Glutathione and hypotaurine in vitro: effects on human sperm motility, DNA integrity and production of reactive oxygen species.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Mutagenesis

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1093/MUTAGE/15.1.61PMID 10640532
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Taurine and Hypotaurine

  2000cited by this paper
• The effect of ascorbate and alpha-tocopherol supplementation in vitro on DNA integrity and hydrogen peroxide-induced DNA damage in human spermatozoa.

  1999cited by this paper
• Antioxidant supplementation in vitro does not improve human sperm motility.

  1999influential reference
• In vitro fertilization and pregnancy rates: the influence of sperm motility and morphology on IVF outcome.

  1998cited by this paper
• Reactive oxygen species: potential cause for DNA fragmentation in human spermatozoa.

  1998influential reference
• The effects of antioxidant supplementation during Percoll preparation on human sperm DNA integrity.

  1998cited by this paper
• Comparison of individual antioxidants of sperm and seminal plasma in fertile and infertile men.

  1997cited by this paper
• Reproducibility of human sperm DNA measurements using the alkaline single cell gel electrophoresis assay.

  1997cited by this paper
• Enhancement of motility by treating spermatozoa with an antioxidant solution (Sperm-Fit) following ejaculation.

  1997cited by this paper
• WHO LABORATORY MANUAL FOR THE EXAMINATION OF HUMAN SEMEN AND SPERM‐CERVICAL MUCUS INTERACTION

  1996cited by this paper
• Protective effect of antioxidants on the impairment of sperm motility by activated polymorphonuclear leukocytes.

  1996influential reference
• A comparison of baseline and induced DNA damage in human spermatozoa from fertile and infertile men, using a modified comet assay.

  1996cited by this paper
• Glutathione as a treatment for male infertility.

  1996cited by this paper
• Hypotaurine and taurine in gamete and embryo environments: de novo synthesis via the cysteine sulfinic acid pathway in oviduct cells

  1995cited by this paper
• Effects of antioxidants on human sperm preparation techniques.

  1994cited by this paper
• Cloning and phenotypic characterization of a gene enhancing resistance against oxidative stress in saccharomyces cerevisiae

  1993cited by this paper
• Placebo-controlled, double-blind, cross-over trial of glutathione therapy in male infertility.

  1993cited by this paper
• Transport of glutathione diethyl ester into human cells.

  1993cited by this paper
• Detection of aneuploid human sperm by fluorescence in situ hybridization: evidence for a donor difference in frequency of sperm disomic for chromosomes 1 and Y.

  1993cited by this paper
• Hypotaurine requirement for in vitro development of golden hamster one-cell embryos into morulae and blastocysts, and production of term offspring from in vitro-fertilized ova.

  1992cited by this paper
• Effect of aging on glutathione metabolism. Protection by antioxidants.

  1992cited by this paper
• Development of a technique for monitoring the contamination of human semen samples with leukocytes.

  1992influential reference
• The taurine and hypotaurine content of human semen.

  1992cited by this paper
• On the antioxidant effects of ascorbic acid and glutathione.

  1992cited by this paper
• Physiological actions of taurine.

  1992cited by this paper
• Formation of reactive oxygen species in spermatozoa of infertile patients.

  1992cited by this paper
• Immunochemical detection of DNA damage induction and repair at different cellular stages of spermatogenesis of the hamster after in vitro or in vivo exposure to ionizing radiation.

  1991cited by this paper
• Glutathione-dependent defence mechanisms in isolated round spermatids from the rat.

  1990cited by this paper
• Addition of hypotaurine can reactivate immotile golden hamster spermatozoa.

  1990cited by this paper
• Glutathione metabolism in cultured Sertoli cells and spermatogenic cells from hamsters.

  1989cited by this paper
• Purine bases, nucleosides, and nucleotides: aqueous solution redox chemistry and transformation reactions of their radical cations and e- and OH adducts

  1989cited by this paper
• Generation of reactive oxygen species, lipid peroxidation, and human sperm function.

  1989cited by this paper
• CRC Handbook of free radicals and antioxidants in biomedicine

  1989cited by this paper
• The antioxidant action of taurine, hypotaurine and their metabolic precursors.

  1988influential reference
• Glutathione, L‐glutamic acid and γ‐glutamyl transpeptidase in the bull reproductive tissues

  1988cited by this paper
• DNA damage and oxygen radical toxicity.

  1988cited by this paper
• Glutathione, L-glutamic acid and gamma-glutamyl transpeptidase in the bull reproductive tissues.

  1987cited by this paper
• Cellular basis of defective sperm function and its association with the genesis of reactive oxygen species by human spermatozoa.

  1987cited by this paper
• Iron-mediated induction of sister-chromatid exchanges by hydrogen peroxide and superoxide anion.

  1987cited by this paper
• Free amino acids in human uterine fluid. Possible role of high taurine concentration.

  1987cited by this paper
• Free radicals in biology and medicine

  1985cited by this paper
• Chemical changes induced in DNA by ionizing radiation.

  1985cited by this paper
• Enzymatic excision of DNA bases damaged by exposure to ionizing radiation or oxidizing agents.

  1985cited by this paper
• Estimation of glutathione in purified populations of mouse testis germ cells.

  1985cited by this paper
• Mutagenicity of quinones: pathways of metabolic activation and detoxification.

  1984cited by this paper
• Taurine, hypotaurine, epinephrine and albumin inhibit lipid peroxidation in rabbit spermatozoa and protect against loss of motility.

  1983cited by this paper
• Effect of compounds structurally related to taurine and of taurine uptake inhibitors on the motility of hamster sperm in vitro

  1983cited by this paper
• Superoxide radical: an endogenous toxicant.

  1983cited by this paper
• CHAPTER 5 – Peroxidative Reactions in Red Cell Biology

  1982cited by this paper
• 5,6-Saturated thymine lesions in DNA: production by ultraviolet light or hydrogen peroxide.

  1982cited by this paper
• The effects of taurine and hypotaurine on in vitro fertilization in the golden hamster

  1981cited by this paper
• TAURINE AND HYPOTAURINE: THEIR EFFECTS ON MOTILITY, CAPACITATION AND THE ACROSOME REACTION OF HAMSTER SPERM IN VITRO AND THEIR PRESENCE IN SPERM AND REPRODUCTIVE TRACT FLUIDS OF SEVERAL MAMMALS *

  1980cited by this paper
• Taurine maintains and stimulates motility of hamster sperm during capacitation in vitro.

  1979cited by this paper
• Free Radicals in Biology

  1976cited by this paper
• Hypotaurine: Regulation of Production in Seminal Vesicles and Prostate of Guinea-pig by Testosterone

  1973cited by this paper
• Methods in mammalian embryology

  1971cited by this paper
• The culture of mouse embryos in vitro.

  1971cited by this paper
• Occurrence of Hypotaurine and Inositol in the Reproductive Tract of the Ewe and its Regulation by Pregnenolone and Progesterone

  1969cited by this paper
• The occurrence of hypotaurine and other sulfur-containing amino acids in seminal plasma and spermatozoa of boar, bull and dog.

  1966cited by this paper

• Comparing Extracellular and Intracellular Antioxidants in Human Sperm Rapid Freezing: Hypotaurine Versus Melatonin

  2025cites this paper
• The Oxidative Stress of Human Sperm Cryopreservation

  2025cites this paper
• Associations between seminal plasma metal mixture and semen quality: A metabolome-mediated case-control study.

  2025cites this paper
• Impact of Particle Size of Nanoliposomes on the Biological Response of Frozen-Thawed Sperm in Holstein Bulls.

  2025cites this paper
• Optimizing Gamete Cryopreservation in Saanen Bucks: The Contribution of Vitamin D

  2025cites this paper
• Selection of functional sperm by using hyaluronic acid modified magnetic microbeads and an electromagnetic manipulation system.

  2024cites this paper
• The impact of mitochondrial impairments on sperm function and male fertility: a systematic review

  2024cites this paper
• The effects of supplementation of vitamin D to the egg‐yolk extender on cryopreservation of ram semen

  2024cites this paper
• Exogenous GSH Supplementation to Raw Semen Alters Sperm Kinematic Parameters in Infertile Patients

  2023influential citation
• Human Sperm as an In Vitro Model to Assess the Efficacy of Antioxidant Supplements during Sperm Handling: A Narrative Review

  2023cites this paper
• The Addition of Opuntia ficus-indica Ethanolic Extract to a Skimmed Milk-Based Extender Impacts Ram Sperm Quality

  2023cites this paper
• OXIDATIVE STRESS IN RAM SEMEN AND ANTIOXIDANT TREATMENT

  2023cites this paper
• Use of cryoprotectors and antioxidants in sturgeon semen cryopreservation.

  2023cites this paper
• Molecular Markers: A New Paradigm in the Prediction of Sperm Freezability

  2023cites this paper
• Supplementation of freezing medium with encapsulated or free glutathione during cryopreservation of bull sperm.

  2022cites this paper
• Advances in storage of poultry semen.

  2022cites this paper
• Tingkat Maturasi Oosit Sapi Bali pada Media TCM 199 dengan Penambahan Hipotaurin

  2022influential citation
• The Effect of L-Carnitine Added Extenders on Spermatological Parameters of Goat Sperma Post-Thawing

  2022cites this paper
• Effects of Inositol Supplementation in Sperm Extender on the Quality of Cryopreserved Mesopotamian Catfish (Silurus triostegus, H. 1843) Sperm

  2021cites this paper
• Antioxidant or Apoptosis Inhibitor Supplementation in Culture Media Improves Post-Thaw Recovery of Murine Spermatogonial Stem Cells

  2021cites this paper
• Eurasian Journal of Veterinary Sciences

  2021cites this paper
• Protective effect of natural antioxidant Opuntia �cus-indica on ram semen quality stored at 5 °C for 72

  2021cites this paper
• Arı Spermasının Dondurma-Çözdürme Sonrası Spermatolojik Parametreleri Üzerine Metiyonin ve Sisteaminin Etkileri

  2021cites this paper
• Supplementation of Avian Semen Extenders with Antioxidants to Improve Semen Quality—Is It an Effective Strategy?

  2021cites this paper
• Beneficial effects of hypotaurine supplementation in preparation and freezing media on human sperm cryo-capacitation and DNA quality

  2021cites this paper
• In Vitro Studies of Antioxidants for Male Reproductive Health

  2020cites this paper
• Pistachio Antioxidants Can Decrease Negative Effects of Free Radicals on Male Reproductive System: An Assessment and Review

  2020cites this paper
• Sperm DNA fragmentation testing: Summary evidence and clinical practice recommendations

  2020cites this paper
• ProAKAP4 as Novel Molecular Marker of Sperm Quality in Ram: An Integrative Study in Fresh, Cooled and Cryopreserved Sperm

  2020cites this paper
• Characterization of the nonheme iron center of cysteamine dioxygenase and its interaction with substrates

  2020cites this paper
• Metabolomic fingerprinting of bull spermatozoa for identification of fertility signature metabolites

  2020cites this paper
• Adverse effects of in vitro manipulation of spermatozoa.

  2020cites this paper
• 'Semen dilution effect' on sperm variables and conception rate in buffalo.

  2020cites this paper
• Effect of olive-derived antioxidants (3,4-dihydroxyphenylethanol and 3,4 dihydroxyphenylglycol) on sperm motility and fertility in liquid ram sperm stored at 15ºC or 5ºC.

  2020cites this paper
• Antioxidants in Sperm Cryopreservation

  2020cites this paper
• Effect of antioxidants on BPA-induced stress on sperm function in a mouse model

  2019cites this paper
• The anti-oxidant roles of Taurine and Hypotaurine on acrosome integrity, HBA and HSPA2 of the human sperm during vitrification and post warming in two different temperature.

  2019cites this paper
• The Effect of Intramuscular Administration of Glutathione as Antioxidant on Semen analysis parameters of Infertile Patients Affected with Oligoasthenozoospermia

  2019cites this paper
• Cofactor Biogenesis in Cysteamine Dioxygenase: C-F Bond Cleavage with Genetically Incorporated Unnatural Tyrosine.

  2018cites this paper
• Role of oxidative stress in pathology of chronic prostatitis/chronic pelvic pain syndrome and male infertility and antioxidants function in ameliorating oxidative stress.

  2018cites this paper
• Antioxidants modulation of sperm genome and epigenome damage: Fact or fad? Converging evidence from animal and human studies

  2018cites this paper
• Strategies to Diminish DNA Damage in Sperm Samples Used for ART

  2018cites this paper
• Effect of reduced glutathione (GSH) supplementation to Tris-egg yolk extender on chilled semen variables of dogs.

  2018cites this paper
• Unraveling the sperm transcriptome by next generation sequencing and the global epigenetic landscape in infertile men

  2018cites this paper
• SUPPLEMENTATION OF EXTENDER WITH REDUCED GLUTATHIONE ( GSH ) PRESERVES RABBIT SPERM QUALITY AFTER CRYOPRESERVATION

  2017cites this paper
• The Effect of L-Carnitine, Hypotaurine, and Taurine Supplementation on the Quality of Cryopreserved Chicken Semen

  2017cites this paper
• Yeast Cells as Antioxidant-Producing Probiotics : Can they emulate Vitamin E on in-vitro protection of human spermatozoa against oxidative stress ?

  2017cites this paper
• Therapeutic Role of Antioxidants (AOX) in the Treatment of Infertility

  2017cites this paper
• Recent Technical Breakthroughs for ARTs in Mice

  2017cites this paper
• Improvement of in vitro fertilization in buffalo by increasing the fertilizing capacity of spermatozoa.

  2017cites this paper
• Maternal antioxidant provisioning mitigates pollutant-induced oxidative damage in embryos of the temperate sea urchin Evechinus chloroticus

  2017cites this paper
• Effects of biological active substances to the spermatozoa quality.

  2016influential citation
• Sperm pHertility : male gamete responses to ocean acidification and other stressors

  2016cites this paper
• Effects of glutathione on sperm quality during liquid storage in boars.

  2016cites this paper
• Sperm pretreatment with glutathione improves IVF embryos development through increasing the viability and antioxidative capacity of sex-sorted and unsorted bull semen

  2016cites this paper
• Phytopreventive effect of Salvia officinalis L. on infertiliy induced by hypothyroidism in male albino rats

  2015cites this paper
• Influence of fetuin and hyaluronan on the post-thaw quality and fertilizing ability of Holstein bull semen.

  2015cites this paper
• Perfil oxidativo e funcional de sêmen bovino criopreservado em diferentes estações do ano

  2015cites this paper
• Environmental pollution due to cadmium: measure of semen quality as a marker of exposure and correlation with reproductive potential.

  2015cites this paper
• In vivo effects of UV radiation on multiple endpoints and expression profiles of DNA repair and heat shock protein (Hsp) genes in the cycloid copepod Paracyclopina nana.

  2015cites this paper
• The influence of cryoprotectants on sturgeon (Acipenser ruthenus) sperm quality, DNA integrity, antioxidant responses, and resistance to oxidative stress.

  2015cites this paper
• Protective effect of hypotaurine against oxidative stress-induced cytotoxicity in rat placental trophoblasts.

  2015cites this paper
• Sperm fucosyltransferase-5 mediates spermatozoa-oviductal epithelial cell interaction to protect human spermatozoa from oxidative damage.

  2015cites this paper
• Pollutant resilience in embryos of the Antarctic sea urchin Sterechinus neumayeri reflects maternal antioxidant status.

  2015cites this paper
• Laboratory Procedures for Human In Vitro Fertilization

  2014cites this paper
• ATP‐binding cassette transporters protect sea urchin gametes and embryonic cells against the harmful effects of ultraviolet light

  2014cites this paper
• Ocean acidification increases copper toxicity to the early life history stages of the polychaete Arenicola marina in artificial seawater.

  2014cites this paper
• Influence of various antioxidants added to TCM-199 on post-thaw bovine sperm parameters, DNA integrity and fertilizing ability.

  2014cites this paper
• Refrigerated storage of ram sperm in presence of Trolox and GSH antioxidants: effect of temperature, extender and storage time.

  2014cites this paper
• L-carnitine Supplemented Extender Improves Cryopreserved-thawed Cat Epididymal Sperm Motility

  2014cites this paper
• Evaluation of the impact of leucocytospermia on semen oxidative status by chemiluminescence technique in infertile men

  2013cites this paper
• Novel technologies for selecting the best sperm for in vitro fertilization and intracytoplasmic sperm injection.

  2013cites this paper
• Density gradient centrifugation prior to cryopreservation and hypotaurine supplementation improve post-thaw quality of sperm from infertile men with oligoasthenoteratozoospermia.

  2013cites this paper
• Vitamin C in Disease Prevention and Cure: An Overview

  2013cites this paper
• Effect of two sulfur-containing amino acids, taurine and hypotaurine in European sea bass (Dicentrarchus labrax) sperm cryopreservation.

  2013cites this paper
• Effects of combined antioxidant supplementation on human sperm motility and morphology during sperm manipulation in vitro.

  2013cites this paper
• What should it take to describe a substance or product as 'sperm-safe'.

  2013cites this paper
• The role of oxidative stress in male infertility: A review

  2013cites this paper
• Objective Biomarkers of Sperm Development and Fertility: Assessment of Sperm-Zona Pellucida Binding Ability and Hyaluronic Acid-Mediated Selection of Sperm for ICSI Fertilization

  2013cites this paper
• Preconception nutrition and the microenvironment of the human oocyte: Proteomic and epidemiologic studies on IVF/ICSI treatment outcomes

  2013cites this paper
• Genotoxicity and effects on fertility, reproduction, development as well as histology in zebrafish (Danio rerio) in a multi-generation study – is there a relationship?

  2013cites this paper
• Reproductive and genotoxic effects in zebrafish after chronic exposure to methyl methanesulfonate in a multigeneration study

  2013cites this paper
• DNA damage by reactive oxygen species in cryopreservation and the antioxidant properties of cryoprotectors

  2012cites this paper
• EFFECT OF GLUTATHIONE ON SELECTED MOTION PARAMETERS OF RAM COOLING-STORED SPERMATOZOA

  2012cites this paper
• Influence of wounding and aging on 1-MCP sorption and metabolism in fresh-cut tissue and cell-free homogenates from apple fruit

  2012cites this paper
• Effect of Several Antioxidants on Thawed Ram Spermatozoa Submitted to 37 (cid:2) C up to Four Hours 1

  2012cites this paper
• Sperm Testing and ICSI Selection by Hyaluronic Acid Binding: The Hyaluronic Acid-Coated Glass Slide and Petri Dish in the Andrology and IVF Laboratories

  2012cites this paper
• Oxidative Stress in Zebrafish (Danio rerio) Sperm

  2012cites this paper
• Antioxidants in ICSI

  2012cites this paper
• Effect of Adding Taurine, Hypotaurine and Trehalose as Antioxidants to a Tris-based Egg Yolk Extender on Korean Jeju Black Bull Sperm Quality Following Cryopreservation

  2012cites this paper
• Damage of testicular cell macromolecules and reproductive capacity of male rats following co-administration of ethambutol, rifampicin, isoniazid and pyrazinamide

  2012cites this paper
• Comet-assay parameters as rapid biomarkers of exposure to dietary/environmental compounds -- an in vitro feasibility study on spermatozoa and lymphocytes.

  2012cites this paper
• Importance of sperm gluthatione treatment in ART

  2012cites this paper
• Effect of several antioxidants on thawed ram spermatozoa submitted to 37°C up to four hours.

  2012cites this paper
• Role of Sperm–Hyaluronic Acid Binding in the Evaluation and Treatment of Subfertile Men with ROS-Affected Semen: Assessment of Sperm with Oxidative Damage and HA-Mediated ICSI Sperm Selection

  2012cites this paper
• Quality, oxidative markers and DNA damage (DNA) fragmentation of red deer thawed spermatozoa after incubation at 37 °C in presence of several antioxidants.

  2012cites this paper
• EFFECT OF GLUTATHIONE ON SELECTED MOTION PARAMETERS OF RAM COOLING-STORED SPERMATOZOA EFEKT GLUTATIÓNU NA VYBRANÉ PARAMETRE POHYBLIVOSTI BARANÍCH SPERMIÍ UCHOVÁVAN›CH V SCHLADENOM STAVE

  2012cites this paper
• In Vitro Study of the Effect of Cypermethrin on Human Sperm Function, DNA Fragmentation and the Possible Protective Role of Vitamins C and/ or E

  2012cites this paper
• Novel Approaches of Sperm Selection for ART: The Role of Objective Biochemical Markers of Nuclear and Cytoplasmic Integrity and Sperm Function

  2011cites this paper
• Reduced glutathione content in human sperm is decreased after cryopreservation: Effect of the addition of reduced glutathione to the freezing and thawing extenders.

  2011cites this paper