Regulation of plasmacytoid dendritic cell development in mice by aryl hydrocarbon receptor

Aryl hydrocarbon receptor (AhR) has an important role in the regulation of cell responses to different environmental stimuli, as well as to various endogenous ligands. Although AhR was previously implicated in the regulation of dendritic cell (DC) activation, very little is known about its potential role in the development of these cells. Here we report our unexpected findings that AhR may regulate the differentiation of plasmacytoid DCs (pDCs). Agonist of AhR markedly decreased the generation of pDCs in vitro, whereas the AhR antagonist had an opposite effect. The differentiation of conventional DCs (cDCs) was not affected. AhR‐knockout mice had a substantial accumulation of pDCs in peripheral lymphoid organs; whereas no changes in cDCs were seen. Thus, this study has identified AhR as a transcription factor involved in the development of one population of DCs—pDCs.

• Publication year

  2013

• Venue

  Immunology and Cell Biology

• Publication date

  2013-10-29

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/icb.2013.65PMID 24165981PMCID 3945671
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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