Overexpression of the sarcoplasmic reticulum Ca(2+)-ATPase improves myocardial contractility in diabetic cardiomyopathy.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Diabetes

• Publication date

  2002-04-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.2337/DIABETES.51.4.1166PMID 11916940
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Improvement in Survival and Cardiac Metabolism After Gene Transfer of Sarcoplasmic Reticulum Ca2+-ATPase in a Rat Model of Heart Failure

  2001cited by this paper
• Stimulus interval-dependent differences in Ca2+ transients and contractile responses of diabetic rat cardiomyocytes.

  2000cited by this paper
• Phospholamban-to-SERCA2 ratio controls the force-frequency relationship.

  1999cited by this paper
• Overexpression of sarcoplasmic reticulum Ca(2+)-ATPase improves cardiac contractile function in hypothyroid mice.

  1999cited by this paper
• Diabetic cardiomyopathy

  1998cited by this paper
• Protection against myocardial dysfunction after a brief ischemic period in transgenic mice expressing inducible heat shock protein 70.

  1998cited by this paper
• Targeted overexpression of the sarcoplasmic reticulum Ca2+-ATPase increases cardiac contractility in transgenic mouse hearts.

  1998cited by this paper
• Adenovirus-mediated gene transfer reconstitutes depressed sarcoplasmic reticulum Ca2+-ATPase levels and shortens prolonged cardiac myocyte Ca2+ transients.

  1997cited by this paper
• Overexpression of the rat sarcoplasmic reticulum Ca2+ ATPase gene in the heart of transgenic mice accelerates calcium transients and cardiac relaxation.

  1997cited by this paper
• Regulation of intracellular Ca2+ in the heart during diabetes.

  1997cited by this paper
• Phorbol myristate acetate-induced hypertrophy of neonatal rat cardiac myocytes is associated with decreased sarcoplasmic reticulum Ca2+ ATPase (SERCA2) gene expression and calcium reuptake.

  1996cited by this paper
• Altered Ca2+ handling in ventricular myocytes isolated from diabetic rats.

  1996cited by this paper
• Accelerated desensitization of nicotinic receptor channels and its dependence on extracellular calcium in isolated skeletal muscles of streptozotocin‐diabetic mice

  1995cited by this paper
• Alterations of sarcoplasmic reticulum proteins in failing human dilated cardiomyopathy.

  1995cited by this paper
• Cardiac sarcoplasmic reticulum Ca(2+)-ATPase expression in streptozotocin-induced diabetic rat heart.

  1994cited by this paper
• Depressed [Ca2+]i responses to isoproterenol and cAMP in isolated cardiomyocytes from experimental diabetic rats.

  1994cited by this paper
• Relaxation in rabbit and rat cardiac cells: species‐dependent differences in cellular mechanisms.

  1994cited by this paper
• Selective changes in cardiac gene expression during compensated hypertrophy and the transition to cardiac decompensation in rats with chronic aortic banding.

  1993cited by this paper
• Diabetes-induced decrease in the mRNA coding for sarcoplasmic reticulum Ca(2+)-ATPase in adult rat cardiomyocytes.

  1991cited by this paper
• Influence of thyroid hormone and retinoic acid on slow sarcoplasmic reticulum Ca2+ ATPase and myosin heavy chain alpha gene expression in cardiac myocytes. Delineation of cis-active DNA elements that confer responsiveness to thyroid hormone but not to retinoic acid.

  1991cited by this paper
• Influence of experimental diabetes on sarcoplasmic reticulum function in rat ventricular muscle.

  1991cited by this paper
• Age-induced decreases in the messenger RNA coding for the sarcoplasmic reticulum Ca2(+)-ATPase of the rat heart.

  1990cited by this paper
• Function of the sarcoplasmic reticulum and expression of its Ca2(+)-ATPase gene in pressure overload-induced cardiac hypertrophy in the rat.

  1990cited by this paper
• Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

  1987cited by this paper
• Calcium uptake by cardiac sarcoplasmic reticulum in human dilated cardiomyopathy.

  1987cited by this paper
• Diabetic cardiomyopathy.

  1985cited by this paper
• Pathogenesis of cardiac dysfunction in diabetes mellitus.

  1985cited by this paper
• Mechanisms of the defect in cardiac myofibrillar function during diabetes.

  1985cited by this paper
• Increased congestive heart failure after myocardial infarction of modest extent in patients with diabetes mellitus.

  1984cited by this paper
• Defective sarcoplasmic reticular calcium transport in diabetic cardiomyopathy.

  1983cited by this paper
• Influence of thyroid hormone administration on myosin ATPase activity and myosin isoenzyme distribution in the heart of diabetic rats.

  1982cited by this paper
• Reversibility of Diabetic Cardiomyopathy with Insulin in Rats

  1981cited by this paper
• Depressed cardiac sarcoplasmic reticular function from diabetic rats.

  1981cited by this paper
• Diabetes Mellitus Induces Changes in Cardiac Myosin of the Rat

  1980cited by this paper
• The Effect of Diabetes on Performance and Metabolism of Rat Hearts

  1980cited by this paper
• Altered Myocardial Mechanics in Diabetic Rats

  1980cited by this paper
• Noninvasive Estimation of Myocardial Performance in Patients with Diabetes: Effect of Alcohol Administration

  1978cited by this paper
• Preclinical abnormality of left ventricular function in diabetes mellitus.

  1975cited by this paper
• Role of diabetes in congestive heart failure: the Framingham study.

  1974cited by this paper
• Longevity of Diabetic Patients in Recent Years

  1964cited by this paper

• Cardiac Energy Metabolism in Diabetes: Emerging Therapeutic Targets and Clinical Implications.

  2025cites this paper
• Resmetirom in the Management of MASLD: What Clinicians Need to Know

  2025cites this paper
• Cardioprotective effects of naringin in a type 2 diabetes rodent model by reducing calcium overload and oxidative stress

  2025cites this paper
• Gene and drug-mediated SERCA2a activation restores cardiac function and metabolic balance in diabetic mice.

  2025cites this paper
• Acid sphingomyelinase promotes diabetic cardiomyopathy via disruption of mitochondrial calcium homeostasis

  2025cites this paper
• l-Arginine: A multifaceted regulator of diabetic cardiomyopathy.

  2025cites this paper
• Tibia length is an appropriate standard for evaluating hypertrophy in streptozotocin-induced diabetic complications

  2025cites this paper
• Empagliflozin in diabetic cardiomyopathy: elucidating mechanisms, therapeutic potentials, and future directions

  2025cites this paper
• Primordial Drivers of Diabetes Heart Disease: Comprehensive Insights into Insulin Resistance

  2024cites this paper
• MG53/TRIM72: multi-organ repair protein and beyond

  2024cites this paper
• ATP-binding cassette family C member 1 constrains metabolic responses to high-fat diet in male mice

  2024cites this paper
• Understanding Diabetic Cardiomyopathy: Insulin Resistance and Beyond.

  2024cites this paper
• Diabetic Cardiomyopathy: An Update on Emerging Pathological Mechanisms

  2024cites this paper
• Activation of the cannabinoid type 2 (CB2) receptor improves cardiac contractile performance in fish, Brycon amazonicus.

  2023cites this paper
• Chinese herbal medicine and active ingredients for diabetic cardiomyopathy: molecular mechanisms regulating endoplasmic reticulum stress

  2023cites this paper
• Cardiac-specific overexpression of insulin-like growth factor II receptor-α interferes with the regulation of calcium homeostasis in the heart under hyperglycemic conditions

  2023cites this paper
• Salvianolic acid A improve mitochondrial respiration and cardiac function via inhibiting apoptosis pathway through CRYAB in diabetic cardiomyopathy.

  2023cites this paper
• Effect of stress on the chronotropic and inotropic responses to β-adrenergic agonists in isolated atria of KOβ2 mice.

  2023cites this paper
• The interplay of inflammation, exosomes and Ca2+ dynamics in diabetic cardiomyopathy

  2023cites this paper
• Ketogenic Diet Regulates Cardiac Remodeling and Calcium Homeostasis in Diabetic Rat Cardiomyopathy

  2023cites this paper
• Diabetes disturbs functional adaptation of the remote myocardium after ischemia/reperfusion.

  2022cites this paper
• Alpha-lipoic acid treatment improves adverse cardiac remodelling in the diabetic heart - The role of cardiac hydrogen sulfide-synthesizing enzymes.

  2022cites this paper
• Lymphatic Collecting Vessel: New Perspectives on Mechanisms of Contractile Regulation and Potential Lymphatic Contractile Pathways to Target in Obesity and Metabolic Diseases

  2022cites this paper
• Metabolic, structural and biochemical changes in diabetes and the development of heart failure

  2022cites this paper
• Fibronectin improves the impaired calcium signaling and myofilament activation in diabetic cardiomyocytes

  2022cites this paper
• Knowledge domain and emerging trends in diabetic cardiomyopathy: A scientometric review based on CiteSpace analysis

  2022cites this paper
• Combination Therapy of Alpha-Lipoic Acid, Gliclazide and Ramipril Protects Against Development of Diabetic Cardiomyopathy via Inhibition of TGF-β/Smad Pathway

  2022cites this paper
• Roflumilast-Mediated Phosphodiesterase 4D Inhibition Reverses Diabetes-Associated Cardiac Dysfunction and Remodeling: Effects Beyond Glucose Lowering.

  2022cites this paper
• The need for adjusting experimental models to meet clinical reality.

  2022cites this paper
• STZ‐diabetic rat heart maintains developed tension amplitude by increasing sarcomere length and crossbridge density

  2021cites this paper
• Diabetes and Heart Failure: Multi-Omics Approaches

  2021cites this paper
• Heart failure in diabetes.

  2021cites this paper
• Systolic Dysfunction of the Heart in Type 1 Diabetes Mellitus

  2021cites this paper
• N-Acetyl Cysteine, Selenium, and Ascorbic Acid Rescue Diabetic Cardiac Hypertrophy via Mitochondrial-Associated Redox Regulators

  2021cites this paper
• Epidemiology, Pathophysiology, Diagnosis and Treatment of Heart Failure in Diabetes

  2021cites this paper
• Concurrent diabetes and heart failure: interplay and novel therapeutic approaches.

  2021cites this paper
• Muscle‐specific sirtuin 3 overexpression does not attenuate the pathological effects of high‐fat/high‐sucrose feeding but does enhance cardiac SERCA2a activity

  2021cites this paper
• The Diabetic Cardiomyopathy: The Contributing Pathophysiological Mechanisms

  2021cites this paper
• Mitochondrial TFAM as a Signaling Regulator between Cellular Organelles: A Perspective on Metabolic Diseases

  2021cites this paper
• Prognostic impact of diabetes in chronic and acute heart failure

  2021cites this paper
• Roles of sarcoplasmic reticulum Ca2+ ATPase pump in the impairments of lymphatic contractile activity in a metabolic syndrome rat model

  2020cites this paper
• Electrocardiological effects of ranolazine and lidocaine on normal and diabetic rat atrium

  2020cites this paper
• Inhibition of brain-type glycogen phosphorylase ameliorates high glucose-induced cardiomyocyte apoptosis via Akt-HIF-1α activation.

  2020cites this paper
• Effect of Stem Cells, Ascorbic Acid and SERCA1a Gene Transfected Stem Cells in Experimentally Induced Type I Diabetic Myopathy

  2020cites this paper
• Loss of function of transcription factor EB remodels lipid metabolism and cell death pathways in the cardiomyocyte.

  2020cites this paper
• Diabetic cardiomyopathy: definition, diagnosis criteria, treatment directions and prevention of heart failure

  2020cites this paper
• Myocardial glucotoxicity: Mechanisms and potential therapeutic targets.

  2020cites this paper
• Mitochondrial Calcium Handling and Heart Disease in Diabetes Mellitus.

  2020cites this paper
• SERCA stimulation: A potential approach in therapeutics

  2020cites this paper
• Early changes in myocyte contractility and cardiac function in streptozotocin-induced type 1 diabetes in rats

  2020cites this paper
• Value of peak strain dispersion in discovering left ventricular dysfunction in diabetes mellitus

  2020cites this paper
• Deneysel Tip 1 Diabetes Mellitusta Aralıklı Hipoksinin Kardiyak Kas Kalsiyum Homeostazına Etkisi

  2019cites this paper
• Heart Failure in Type 2 Diabetes Mellitus.

  2019influential citation
• Dendropanax morbifera Extract Protects Cardiomyocytes against Hypoxia/Reoxygenation Injury by Inhibition of Reactive Oxygen Species Generation and Calcium Perturbation

  2019cites this paper
• Fas/FasL-mediated cell death in rat's diabetic hearts involves activation of calcineurin/NFAT4 and is potentiated by a high-fat diet rich in corn oil.

  2019cites this paper
• Astragaloside IV alleviates myocardial damage induced by type 2 diabetes via improving energy metabolism

  2019cites this paper
• Myocardial Energy Stress, Autophagy Induction, and Cardiomyocyte Functional Responses

  2019cites this paper
• Molecular Mechanisms Responsible for Diastolic Dysfunction in Diabetes Mellitus Patients

  2019cites this paper
• Impact of diabetes on cardiac and vascular disease: Role of calcium signaling.

  2019cites this paper
• Geranylgeraniol prevents statin-induced skeletal muscle fatigue without causing adverse effects in cardiac or vascular smooth muscle performance.

  2019cites this paper
• Diabetic Cardiomyopathy: What Is It and Can It Be Fixed?

  2019cites this paper
• Effect Of Intermittent Hypoxia On Cardiac Muscle Calcium Homeostasis In Experimental Type 1 Diabetes Mellitus

  2019cites this paper
• Empagliflozin Attenuates Myocardial Sodium and Calcium Dysregulation and Reverses Cardiac Remodeling in Streptozotocin-Induced Diabetic Rats

  2019influential citation
• The Effect of Alpha Lipoic Acid and Melatonin on the progression of Streptozotocin-induced diabetic cardiomyopathy in rats

  2018cites this paper
• Of mice and men: models and mechanisms of diabetic cardiomyopathy

  2018cites this paper
• The DWORF micropeptide enhances contractility and prevents heart failure in a mouse model of dilated cardiomyopathy

  2018cites this paper
• Proarrhythmic Remodeling of Calcium Homeostasis in Cardiac Disease; Implications for Diabetes and Obesity

  2018cites this paper
• Novel approaches in the treatment of diabetic cardiomyopathy.

  2018cites this paper
• Thyroid Hormones, Thyromimetics and Their Metabolites in the Treatment of Liver Disease

  2018cites this paper
• Restoring mitochondrial calcium uniporter expression in diabetic mouse heart improves mitochondrial calcium handling and cardiac function

  2018cites this paper
• ВУЗЛОВІ УТВОРЕННЯ ЩИТОПОДІБНОЇ ЗАЛОЗИ. СТАН ПРОБЛЕМИ (ОГЛЯД ЛІТЕРАТУРИ)

  2018cites this paper
• Sex differences in metabolic cardiomyopathy

  2017cites this paper
• Changes in the Cardiac GHSR1a-Ghrelin System Correlate With Myocardial Dysfunction in Diabetic Cardiomyopathy in Mice

  2017cites this paper
• GSK-3 protein and the heart: friend or foe?

  2017cites this paper
• Pathological Effects of Exosomes in Mediating Diabetic Cardiomyopathy.

  2017cites this paper
• Arterial-ventricular coupling in type 1 diabetes: arterial stiffness is associated with impaired global longitudinal strain in type 1 diabetes patients—the Thousand & 1 Study

  2017cites this paper
• Glyoxalase 1 Attenuates the Effects of Chronic Hyperglycemia on Explant-Derived Cardiac Stem Cells

  2017cites this paper
• Argatroban Attenuates Diabetic Cardiomyopathy in Rats by Reducing Fibrosis, Inflammation, Apoptosis, and Protease-Activated Receptor Expression

  2017cites this paper
• Pathophysiological Fundamentals of Diabetic Cardiomyopathy.

  2017cites this paper
• PHARMACOLOGICAL PRECONDITIONING OF ENDOTHELIAL PROGENITOR CELLS FOR THE REPAIR OF DIABETIC CARDIOMYOPATHY

  2016cites this paper
• Expression of the mitochondrial calcium uniporter in cardiac myocytes improves impaired mitochondrial calcium handling and metabolism in simulated hyperglycemia.

  2016cites this paper
• The Effects of Dietary Supplements on Skeletal Muscle Function in Type 2 Diabetic Rats

  2016cites this paper
• Implications physiopathologiques de la Nestine lors du remodelage pulmonaire et cardiaque à la suite de l’infarctus du myocarde, du diabète et de l’hypertension pulmonaire

  2016cites this paper
• Non-ischemic diabetic cardiomyopathy may initially exhibit a transient subclinical phase of hyperdynamic myocardial performance.

  2016cites this paper
• Hyperglycemia-Induced Hypovolemia Is Involved in Early Cardiac Magnetic Resonance Alterations in Streptozotocin-Induced Diabetic Mice: A Comparison with Furosemide-Induced Hypovolemia

  2016cites this paper
• Assessment of left ventricular function in young type 1 diabetes mellitus patients by two-dimensional speckle tracking echocardiography: Relation to duration and control of diabetes

  2016cites this paper
• Association of cardiac injury with iron-increased oxidative and nitrative modifications of the SERCA2a isoform of sarcoplasmic reticulum Ca(2+)-ATPase in diabetic rats.

  2016cites this paper
• SERCA2a upregulation ameliorates cellular alternans induced by metabolic inhibition.

  2016cites this paper
• Levosimendan suppresses oxidative injury, apoptotic signaling and mitochondrial degeneration in streptozotocin-induced diabetic cardiomyopathy

  2016cites this paper
• Thyroid Hormone and Cardioprotection.

  2016cites this paper
• Contribution of redox-dependent activation of endothelial Nlrp3 inflammasomes to hyperglycemia-induced endothelial dysfunction

  2016cites this paper
• Implication des cellules Nestin+ dans le remodelage vasculaire en conditions pathologiques

  2015cites this paper
• Studies of Human Mutations in Phospholamban and Heat Shock Protein 20

  2015influential citation
• Effect of intermittent hypoxia on the cardiac HIF-1/VEGF pathway in experimental type 1 diabetes mellitus

  2015cites this paper
• Myocardial Metabolism in Diabetic Cardiomyopathy: Potential Therapeutic Targets

  2015cites this paper
• Sarcoplasmic reticulum Ca2+ ATPase pump is a major regulator of glucose transport in the healthy and diabetic heart.

  2015cites this paper
• The roles of genetics and glycaemic control in the development of LVH and Heart Failure in Type 2 Diabetes

  2015cites this paper
• Animal Models of Diabetic Cardiomyopathy

  2015cites this paper
• Targeting caveolin-3 for the treatment of diabetic cardiomyopathy.

  2015cites this paper
• Intrinsic nanomechanical changes in live diabetic cardiomyocytes

  2015cites this paper