Disruption of the low affinity receptor-binding site in NGF allows neuronal survival and differentiation by binding to the trk gene product.

No abstract is available for this paper.

• Publication year

  1992

• Venue

  Cell

• Publication date

  1992-04-17

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/0092-8674(92)90413-7PMID 1314703
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.

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  1991cited by this paper
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  1991cited by this paper
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  1991cited by this paper
• Evidence that biological activity of NGF is mediated through a novel subclass of high affinity receptors.

  1991cited by this paper
• The trk proto-oncogene encodes a receptor for nerve growth factor.

  1991influential reference
• Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF

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• Chimeric NGF-EGF receptors define domains responsible for neuronal differentiation.

  1991influential reference
• trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor.

  1991cited by this paper
• High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

  1991cited by this paper
• Structure and expression of the nerve growth factor gene in Xenopus oocytes and embryos

  1991cited by this paper
• New protein fold revealed by a 2.3-Å resolution crystal structure of nerve growth factor

  1991influential reference
• Molecular investigations on the high-affinity nerve growth factor receptor.

  1991cited by this paper
• Biological and Immunological Properties of Recombinant Human, Rat, and Chicken Nerve Growth Factors: A Comparative Study

  1991cited by this paper
• Two conserved domains in the NGF propeptide are necessary and sufficient for the biosynthesis of correctly processed and biologically active NGF.

  1991cited by this paper
• The low-affinity p75 nerve growth factor (NGF) receptor mediates NGF-induced tyrosine phosphorylation.

  1991cited by this paper
• The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3.

  1991cited by this paper
• Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary.

  1991cited by this paper
• Localization in human interleukin 2 of the binding site to the alpha chain (p55) of the interleukin 2 receptor.

  1991cited by this paper
• Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family

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  1990cited by this paper
• Binding of brain-derived neurotrophic factor to the nerve growth factor receptor.

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  1990cited by this paper
• Structure‐function studies of nerve growth factor: functional importance of highly conserved amino acid residues.

  1990cited by this paper
• Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain.

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  1990cited by this paper
• Primary structure and biological activity of a novel human neurotrophic factor.

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  1989cited by this paper
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  1989cited by this paper
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  1988cited by this paper
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  1987cited by this paper
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  1987cited by this paper
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  1986cited by this paper
• Nerve growth factor rapidly induces c-fos mRNA in PC12 rat pheochromocytoma cells.

  1986cited by this paper
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  1986cited by this paper
• Molecular cloning of bovine and chick nerve growth factor (NGF): delineation of conserved and unconserved domains and their relationship to the biological activity and antigenicity of NGF.

  1986cited by this paper
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  1986cited by this paper
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  1986cited by this paper
• Molecular characteristics of nerve growth factor receptors on PC12 cells.

  1985cited by this paper
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  1985cited by this paper
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  1983cited by this paper
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  1983cited by this paper
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  1983cited by this paper
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  1983cited by this paper
• Human β-nerve growth factor gene sequence highly homologous to that of mouse

  1983cited by this paper
• Purification of a new neurotrophic factor from mammalian brain.

  1982cited by this paper
• Physiology of nerve growth factor.

  1980cited by this paper
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  1979cited by this paper
• Properties of the nerve growth factor receptor of a clonal line of rat pheochromocytoma (PC12) cells.

  1979cited by this paper
• DNA sequencing with chain-terminating inhibitors.

  1977cited by this paper
• Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

  1976cited by this paper
• Nerve growth factor.

  1975cited by this paper
• Properties of the beta nerve growth factor receptor of avian dorsal root ganglia.

  1973cited by this paper
• Binding of nerve growth factor receptor in sympathetic ganglia.

  1973cited by this paper
• Amino acid sequences of mouse 2.5S nerve growth factor. II. Isolation and characterization of the thermolytic and peptic peptides and the complete covalent structure.

  1973cited by this paper
• Properties of the β Nerve Growth Factor Receptor of Avian Dorsal Root Ganglia

  1973cited by this paper
• Nerve growth factor from mouse submaxillary gland: amino acid sequence.

  1971cited by this paper
• Nerve growth factor.

  1968cited by this paper

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  2015cites this paper
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  2014cites this paper
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