Human Na(v)1.8: enhanced persistent and ramp currents contribute to distinct firing properties of human DRG neurons.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Journal of Neurophysiology

• Publication date

  2015-05-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1152/jn.00113.2015PMID 25787950PMCID PMC4432682
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2014influential reference
• Dynamic-clamp analysis of wild-type human Nav1.7 and erythromelalgia mutant channel L858H.

  2014influential reference
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  2013influential reference
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  2012influential reference
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  2012influential reference
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  2012cited by this paper
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  2012cited by this paper
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  2011influential reference
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  2011cited by this paper
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  2009cited by this paper
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  2009cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2005influential reference
• The TTX‐Resistant Sodium Channel Nav1.8 (SNS/PN3): Expression and Correlation with Membrane Properties in Rat Nociceptive Primary Afferent Neurons

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  2001influential reference
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  1998cited by this paper
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  1998cited by this paper
• Structure and Function of a Novel Voltage-gated, Tetrodotoxin-resistant Sodium Channel Specific to Sensory Neurons (*)

  1996cited by this paper
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  1996cited by this paper
• A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons

  1996cited by this paper
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  1996cited by this paper
• Pharmacologically novel GABA receptor in human dorsal root ganglion neurons.

  1996influential reference
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  1994cited by this paper
• Dynamic clamp: computer-generated conductances in real neurons.

  1993influential reference
• Journal of Neuroscience Methods

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