Investigation of PARP-1, PARP-2, and PARG interactomes by affinity-purification mass spectrometry

BackgroundPoly(ADP-ribose) polymerases (PARPs) catalyze the formation of poly(ADP-ribose) (pADPr), a post-translational modification involved in several important biological processes, namely surveillance of genome integrity, cell cycle progression, initiation of the DNA damage response, apoptosis, and regulation of transcription. Poly(ADP-ribose) glycohydrolase (PARG), on the other hand, catabolizes pADPr and thereby accounts for the transient nature of poly(ADP-ribosyl)ation. Our investigation of the interactomes of PARP-1, PARP-2, and PARG by affinity-purification mass spectrometry (AP-MS) aimed, on the one hand, to confirm current knowledge on these interactomes and, on the other hand, to discover new protein partners which could offer insights into PARPs and PARG functions.ResultsPARP-1, PARP-2, and PARG were immunoprecipitated from human cells, and pulled-down proteins were separated by gel electrophoresis prior to in-gel trypsin digestion. Peptides were identified by tandem mass spectrometry. Our AP-MS experiments resulted in the identifications of 179 interactions, 139 of which are novel interactions. Gene Ontology analysis of the identified protein interactors points to five biological processes in which PARP-1, PARP-2 and PARG may be involved: RNA metabolism for PARP-1, PARP-2 and PARG; DNA repair and apoptosis for PARP-1 and PARP-2; and glycolysis and cell cycle for PARP-1.ConclusionsThis study reveals several novel protein partners for PARP-1, PARP-2 and PARG. It provides a global view of the interactomes of these proteins as well as a roadmap to establish the systems biology of poly(ADP-ribose) metabolism.

• Publication year

  2010

• Venue

  Proteome Science

• Publication date

  2010-04-13

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1186/1477-5956-8-22PMID 20388209PMCID 2861645
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2009influential reference
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  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2007cited by this paper
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  2007cited by this paper
• Analysis and validation of proteomic data generated by tandem mass spectrometry

  2007cited by this paper
• The Gene Ontology project in 2008

  2007cited by this paper
• Analysis of protein complexes using mass spectrometry

  2007influential reference
• Role of glycolysis inhibition and poly(ADP‐ribose) polymerase activation in necrotic‐like cell death caused by ascorbate/menadione‐induced oxidative stress in K562 human chronic myelogenous leukemic cells

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  2007cited by this paper
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  2006cited by this paper
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  2006cited by this paper
• Proteome survey reveals modularity of the yeast cell machinery

  2006cited by this paper
• The Cajal body: a meeting place for spliceosomal snRNPs in the nuclear maze

  2006cited by this paper
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  2006cited by this paper
• Human mRNA export machinery recruited to the 5' end of mRNA.

  2006cited by this paper
• General framework for developing and evaluating database scoring algorithms using the TANDEM search engine

  2006cited by this paper
• Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death

  2006cited by this paper
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  2006cited by this paper
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  2005cited by this paper
• The Gene Ontology project

  2005cited by this paper
• Poly-ADP-ribosylation in health and disease

  2005cited by this paper
• Regulation of poly(ADP-ribose) metabolism by poly(ADP-ribose) glycohydrolase: where and when?

  2005cited by this paper
• Recruitment of the human TREX complex to mRNA during splicing.

  2005cited by this paper
• Poly(ADP-ribose) glycohydrolase is a component of the FMRP-associated messenger ribonucleoparticles.

  2005cited by this paper
• The role of poly(ADP-ribose) in the DNA damage signaling network.

  2005cited by this paper
• Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair

  2004influential reference
• Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase.

  2004cited by this paper
• Poly(ADP-ribose) is required for spindle assembly and structure

  2004cited by this paper
• A dual approach in the study of poly (ADP-ribose) polymerase: In vitro random mutagenesis and generation of deficient mice

  2004cited by this paper
• Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality.

  2004cited by this paper
• Poly ADP-ribosylation: A DNA break signal mechanism

  2004cited by this paper
• Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1.

  2003cited by this paper
• Functional interaction between PARP‐1 and PARP‐2 in chromosome stability and embryonic development in mouse

  2003cited by this paper
• NAD+ repletion prevents PARP-1-induced glycolytic blockade and cell death in cultured mouse astrocytes.

  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
• Physical and Functional Interaction between DNA Ligase IIIα and Poly(ADP-Ribose) Polymerase 1 in DNA Single-Strand Break Repair

  2003cited by this paper
• XRCC1 and DNA strand break repair.

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  2001cited by this paper
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• Base excision repair is efficient in cells lacking poly(ADP-ribose) polymerase 1.

  2000influential reference
• Base excision repair is impaired in mammalian cells lacking Poly(ADP-ribose) polymerase-1.

  2000influential reference
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  1999cited by this paper
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  1999cited by this paper
• Translational regulation by Y-box transcription factor: involvement of the major mRNA-associated protein, p50.

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  1999cited by this paper
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  1998cited by this paper
• Stimulation of the DNA-dependent Protein Kinase by Poly(ADP-Ribose) Polymerase*

  1998influential reference
• Replication Factor C Interacts with the C-terminal Side of Proliferating Cell Nuclear Antigen*

  1997cited by this paper
• Effect of inhibitors of poly(ADP-ribose) polymerase on the induction of GRP78 and subsequent development of resistance to etoposide.

  1995cited by this paper
• NAD and poly(ADP-ribose) regulation of proteins involved in response to cellular stress and DNA damage.

  1995cited by this paper
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  1993influential reference

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