Use‐dependent block of Ih in mouse dorsal root ganglion neurons by sinus node inhibitors

No abstract is available for this paper.

• Publication year

  1998

• Venue

  British Journal of Pharmacology

• Publication date

  1998-10-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/sj.bjp.0702153PMID 9831910PMCID PMC1571028
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Transcription profiling of HCN-channel isotypes throughout mouse cardiac development

  2009cited by this paper
• Passive and active membrane properties of isolated rat intracardiac neurons: regulation by H- and M-currents.

  1997cited by this paper
• Defective "pacemaker" current (Ih) in a zebrafish mutant with a slow heart rate.

  1997cited by this paper
• Effect of cAMP and ATP on the hyperpolarization-activated current in mouse dorsal root ganglion neurons

  1997cited by this paper
• Postnatal Development of Membrane Properties and δ Oscillations in Thalamocortical Neurons of the Cat Dorsal Lateral Geniculate Nucleus

  1997influential reference
• Hyperpolarization-activated currents in the growth cone and soma of neonatal rat dorsal root ganglion neurons in culture.

  1997cited by this paper
• The hyperpolarization‐activated current (Ih) and its contribution to pacemaker activity in rat CA1 hippocampal stratum oriens‐alveus interneurones.

  1996cited by this paper
• Queer current and pacemaker: the hyperpolarization-activated cation current in neurons.

  1996influential reference
• Class III antiarrhythmic effects of zatebradine. Time-, state-, use-, and voltage-dependent block of hKv1.5 channels.

  1996cited by this paper
• Mode of action of bradycardic agent, S 16257, on ionic currents of rabbit sinoatrial node cells

  1996cited by this paper
• Addition of zatebradine, a direct sinus node inhibitor, provides no greater exercise tolerance benefit in patients with angina taking extended-release nifedipine: results of a multicenter, randomized, double-blind, placebo-controlled, parallel-group study. The Zatebradine Study Group.

  1995cited by this paper
• Cesium, Na(+)-K(+) Pump and Pacemaker Potential in Cardiac Purkinje Fibers.

  1995cited by this paper
• Intracellular QX-314 blocks the hyperpolarization-activated inward current Iq in hippocampal CA1 pyramidal cells.

  1995cited by this paper
• Hyperpolarization-activated currents, IH and IKIR, in rat dorsal motor nucleus of the vagus neurons in vitro.

  1994cited by this paper
• Selective blockade of the hyperpolarization-activated cationic current (Ih) in guinea pig substantia nigra pars compacta neurones by a novel bradycardic agent, Zeneca ZM 227189.

  1994cited by this paper
• Specific bradycardic agents block the hyperpolarization-activated cation current in central neurons.

  1994influential reference
• Variation in IH, IIR, and ILEAK between acutely isolated adult rat dorsal root ganglion neurons of different size.

  1994cited by this paper
• Use‐Dependent Block of the Pacemaker Current If in Rabbit Sinoatrial Node Cells by Zatebradine (UL‐FS 49) On the Mode of Action of Sinus Node Inhibitors

  1993cited by this paper
• Pacemaker mechanisms in cardiac tissue.

  1993cited by this paper
• Hyperpolarization‐activated currents in isolated superior colliculus‐projecting neurons from rat visual cortex.

  1993cited by this paper
• Inhibitory actions of ZENECA ZD7288 on whole‐cell hyperpolarization activated inward current (If) in guinea‐pig dissociated sinoatrial node cells

  1993cited by this paper
• Ionic selectivity of Ih channels of rod photoreceptors in tiger salamanders

  1992cited by this paper
• Simulation of the currents involved in rhythmic oscillations in thalamic relay neurons.

  1992cited by this paper
• A model of the electrophysiological properties of thalamocortical relay neurons.

  1992cited by this paper
• Blockade of the pacemaker current by intracellular application of UL-FS 49 and UL-AH 99 in sheep cardiac Purkinje fibers.

  1992cited by this paper
• Correction for liquid junction potentials in patch clamp experiments.

  1992influential reference
• Hyperpolarization-activated inward current in histaminergic tuberomammillary neurons of the rat hypothalamus.

  1991cited by this paper
• Efficacy and duration of action of three doses of Zatebradine (ULFS 49 CL) in patients with chronic angina pectoris compared to placebo

  1991cited by this paper
• Block of the cardiac pacemaker current (If) in the rabbit sino-atrial node and in canine Purkinje fibres by 9-amino-1,2,3,4-tetrahydroacridine

  1991cited by this paper
• The contribution of the ‘pacemaker’ current (if) to generation of spontaneous activity in rabbit sino‐atrial node myocytes.

  1991cited by this paper
• On the mechanism of the “specific bradycardic action” of the verapamil derivative UL-FS 49

  1990cited by this paper
• Volatile anaesthetics inhibit a cyclic AMP‐dependent sodium‐potassium current in cultured sensory neurones of bullfrog

  1990cited by this paper
• Noradrenergic and serotonergic modulation of a hyperpolarization‐activated cation current in thalamic relay neurones.

  1990cited by this paper
• Use- and frequency-dependent blockade by UL-FS 49 of the if pacemaker current in sheep cardiac Purkinje fibres.

  1990cited by this paper
• Specific bradycardic agents--a novel pharmacological class?

  1987cited by this paper
• Alinidine modifies the pacemaker current in sheep Purkinje fibers

  1987cited by this paper
• Theoretical characterization of ion channel blockade: ligand binding to periodically accessible receptors.

  1986cited by this paper
• The cardiac hyperpolarizing-activated current, if. Origins and developments.

  1985cited by this paper
• Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels.

  1977cited by this paper
• Mouse spinal cord in cell culture. I. Morphology and intrinsic neuronal electrophysiologic properties.

  1977cited by this paper
• Mouse spinal cord in cell culture. III. Neuronal chemosensitivity and its relationship to synaptic activity.

  1977cited by this paper
• Cardiac Purkinje fibers: Cesium as a tool to block inward rectifying potassium currents

  1976cited by this paper
• The ionic channels in excitable membranes.

  1975cited by this paper
• Intracellular sodium activity and the sodium pump in snail neurones

  1972cited by this paper
• Potential Changes produced by Application of Current Steps in Motoneurones

  1961cited by this paper

• Cyclic nucleotide-regulated channels (CNG) in GtoPdb v.2025.4

  2025cites this paper
• Cyclic nucleotide-regulated channels (CNG) in GtoPdb v.2023.1

  2023cites this paper
• Running title : HCN channels and spontaneous activity in uninjured C-nociceptors

  2018cites this paper
• Hyperpolarization-activated cyclic nucleotide–gated channels contribute to spontaneous activity in L4 C-fiber nociceptors, but not A&bgr;-non-nociceptors, after axotomy of L5-spinal nerve in the rat in vivo

  2018cites this paper
• Nitric oxide/cGMP signaling via guanylyl cyclase isoform 1 modulates glutamate and GABA release in somatosensory cortex of mice.

  2017cites this paper
• The Hyperpolarization-Activated Cyclic Nucleotide–Gated Channels: from Biophysics to Pharmacology of a Unique Family of Ion Channels

  2017influential citation
• HCN2 Channels: A Permanent Open State and Conductance Changes

  2014cites this paper
• Postsynaptic NO/cGMP increases NMDA receptor currents via hyperpolarization-activated cyclic nucleotide-gated channels in the hippocampus.

  2014cites this paper
• Pharmacology of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels

  2011cites this paper
• Presynaptic nitric oxide/cGMP facilitates glutamate release via hyperpolarization‐activated cyclic nucleotide‐gated channels in the hippocampus

  2011cites this paper
• HCN channels as targets for drug discovery.

  2009cites this paper
• HCN pacemaker channels and pain: a drug discovery perspective.

  2009cites this paper
• Non-selective cation channel blockers: potential use in nervous system basic research and therapeutics.

  2008cites this paper
• Novel pharmacological activity of loperamide and CP-339,818 on human HCN channels characterized with an automated electrophysiology assay.

  2008cites this paper
• [Selective I(f) channel inhibition: an alternative for treating coronary artery disease?].

  2006cites this paper
• Selektive If-Kanal-Hemmung: eine Alternative in der Behandlung der koronaren Herzkrankheit?

  2006cites this paper
• Bradycardic and Proarrhythmic Properties of Sinus Node Inhibitors

  2006cites this paper
• Design, synthesis and preliminary biological evaluation of zatebradine analogues as potential blockers of the hyperpolarization-activated current.

  2005cites this paper
• Inhibition of hyperpolarization-activated current by ZD7288 suppresses ectopic discharges of injured dorsal root ganglion neurons in a rat model of neuropathic pain.

  2005cites this paper
• International Union of Pharmacology. LI. Nomenclature and Structure-Function Relationships of Cyclic Nucleotide-Regulated Channels

  2005cites this paper
• Characterization of the human HCN1 channel and its inhibition by capsazepine

  2004influential citation
• Pacemaker channels and sinus node arrhythmia.

  2004cites this paper
• International Union of Pharmacology. XLII. Compendium of Voltage-Gated Ion Channels: Cyclic Nucleotide-Modulated Channels

  2003cites this paper
• The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart

  2003cites this paper
• Local anaesthetics block hyperpolarization‐activated inward current in rat small dorsal root ganglion neurones

  2003influential citation
• Use-dependent blockade of cardiac pacemaker current (If) by cilobradine and zatebradine.

  2003cites this paper
• Temporal synaptic tagging by I(h) activation and actin: involvement in long-term facilitation and cAMP-induced synaptic enhancement.

  2002cites this paper
• Assessing the role of Ih channels in synaptic transmission and mossy fiber LTP

  2002cites this paper
• Multiple inhibitory effects of zatebradine (UL-FS 49) on the electrophysiological properties of retinal rod photoreceptors

  2002influential citation
• H-channels in epilepsy: new targets for seizure control?

  2002cites this paper
• Blocker State Dependence and Trapping in Hyperpolarization-Activated Cation Channels

  2001cites this paper
• Modulation of the hyperpolarisation-activated current, Ih, in rat facial motoneurones in vitro by ZD-7288.

  2001cites this paper
• International Union of Pharmacology. XLII. Compendium of Voltage-Gated Ion Channels: Cyclic Nucleotide-Modulated Channels

  year unknowncites this paper
• International Union of Pharmacology. XLII. Compendium of Voltage-Gated Ion Channels: Cyclic Nucleotide-Modulated Channels

  year unknowncites this paper