Treatment of Colon and Lung Cancer Patients with ex Vivo Heat Shock Protein 70-Peptide-Activated, Autologous Natural Killer Cells

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Clinical Cancer Research

• Publication date

  2004-06-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1158/1078-0432.CCR-03-0683PMID 15173076
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Biology of Natural Killer Cells

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  2000cited by this paper
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  2000cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
• Association of DAP12 with activating CD94/NKG2C NK cell receptors.

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  1998cited by this paper
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  1998cited by this paper
• Structure and function of the CD94 C‐type lectin receptor complex involved in recognition of HLA class I molecules

  1997cited by this paper
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  1997cited by this paper
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  1996cited by this paper
• CD3- large granular lymphocytes recognize a heat-inducible immunogenic determinant associated with the 72-kD heat shock protein on human sarcoma cells.

  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1988cited by this paper
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  1986cited by this paper
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