphingolipids on the Formation of Ordered Sphingolipid/Sterol Domains (Rafts)

  2001cited by this paper
• Identification of HE1 as the second gene of Niemann-Pick C disease.

  2000cited by this paper
• Dissecting the role of the golgi complex and lipid rafts in biosynthetic transport of cholesterol to the cell surface.

  2000cited by this paper
• Regional and Developmental Expression of the Npc1 mRNA in the Mouse Brain

  2000cited by this paper
• ABC transporters in cellular lipid trafficking

  2000cited by this paper
• Astrocyte lipoproteins, effects of apoE on neuronal function, and role of apoE in amyloid‐β deposition in vivo

  2000cited by this paper
• Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes.

  2000cited by this paper
• Localization of human acyl-coenzyme A: cholesterol acyltransferase-1 (ACAT-1) in macrophages and in various tissues.

  2000cited by this paper
• Regional distribution of NPC1 protein in monkey brain

  2000cited by this paper
• cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain.

  1999cited by this paper
• Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi.

  1999cited by this paper

• Hypothalamic CYP46A1 cholesterol metabolism regulates diet-induced obesity

  2026cites this paper
• ApoE-Dependent Lipid Handling by Median Eminence Microglia Preserves Myelin Integrity and Metabolic Function

  2026cites this paper
• Chronic salicylate administration induces transcriptomic and metabolomic remodeling in the rat cochlear nucleus and hippocampus.

  2026cites this paper
• Impact of Prenatal Alcohol Exposure on Cerebral Cortex Development.

  2026cites this paper
• Cellular mechanisms of brain lipid metabolism in health and disease.

  2026cites this paper
• Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission.

  2026cites this paper
• The role of lipids in neuromodulation for psychiatric disorders: A narrative review

  2026cites this paper
• The neurobiology of fatty acids: Metabolism, signaling, and roles in neurodegenerative diseases.

  2026cites this paper
• Cell-specific effects of acute sleep deprivation on transcriptomic signatures of non-neuronal cells in the mouse hippocampus and prefrontal cortex

  2026cites this paper
• The Role of Lipid Alteration in Multiple Sclerosis

  2026cites this paper
• Organ cross-talk: molecular mechanisms, biological functions, and therapeutic interventions for diseases

  2026cites this paper
• Advances in cholesterol and lipoproteins detection for healthcare: A review

  2026cites this paper
• Amyloid β—Cholesterol Interplay: Removal of Cholesterol From the Membranes to Catalyze Aggregation and Amyloid Pathology

  2026cites this paper
• Oxysterol signaling in the central nervous system: cellular mechanisms and implications for neurodegeneration.

  2026cites this paper
• Brain lipid metabolism and transport: implications for neurodegeneration and therapeutic strategies: a comprehensive review

  2026cites this paper
• Brain lipid profiles and oligodendrocyte gene expression show discordant responses to high-fat diet in Alzheimer’s disease mice

  2026cites this paper
• An alternative source of medicines: pharmaceutical utilization of animal-derived metabolites

  2025cites this paper
• Daily high doses of atorvastatin alter neuronal morphology in a juvenile songbird model

  2025cites this paper
• Coenzyme Q10 deficiency disrupts lipid metabolism by altering cholesterol homeostasis in neurons.

  2025cites this paper
• Exploring Human Brain Metabolism via Genome-Scale Metabolic Modeling with Highlights on Multiple Sclerosis

  2025cites this paper
• Development of a Novel 18F-Labeled Radioligand for Imaging Cholesterol 24-Hydroxylase with Positron Emission Tomography

  2025cites this paper
• Brain Cytochrome P450: Navigating Neurological Health and Metabolic Regulation

  2025cites this paper
• Neuropsychiatric Abnormalities in Metabolic Disturbances: Interplay of Adipokines and Neurotransmission

  2025cites this paper
• Modulation of the human GlyT1 by clinical drugs and cholesterol

  2025cites this paper
• Lipidomic and sterolomic profiles of different brain regions in the mouse model of Alzheimer's disease.

  2025cites this paper
• Regulation of CNS Lipids by Protease Activated Receptor 1

  2025cites this paper
• Role of glial cells in motor neuron degeneration in hereditary spastic paraplegias

  2025cites this paper
• The Role of the Gut Microbiome in the Associations Between Lead Exposure and Child Neurodevelopment.

  2025cites this paper
• Recent progress in the design and research of cholesterol adsorption materials

  2025cites this paper
• Genetic insights of lipid metabolism and lipid-lowering drugs with Lewy body dementia risk: Evidence from Mendelian randomization.

  2025cites this paper
• Associations between plasma 24(S)-hydroxycholesterol and neuropsychological profile in fragile X syndrome

  2025cites this paper
• Neuronal PCSK9 regulates cognitive performances via the modulation of ApoER2 synaptic localization.

  2025cites this paper
• C/EBPβ in Alzheimer's Disease: An Integrative Regulator of Pathological Mechanisms.

  2025cites this paper
• Identification of Key Genes in Esketamine’s Therapeutic Effects on Perioperative Neurocognitive Disorders via Transcriptome Sequencing

  2025cites this paper
• Emulgels for dermal delivery based on amphiphilic polymers bearing cholesteryl moiety: tuning surface properties via polymer chain length

  2025cites this paper
• Lipidomics of Huntington’s Disease: A Comprehensive Review of Current Status and Future Directions

  2025cites this paper
• DHCR24 deficiency causes AD-like pathology and cognitive decline via the cGAS-STING signaling pathway

  2025cites this paper
• DHCR24 knockdown-induced cellular cholesterol deficiency triggers tau hyperphosphorylation at Thr181, Ser199 and Ser202/Thr205 via p38 MAPK/JNK signaling.

  2025cites this paper
• APOE Lipoprotein Particles: Pathophysiology, Therapy, and the Crosstalk in Alzheimer’s Disease and Cardiovascular Disease

  2025cites this paper
• Targeting lipid metabolism in neurodegenerative diseases: From experimental to clinical.

  2025cites this paper
• Neuroimaging-derived brain endophenotypes link molecular mechanisms to Alzheimer’s disease and aging

  2025cites this paper
• Differential Regulation of APOE4-Mediated Astrocytic Lipid Metabolism by BMP Signaling Exacerbates Alzheimer’s Disease Pathologies in Neurons

  2025cites this paper
• Bile Acid Metabolism Changes in Patients with a CRB1-Associated Inherited Retinal Degeneration

  2025cites this paper
• Cholesterol Metabolism in CNS Diseases: The Potential of SREBP2 and LXR as Therapeutic Targets

  2025influential citation
• Revealing rutaecarpine's promise: A pathway to parkinson's disease relief through PPAR modulation.

  2025cites this paper
• The Cross-Talk Between the Peripheral and Brain Cholesterol Metabolisms

  2025cites this paper
• The Essence of Nature Can Be the Simplest (7)—Plant Growth: Powered by Extracellular Fenton Chemistry

  2025cites this paper
• Intestinal inflammation induces glymphatic remodeling, priming early neurodegenerative signals in male mice

  2025cites this paper
• Implications for soluble iron accumulation, oxidative stress, and glial glutamate release in motor neuron death associated with sporadic amyotrophic lateral sclerosis

  2025cites this paper
• The role of intracellular and extracellular copper compartmentalization in Alzheimer’s disease pathology and its implications for diagnosis and therapy

  2025cites this paper
• PINK1 regulates cholesterol homeostasis via SCAP phosphorylation in human dopaminergic neurons

  2025cites this paper
• PCSK9 Regulation of Lipid Metabolism in the Nervous System: Implications for Schwann Cell Function and Peripheral Neuropathy

  2025influential citation
• Amyloid β interaction with membranes: Removal of cholesterol from the membranes to catalyze aggregation and amyloid pathology

  2025cites this paper
• Association between hyperlipidemia and postoperative delirium risk: a systematic review and meta-analysis

  2025cites this paper
• Mass Spectrometry Imaging Reveals the Distribution of a GABRG2 Targeting Antisense Oligonucleotide and Its Functional Effect in Rat Brain

  2025cites this paper
• GABA and astrocytic cholesterol determine the lipid environment of GABAAR in cultured cortical neurons

  2025cites this paper
• ApoE is Secreted as a Lipid Nanoparticle by Mammalian Cells: Implications for Alzheimer's Disease Pathogenesis.

  2025cites this paper
• Deciphering the Janus‐Faced Nature of the Apolipoprotein Superfamily in Parkinsonian Neurodegeneration: Molecular Crosstalk Between the Astroglial Secretome and Neuronal Homeostasis

  2025cites this paper
• Epigenetic Regulation of Cholesterol and Oxysterol Homeostasis.

  2025cites this paper
• Regulation of synaptic function and lipid metabolism

  2025cites this paper
• Oxysterol-binding protein ORP6 regulates lipid metabolism and brain Aβ production

  2025cites this paper
• Astrocyte Dysfunctions in Obsessive Compulsive Disorder: Rethinking Neurobiology and Therapeutic Targets

  2025cites this paper
• Linking oxysterols and different stages of mild cognitive impairment: insights from gut metabolites and N6-methyladenosine

  2025cites this paper
• Lipidomic profiling of the cerebrospinal fluid in moyamoya angiopathy patients

  2025cites this paper
• Single-cell multiomics of neuronal activation reveals context-dependent genetic control of brain disorders

  2025cites this paper
• Multiomic Evidence for a Unified Model of Alzheimer’s Disease Etiology Linking Microglial Flux Capacity and Astrocyte-Neuron Metabolic Breakdown

  2025cites this paper
• Increased Complement C4 in a Sparse Neuronal Subset Induces Network-Wide Transcriptomic Alterations in the Prefrontal Cortex

  2025cites this paper
• Blood Phenylalanine lowering partially reverses white matter changes in a mouse model of Phenylketonuria.

  2025cites this paper
• Associations between lipid parameters and depression with the moderating role of inflammation: Network analyses of 87,636 UK Biobank participants.

  2025cites this paper
• Lipid metabolism in microglia: Emerging mechanisms and therapeutic opportunities for neurodegenerative diseases (Review)

  2025cites this paper
• APOE4 reprograms microglial lipid metabolism in Alzheimer's disease: Mechanisms and therapeutic implications.

  2025cites this paper
• PPARα-dependent lipid metabolic disruption mediates triphenyl phosphate–induced hepato- and neurotoxicity in zebrafish

  2025cites this paper
• TDP-43 dysregulation impairs cholesterol metabolism linked with myelination defects

  2025cites this paper
• Investigation on Inhibiting SPHK - S1P Pathway to Improve ADHD Model Rats Behavior via Lipidomics

  2025cites this paper
• Effect of cholesterol metabolism on hepatolithiasis

  2025cites this paper
• HMGCR genetic variability in Parkinson’s disease in a Spanish cohort: associations with lipid metabolism and early onset

  2025cites this paper
• Compromised lipid metabolism, mitochondria respiration and neuroprotective effects in iPSC-derived astrocytes from a Smith-Lemli-Opitz syndrome patient

  2025cites this paper
• Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

  2025cites this paper
• L-Lysine-Linked Modular Fluorescent Cholesteryl Mimics: Biophysical Properties, Molecular Interactions, and Cellular Applications

  2025cites this paper
• The cholesterol 24-hydroxylase CYP46A1 promotes α-synuclein pathology in Parkinson’s disease

  2025cites this paper
• The preoperative risk factors of chronic post-surgical pain: a retrospective cohort study in the UK Biobank.

  2025cites this paper
• Cholesterol metabolism regulates macrophage function and inflammation-related diseases.

  2025cites this paper
• Emerging roles of astrocytes in hippocampal circuitry and behavior

  2025cites this paper
• CRISPR editing of miR-33 restores ApoE lipidation and amyloid-β metabolism in ApoE4 sporadic Alzheimer's disease.

  2025cites this paper
• Divergent regulation of cellular cholesterol metabolism by seaweed-derived fucosterol and saringosterol

  2025cites this paper
• Exploration of Homocysteine Metabolism and Genetics in Autism Spectrum Disorder

  2025cites this paper
• Sex-related differences and associated transcriptional signatures in the brain ventricular system and cerebrospinal fluid development in full-term neonates

  2025cites this paper
• Mission cholesterol: Uncovering its hidden role in ALS neurodegeneration.

  2025cites this paper
• 6-PPD quinone reduces lifespan by activating a feedback loop between cholesterol transformation related signal and insulin signaling in C. elegans

  2025cites this paper
• Guardians of Homeostasis: Natural Products Target Metabolic Reprogramming in Alzheimer's Disease.

  2025cites this paper
• Cholesterol Metabolism in Neurodegenerative Diseases

  2024influential citation
• Apolipoprotein E2 Expression Alters Endosomal Pathways in a Mouse Model With Increased Brain Exosome Levels During Aging

  2024cites this paper
• Direct modulation of G protein-gated inwardly rectifying potassium (GIRK) channels

  2024cites this paper
• Mapping dynamic molecular changes in hippocampal subregions after traumatic brain injury through spatial proteomics

  2024cites this paper
• Low-Temperature Plasma Pretreatment Enhanced Cholesterol Detection in Brain by Desorption Electrospray Ionization-Mass Spectrometry Imaging.

  2024cites this paper
• TEMR: Trans-ethnic mendelian randomization method using large-scale GWAS summary datasets

  2024cites this paper
• GABA and astrocytic cholesterol determine the lipid environment of GABAAR in cultured cortical neurons

  2024cites this paper
• Mechanical activation of TWIK-related potassium channel by nanoscopic movement and rapid second messenger signaling

  2024cites this paper
• Defining a vitamin A5/X specific deficiency - vitamin A5/X as a critical dietary factor for mental health.

  2024cites this paper
• Lipid metabolism in crocodilians: a field with promising applications in the field of ecotoxicology.

  2024cites this paper