Resveratrol induces growth inhibition, S-phase arrest, apoptosis, and changes in biomarker expression in several human cancer cell lines.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Clinical Cancer Research

• Publication date

  2002-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 11895924
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• [Oncogene].

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  2001influential reference
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  2001influential reference
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  2001influential reference
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  2001influential reference
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