The cAMP signaling system regulates LHbeta gene expression: roles of early growth response protein-1, SP1 and steroidogenic factor-1.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Journal of Molecular Endocrinology

• Publication date

  2004-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1677/JME.0.0320291PMID 14766009
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecules and Cells

  2013cited by this paper
• Early growth response gene-1 regulates the expression of the rat luteinizing hormone receptor gene

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• Involvement of Both Gq/11 and Gs Proteins in Gonadotropin-releasing Hormone Receptor-mediated Signaling in LβT2 Cells*

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• Evidence that PACAP and GnRH down-regulate follicle-stimulating hormone-beta mRNA levels by stimulating follistatin gene expression: effects on folliculostellate cells, gonadotrophs and LbetaT2 gonadotroph cells.

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• Activation of cAMP-Dependent Protein Kinase Increases the Protein Level of Steroidogenic Factor-1.

  2002cited by this paper
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  2002cited by this paper
• Different signaling pathways control acute induction versus long-term repression of LHbeta transcription by GnRH.

  2002cited by this paper
• Activation of cAMP-dependent protein kinase increases the protein level of steroidogenic factor-1.

  2002cited by this paper
• Involvement of both G(q/11) and G(s) proteins in gonadotropin-releasing hormone receptor-mediated signaling in L beta T2 cells.

  2002cited by this paper
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  2002cited by this paper
• GnRH regulates early growth response protein 1 transcription through multiple promoter elements.

  2002cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2000cited by this paper
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  2000cited by this paper
• NF-Y and Sp1 Cooperate for the Transcriptional Activation and cAMP Response of Human Tissue Inhibitor of Metalloproteinases-2*

  2000cited by this paper
• Sp1, steroidogenic factor 1 (SF-1), and early growth response protein 1 (egr-1) binding sites form a tripartite gonadotropin-releasing hormone response element in the rat luteinizing hormone-beta gene promoter: an integral role for SF-1.

  2000influential reference
• Activation of Serum Response Factor in the Depolarization Induction of Egr-1 Transcription in Pancreatic Islet β-Cells*

  2000cited by this paper
• Ptx1 regulates SF‐1 activity by an interaction that mimics the role of the ligand‐binding domain

  1999cited by this paper
• Early growth response protein 1 binds to the luteinizing hormone-beta promoter and mediates gonadotropin-releasing hormone-stimulated gene expression.

  1999cited by this paper
• Egr-1 Is a Downstream Effector of GnRH and Synergizes by Direct Interaction with Ptx1 and SF-1 To Enhance Luteinizing Hormone β Gene Transcription

  1999cited by this paper
• The equine luteinizing hormone beta-subunit promoter contains two functional steroidogenic factor-1 response elements.

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• Gonadotropin-Releasing Hormone Receptor Concentration Differentially Regulates Intracellular Signaling Pathways in GGH3 Cells

  1999cited by this paper
• Activation of luteinizing hormone beta gene by gonadotropin-releasing hormone requires the synergy of early growth response-1 and steroidogenic factor-1.

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• Interactions of ovarian steroids with pituitary adenylate cyclase-activating polypeptide and GnRH in anterior pituitary cells.

  1999cited by this paper
• The protein kinase C system acts through the early growth response protein 1 to increase LHbeta gene expression in synergy with steroidogenic factor-1.

  1999influential reference
• Molecular mechanism for cooperation between Sp1 and steroidogenic factor-1 (SF-1) to regulate bovine CYP11A gene expression.

  1999cited by this paper
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  1998influential reference
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  1998influential reference
• Mutations in the Activation Function-2 Core Domain of Steroidogenic Factor-1 Dominantly Suppresses PKA-dependent Transactivation of the Bovine CYP17 Gene*

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• Differential use of signal transduction pathways in the gonadotropin-releasing hormone-mediated regulation of gonadotropin subunit gene expression.

  1998influential reference
• Mechanism of Action of Pituitary Adenylate Cyclase-Activating Polypeptide on Human Glycoprotein Hormone α-Subunit Transcription inα T3-1 Gonadotropes.

  1998cited by this paper
• Sp1 binds to the rat luteinizing hormone beta (LHbeta) gene promoter and mediates gonadotropin-releasing hormone-stimulated expression of the LHbeta subunit gene.

  1998cited by this paper
• Transcriptional regulation of the glycoprotein hormone α-subunit gene by pituitary adenylate cyclase-activating polypeptide (PACAP) in αT3-1 cells1This work was presented in part at the 10th International Congress of Endocrinology, 1996.1

  1998cited by this paper
• Steroidogenic Factor-1 and Early Growth Response Protein 1 Act through Two Composite DNA Binding Sites to Regulate Luteinizing Hormone β-Subunit Gene Expression*

  1998influential reference
• Identification of cis-acting deoxyribonucleic acid elements that mediate gonadotropin-releasing hormone stimulation of the rat luteinizing hormone beta-subunit gene.

  1998cited by this paper
• Multiple splice variants of the pituitary adenylate cyclase-activating polypeptide type 1 receptor detected by RT-PCR in single rat pituitary cells.

  1998cited by this paper
• cAMP and protein kinase C elevate LH beta mRNA levels by activating transcription rather than stabilizing mRNA in rat pituitary cells.

  1997cited by this paper
• The activation function-2 hexamer of steroidogenic factor-1 is required, but not sufficient for potentiation by SRC-1.

  1997cited by this paper
• Evidence That Pituitary Adenylate Cyclase Activating Polypeptide Suppresses Follicle-Stimulating Hormone-β Messenger Ribonucleic Acid Levels by Stimulating Follistatin Gene Transcription.

  1997cited by this paper
• The bicoid-related homeoprotein Ptx1 defines the most anterior domain of the embryo and differentiates posterior from anterior lateral mesoderm.

  1997cited by this paper
• Functional interactions, phosphorylation, and levels of 3',5'-cyclic adenosine monophosphate-regulatory element binding protein and steroidogenic factor-1 mediate hormone-regulated and constitutive expression of aromatase in gonadal cells.

  1997cited by this paper
• Gonadotropin-releasing hormone and pituitary adenylate cyclase-activating polypeptide affect levels of cyclic adenosine 3',5'-monophosphate-dependent protein kinase A (PKA) subunits in the clonal gonadotrope alphaT3-1 cells: evidence for cross-talk between PKA and protein kinase C pathways.

  1997cited by this paper
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• A putative binding site for Sp1 is involved in transcriptional regulation of CYP17 gene expression in bovine ovary.

  1997cited by this paper
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• Gonadotropin-Releasing Hormone and Pituitary Adenylate Cyclase-Activating Polypeptide Affect Levels of Cyclic Adenosine 3',5'-Monophosphate-Dependent Protein Kinase A (PKA) Subunits in the Clonal Gonadotrope αT3-1 Cells: Evidence for Cross-Talk between PKA and Protein Kinase C Pathways.

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• Two Sp1-binding Sites Mediate cAMP-induced Transcription of the Bovine CYP11A Gene through the Protein Kinase A Signaling Pathway (*)

  1995cited by this paper
• Effects of pituitary adenylate cyclase-activating polypeptide on gonadotropin secretion and subunit messenger ribonucleic acids in perifused rat pituitary cells.

  1994cited by this paper
• Functional and morphological characterization of four cell lines derived from GH3 cells stably transfected with gonadotropin-releasing hormone receptor complementary deoxyribonucleic acid.

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• Effects of pituitary adenylate cyclase-activating polypeptide in the pituitary: activation of two signal transduction pathways in the gonadotrope-derived alpha T3-1 cell line.

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  1992cited by this paper
• Expression of luteinising hormone-β subunit chloramphenicol acetyltransferase (LH-β-CAT) fusion gene in rat pituitary cells: Induction by cyclic 3′-adenosine monophosphate (cAMP)

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  1991cited by this paper
• DNA sequences required for expression of the LH beta promoter in primary cultures of rat pituitary cells.

  1990cited by this paper
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• The gene encoding the beta-subunit of rat luteinizing hormone. Analysis of gene structure and evolution of nucleotide sequence.

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