Fifty years of studies of the biology and therapy of childhood leukemia.

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Blood

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1182/blood.v92.5.1838.spll2_1838_1838PMID 9373234
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Childhood leukemia: cooperative Berlin-Frankfurt-Münster trials in the Federal Republic of Germany

  2005cited by this paper
• Case-control study suggests a favorable impact of TEL rearrangement in patients with B-lineage acute lymphoblastic leukemia treated with antimetabolite-based therapy: a Pediatric Oncology Group study.

  1997cited by this paper
• The t(11;16)(q23;p13) translocation in myelodysplastic syndrome fuses the MLL gene to the CBP gene.

  1997cited by this paper
• MLL self fusion mediated by Alu repeat homologous recombination and prognosis of AML-M4/M5 subtypes.

  1997cited by this paper
• Unrelated donor bone marrow transplantation for children with acute leukemia.

  1997cited by this paper
• EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia.

  1997cited by this paper
• TEL gene rearrangement in acute lymphoblastic leukemia: a new genetic marker with prognostic significance.

  1997cited by this paper
• Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia.

  1997cited by this paper
• Fifty years of studies of the biology and therapy of childhood leukemia.

  1997cited by this paper
• The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1.

  1996cited by this paper
• Selecting treatment for children with acute lymphoblastic leukemia.

  1996cited by this paper
• An RNA Polymerase II Elongation Factor Encoded by the Human ELL Gene

  1996cited by this paper
• Malignant neoplasms following bone marrow transplantation.

  1996cited by this paper
• Differentiating therapy in acute myeloid leukemia.

  1996cited by this paper
• Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia.

  1996cited by this paper
• Differentiating therapy in acute myeloid leukemia.

  1996cited by this paper
• Successful transplantation of HLA-matched and HLA-mismatched umbilical cord blood from unrelated donors: analysis of engraftment and acute graft-versus-host disease.

  1996cited by this paper
• Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia

  1996cited by this paper
• The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB–binding protein

  1996cited by this paper
• Childhood leukemias.

  1995cited by this paper
• The t(10;11) translocation in acute myeloid leukemia (M5) consistently fuses the leucine zipper motif of AF10 onto the HRX gene.

  1995cited by this paper
• Frequent deletion of p16INK4a/MTS1 and p15INK4b/MTS2 in pediatric acute lymphoblastic leukemia.

  1995cited by this paper
• Recurrent chromosomal translocations and fusion genes in leukemia-lymphoma cell lines.

  1995cited by this paper
• Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia.

  1995cited by this paper
• The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion.

  1995cited by this paper
• A novel gene, AF1q, fused to MLL in t(1;11) (q21;q23), is specifically expressed in leukemic and immature hematopoietic cells.

  1995cited by this paper
• Favorable prognosis of hyperdiploid common acute lymphoblastic leukemia may be explained by sensitivity to antimetabolites and other drugs: results of an in vitro study.

  1995cited by this paper
• Synthetic peptide ligands of the antigen binding receptor induce programmed cell death in a human B-cell lymphoma.

  1994cited by this paper
• Molecular analysis of the T-cell acute lymphoblastic leukemia-associated t(1;7)(p34;q34) that fuses LCK and TCRB.

  1994cited by this paper
• Chromosomal translocations in human cancer

  1994cited by this paper
• A novel gene, AF-1p, fused to HRX in t(1;11)(p32;q23), is not related to AF-4, AF-9 nor ENL.

  1994cited by this paper
• Leucine-zipper dimerization motif encoded by the AF17 gene fused to ALL-1 (MLL) in acute leukemia.

  1994cited by this paper
• Bone marrow transplants from HLA-identical siblings as compared with chemotherapy for children with acute lymphoblastic leukemia in a second remission.

  1994cited by this paper
• Chemotherapy for induction of remission of childhood acute myeloid leukemia followed by marrow transplantation or multiagent chemotherapy: a report from the Childrens Cancer Group.

  1994cited by this paper
• Cloning and characterization of the t(X;II) breakpoint from a leukemic cell line identify a new member of the forkhead gene family

  1994cited by this paper
• Treatment of newly diagnosed children and adolescents with acute myeloid leukemia: a Childrens Cancer Group study.

  1994cited by this paper
• The acute promyelocytic leukemia-specific PML-RAR alpha fusion protein inhibits differentiation and promotes survival of myeloid precursor cells.

  1993cited by this paper
• Clinical features and outcome of T-cell acute lymphoblastic leukemia in childhood with respect to alterations at the TAL1 locus: a Pediatric Oncology Group study.

  1993cited by this paper
• Gene-marking to trace origin of relapse after autologous bone-marrow transplantation.

  1993cited by this paper
• Prospective comparative study of bone marrow transplantation and postremission chemotherapy for childhood acute myelogenous leukemia. The Associazione Italiana Ematologia ed Oncologia Pediatrica Cooperative Group.

  1993cited by this paper
• Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome.

  1993cited by this paper
• Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia.

  1993cited by this paper
• A serine/proline-rich protein is fused to HRX in t(4;11) acute leukemias.

  1993cited by this paper
• Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity induces K562 to differentiate.

  1993cited by this paper
• Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs.

  1993cited by this paper
• Unrelated-donor bone marrow transplantation for Philadelphia chromosome-positive chronic myelogenous leukemia in children.

  1993cited by this paper
• Improved outcome with delayed intensification for children with acute lymphoblastic leukemia and intermediate presenting features: a Childrens Cancer Group phase III trial.

  1993cited by this paper
• HRX involvement in de novo and secondary leukemias with diverse chromosome 11q23 abnormalities.

  1993cited by this paper
• Ribozyme-mediated cleavage of the BCRABL oncogene transcript: in vitro cleavage of RNA and in vivo loss of P210 protein-kinase activity.

  1993cited by this paper
• Antisense oligonucleotides as therapeutic agents--is the bullet really magical?

  1993cited by this paper
• Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6;11) chromosome translocation.

  1993cited by this paper
• The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene.

  1992cited by this paper
• All-transretinoic acid followed by intensive chemotherapy gives a high complete remission rate and may prolong remissions in newly diagnosed acute promyelocytic leukemia: a pilot study on 26 cases.

  1992cited by this paper
• Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias.

  1992cited by this paper
• T cell immunity to the joining region of p210^ protein.

  1992cited by this paper
• Specific inhibition of transcription by triple helix-forming oligonucleotides.

  1992cited by this paper
• Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt.

  1992cited by this paper
• The translocation (6;9) (p23;q34) shows consistent rearrangement of two genes and defines a myeloproliferative disorder with specific clinical features.

  1992cited by this paper
• Pediatric leukemia/lymphoma with t(8;14)(q24;q11).

  1992cited by this paper
• Recent developments in radiotherapy

  1992cited by this paper
• T-cell immunity to the joining region of p210BCR-ABL protein.

  1992cited by this paper
• Apoptosis induced by anticancer drugs

  1992cited by this paper
• Accumulation of high levels of methotrexate polyglutamates in lymphoblasts from children with hyperdiploid (greater than 50 chromosomes) B-lineage acute lymphoblastic leukemia: a Pediatric Oncology Group study.

  1992cited by this paper
• High-dose cytarabine for intensification of early therapy of childhood acute myeloid leukemia: a Pediatric Oncology Group study.

  1991cited by this paper
• Second neoplasms after acute lymphoblastic leukemia in childhood.

  1991cited by this paper
• The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13.

  1991cited by this paper
• A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t(10;14).

  1991cited by this paper
• Consistent involvement of the bcr gene by 9;22 breakpoints in pediatric acute leukemias.

  1991cited by this paper
• Graft-versus-leukemia reactions after bone marrow transplantation.

  1990cited by this paper
• The role of timing of high‐dose cytosine arabinoside intensification and of maintenance therapy in the treatment of children with acute nonlymphocytic leukemia

  1990cited by this paper
• A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL.

  1990cited by this paper
• Mature T-lineage leukemia with growth factor-induced multilineage differentiation

  1989cited by this paper
• Secondary cancers after bone marrow transplantation for leukemia or aplastic anemia.

  1989cited by this paper
• Autologous bone-marrow transplantation.

  1987cited by this paper
• Comparison of autologous and allogeneic bone marrow transplantation for treatment of high-risk refractory acute lymphoblastic leukemia.

  1987cited by this paper
• Bone marrow transplantation for patients with Philadelphia chromosome-positive acute lymphoblastic leukemia.

  1987cited by this paper
• Prognostic importance of blast cell DNA content in childhood acute lymphoblastic leukemia.

  1985cited by this paper
• Molecular basis of human B cell neoplasia.

  1985cited by this paper
• Survival in childhood acute lymphocytic leukemia: effect of protocol and place of treatment.

  1983cited by this paper
• Allogeneic bone marrow transplantation in acute nonlymphocytic leukemia: a pilot study.

  1982cited by this paper
• [French-American-British (FAB) classification of acute leukemia].

  1982cited by this paper
• Expression of myeloid differentiation antigens on normal and malignant myeloid cells.

  1981cited by this paper
• The Morphological Classification of Acute Lymphoblastic Leukaemia: Concordance among Observers and Clinical Correlations

  1981cited by this paper
• Presymptomatic central nervous system therapy in previously untreated childhood acute lymphoblastic leukaemia: comparison of 1800 rad and 2400 rad. A report for Children's Cancer Study Group.

  1981cited by this paper
• [Acute lymphoblastic leukemia in childhood].

  1980cited by this paper
• Pre-B-cell leukemia. A new phenotype of childhood lymphoblastic leukemia.

  1978cited by this paper
• Acute Lymphoblastic Leukemic Cells with T (Thymus-Derived) Lymphocyte Markers

  1973cited by this paper
• Use of pituitary adrenocorticotropic hormone (ACTH) and cortisone in lymphomas and leukemias.

  1950cited by this paper
• Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid.

  1948cited by this paper
• Antisense Oligonucleotides as Therapeutic Agents Is the Bullet Really Magical ?

  year unknowncited by this paper

• Blinatumomab in pediatric B-acute lymphoblastic leukemia

  2025cites this paper
• Episodes of acute methotrexate‐related neurotoxicity linked to compromised long‐term neurocognitive function

  2024cites this paper
• The global burden of childhood and adolescent leukaemia and attributable risk factors: An analysis of the Global Burden of Disease Study 2019

  2024cites this paper
• Evolutionary determinants of curability in cancer

  2023cites this paper
• Survival estimates of childhood malignancies treated at the Mexican telethon pediatric oncology hospital

  2022cites this paper
• Mutant IL7R collaborates with MYC to induce T-cell acute lymphoblastic leukemia

  2022cites this paper
• Culturally Adapted Motivational Interviewing for Pediatric Acute Lymphoblastic Leukemia Adherence: Feasibility and Acceptability

  2022cites this paper
• Kinase Inhibition in Relapsed/Refractory Leukemia and Lymphoma Settings: Recent Prospects into Clinical Investigations

  2021cites this paper
• Parental decision making regarding consent to randomization on Children's Oncology Group AALL0932

  2021cites this paper
• Hope on the horizon: promising novel therapies for necrotizing enterocolitis

  2020cites this paper
• Prediction of Cranial Radiotherapy Treatment in Pediatric Acute Lymphoblastic Leukemia Patients Using Machine Learning: A Case Study at MAHAK Hospital

  2020cites this paper
• 16 Hematopoietic Stem Cells Therapeutic Applications

  2018cites this paper
• The Evolution and Future of CAR T Cells for B‐Cell Acute Lymphoblastic Leukemia

  2018cites this paper
• Ontogenic growth as the root of fundamental differences between childhood and adult cancer

  2016cites this paper
• High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells*

  2016cites this paper
• Precision Medicine in Gastrointestinal Pathology.

  2016cites this paper
• Blocking autophagy enhanced leukemia cell death induced by recombinant human arginase

  2016cites this paper
• Obesity and Metabolic Disease After Childhood Cancer.

  2015cites this paper
• Clinical Guidelines for the Care of Childhood Cancer Survivors

  2014cites this paper
• Anti-leukemic response of a NSAID, tolfenamic acid

  2014cites this paper
• Targeted Nanoparticles for Pediatric Leukemia Therapy

  2014cites this paper
• Combined multiplex and monoplex RT-PCR as a reliable and cost-effective method for molecular diagnostics of pediatric acute lymphoblastic leukemia.

  2014cites this paper
• TOSCA: no longer just an opera.

  2014cites this paper
• Contribution of Polymorphisms in IKZF1 Gene to Childhood Acute Leukemia: A Meta-Analysis of 33 Case-Control Studies

  2014cites this paper
• AAML0523: A report from the Children's Oncology Group on the efficacy of clofarabine in combination with cytarabine in pediatric patients with recurrent acute myeloid leukemia

  2014cites this paper
• Birth rates among female cancer survivors

  2013cites this paper
• childhood T-cell acute lymphoblastic leukemia in immunodeficient mice Preconditioning with fetal cord blood facilitates engraftment of primary

  2013cites this paper
• Targeted Drug Discovery for Pediatric Leukemia

  2013cites this paper
• Getting from the bench to the patient: biotechnology strategies.

  2013cites this paper
• High modal number and triple trisomies are highly correlated favorable factors in childhood B-cell precursor high hyperdiploid acute lymphoblastic leukemia treated according to the NOPHO ALL 1992/2000 protocols

  2013cites this paper
• Phase I/II trial of clofarabine and cytarabine in children with relapsed/refractory acute lymphoblastic leukemia (AAML0523): A report from the Children's Oncology Group

  2013cites this paper
• Hematopoietic stem cell transplantation for children with high-risk acute lymphoblastic leukemia in first complete remission: a report from the AIEOP registry

  2013cites this paper
• Preclinical and clinical evaluation of forodesine in pediatric and adult B-cell acute lymphoblastic leukemia.

  2013cites this paper
• Correlation of SRSF1 and PRMT1 expression with clinical status of pediatric acute lymphoblastic leukemia

  2012cites this paper
• Lessons from the past: Opportunities to improve childhood cancer survivor care through outcomes investigations of historical therapeutic approaches for pediatric hematological malignancies

  2012cites this paper
• A HISTORY OF THE RONALD McDONALD HOUSE OF INDIANA, 1980-2004

  2012cites this paper
• HLA-DPβ1 Asp84-Lys69 antigen-binding signature predicts event-free survival in childhood B-cell precursor acute lymphoblastic leukaemia: results from the MRC UKALL XI childhood ALL trial

  2012cites this paper
• Hematopoietic Stem Cells Therapeutic Applications

  2012cites this paper
• The oncologist's impact on drug choices.

  2012cites this paper
• In vitro sensitivity to dasatinib in lymphoblasts from a patient with t(17;19)(q22;p13) gene rearrangement pre-B acute lymphoblastic leukemia

  2012cites this paper
• The indicative effect of Notch1 expression for the prognosis of T-cell acute lymphocytic leukemia: a systematic review

  2012cites this paper
• Genomic characterization of ETV 6 / RUNX 1-positive acute lymphoblastic leukemia

  2011cites this paper
• ROR1 expression and function in B-cell malignancies

  2011cites this paper
• Genomic characterization of ETV6/RUNX1-positive acute lymphoblastic leukemia

  2011cites this paper
• Targeting survivin and p53 in pediatric acute lymphoblastic leukemia

  2011cites this paper
• Ten-year Experiences on Initial Genetic Examination in Childhood Acute Lymphoblastic Leukaemia in Hungary (1993–2002). Technical Approaches and Clinical Implementation

  2011cites this paper
• Marrow purging in autologous bone marrow transplantation for mexican children with acute leukemia: a successful treatment

  2010cites this paper
• Resultados de tratamiento para cáncer infantil en una población de recursos limitados en Bogotá, Colombia

  2010influential citation
• Use of clofarabine for acute childhood leukemia

  2010cites this paper
• Stem-like tumor cells confer drug resistant properties to mantle cell lymphoma

  2010cites this paper
• Outcome for children treated for relapsed or refractory acute myelogenous leukemia (rAML): A therapeutic advances in childhood leukemia (TACL) consortium study

  2010cites this paper
• Aetiology of childhood leukaemia.

  2010cites this paper
• Lentiviral-mediated Foxp3 RNAi suppresses tumor growth of regulatory T cell-like leukemia in a murine tumor model

  2010cites this paper
• Outcome of patients treated for relapsed or refractory acute lymphoblastic leukemia: a Therapeutic Advances in Childhood Leukemia Consortium study.

  2010cites this paper
• Molecular And Therapeutic Implications Of Notch1 Signaling In Pediatric T-Cell Acute Lymphoblastic Leukemia

  2010cites this paper
• No evidence of a trial effect in newly diagnosed pediatric acute lymphoblastic leukemia.

  2010cites this paper
• Follow up of Survivors of Childhood Acute Lymphoblastic Leukemia with Detection of Parental Psychiatric Disorders

  2010cites this paper
• On the effect of digitising flows in networked microfluidic systems for nucleic acid analysis

  2010cites this paper
• The Use and Refinement of Rodent Models in Anti-cancer Drug Discovery: A Review

  2009cites this paper
• The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T- cell acute lymphoblastic leukemia: A report from the Children's Oncology Group

  2009cites this paper
• Results of Chemotherapy with BFM-87 Protocol in Children with Acute Myeloid Leukemia at a Referral Center in the Southwest of Iran : Clinical Characteristics and Outcome

  2009cites this paper
• Relationship between HLA‐DP supertype and survival in childhood acute lymphoblastic leukaemia: evidence for selective loss of immunological control of residual disease?

  2009cites this paper
• High hyperdiploid childhood acute lymphoblastic leukemia

  2009cites this paper
• Phase II study of clofarabine in pediatric patients with refractory or relapsed acute myeloid leukemia.

  2009cites this paper
• Flow cytometric chemosensitivity assay as a predictive tool of early clinical response in acute lymphoblastic leukemia

  2009cites this paper
• Establishment and validation of a standard protocol for the detection of minimal residual disease in B lineage childhood acute lymphoblastic leukemia by flow cytometry in a multi-center setting;

  2009cites this paper
• O‐acetylated sialic acids: Multifaceted role in childhood acute lymphoblastic leukaemia

  2009cites this paper
• Haploidentical hematopoietic stem cell transplantation without in vitro T cell depletion for treatment of hematological malignancies in children.

  2008cites this paper
• Factors influencing survival after relapse from acute lymphoblastic leukemia: a Children's Oncology Group study

  2008cites this paper
• Progress in the curative treatment of childhood hematologic malignancies.

  2008cites this paper
• MR features of isolated uterine relapse in an adolescent with acute lymphoblastic leukaemia

  2008cites this paper
• Allogeneic bone marrow transplantation in first remission for children with ultra-high-risk features of acute lymphoblastic leukemia: A children's oncology group study report.

  2007cites this paper
• Prognostic Role of the Reduced Folate Carrier, the Major Membrane Transporter for Methotrexate, in Childhood Acute Lymphoblastic Leukemia: A Report from the Children's Oncology Group

  2007influential citation
• Integrating Functional Knowledge during Sample Clustering for Microarray Data using Unsupervised Decision Trees

  2007cites this paper
• Stem and progenitor cell involvement in acute lymphoblastic leukemia

  2007cites this paper
• FISH detection of chimerism in pediatric hematopoietic stem cell transplantation

  2007cites this paper
• Discovery and development of clofarabine: a nucleoside analogue for treating cancer

  2006cites this paper
• Infection, immune responses and the aetiology of childhood leukaemia

  2006cites this paper
• Translating microarray data for diagnostic testing in childhood leukaemia

  2006cites this paper
• Lentiviral-based RNA interference of genes in leukaemic cells

  2006cites this paper
• Phase II study of clofarabine in pediatric patients with refractory or relapsed acute lymphoblastic leukemia.

  2006cites this paper
• Investigating Childhood Leukemia in Churchill County, Nevada

  2006cites this paper
• Superiority of allogeneic hematopoietic stem-cell transplantation compared with chemotherapy alone in high-risk childhood T-cell acute lymphoblastic leukemia: results from ALL-BFM 90 and 95.

  2006cites this paper
• Expression of Death Receptors and Associated Regulatory Proteins in Pediatric Acute Lymphoblastic Leukemia: Preliminary Results

  2005cites this paper
• Therapy of low‐risk subsets of childhood acute lymphoblastic leukemia: When do we say enough?

  2005cites this paper
• In utero origins of childhood leukaemia.

  2005cites this paper
• Bayesian Error‐in‐Variable Survival Model for the Analysis of GeneChip Arrays

  2005cites this paper
• Aetiology of childhood leukemia

  2005cites this paper
• Valor pronóstico del inmunofenotipo en la respuesta temprana de la leucemia aguda linfoblástica pre-B en niños

  2005cites this paper
• Interleukin-7 in T-cell acute lymphoblastic leukemia: An extrinsic factor supporting leukemogenesis?

  2005cites this paper
• Dexamethasone resistance in B-cell precursor childhood acute lymphoblastic leukemia occurs downstream of ligand-induced nuclear translocation of the glucocorticoid receptor.

  2005cites this paper
• Gene Expression Profiles of B-lineage Adult Acute Lymphocytic Leukemia Reveal Genetic Patterns that Identify Lineage Derivation and Distinct Mechanisms of Transformation

  2005cites this paper
• Spectral characteristics of acute lymphoblastic leukemia in childhood.

  2004cites this paper
• The quality of life for cancer children (QOLCC) in Taiwan (part I): Reliability and construct validity by confirmatory factor analysis

  2004cites this paper
• Causes of childhood leukaemia and lymphoma.

  2004cites this paper
• Treating childhood acute myeloid leukaemia with the AML‐BFM‐83 protocol: experience in a developing country

  2004cites this paper
• Analysis of ETV6/RUNX1 fusions for evaluating the late effects of cancer therapy in ALL (acute lymphoblastic leukemia) cured patients

  2004cites this paper
• Characterization of childhood acute lymphoblastic leukemia xenograft models for the preclinical evaluation of new therapies.

  2004cites this paper
• A new model of plasma cell proliferation

  2004cites this paper
• Risky Trade-offs: Bangladeshi Quest for Safe Water

  2004cites this paper