Inhibition of hyperpolarization-activated current by ZD7288 suppresses ectopic discharges of injured dorsal root ganglion neurons in a rat model of neuropathic pain.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Brain Research

• Publication date

  2005-01-25

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/J.BRAINRES.2004.10.033PMID 15680942
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Ectopic discharges from injured nerve fibers are highly correlated with tactile allodynia only in early, but not late, stage in rats with spinal nerve ligation.

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• Ivabradine, a hyperpolarization-activated channel blocker, attenuates mechanical, but not heat, hypersensitivity in hyperglycemic and normoglycemic rat models of diabetic neuropathy.

  2025cites this paper
• Spinal Nerve Axotomy: Effects on Ih In Vivo and HCNs in DRG Neurons

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• Probucol is anti-hyperalgesic in a mouse peripheral nerve injury model of neuropathic pain

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• Activation of HCN channels caused by elevated cAMP levels in periaqueductal gray promotes bone cancer pain.

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• Characterization of drug binding within the HCN1 channel pore

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• Upregulation of Cav3.2 T-type calcium channels in adjacent intact L4 dorsal root ganglion neurons in neuropathic pain rats with L5 spinal nerve ligation.

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• Dexmedetomidine relieves neuropathic pain by inhibiting hyperpolarization-activated cyclic nucleotide-gated currents in dorsal root ganglia neurons

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• Hyperpolarization-activated cyclic nucleotide–gated channels contribute to spontaneous activity in L4 C-fiber nociceptors, but not A&bgr;-non-nociceptors, after axotomy of L5-spinal nerve in the rat in vivo

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• Running title : HCN channels and spontaneous activity in uninjured C-nociceptors

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• Ectopic Spontaneous Afferent Activity and Neuropathic Pain.

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• HCN Channels: New Therapeutic Targets for Pain Treatment

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• Inhibition of Hyperpolarization-Activated Cation Current in Medium-Sized DRG Neurons Contributed to the Antiallodynic Effect of Methylcobalamin in the Rat of a Chronic Compression of the DRG

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