Delta inulin: a novel, immunologically active, stable packing structure comprising β-D-[2 -> 1] poly(fructo-furanosyl) α-D-glucose polymers.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Glycobiology

• Publication date

  2011-05-01

• Fields of study

  Biology, Medicine, Materials Science, Chemistry

• Identifiers
  DOI 10.1093/glycob/cwq201PMID 21147758PMCID PMC3106373
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• An inactivated Vero cell-grown Japanese encephalitis vaccine formulated with Advax, a novel inulin-based adjuvant, induces protective neutralizing antibody against homologous and heterologous flaviviruses

  2010cited by this paper
• The complement fitness factor H: role in human diseases and for immune escape of pathogens, like pneumococci.

  2008cited by this paper
• Discrimination between host and pathogens by the complement system.

  2008cited by this paper
• A new NMR method for directly monitoring and quantifying the dissolution kinetics of starch in DMSO.

  2007cited by this paper
• Potentiation of photodynamic therapy of cancer by complement: the effect of γ-inulin

  2006cited by this paper
• Inulin‐derived adjuvants efficiently promote both Th1 and Th2 immune responses

  2004cited by this paper
• Use of gamma-inulin/liposomes/Vitamin E adjuvant combination in contraceptive vaccines.

  2003cited by this paper
• Use of γ-inulin/liposomes/Vitamin E adjuvant combination in contraceptive vaccines

  2003cited by this paper
• Chemical syntheses of inulin and levan structures.

  2002cited by this paper
• Molecular characteristics of amylose and starch in dimethyl sulfoxide.

  2001cited by this paper
• Adjuvant effect of gamma-inulin is mediated by C3 fragments deposited on antigen-presenting cells.

  2001cited by this paper
• Adjuvant effect of γ‐inulin is mediated by C3 fragments deposited on antigen‐presenting cells

  2001cited by this paper
• Vaccines for Human Papillomavirus Infection and Anogenital Disease

  1999cited by this paper
• Safety and Immunogenicity of HPV16 E7/Algammulin

  1999cited by this paper
• Size and shape of inulin in dimethyl sulphoxide solution

  1999cited by this paper
• Forces contributing to the conformational stability of proteins

  1996cited by this paper
• C3d of Complement as a Molecular Adjuvant: Bridging Innate and Acquired Immunity

  1996cited by this paper
• Molecular and Crystal Structures of Inulin from Electron Diffraction Data

  1996cited by this paper
• Single crystals of inulin.

  1996cited by this paper
• Progress in the elucidation of the composition of chicory inulin

  1994cited by this paper
• Specificity of the thioester-containing reactive site of human C3 and its significance to complement activation.

  1993cited by this paper
• Algammulin (gamma inulin/alum hybrid adjuvant) has greater adjuvanticity than alum for hepatitis B surface antigen in mice.

  1991cited by this paper
• Algammulin, a new vaccine adjuvant comprising gamma inulin particles containing alum: preparation and in vitro properties.

  1991cited by this paper
• Discrimination between activators and nonactivators of the alternative pathway of complement: regulation via a sialic acid/polyanion binding site on factor H.

  1990cited by this paper
• Molecular organization and function of the complement system.

  1988cited by this paper
• Alternative pathway of complement.

  1988cited by this paper
• Antigen-bound C3b and C4b enhance antigen-presenting cell function in activation of human T-cell clones.

  1988cited by this paper
• The adjuvanticity of gamma inulin

  1988cited by this paper
• The anti-melanoma activity of inulin in mice.

  1986cited by this paper
• Anti-complementary action of polymorphic "solubility forms" of particulate inulin.

  1986cited by this paper
• The alternative pathway of complement.

  1984cited by this paper
• Other Plant Polysaccharides

  1983cited by this paper
• Molecular biology and chemistry of the alternative pathway of complement.

  1980cited by this paper
• THE C3-ACTIVATOR SYSTEM: AN ALTERNATE PATHWAY OF COMPLEMENT ACTIVATION

  1971cited by this paper
• The C3-activator system: an alternate pathway of complement activation.

  1971cited by this paper
• A PLASMIN-SPLIT FRAGMENT OF C'3 AS A NEW CHEMOTACTIC FACTOR

  1967cited by this paper
• Methods in Immunology and Immunochemistry

  1967cited by this paper
• THE PHYSICAL PROPERTIES OF INULIN SOLUTIONS.

  1965cited by this paper
• The Polyfructosans and Difructose Anhydrides

  1946cited by this paper

• Delta inulin alone or combined with CpG oligonucleotide enhances antibody‐dependent influenza vaccine protection in mice and nonhuman primate newborns

  2025cites this paper
• Phase 2 randomized controlled trial of seasonal influenza vaccine shows Advax® delta inulin adjuvant accelerates the humoral anti‐influenza response

  2025cites this paper
• Fungal Inulinase: An insight into the unexplored dimension of multiproduct biorefineries

  2025cites this paper
• Inulin-based colon targeted drug delivery systems: advancing site-specific therapeutics

  2025cites this paper
• Efficacy of Immunostimulatory Adjuvants and Nano‐Adjuvants in Current SARS‐CoV‐2 Vaccines: A Comprehensive Review

  2025cites this paper
• Deciphering inulin from Jerusalem artichoke: Extraction, structural characteristics, bioactivities, structure-activity relationship, modifications, pharmacokinetics and applications.

  2025cites this paper
• Techno-Functional Properties and Applications of Inulin in Food Systems

  2025cites this paper
• Progress in the development of an Advax-adjuvanted protein capsular matrix vaccine against typhoid fever

  2024cites this paper
• Vaccine adjuvants for infectious disease in the clinic

  2024cites this paper
• HeberNasvac: Development and Application in the Context of Chronic Hepatitis B

  2024cites this paper
• An Advax-CpG55.2 adjuvanted recombinant hemagglutinin vaccine provides immunity against H7N9 influenza in adult and neonatal mice.

  2023cites this paper
• Recovery of Alkali-Extracted Soluble Fiber from Coconut Pulp by Single-Step and Sequential Ethanol Precipitation and Characterization of the Products

  2023cites this paper
• Adjuvant action of needle-shaped BC microfibrils

  2023cites this paper
• Importance of adjuvant selection in tuberculosis vaccine development: Exploring basic mechanisms and clinical implications

  2023cites this paper
• Optimizing the Immunogenicity of HIV Vaccines by Adjuvants - NIAID Workshop Report.

  2023cites this paper
• Biopolymers and Osmolytes — A Focus towards the Prospects of Stability and Adjuvanticity of Vaccines

  2022cites this paper
• Health benefits of inulin-type fructan on gut microbiome, digestive health, immunity, and nutrition

  2022cites this paper
• Peptide Nanoarray Scaffold Vaccine for SARS-COV-2 and Its Variants of Concerns

  2022cites this paper
• Mucosal immunization with a delta-inulin adjuvanted recombinant spike vaccine elicits lung-resident immune memory and protects mice against SARS-CoV-2

  2022cites this paper
• Plant-derived immuno-adjuvants in vaccines formulation: a promising avenue for improving vaccines efficacy against SARS-CoV-2 virus

  2022cites this paper
• A typhoid fever protein capsular matrix vaccine candidate formulated with Advax-CpG adjuvant induces a robust and durable anti-typhoid Vi polysaccharide antibody response in mice, rabbits and nonhuman primates.

  2022cites this paper
• Role of site-directed mutagenesis and adjuvants in the stability and potency of anthrax protective antigen

  2022cites this paper
• Conversion of inulin-rich raw plant biomass to 2,5-furandicarboxylic acid (FDCA): Progress and challenge towards biorenewable plastics.

  2021cites this paper
• Developments in Vaccine Adjuvants.

  2021cites this paper
• Novel adjuvants enhance immune responses elicited by a replication-defective human cytomegalovirus vaccine in nonhuman primates.

  2021cites this paper
• Inulin-based hydrogel

  2021cites this paper
• Inulin and Its Application in Drug Delivery

  2021cites this paper
• Biomaterials and nanomaterials for sustained release vaccine delivery.

  2021cites this paper
• Intranasal powder live attenuated influenza vaccine is thermostable, immunogenic, and protective against homologous challenge in ferrets

  2021cites this paper
• Natural and synthetic carbohydrate-based vaccine adjuvants and their mechanisms of action

  2021cites this paper
• Inulin as a delivery vehicle for targeting colon-specific cancer.

  2020cites this paper
• Adjuvant selection impacts the correlates of vaccine protection against Ebola infection.

  2020cites this paper
• Impact of Prebiotics on Enteric Diseases and Oxidative Stress.

  2020cites this paper
• Vaccine formulations in clinical development for the prevention of severe acute respiratory syndrome coronavirus 2 infection

  2020cites this paper
• Developing Translational Vaccines against Heroin and Fentanyl through Investigation of Adjuvants and Stability.

  2020cites this paper
• Polymeric Nanoparticle-Based Vaccine Adjuvants and Delivery Vehicles.

  2020cites this paper
• Stereochemical properties of inulins

  2020cites this paper
• Influence of Oxidation Degree on the Physicochemical Properties of Oxidized Inulin

  2020cites this paper
• Combination of inulin and β-cyclodextrin properties for colon delivery of hydrophobic drugs.

  2020cites this paper
• The physiological functions and pharmaceutical applications of inulin: A review.

  2020cites this paper
• Potential adjuvants for the development of a SARS-CoV-2 vaccine based on experimental results from similar coronaviruses

  2020cites this paper
• A GROMOS Force Field for Furanose-Based Carbohydrates.

  2019cites this paper
• Preparation and Characterization of Oxidized Inulin Hydrogel for Controlled Drug Delivery

  2019cites this paper
• Randomized controlled trial demonstrating the benefits of delta inulin adjuvanted immunotherapy in patients with bee venom allergy

  2019cites this paper
• Synthesis and Characterization of pH-Sensitive Inulin Conjugate of Isoniazid for Monocyte-Targeted Delivery

  2019cites this paper
• Neonatal vaccine effectiveness and the role of adjuvants

  2019cites this paper
• Microfluidic formation of core-shell alginate microparticles for protein encapsulation and controlled release.

  2019cites this paper
• Adjuvant Strategies for More Effective Tuberculosis Vaccine Immunity

  2019cites this paper
• Design and Characterization of Inulin Conjugate for Improved Intracellular and Targeted Delivery of Pyrazinoic Acid to Monocytes

  2019cites this paper
• Review of polysaccharide particle-based functional drug delivery.

  2019cites this paper
• Doxorubicin-Loaded Delta Inulin Conjugates for Controlled and Targeted Drug Delivery: Development, Characterization, and In Vitro Evaluation

  2019cites this paper
• Carbohydrate-Based Adjuvants for Vaccine Production

  2018cites this paper
• Advax augments B and T cell responses upon influenza vaccination via the respiratory tract and enables complete protection of mice against lethal influenza virus challenge

  2018cites this paper
• Passive inhalation of dry powder influenza vaccine formulations completely protects chickens against H5N1 lethal viral challenge

  2018cites this paper
• Characterization of inulin from dahlia tubers isolated by microwave and ultrasound-assisted extractions.

  2018cites this paper
• Advax4 delta inulin combination adjuvant together with ECMX, a fusion construct of four protective mTB antigens, induces a potent Th1 immune response and protects mice against Mycobacterium tuberculosis infection

  2017cites this paper
• Delta inulin-based adjuvants promote the generation of polyfunctional CD4+ T cell responses and protection against Mycobacterium tuberculosis infection

  2017cites this paper
• Investigation of the biodistribution, breakdown and excretion of delta inulin adjuvant.

  2017cites this paper
• Immune responses to killed reassorted influenza virus supplemented with natural adjuvants.

  2017cites this paper
• Panblok-H1+advax H1N1/2009pdm vaccine: Insights into rapid development of a delta inulin adjuvanted recombinant pandemic influenza vaccine

  2017cites this paper
• An inulin-type fructan isolated from Artemisia japonica and its anti-arthritic effects

  2017cites this paper
• Advax Adjuvant

  2017cites this paper
• Vaccine Adjuvant Nanotechnologies

  2016cites this paper
• Chemically modified inulin microparticles serving dual function as a protein antigen delivery vehicle and immunostimulatory adjuvant.

  2016cites this paper
• Delta inulin-derived adjuvants that elicit Th1 phenotype following vaccination reduces respiratory syncytial virus lung titers without a reduction in lung immunopathology

  2016cites this paper
• The Immunomodulatory Role of Adjuvants in Vaccines Formulated with the Recombinant Antigens Ov-103 and Ov-RAL-2 against Onchocerca volvulus in Mice

  2016cites this paper
• Natural Vaccine Adjuvants and Immunopotentiators Derived From Plants, Fungi, Marine Organisms, and Insects

  2016cites this paper
• Implications of plant glycans in the development of innovative vaccines

  2016cites this paper
• Advax, a Delta Inulin Microparticle, Potentiates In-built Adjuvant Property of Co-administered Vaccines

  2016cites this paper
• SARS coronavirus infections of the lower respiratory tract and their prevention

  2016cites this paper
• Insights into furanose solution conformations: beyond the two-state model

  2016cites this paper
• Maturation of Mouse Bone Marrow Dendritic Cells Induced by Saposhnikovia Divaricate Polysaccharides (SDPs)

  2016cites this paper
• Preliminary results on innocuity and immunogenicity of an inactivated vaccine against Peste des petits ruminants.

  2016cites this paper
• Human Phase 1 trial of low-dose inactivated seasonal influenza vaccine formulated with Advax™ delta inulin adjuvant

  2016cites this paper
• Physical characterization and in silico modeling of inulin polymer conformation during vaccine adjuvant particle formation.

  2016influential citation
• Microparticles formulated from a family of novel silylated polysaccharides demonstrate inherent immunostimulatory properties and tunable hydrolytic degradability.

  2016cites this paper
• Water effect on the physicochemical properties of oligomeric polysaccharide inulin

  2016cites this paper
• Inulin, a flexible oligosaccharide. II: Review of its pharmaceutical applications.

  2015cites this paper
• Enhanced pulmonary immunization with aerosolized inactivated influenza vaccine containing delta inulin adjuvant.

  2015cites this paper
• Cellulose alters the expression of nuclear factor kappa B-related genes and Toll-like receptor-related genes in human peripheral blood mononuclear cells

  2015cites this paper
• Polysaccharides: Candidates of promising vaccine adjuvants.

  2015cites this paper
• Development of a SARS Coronavirus Vaccine from Recombinant Spike Protein Plus Delta Inulin Adjuvant

  2015cites this paper
• Advax™, a novel microcrystalline polysaccharide particle engineered from delta inulin, provides robust adjuvant potency together with tolerability and safety

  2015cites this paper
• Identification and characterisation of T-cell epitopes for incorporation into dendritic cell-delivered Listeria vaccines

  2015cites this paper
• Advax delta inulin adjuvant overcomes immune immaturity in neonatal mice thereby allowing single–dose influenza vaccine protection

  2015cites this paper
• Comparative Safety of Vaccine Adjuvants: A Summary of Current Evidence and Future Needs

  2015cites this paper
• Differentially expressed proteins in the blood serum of piglets in response to a diet supplemented with inulin.

  2015cites this paper
• Carbohydrate-based vaccine adjuvants – discovery and development

  2015cites this paper
• Inulin, a flexible oligosaccharide I: Review of its physicochemical characteristics.

  2015cites this paper
• Glycans as Vaccine Antigens and Adjuvants: Immunological Considerations.

  2015cites this paper
• Inulin crystal initiation via a glucose-fructose cross-link of adjacent polymer chains: atomic force microscopy and static molecular modelling.

  2015cites this paper
• Immunogenicity and safety of Advax™, a novel polysaccharide adjuvant based on delta inulin, when formulated with hepatitis B surface antigen: a randomized controlled Phase 1 study.

  2014cites this paper
• Inulin isoforms differ by repeated additions of one crystal unit cell.

  2014cites this paper
• Safety and immunogenicity of a delta inulin-adjuvanted inactivated Japanese encephalitis virus vaccine in pregnant mares and foals

  2014cites this paper
• A single immunization with inactivated H1N1 influenza vaccine formulated with delta inulin adjuvant (Advax™) overcomes pregnancy-associated immune suppression and enhances passive neonatal protection.

  2014cites this paper
• Gamma ray sterilization of delta inulin adjuvant particles (Advax™) makes minor, partly reversible structural changes without affecting adjuvant activity.

  2014cites this paper
• Sugar-Based Immune Adjuvants for Use in Recombinant, Viral Vector, DNA and Other Styles of Vaccines

  2014cites this paper
• Structure of a homofructosan from Saussurea costus and anti-complementary activity of its sulfated derivatives.

  2014cites this paper
• Severe Acute Respiratory Syndrome-Associated Coronavirus Vaccines Formulated with Delta Inulin Adjuvants Provide Enhanced Protection while Ameliorating Lung Eosinophilic Immunopathology

  2014cites this paper
• Advax-Adjuvanted Recombinant Protective Antigen Provides Protection against Inhalational Anthrax That Is Further Enhanced by Addition of Murabutide Adjuvant

  2014cites this paper