Characterization of the biochemical mechanism of action of alpha-(N)-heterocyclic carboxaldehyde thiosemicarbazones.

No abstract is available for this paper.

• Publication year

  1976

• Venue

  Advances in Enzyme Regulation

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/0065-2571(77)90012-7PMID 1030181
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Development of α-(N)-Heterocyclic Carboxaldehyde Thiosemicarbazones with Clinical Potential as Antineoplastic Agents

  1976cited by this paper
• Potential antitumor agents. 13. 4-Methyl-5-amino-1-formylisoquinoline thiosemicarbazone.

  1976cited by this paper
• Strand-scission of Sarcoma 180 tumor cell DNA induced by 1-formylisoquinoline thiosemicarbazone.

  1975cited by this paper
• Potential antitumor agents. 12. 2-Formyl-4-aminophenylpyridine thiosemicarbazones.

  1975cited by this paper
• Potential antitumor agents. 10. Synthesis and biochemical properties of 5-N-alkylamino-,N,N-dialkylamino-, and N-alkylacetamido-1-formylisoquinoline thiosemicarbazones.

  1974cited by this paper
• Alpha-(N)-heterocyclic carboxaldehyde thiosemicarbazone inhibitors of ribonucleoside diphosphate reductase.

  1974cited by this paper
• Picoline-2-aldehyde thiosemicarbazone

  1974cited by this paper
• Picoline-2-aldehyde thiosemicarbazone: The acid dissociation constants and reactions with various metals.

  1974cited by this paper
• Clinical trial of 5-hydroxypicolinaldehyde thiosemicarbazone (5-HP; NSC-107392), with special reference to its iron-chelating properties.

  1974cited by this paper
• Potential antitumor agents. 9. 2-Formyl(m-amino)phenylpyridine thiosemicarbazones.

  1974cited by this paper
• NUCLEOSIDE TRIPHOSPHATE-NUCLEOSIDE DIPHOSPHATE TRANSPHOSPHORYLASE (NUCLEOSIDE DIPHOSPHOKINASE). I. ISOLATION OF THE CRYSTALLINE ENZYME FROM BREWERS' YEAST.

  1973cited by this paper
• Induction of alkali labile links in cellular DNA by camptothecin.

  1973cited by this paper
• Biochemical studies of the effects of 1-formylisoquinoline thiosemicarbazone (IQ-1) in Escherichia coli B.

  1972cited by this paper
• Studies of the antineoplastic activity and metabolism of -(N)-heterocyclic carboxaldehyde thiosemicarbazones in dogs and mice.

  1972cited by this paper
• The effect of cyclic adenosine 3',5'-phosphate on tumor immunity.

  1972cited by this paper
• Clinical and pharmacological studies with 5-hydroxy-2-formylpyridine thiosemicarbazone.

  1972cited by this paper
• Chromatid Breakage: Differential Effect of Inhibitors of DNA Synthesis during G2 Phase

  1972cited by this paper
• Localization in Escherichia coli B of two enzymatic sites of action by 1-formylisoquinoline thiosemicarbazone (IQ-1) on ribonucleic acid biosynthetic pathways.

  1972cited by this paper
• Metabolic effects of some tumor-inhibitory pyridine carboxaldehyde thiosemicarbazones.

  1971cited by this paper
• Mechanism of inhibition of ribonucleoside diphosphate reductase by a-(N)-heterocyclic aldehyde thiosemicarbazones.

  1971cited by this paper
• Intracellular degradation of HeLa and adenovirus type 2 DNA induced by camptothecin.

  1971cited by this paper
• Heterocyclic Thiosemicarbazones: Correlation Between Structure, Inhibition of Ribonucleotide Reductase, and Inhibition of DNA Viruses 1

  1970cited by this paper
• Inhibition of ribonucleoside diphosphate reductase by 1-formylisoquinoline thiosemicarbazone and related compounds.

  1970cited by this paper
• Ribonucleotide reductase and cell proliferation. I. Variations of ribonucleotide reductase activity with tumor growth rate in a series of rat hepatomas.

  1970cited by this paper
• Potential antitumor agents. II. Effects of modifications in the side chain of 1-formylisoquinoline thiosemicarbazone.

  1969cited by this paper
• The effects of ferrous ion and dithioerythritol on inhibition by hydroxyruea of ribonucleotide reductase.

  1969cited by this paper
• Some approaches to the therapeutic exploitation of metabolic sites of vulnerability of neoplastic cells.

  1969cited by this paper
• Potential antitumor agents. I. A series of 5-substituted 1-formylisoquinoline thiosemicarbazones.

  1968cited by this paper
• Effect of chelating agents upon the synthesis of nucleic acids and protein: inhibition of DNA synthesis by 1-formylisoquinoline thiosemicarbazone.

  1967cited by this paper
• [21] Mammalian ribonucleoside diphosphate reductases

  1967cited by this paper
• [24b] Biosynthetic preparation of 32P-labeled nucleoside 5′-phosphates and derivatives☆

  1967cited by this paper
• A one-step method for the isolation of nuclei from Krebs-2 tumor cells

  1967cited by this paper
• Enzymatic Synthesis of Deoxyribonucleotides

  1967cited by this paper
• The carcinostatic activity of thiosemicarbazones of formyl heteroaromatic compounds. 3. Primary correlation.

  1966cited by this paper
• The Carcinostatic Activity of α-(N)-Heterocyclic Carboxaldehyde Thiosemicarbazones

  1965cited by this paper
• The carcinostatic activity of alpha-(N) heterocyclic carboxaldehyde thiosemicarbazones. I. Isoquinoline-1-carboxaldehyde thiosemicarbazone.

  1965cited by this paper
• DEVELOPMENT, MAINTENANCE AND ASSAY OF DRUG RESISTANCE.

  1964cited by this paper
• DEVELOPMENT, MAINTENANCE AND ASSAY OF DRUG RESISTANCE.

  1964cited by this paper
• The kinetics of enzyme-catalyzed reactions with two or more substrates or products. III. Prediction of initial velocity and inhibition patterns by inspection.

  1963cited by this paper
• Computer Programmes for Processing Enzyme Kinetic Data

  1963cited by this paper
• Reduction of cytidine nucleotides to deoxycytidine nucleotides by mammalian enzymes.

  1962cited by this paper
• Studies on fluorinated pyrimidines. IV. Effects on nucleic acid metabolism in vivo.

  1958cited by this paper
• Studies on fluorinated pyrimidines. II. Effects on transplanted tumors.

  1958cited by this paper
• Chromatographic Separations of Cytosine Containing Compounds.

  1958cited by this paper
• [99] Determination of nucleic acids in tissues by pentose analysis

  1957cited by this paper
• Observations on the antileukemic activity of pyridine-2-carboxaldehyde thiosemicarbazone and thiocarbohydrazone.

  1956cited by this paper
• A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.

  1956cited by this paper
• Intracellular distribution of radioactivity in nucleic acid nucleotides and proteins following simultaneous administration of P32 and glycine-2-C14.

  1953cited by this paper
• Microdetermination of purines and pyrimidines in biological materials.

  1951cited by this paper

• Computational Studies of Thiosemicarbazone-Based Metal Complexes and Their Biological Applications

  2026cites this paper
• Ribonucleotide reductase (RNR) inhibitors as target-based weapon for future cancer drug development.

  2025cites this paper
• Thiosemicarbazonecopper/Halido Systems: Structure and DFT Analysis of the Magnetic Coupling

  2023cites this paper
• Desulfurization of thiosemicarbazones: the role of metal ions and biological implications

  2023cites this paper
• Chitosan functionalized thiophene-2-thiosemicarbazones, and their copper(II) complexes: synthesis, characterization, and anticancer activity

  2022cites this paper
• Structural characterization of benzketozone monohydrate

  2022cites this paper
• In silico screening identifies a novel small molecule inhibitor that counteracts PARP inhibitor resistance in ovarian cancer

  2021cites this paper
• Iron(III) complexes based on tetradentate thiosemicarbazones: Synthesis, characterization, radical scavenging activity and in vitro cytotoxicity on K562, P3HR1 and JURKAT cells

  2021cites this paper
• The Role of Metal Coordination in the Antineoplastic Effects of Schiff‐Base‐Derived Compounds

  2021cites this paper
• Thiosemicarbazones as a Potent Anticancer Agents and Their Modes of Action.

  2020cites this paper
• THIOSEMICARBAZONE COMPLEXES AS VERSATILE MEDICINAL CHEMISTRY AGENTS: A REVIEW

  2019cites this paper
• Characterization of Palladium Chelates and Their Interactions with Z-N'-(Benzo(d)Thiazol-2-yl)-N,N-Dimethylformimidamide using the Spectrophotometric and Computational Methods

  2019cites this paper
• Potent ribonucleotide reductase inhibitors: Thiazole‐containing thiosemicarbazone derivatives

  2019cites this paper
• Copper-Binding Small Molecule Induces Oxidative Stress and Cell-Cycle Arrest in Glioblastoma-Patient-Derived Cells.

  2018cites this paper
• Synthesis, characterization and antimicrobial activities of Co(III) and Ni(II) complexes with 5-methyl-3-formylpyrazole-N(4)-dihexylthiosemicarbazone (HMPzNHex2): X-ray crystallography and DFT calculations of [Co(MPzNHex2)2]ClO4·1.5H2O (I) and [Ni(HMPzNHex2)2]Cl2·2H2O (II)

  2018cites this paper
• Structural and Metal Ion Effects on Human Topoisomerase IIα Inhibition by α-(N)-Heterocyclic Thiosemicarbazones.

  2018cites this paper
• Targeting Cyclin-Dependent Kinases for Treatment of Gynecologic Cancers

  2018cites this paper
• Synthesis, structural and antimicrobial studies of binary and ternary complexes of a new tridentate thiosemicarbazone.

  2018cites this paper
• Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics.

  2016cites this paper
• Triapine potentiates platinum-based combination therapy by disruption of homologous recombination repair

  2016cites this paper
• New trends in platinum and palladium complexes as antineoplastic agents

  2016cites this paper
• The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the "Triad of Death" in cancer by Di-2-pyridylketone thiosemicarbazones.

  2015cites this paper
• Distinct mechanisms of cell-kill by triapine and its terminally dimethylated derivative Dp44mT due to a loss or gain of activity of their copper(II) complexes.

  2014cites this paper
• Design of Schiff Base‐derived Ligands: Applications in Therapeutics and Medical Diagnosis

  2014cites this paper
• Triapine Disrupts CtIP-Mediated Homologous Recombination Repair and Sensitizes Ovarian Cancer Cells to PARP and Topoisomerase Inhibitors

  2014cites this paper
• Synthesis, Characterization and Antimicrobial Activity of Metal Complexes of Schiff's Base Derived from S- benzyldithiocarbazate with 2-hydroxyacetophenone

  2013cites this paper
• Palladium(II) and platinum(II) bis(thiosemicarbazone) complexes of the 2,6-diacetylpyridine series with high cytotoxic activity in cisplatin resistant A2780cisR tumor cells and reduced toxicity.

  2013cites this paper
• Synthesis, characterization, optical band gap, in vitro antimicrobial activity and DNA cleavage studies of some metal complexes of pyridyl thiosemicarbazone

  2013cites this paper
• Synthesis, Physicochemical Properties, and in vitro Antibacterial Screening of Palladium(II) Complexes Derived from Thiosemicarbazone

  2013cites this paper
• Novel Chelators for Cancer Treatment: Where Are We Now?

  2013cites this paper
• Unprecedented Pt(II) complex of an asymmetric 2,6-diacetylpyridine bis(4N-substituted thiosemicarbazone) ligand

  2013cites this paper
• Synthesis, spectroscopic, and thermal properties of some azomethine complexes of Cu(II), Ni(II), and Pt(II)

  2012cites this paper
• Co(II), Cu(II), Cd(II), Fe(III) and U(VI) complexes containing a NSNO donor ligand: Synthesis, characterization, optical band gap, in vitro antimicrobial and DNA cleavage studies

  2012cites this paper
• Ab initio and semiempirical computational studies on 1-{(2E)-2-[(aminocarbonothioyl)hydrazono]-2-(3-mesityl-3-methylcyclobutyl)ethyl}-pyrrolidine-2,5-dione

  2012cites this paper
• Triple hydrogen bonding in a circular arrangement: ab initio, DFT and first-principles MD studies of tris-hydroxyaryl enamines

  2012cites this paper
• Ribonucleotide reductase inhibition by metal complexes of Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone): a combined experimental and theoretical study.

  2011cites this paper
• A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo.

  2011cites this paper
• The medicinal chemistry of novel iron chelators for the treatment of cancer.

  2011cites this paper
• Modeling and proposed mechanism of two radical scavengers through docking to curtail the action of ribonucleotide reductase

  2011cites this paper
• Synthesis, Crystal Structures and Fluorescence Properties of Ni (II) and Cu (II) Complexes with 1-(Furan-2-ylmethylene)-4-phenylthiosemicarbazone

  2010cites this paper
• Thiosemicarbazone Metal Complexes: From Structure to Activity

  2010cites this paper
• The conformational analysis of 2-hydroxyaryl Schiff thiosemicarbazones

  2010cites this paper
• Synthesis, spectroscopic characterization and X-ray structures of five-coordinate diorganotin(IV) complexes containing 5-hydroxypyrazoline derivatives as ligands

  2010cites this paper
• Thiosemicarbazones: the new wave in cancer treatment.

  2009cites this paper
• Synthesis, structural characterization, and biological evaluation of oxorhenium(V) complexes with a novel type of thiosemicarbazones derived from N-[N',N'-dialkylamino(thiocarbonyl)]benzimidoyl chlorides.

  2009cites this paper
• Synthesis and spectroscopic characterization of new iron(III) complexes of S-Alkyl/Aryl dithiocarbazates of 5-methyl-3-formylpyrazole and 5-methyl-3-formylpyrazolyl-thiosemicarbazones

  2009cites this paper
• Thiosemicarbazones from the old to new: iron chelators that are more than just ribonucleotide reductase inhibitors.

  2009cites this paper
• Iron(III) complex of 2-acetylpyrazine thiosemicarbazone: synthesis, spectral characterization, structural studies and antitumoral activity

  2009cites this paper
• Variable Coordination Modes of Benzaldehyde Thiosemicarbazones – Synthesis, Structure, and Electrochemical Properties of Some Ruthenium Complexes

  2008cites this paper
• Structural and spectral studies of a new copper(II) complex with a tridentate thiosemicarbazone ligand

  2008cites this paper
• Metal complexes with the ligand derived from 6-acetyl-1,3,7-trimethyllumazine and benzohydrazide. Molecular structures of two new Co(II) and Rh(III) complexes and analysis of in vitro antitumor activity.

  2008cites this paper
• Syntheses, characterization and X-ray crystal structures of Co(III) and Mn(II) complexes of pyrimidine derived Schiff base ligands

  2008cites this paper
• Pt4S4 Clusters with Functionalized Thiosemicarbazones derived from 5-Acetylbarbituric Acid†

  2007cites this paper
• Structural Features of ONS-Donor Salicylidene Schiff Base Complexes

  2007cites this paper
• Synthesis, structure and spectroscopic properties of some thiosemicarbazone complexes of platinum

  2007cites this paper
• Metal complexes of pyrimidine derived ligands – Syntheses, characterization and X-ray crystal structures of Ni(II), Co(III) and Fe(III) complexes of Schiff base ligands derived from S -methyl/ S -benzyl dithiocarbazate and 2- S -methylmercapto-6-methylpyrimidine-4-carbaldehyde

  2007cites this paper
• Correlation between quadrupole splitting (Δ) and the θ angle (C–Sn–C) in five-coordinate diphenyltin(IV) complexes. X-ray crystal structures of [Ph2Sn(hacm)] and [Ph2Sn(hacmm)] containing O,N,S-tridentate N4-heterocyclic thiosemicarbazones

  2007cites this paper
• Copper(II) complexes of N(4)-substituted thiosemicarbazones derived from pyridine-2-carbaldehyde: Crystal structure of a binuclear complex

  2007cites this paper
• Synergistic interaction between a mixed ligand copper (II) chelate complex and two anticancer agents in T47D human breast cancer cells in vitro.

  2006cites this paper
• Crystal structure and conformation study of N‐methyl‐t‐3‐methyl‐r‐2, c‐6‐diphenylpiperidin‐4‐one thiosemicarbazone

  2006cites this paper
• Synergistic interaction between a mixed ligand copper ( II ) chelate complex and two anticancer agents in T 47 D human breast cancer cells in vitro

  2006cites this paper
• Salicylaldehyde 4,4'-(hexane-1,6-diyl)thiosemicarbazone.

  2006cites this paper
• Chemotherapy Ribonucleotide Reductase as an Approach to Combination Specific Inhibitors Directed at the Individual Components of Updated

  2006cites this paper
• Synergistic interaction between a novel mixed ligand copper ( II ) chelate complex and a panel of anticancer agents in T 47 D human breast cancer cells in vitro

  2005cites this paper
• Synergistic interaction between a novel mixed ligand copper(II) chelate complex and a panel of anticancer agents in T47D human breast cancer cells in vitro.

  2005cites this paper
• Antifungal and antitumor activity of heterocyclic thiosemicarbazones and their metal complexes: current status

  2005cites this paper
• Iron chelators in cancer chemotherapy.

  2004cites this paper
• Structural and spectral studies of nickel(II) complexes of di-2-pyridyl ketone N4,N4-(butane-1,4-diyl) thiosemicarbazone

  2004cites this paper
• Structural, spectral and antimicrobial studies of copper(II) complexes of 2-benzoylpyridine N(4)-cyclohexyl thiosemicarbazone

  2004cites this paper
• Stable gold(III) complexes with thiosemicarbazone derivatives.

  2004cites this paper
• The role of iron chelation in cancer therapy.

  2003cites this paper
• The wide pharmacological versatility of semicarbazones, thiosemicarba-zones and their metal complexes.

  2003cites this paper
• Examination of the antiproliferative activity of iron chelators: multiple cellular targets and the different mechanism of action of triapine compared with desferrioxamine and the potent pyridoxal isonicotinoyl hydrazone analogue 311.

  2003cites this paper
• Unprecedented chemical transformation of semicarbazones mediated by Wilkinson's catalyst.

  2003cites this paper
• Identification of the di‐pyridyl ketone isonicotinoyl hydrazone (PKIH) analogues as potent iron chelators and anti‐tumour agents

  2003cites this paper
• Synthesis and structural studies of novel Co(III) ternary complexes containing N(4)-substituted thiosemicarbazones of 2-hydroxyacetophenone and heterocyclic bases

  2002cites this paper
• Synthesis and structural characterisation of new iron(III) complexes with biologically relevant pyrazolyl thiosemicarbazones

  2002cites this paper
• Synthesis, structure and redox properties of some thiosemicarbazone complexes of rhodium

  2002cites this paper
• Preparation, spectral characterization, in vitro antitumor and thermal studies of new platinum(IV) and palladium(II) thiohydrazone complexes

  2002cites this paper
• Novel "hybrid" iron chelators derived from aroylhydrazones and thiosemicarbazones demonstrate selective antiproliferative activity against tumor cells.

  2002cites this paper
• Platinum(II) and palladium(II) complexes with 2-acetylpyridine thiosemicarbazone: cytogenetic and antineoplastic effects

  2001cites this paper
• Gold complexes with thiosemicarbazones: reactions of bi- and tridentate thiosemicarbazones with dichloro[2-(dimethylaminomethyl)phenyl-C1,N]gold(III), [Au(damp-C1,N)Cl2]

  2000cites this paper
• Synthesis, crystal structure, spectral properties and cytotoxic activity of platinum(II) complexes of 2-acetyl pyridine and pyridine-2-carbaldehyde N(4)-ethyl-thiosemicarbazones.

  2000cites this paper
• Triapine (3-aminopyridine-2-carboxaldehyde- thiosemicarbazone): A potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity.

  2000cites this paper
• Palladium(II) and platinum(II) complexes of pyridine-2-carbaldehyde thiosemicarbazone with potential biological activity. Synthesis, structure and spectral properties. Extended network via hydrogen bond linkages of [Pd(PyTsc)Cl]

  1999cites this paper
• Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity.

  1999cites this paper
• Structural characterization of a novel tetranuclear palladium(II) complex containing the Pd4S4 core, with the N,N,S-tridentate 6-amino-5-formyl-1,3-dimethyluracil-thiosemicarbazonate ligand

  1999cites this paper
• Synthesis and characterization of indium(III) complexes with tri- and pentadentate thiosemicarbazones. Crystal and molecular structure of [InCl2(HDAPTSC)] · 2 DMSO, {O[In(HDAPTSC)(OH)]2} · 5MeOH, [InCl2(APTSC)(MeOH)], [In(APTSC)2]PF6 and (H2APTSC)][InCl(APTSC)(mnt)] · 0.5 H2O (H2DAPTSC = 2,6-diacety

  1998cites this paper
• Epr, cyclic voltammetric and biological activities of copper(II) complexes of salicylaldehyde N(4)-substituted thiosemicarbazone and heterocyclic bases

  1998cites this paper
• Synthesis, structural and biochemical aspects of titanocene and zirconocene chelates of acetylferrocenyl thiosemicarbazones

  1998cites this paper
• Palladium(II) complexes of 2-acetylpyridine N(4)-propyl, N(4)-dipropyl- and 3-hexamethyleneiminylthiosemicarbazones with potentially interesting biological activity. Synthesis, spectral properties, antifungal and in vitro antitumor activity

  1997cites this paper
• Palladium(II) complexes of 2-acetylpyridine N(4)-methyl, N(4)-ethyl and N(4)-phenyl-thiosemicarbazones. Crystal structure of chloro(2-acetylpyridine N(4)-methylthiosemicarbazonato) palladium(II). Synthesis, spectral studies, in vitro and in vivo antitumour activity.

  1997cites this paper
• Overexpression of the multidrug resistance genes mdr1, mdr3, and mrp in L1210 leukemia cells resistant to inhibitors of ribonucleotide reductase.

  1997cites this paper
• Iron(III), Cobalt(II), Nickel(II), Copper(II) and Zinc(II) Complexes of 4-Formylantipyrine Thiosemicarbazone

  1997cites this paper
• Synthesis, Spectroscopy and Structures of Complexes of PD(II) with 4N-Substituted Derivatives of 2-Acetylpyridine Thiosemicarbazone

  1997cites this paper
• Synthesis, structure, and spectroscopic properties of acetato(dimethyl)(pyridine-2-carbaldehydethiosemicarbazonato)tin(IV) acetic acid solvate, [SnMe2(PyTSC)(OAc)].HOAc. Comparison of its biological activity with that of some structurally related diorganotin(IV) bis(thiosemicarbazonates).

  1996cites this paper
• Synthesis and biological activity of 3- and 5-amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone.

  1996cites this paper
• Structure-function relationships for a new series of pyridine-2-carboxaldehyde thiosemicarbazones on ribonucleotide reductase activity and tumor cell growth in culture and in vivo.

  1995cites this paper
• 1 Chemical and Biological Properties of Cytotoxic α-(N)-Heterocyclic Carboxaldehyde Thiosemicarbazones

  1995cites this paper
• Inhibitors of ribonucleotide reductase. Comparative effects of amino- and hydroxy-substituted pyridine-2-carboxaldehyde thiosemicarbazones.

  1994cites this paper