Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell–dendritic cell interaction

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Nature

• Publication date

  2006-04-13

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nature04651PMID 16612374
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• T cell costimulation by chemokine receptors

  2005cited by this paper
• Directed Migration of Positively Selected Thymocytes Visualized in Real Time

  2005cited by this paper
• Immunotherapeutic uses of CpG oligodeoxynucleotides

  2004cited by this paper
• Illuminating the landscape of in vivo immunity: insights from dynamic in situ imaging of secondary lymphoid tissues.

  2004cited by this paper
• Helping the CD8+ T-cell response

  2004cited by this paper
• Cytokine and chemokine expression profiles of maturing dendritic cells using multiprotein platform arrays.

  2004cited by this paper
• Differential production of inflammatory chemokines by murine dendritic cell subsets.

  2004cited by this paper
• Visualizing the first 50 hr of the primary immune response to a soluble antigen.

  2004cited by this paper
• Visualizing dendritic cell networks in vivo

  2004cited by this paper
• T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases

  2004cited by this paper
• T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node.

  2004cited by this paper
• Regulation of Dendritic Cell Migration to the Draining Lymph Node

  2003cited by this paper
• Homing and cellular traffic in lymph nodes

  2003cited by this paper
• Dynamic Changes During the Immune Response in T Cell–Antigen-presenting Cell Clusters Isolated from Lymph Nodes

  2003cited by this paper
• Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy

  2003cited by this paper
• CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes

  2003cited by this paper
• Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help

  2003cited by this paper
• Dynamics of CD8+ T cell priming by dendritic cells in intact lymph nodes

  2003cited by this paper
• Lymphoid organ development and cell migration

  2003cited by this paper
• Requirement for CD4 T Cell Help in Generating Functional CD8 T Cell Memory

  2003cited by this paper
• Two-Photon Imaging of Lymphocyte Motility and Antigen Response in Intact Lymph Node

  2002cited by this paper
• Dynamic Imaging of T Cell-Dendritic Cell Interactions in Lymph Nodes

  2002cited by this paper
• Vaccines: Effector and memory T-cell differentiation: implications for vaccine development

  2002cited by this paper
• A Role for CD40 Expression on CD8+ T Cells in the Generation of CD8+ T Cell Memory

  2002cited by this paper
• Identification of Human Macrophage Inflammatory Proteins 1α and 1β as a Native Secreted Heterodimer*

  2001cited by this paper
• Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer.

  2001cited by this paper
• Understanding dendritic cell and T‐lymphocyte traffic through the analysis of chemokine receptor expression

  2000cited by this paper
• Characterization of the ovalbumin‐specific TCR transgenic line OT‐I: MHC elements for positive and negative selection

  2000cited by this paper
• Defective TCR expression in transgenic mice constructed using cDNA‐based α‐ and β‐chain genes under the control of heterologous regulatory elements

  1998cited by this paper
• T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

  1998cited by this paper
• Dendritic cells and the control of immunity

  1998cited by this paper
• A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

  1998cited by this paper
• Help for cytotoxic-T-cell responses is mediated by CD40 signalling

  1998cited by this paper
• A fail-safe mechanism for maintaining self-tolerance

  1992cited by this paper
• Resolution of the two components of macrophage inflammatory protein 1, and cloning and characterization of one of those components, macrophage inflammatory protein 1 beta

  1988cited by this paper
• Helper activity is required for the in vivo generation of cytotoxic T lymphocytes

  1982cited by this paper
• The effects of antigen on the migration of recirculating lymphocytes through single lymph nodes

  1976cited by this paper
• The immediate effect of antigens on the cell output of a lymph node.

  1965cited by this paper

• CD4+ T cells facilitate the RT-induced abscopal effect by promoting antigen cross-presentation to CD8+ T cells at unirradiated tumor sites

  2026cites this paper
• Lipid nanoparticle-mediated in vivo generation of panCAR immune cells for solid tumor immunotherapy.

  2026cites this paper
• Disparities in Tumor Microenvironment Between Primary and Metastatic Colorectal Cancer: Impact on Immune Infiltration and Survival.

  2026cites this paper
• Chemoradiation of glioblastoma cells alters expression of activation and immune checkpoint molecules on type 1 and 2 dendritic cells and impacts on subsequent T cell proliferation

  2026cites this paper
• NKG2D upregulation sensitizes tumors to combined anti-PD1 and anti-VEGF therapy and prevents hearing loss

  2026cites this paper
• Metabolic and proteomic signatures differentiate inflammatory phenotypes from cancer and predict treatment response in patient sera

  2025cites this paper
• Synergy between TLR3-ligand and IFN-α in the transient sensitization of “Cold” tumors to PD-1 blockade and the induction of systemic immunity

  2025cites this paper
• PD-1-engineered manganese-based nanoplatform loaded with CXCL9 induces ICD and intensifies T-cell infiltration for melanoma treatment

  2025cites this paper
• Intratumoral three-cell-type clusters are a conserved feature of endogenous antitumor immunity.

  2025cites this paper
• Suppression of multiple mouse models of refractory malignancies by reprogramming IL-18 ligand-receptor interaction

  2025cites this paper
• Discovery of a novel diphenyl piperidinone-naphthoquinone STAT3 inhibitor as chemoimmunotherapeutic agent.

  2025cites this paper
• Chemokine System Changes Drive Age-Related Macular Degeneration and Influence Treatment Outcomes

  2025cites this paper
• Intra-Tumoral Treg Ablation Unleashes NK Cell-Mediated Control of CD8 T Cell-Resistant Tumors

  2025cites this paper
• Stimulation of regulatory dendritic cells suppresses cytotoxic T cell function and alleviates DEN-induced liver injury, fibrosis and hepatocellular carcinoma

  2025cites this paper
• Human CD4+ T cells recognize Mycobacterium tuberculosis–infected macrophages amid broader responses

  2025cites this paper
• Tissue-resident CCR2+ macrophage TREM-1/3 signaling is necessary for monocyte and neutrophil recruitment to injured hearts

  2025cites this paper
• Liver sinusoid constraints make random search of CD8 T cells for Plasmodium parasites efficient

  2025cites this paper
• Immune and non-immune cell fencing of tumor cells is a widespread and functionally relevant spatial pattern in solid cancers

  2025cites this paper
• MIP-3α-antigen fusion DNA vaccine enhances sex differences in tuberculosis model and alters dendritic cell activity early post vaccination

  2025cites this paper
• Rapid generation of a murine RSV infectious model by transducing a conditional knock-in mouse harboring human IGF1 receptor with adenoviral vector.

  2025cites this paper
• Novel Vaccines Targeting the Highly Conserved SARS-CoV-2 ORF3a Ectodomain Elicit Immunogenicity in Mouse Models

  2025cites this paper
• Distinctive CD8+ T cell activation by antigen-presenting plasmacytoid dendritic cells compared to conventional dendritic cells.

  2025cites this paper
• Distinct type 1 immune networks underlie the severity of restrictive lung disease after COVID-19

  2025cites this paper
• Ex vivo prediction of the sensitization potential of biocides.

  2025cites this paper
• [Role of CD4 T cells in the immune response].

  2025cites this paper
• A review of the progress and challenges of developing dendritic-based vaccines against hepatitis B virus (HBV).

  2025cites this paper
• Bridging single cells to organs: Mesoscale modules as fundamental units of tissue function

  2025cites this paper
• Dendritic cells regulate the innate-adaptive balance in lymph nodes for optimal host defense.

  2025cites this paper
• CCR5 expression defines the functional heterogeneity of tumor-infiltrating CD8+ T cells and predicts enhanced antitumor immunity and favorable prognosis in non-small cell lung cancer.

  2025cites this paper
• MIP-3α-antigen fusion DNA vaccine enhances sex differences in tuberculosis model and alters dendritic cell activity early post vaccination

  2025cites this paper
• Caspase-11 Mediated Hyperinflammation Impairs CD8+ T Cell Immunity and Viral Clearance in Severe SARS-CoV-2 Infection

  2025influential citation
• Association between soluble immune mediators and outcomes in patients with unresectable stage III non-small cell lung cancer treated with concurrent chemoradiotherapy followed by durvalumab

  2025cites this paper
• Single‐Cell Transcriptome Atlas Reveals the Underlying Mechanism of Kynurenic Acid in the Regulation of Tumor Immune Microenvironment in Glioblastoma

  2025cites this paper
• Single-cell RNA sequencing of bone marrow reveals the immune response mechanisms of lymphocytes under avian leukosis virus subgroup J infection

  2025cites this paper
• Early cytokine and chemokine signals shape the anti-AML activity of bispecific engager-secreting T cells

  2025cites this paper
• Original Antigenic Sin in CD4+ T Cells

  2025cites this paper
• Chemokines: humble yet mighty players in the tumour microenvironment

  2025cites this paper
• Targeted delivery of CCL3 reprograms macrophage antigen presentation and enhances the efficacy of immune checkpoint blockade therapy in hepatocellular carcinoma

  2025cites this paper
• Self-adaptive biomaterials for tissue repair: from design to application

  2025cites this paper
• Dendritic Cell Organization and Function in Innate and Adaptive Immune Defense Within Lymph Nodes

  2025cites this paper
• Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

  2025cites this paper
• Distinct CD8+ T-cell types Associated with COVID-19 Severity in Unvaccinated HLA-A2+ Patients

  2025cites this paper
• An mRNA platform to create isolated, monospecific Th1 responses.

  2025cites this paper
• IL-1R2 promotes tumorigenesis and modulates the tumor immune microenvironment in colorectal cancer

  2025cites this paper
• The neuroimmune axis and chronic pain disorders

  2025influential citation
• Human memory CD4+ T-cells recognize Mycobacterium tuberculosis-infected macrophages amid broader pathogen-specific responses

  2025cites this paper
• Architects of immunity: How dendritic cells shape CD8+ T cell fate in cancer.

  2025cites this paper
• TSC22 domain family member 3 links natural killer cells to CD8+ T cell-mediated drug hypersensitivity

  2025cites this paper
• Myeloid cells: key players in tumor microenvironments

  2025cites this paper
• Engineered CD4 T cells for in vivo delivery of therapeutic proteins

  2024cites this paper
• Targeted Drug Screening Leveraging Senescence-Induced T-Cell Exhaustion Signatures in Hepatocellular Carcinoma

  2024cites this paper
• Ischemia Reperfusion Responses in Human Lung Transplants at the Single Cell Resolution.

  2024cites this paper
• Probing T-cell activation in nanoliter tumor co-cultures using membrane displacement trap arrays.

  2024cites this paper
• Single-cell sequencing reveals immune features of treatment response to neoadjuvant immunochemotherapy in esophageal squamous cell carcinoma

  2024cites this paper
• Proximity-dependent labeling identifies dendritic cells that drive the tumor-specific CD4+ T cell response

  2024cites this paper
• Intratumoral immune triads are required for immunotherapy-mediated elimination of solid tumors.

  2024cites this paper
• Proteomic analysis of plasma in healthy adults receiving recombinant vaccinia virus provides novel insights into HIV‐1 neutralizing antibodies

  2024cites this paper
• The vaginal immunoproteome for the prediction of spontaneous preterm birth: A retrospective longitudinal study

  2024cites this paper
• Identification of different functions of CD8+ T cell subpopulations by a novel monoclonal antibody

  2024cites this paper
• Coronavirus disease 2019–related myocardial injury is associated with immune dysregulation in symptomatic patients with cardiac magnetic resonance imaging abnormalities

  2024cites this paper
• Single-cell transcriptomics reveals tumor microenvironment remodeling in hepatocellular carcinoma with varying tumor subclonal complexity

  2024cites this paper
• Contactomics of Microglia and Intercellular Communication.

  2024cites this paper
• The importance of type I interferon in orchestrating the cytotoxic T-cell response to cancer.

  2024cites this paper
• Mendelian Randomization Analysis of Circulating Cytokines and Risk of Autoimmune Neuroinflammatory Diseases

  2024cites this paper
• RNA aggregates harness the danger response for potent cancer immunotherapy.

  2024cites this paper
• CCR5 promotes the migration of pathological CD8+ T cells to the leishmanial lesions

  2024cites this paper
• Tumor–neutrophil cross talk orchestrates the tumor microenvironment to determine the bladder cancer progression

  2024cites this paper
• Revealing the role of SPP1+ macrophages in glioma prognosis and therapeutic targeting by investigating tumor-associated macrophage landscape in grade 2 and 3 gliomas

  2024cites this paper
• Deciphering the potential role of PGRN in regulating CD8+ T cell antitumor immunity

  2024influential citation
• The Role of Infiltrated T Lymphocyte in Oral Squamous Cell Carcinoma: Insights into Clinicopathological Characteristics and Prognosis

  2024cites this paper
• Patients with ankylosing spondylitis present a distinct CD8 T cell subset with osteogenic and cytotoxic potential

  2024cites this paper
• Intrinsic immunogenicity of liposomes for tuberculosis vaccines: effect of cationic lipid and cholesterol.

  2024cites this paper
• Murine MHC-Deficient Nonobese Diabetic Mice Carrying Human HLA-DQ8 Develop Severe Myocarditis and Myositis in Response to Anti-PD-1 Immune Checkpoint Inhibitor Cancer Therapy.

  2024cites this paper
• A Programmable Peptidic Hydrogel Adjuvant for Personalized Immunotherapy in Resected Stage Tumors.

  2024cites this paper
• Immune Cell Migration to Cancer

  2024cites this paper
• Intra-tumoral T cells in pediatric brain tumors display clonal expansion and effector properties

  2024cites this paper
• Mechanisms and measures to modulate T cell trafficking for amplified and tolerogenic immunity

  2024cites this paper
• Cationic pH-sensitive liposomes as tuberculosis subunit vaccine delivery systems: Effect of liposome composition on cellular innate immune responses.

  2024cites this paper
• Chemokines that govern T cell activity in tumors.

  2024cites this paper
• The endocannabinoid anandamide prevents TH17 programming of activated T lymphocytes while preserving TH1 responses

  2024cites this paper
• Single-cell and spatial transcriptomics characterisation of the immunological landscape in the healthy and PSC human liver.

  2024cites this paper
• IRF1 transcriptionally up-regulates CXCL10 which increases CD8+ T cells infiltration in colorectal cancer.

  2024cites this paper
• Aging Deteriorates Blood Brain Barrier Function and Polarizes Adaptive T Cell Expansion Contributing to Neurocognitive Damage in Experimental Cirrhosis

  2024cites this paper
• Rapid protection against viral infections by chemokine-accelerated post-exposure vaccination

  2024cites this paper
• Chemokines Signature and T Cell Dynamics in Leishmaniasis: Molecular Insight and Therapeutic Application

  2024cites this paper
• Decoding NY-ESO-1 TCR T cells: transcriptomic insights reveal dual mechanisms of tumor targeting in a melanoma murine xenograft model

  2024cites this paper
• Cabozantinib inhibits tumor growth in mice with ovarian cancer.

  2024cites this paper
• Chemokine profile in the serum of patients with leptospirosis

  2024cites this paper
• Human CD34+-derived plasmacytoid dendritic cells as surrogates for primary pDCs and potential cancer immunotherapy

  2024cites this paper
• Beyond FOXP3: a 20-year journey unravelling human regulatory T-cell heterogeneity

  2024cites this paper
• Glutaryl-CoA dehydrogenase suppresses tumor progression and shapes an anti-tumor microenvironment in hepatocellular carcinoma.

  2024cites this paper
• Spatial interactions of immune cells as potential predictors to efficacy of toripalimab plus chemotherapy in locally advanced or metastatic pancreatic ductal adenocarcinoma: a phase Ib/II trial

  2024cites this paper
• Distinct Requirements for CD4+ T Cell Help for Immune Responses Induced by mRNA and Adenovirus‐Vector SARS‐CoV‐2 Vaccines

  2024cites this paper
• CCR5 promotes the migration of CD8+ T cells to the leishmanial lesions

  2023cites this paper
• Over-expression of IL-33 enhances rabies virus early antigen presentations and cellular immune responses in mice.

  2023cites this paper
• Role of CdTe quantum dots on peripheral Immunocytes and selenoprotein P: immunotoxicity at the molecular and cellular levels.

  2023cites this paper
• Exploring TCR-like CAR-Engineered Lymphocyte Cytotoxicity against MAGE-A4

  2023cites this paper
• Development and function of chicken XCR1+ conventional dendritic cells

  2023cites this paper
• Systems immunology of regulatory T cells: can one circuit explain it all?

  2023cites this paper
• Glial reactivity and T cell infiltration in frontotemporal lobar degeneration with tau pathology

  2023cites this paper