Hydrops fetalis caused by alpha-thalassemia: an emerging health care problem.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Blood

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  PMID 9516118
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular defects in 2 examples of severe Hb H disease.

  2009cited by this paper
• Carrier detection and prenatal diagnosis of alpha-thalassemia of Southeast Asian deletion by polymerase chain reaction

  2004cited by this paper
• Prenatal diagnosis of haemoglobin Bart's disease by cordocentesis at 12–14 weeks—experience with the first 59 cases

  2000cited by this paper
• Determination of the breakpoint of the common α‐thalassaemia deletion in Filipinos in Hawaii

  1999cited by this paper
• Prevalence and genotypes of alpha‐ and beta‐thalassemia carriers in Hong Kong — Implications for population screening

  1997cited by this paper
• Early ultrasound prediction of pregnancies affected by homozygous alpha-thalassaemia-1.

  1997cited by this paper
• PRENATAL DIAGNOSIS OF HAEMOGLOBIN BART'S DISEASE BY CORDOCENTESIS AT 12–14 WEEKS' GESTATION

  1997cited by this paper
• Limb defects in homozygous alpha-thalassemia: report of three cases.

  1997cited by this paper
• Limb reduction defects in fetuses with homozygous alpha-thalassaemia-1.

  1997cited by this paper
• Molecular defects in Hb H hydrops fetalis

  1997cited by this paper
• MISDIAGNOSIS OF HOMOZYGOUS ALPHA‐THALASSAEMIA 1 MAY OCCUR IF POLYMERASE CHAIN REACTION ALONE IS USED IN PRENATAL DIAGNOSIS

  1997cited by this paper
• Second-trimester hydrops fetalis in pregnancies affected by homozygous alpha-thalassaemia-1.

  1997cited by this paper
• Frequency of deletional alpha-thalassemia genotypes in a predominantly Asian-American population.

  1997cited by this paper
• Prenatal diagnosis of thalassemia in the Chinese

  1997cited by this paper
• The Risk of α‐Thalassaemia in Offspring of β‐Thalassaemia Carriers in Hong Kong

  1997cited by this paper
• The risk of alpha-thalassaemia in offspring of beta-thalassaemia carriers in Hong Kong.

  1997cited by this paper
• α-Thalassemia in The Netherlands: a heterogeneous spectrum of both deletions and point mutations

  1997cited by this paper
• Limb defects and congenital anomalies of the genitalia in an infant with homozygous alpha-thalassemia.

  1997cited by this paper
• Prevalence and genotypes of α- and β-thalassemia carriers in Hong Kong : Implications for population screening

  1997cited by this paper
• Human α‐Thalassemia syndromes: Detection of molecular defects

  1996cited by this paper
• Antenatal sonographic features of 100 alpha‐thalassemia hydrops fetalis fetuses

  1996cited by this paper
• Towards non–invasive prenatal diagnosis

  1996cited by this paper
• Haemoglobinopathies

  1996cited by this paper
• Practical guide to the diagnosis of thalassemia

  1996cited by this paper
• Comparison of the HbH inclusion test and a PCR test in routine screening for alpha thalassaemia in Hong Kong.

  1996cited by this paper
• Prevalence of alpha-thalassemias in northern Thailand.

  1996cited by this paper
• Practical guide to the diagnosis of thalassemia. Council of Regional Networks for Genetic Services (CORN).

  1996cited by this paper
• In utero haematopoietic stem cell transplantation: current perspectives and future potential.

  1996cited by this paper
• Prenatal diagnosis of sickle cell anaemia and thalassaemia by analysis of fetal cells in maternal blood

  1996cited by this paper
• Lack of evidence of permanent engraftment after in utero fetal stem cell transplantation in congenital hemoglobinopathies.

  1996cited by this paper
• Human alpha-thalassemia syndromes: detection of molecular defects.

  1996cited by this paper
• Intrauterine therapy for homozygous alpha-thalassemia.

  1995cited by this paper
• Ultrasonographic scanning of placental thickness and the prenatal diagnosis of homozygous alpha‐thalassaemia 1 in the second trimester

  1995cited by this paper
• Symmetrical terminal transverse limb defects: report of a twenty-week fetus.

  1995cited by this paper
• Human embryonic zeta-globin gene expression in mouse-human hybrid erythroid cell lines.

  1995cited by this paper
• Comparison of haemoglobin H inclusion bodies with embryonic zeta globin in screening for alpha thalassaemia.

  1995cited by this paper
• Detection of alpha-thalassemia-1 (Southeast Asian type) and its application for prenatal diagnosis.

  1995cited by this paper
• Hematologic disorders and nonimmune hydrops fetalis.

  1995cited by this paper
• Comparison ofhaemoglobin H inclusion bodies withembryonic 4globin inscreening forct thalassaemia

  1995cited by this paper
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  1994cited by this paper
• Anti-zeta antibody screening for alpha-thalassemia using dried filter paper blood.

  1994cited by this paper
• Ultrasound measurement of placental thickness to detect pregnancies affected by homozygous alpha-thalassaemia-1.

  1994cited by this paper
• Survival in Medically Treated Patients with Homozygous β-Thalassemia

  1994cited by this paper
• Pathological case of the month. Hydrops fetalis secondary to homozygous alpha-thalassemia-1 (Bart's hemoglobinopathy).

  1994cited by this paper
• Anti-ζ Antibody Screening for α-Thalassemia Using Dried Filter Paper Blood

  1994cited by this paper
• Therapy for beta-thalassemia--a paradigm for the treatment of genetic disorders.

  1994cited by this paper
• Survival in medically treated patients with homozygous beta-thalassemia.

  1994cited by this paper
• alpha-Thalassaemia.

  1993cited by this paper
• Perinatal case report of unexpected thalassemia Hb Bart.

  1993cited by this paper
• Carrier detection and prenatal diagnosis of hemoglobinopathies in Ontario.

  1993cited by this paper
• Immunocytological test to detect adult carriers of (--SEA/) deletional alpha-thalassaemia.

  1993cited by this paper
• Immunocytological test to detect adult carriers of (--SEA/) deletional α-thalassaemia

  1993cited by this paper
• A PCR-based strategy to detect the common severe determinants of alpha thalassaemia.

  1992cited by this paper
• In utero stem cell therapy.

  1992cited by this paper
• Alpha thalassaemia hydrops fetalis in the UK: the importance of screening pregnant women of Chinese, other South East Asian and Mediterranean extraction for alpha thalassaemia trait

  1992cited by this paper
• Identification of an extensive ζ‐α globin gene deletion in a Chinese individual

  1992cited by this paper
• Hydrops fetalis caused by severe alpha-thalassemia.

  1992cited by this paper
• Identification of an extensive zeta-alpha globin gene deletion in a Chinese individual.

  1992cited by this paper
• Human embryonic zeta-globin chain expression in deletional alpha-thalassemias.

  1992cited by this paper
• A PCR‐based strategy to detect the common severe determinants of α thalassaemia

  1992cited by this paper
• Long-term survival of a baby with homozygous alpha-thalassemia-1.

  1992cited by this paper
• Cis-acting sequences regulating expression of the human alpha-globin cluster lie within constitutively open chromatin.

  1992cited by this paper
• [Incidental diagnosis of homozygous alpha-zero thalassemia in a 21 week old fetus].

  1991cited by this paper
• Molecular characterization of severe alpha-thalassemias causing hydrops fetalis in Taiwan.

  1991cited by this paper
• Rapid diagnosis of alpha-thalassemia-1 of southeast Asia type and hydrops fetalis by polymerase chain reaction.

  1991cited by this paper
• Prenatal diagnosis of thalassemia and hemoglobinopathies in Switzerland

  1991cited by this paper
• Découverte fortuite d'une alpha zero thalassémie homozygote chez un foetus de vingt-et-une semaines.

  1991cited by this paper
• Molecular characterization of severe α‐Thalassemias causing hydrops fetalis in Taiwan

  1991cited by this paper
• Fetal hydrops in Sardinia: implications for genetic counselling

  1990cited by this paper
• [Congenital hemoglobinopathies].

  1990cited by this paper
• Prenatal diagnosis of α-thalassemia by polymerase chain reaction and dual restriction enzyme analysis

  1990cited by this paper
• Genetic screening for ethnic minorities.

  1990cited by this paper
• Ultrasonographic method for detection of haemoglobin Bart's hydrops fetalis in the second trimester of pregnancy

  1990cited by this paper
• A major positive regulatory region located far upstream of the human alpha-globin gene locus.

  1990cited by this paper
• Concentrations of alpha-fetoprotein increased in maternal serum but normal in amniotic fluid in a pregnancy involving hemoglobin Bart's disease.

  1990cited by this paper
• Nonimmune hydrops fetalis associated with genetic abnormalities.

  1990cited by this paper
• Alpha-Thalassemia: Prenatal Diagnosis and Neonatal Implications

  1990cited by this paper
• A review of the molecular genetics of the human alpha-globin gene cluster.

  1989cited by this paper
• Hydrops fetalis due to homozygosity for alpha-thalassemia-1, -(alpha)-20.5 kb: the first observation in a Turkish family.

  1989cited by this paper
• Sonographic Evaluation of Hydrops Fetalis

  1989cited by this paper
• Bart's Hydrops Fetalis — Clinical Presentation and Management — An Analysis of 25 Cases

  1989cited by this paper
• The types of hemoglobins and globin chains in hydrops fetalis.

  1989cited by this paper
• Characterization of two deletions that remove the entire human zeta-alpha globin gene complex (- -THAI and - -FIL).

  1988cited by this paper
• Characterization of two deletions that remove the entire human ζ‐α globin gene complex (—THAI and —FIL)

  1988cited by this paper
• A novel monoclonal antibody based diagnostic test for alpha-thalassemia-1 carriers due to the (-SEA/) deletion.

  1988cited by this paper
• Alpha‐Thalassemia hydrops fetalis: Clinical and ultrasonographic considerations

  1987cited by this paper
• Hemoglobin barts hydrops fetalis syndrome.

  1987cited by this paper
• Theca-lutein ovarian cysts associated with homozygous alpha-thalassemia.

  1987cited by this paper
• Hemoglobinopathies in Southeast Asia.

  1987cited by this paper
• Ultrasound evaluation of pregnancies at risk for homozygous α‐thalassaemia‐1

  1987cited by this paper
• Normal long-term survival with alpha-thalassemia.

  1986cited by this paper
• Survival of a hydropic infant with homozygous alpha-thalassemia-1.

  1986cited by this paper
• Embryonic ζ-Globin Chains in Adults: a Marker for α-Thalassemia-1 Haplotype Due to a >17.5-kb Deletion

  1986cited by this paper
• Hydrops fetalis secondary to Bart hemoglobinopathy.

  1986cited by this paper
• Embryonic zeta-globin chains in adults: a marker for alpha-thalassemia-1 haplotype due to a greater than 17.5-kb deletion.

  1986cited by this paper
• Haemoglobin switching in human embryos: asynchrony of ζ → α and ε → γ-globin switches in primitive and definitive erythropoietic lineage

  1985cited by this paper
• Haemoglobin switching in human embryos: asynchrony of zeta----alpha and epsilon----gamma-globin switches in primitive and definite erythropoietic lineage.

  1985cited by this paper
• Alpha zero-thalassemia due to recombination between the alpha 1-globin gene and an AluI repeat.

  1985cited by this paper
• Hematologic genetic disorders among Southeast Asian refugees

  1985cited by this paper
• Homozygous alpha-thalassaemia: clinical presentation, diagnosis and management. A review of 46 cases.

  1985cited by this paper

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• The First Compound Heterozygosity for Two Different α-Thalassemia Determinants Causes Hb Bart’s Hydrops Fetalis in a Chinese Family

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  2019cites this paper
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• Diverse hematological phenotypes of β‐thalassemia carriers

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• Favorable outcomes after in utero transfusion in fetuses with alpha thalassemia major: a case series and review of the literature

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• α−thalassaemia: a genotype–phenotype correlation and management

  2015cites this paper
• Diagnostic pitfalls of less well recognized HbH disease.

  2015cites this paper
• α‐thalassemia‐associated hydrops fetalis: A rare cause of thyrotoxic cardiomyopathy

  2015cites this paper
• Prenatal control of Hb Bart’s hydrops fetalis: a two-year experience at a mainland Chinese hospital

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  2015cites this paper
• Differences in the clinical and genotypic presentation of sickle cell disease around the world.

  2014cites this paper
• Role of Iron Chelation Therapy for Beta-Thalassemia Major: A Review

  2014cites this paper
• In utero hematopoietic cell transplantation for hemoglobinopathies

  2014cites this paper
• Routine screening for α-thalassaemia using an immunochromatographic strip assay for haemoglobin Bart's

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  2014cites this paper
• KLF1-null neonates display hydrops fetalis and a deranged erythroid transcriptome.

  2014cites this paper
• The α-thalassemias.

  2014cites this paper
• A Case of Nonimmune Hydrops Fetalis Caused by Homozygous α-Thalassemia

  2013cites this paper
• Spectrum of α-thalassemia mutations including first observation of - -(FIL) deletion in Hatay Province, Turkey.

  2013cites this paper
• Identification of one or two α-globin gene deletions by isoelectric focusing electrophoresis.

  2013cites this paper
• A Newly Modified Hemoglobin H Inclusion Test as a Secondary Screening for α⁰-Thalassemia in Southeast Asian Populations

  2013cites this paper
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  2013cites this paper
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  2013cites this paper
• Clinical manifestations of α-thalassemia.

  2013cites this paper
• Diagnostic testing for α‐globin gene disorders in a heterogeneous North American population

  2013cites this paper
• Cell Science & Therapy An Approach for the Treatment of β-Thalassemia

  2012cites this paper
• 10 Alpha Thalassemia Disorders

  2012cites this paper
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  2012cites this paper
• α0-Thalassemia Trait with Normal Red Cell Indices: A Report of Two Cases

  2012cites this paper
• Advances in the treatment of alpha-thalassemia.

  2012cites this paper
• The Contribution of Extramedullary Hematopoiesis to Hepatomegaly in Anemic Hydrops Fetalis: A Study in Alpha-Thalassemia Hydrops Fetalis

  2012cites this paper
• Simplified Preimplantation Genetic Diagnosis of Common Determinants of Hemoglobin Bart ’ s Hydrops Fetalis Syndrome Using a Multiplex-Microsatellite PCR Assay

  2012cites this paper
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  2012cites this paper
• Anemia in pregnancy.

  2011cites this paper
• Population genetics of malaria resistance in humans

  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2010cites this paper
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  2010cites this paper