Sphingolipid Metabolic Pathway: An Overview of Major Roles Played in Human Diseases

Sphingolipids, a family of membrane lipids, are bioactive molecules that participate in diverse functions controlling fundamental cellular processes such as cell division, differentiation, and cell death. Given that most of these cellular processes form the basis for several pathologies, it is not surprising that sphingolipids are key players in several pathological processes. This review discusses the role of the sphingolipid metabolic pathway in diabetes, Alzheimer's disease, and hepatocellular carcinoma, with a special emphasis on the changes in gene expression pattern in these disease conditions. For convenience, the sphingolipid metabolic pathway is divided into hypothetical compartments (modules) with each compartment representing a physiological process and changes in gene expression pattern are mapped to each of these modules. It appears that alterations in the gene expression pattern in these disease conditions are biased to manipulate the system in order to result in a particular disease.

• Publication year

  2013

• Venue

  Journal of Lipids

• Publication date

  2013-08-04

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1155/2013/178910PMID 23984075PMCID 3747619
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Ceramide kinase deficiency improves diet‐induced obesity and insulin resistance

  2012cited by this paper
• Hepatocarcinogenesis and ceramide/cholesterol metabolism.

  2012influential reference
• Insulin Resistance, Ceramide Accumulation, and Endoplasmic Reticulum Stress in Human Chronic Alcohol-Related Liver Disease

  2012cited by this paper
• Intracellular APP Domain Regulates Serine-Palmitoyl-CoA Transferase Expression and Is Affected in Alzheimer's Disease

  2011cited by this paper
• Ceramides as modulators of cellular and whole-body metabolism.

  2011cited by this paper
• Type 2 diabetes as an inflammatory disease

  2011cited by this paper
• Sphingolipid Storage Affects Autophagic Metabolism of the Amyloid Precursor Protein and Promotes Aβ Generation

  2011cited by this paper
• Sphingolipid metabolism and analysis in metabolic disease.

  2011cited by this paper
• Apoptotic Sphingolipid Ceramide in Cancer Therapy

  2011cited by this paper
• The sphingolipid rheostat: a potential target for improving pancreatic islet survival and function.

  2011cited by this paper
• Lysosomal lipid storage diseases.

  2011cited by this paper
• Dysregulation of sphingolipid metabolism in cancer

  2011cited by this paper
• Alterations of the Sphingolipid Pathway in Alzheimer’s Disease: New Biomarkers and Treatment Targets?

  2010cited by this paper
• An Introduction to Sphingolipid Metabolism and Analysis by New Technologies

  2010cited by this paper
• Ceramide-1-phosphate in cell survival and inflammatory signaling.

  2010cited by this paper
• Alzheimer's Disease and the Amyloid-β Peptide

  2010cited by this paper
• Cancer treatment strategies targeting sphingolipid metabolism.

  2010cited by this paper
• Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis.

  2010cited by this paper
• Fibrillar Amyloid-β-Activated Human Astroglia Kill Primary Human Neurons via Neutral Sphingomyelinase: Implications for Alzheimer's Disease

  2010cited by this paper
• Deregulation of sphingolipid metabolism in Alzheimer's disease.

  2010cited by this paper
• Alzheimer’s Disease and the β -Amyloid Peptide

  2010cited by this paper
• CERT-mediated trafficking of ceramide.

  2009cited by this paper
• Link between plasma ceramides, inflammation and insulin resistance: association with serum IL-6 concentration in patients with coronary heart disease

  2009cited by this paper
• Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice

  2009cited by this paper
• Ceramides: A new player in the inflammation–insulin resistance paradigm?

  2009cited by this paper
• The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus.

  2009cited by this paper
• Principles of bioactive lipid signalling: lessons from sphingolipids

  2008cited by this paper
• ER stress is involved in Aβ‐induced GSK‐3β activation and tau phosphorylation

  2008cited by this paper
• Sphingolipids and membrane biology as determined from genetic models.

  2008cited by this paper
• TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease

  2008cited by this paper
• Anionic lipids activate group IVA cytosolic phospholipase A2 via distinct and separate mechanisms Published, JLR Papers in Press, September 21, 2007.

  2007cited by this paper
• Translational aspects of sphingolipid metabolism.

  2007cited by this paper
• Intracellular amyloid-β in Alzheimer's disease

  2007cited by this paper
• (Glyco)sphingolipidology: an amazing challenge and opportunity for systems biology.

  2007influential reference
• Gene Expression Alterations in the Sphingolipid Metabolism Pathways during Progression of Dementia and Alzheimer’s Disease: A Shift Toward Ceramide Accumulation at the Earliest Recognizable Stages of Alzheimer’s Disease?

  2007cited by this paper
• Involvement of astroglial ceramide in palmitic acid‐induced Alzheimer‐like changes in primary neurons

  2007cited by this paper
• Lipid mediators of insulin resistance.

  2007cited by this paper
• Intracellular amyloid-beta in Alzheimer's disease.

  2007cited by this paper
• Ceramides in insulin resistance and lipotoxicity.

  2006cited by this paper
• ER stress and neurodegenerative diseases

  2006cited by this paper
• Sphingolipid-binding proteins.

  2006cited by this paper
• Altered Adipose and Plasma Sphingolipid Metabolism in Obesity

  2006cited by this paper
• Sphingolipid metabolism diseases.

  2006cited by this paper
• Inflammation and insulin resistance.

  2006cited by this paper
• Principles of lysosomal membrane digestion: stimulation of sphingolipid degradation by sphingolipid activator proteins and anionic lysosomal lipids.

  2005cited by this paper
• Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective.

  2005cited by this paper
• ReviewTwenty Years of the Alzheimer ’ s Disease Amyloid Hypothesis : A Genetic Perspective

  2005cited by this paper
• Inhibition of Glycosphingolipid Biosynthesis Reduces Secretion of the β-Amyloid Precursor Protein and Amyloid β-Peptide*[boxs]

  2005cited by this paper
• Simulation and validation of modelled sphingolipid metabolism in Saccharomyces cerevisiae

  2005influential reference
• Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

  2004cited by this paper
• Intracellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells.

  2004cited by this paper
• Relationship between insulin sensitivity and sphingomyelin signaling pathway in human skeletal muscle.

  2004cited by this paper
• IPC synthase as a useful target for antifungal drugs.

  2004cited by this paper
• Ceramide content is increased in skeletal muscle from obese insulin-resistant humans.

  2004cited by this paper
• Biologically active sphingolipids in cancer pathogenesis and treatment

  2004cited by this paper
• Glycosphingolipidoses: Beyond the enzymatic defect

  2004cited by this paper
• Enzymes of Sphingolipid metabolism in Drosophila melanogaster

  2004cited by this paper
• Lipid metabolism: ceramide transfer protein adds a new dimension.

  2004cited by this paper
• Induction of neuronal death by ER stress in Alzheimer's disease.

  2004cited by this paper
• Elevation of the level and activity of acid ceramidase in Alzheimer's disease brain

  2004cited by this paper
• Perturbation of sphingolipid metabolism and ceramide production in HIV‐dementia

  2004cited by this paper
• c-Jun N-terminal Kinase (JNK) Mediates Feedback Inhibition of the Insulin Signaling Cascade*

  2003cited by this paper
• Possible role of ceramide as an indicator of chemoresistance: decrease of the ceramide content via activation of glucosylceramide synthase and sphingomyelin synthase in chemoresistant leukemia.

  2003cited by this paper
• Sphingoid bases and de novo ceramide synthesis: enzymes involved, pharmacology and mechanisms of action.

  2003cited by this paper
• Ceramide Kinase Mediates Cytokine- and Calcium Ionophore-induced Arachidonic Acid Release*

  2003cited by this paper
• A Role for Ceramide, but Not Diacylglycerol, in the Antagonism of Insulin Signal Transduction by Saturated Fatty Acids*

  2003cited by this paper
• Ceramide Disables 3-Phosphoinositide Binding to the Pleckstrin Homology Domain of Protein Kinase B (PKB)/Akt by a PKCζ-Dependent Mechanism

  2003cited by this paper
• Inflammation and insulin resistance.

  2003cited by this paper
• Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism.

  2003cited by this paper
• Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis.

  2003cited by this paper
• Withdrawal: Ceramide stabilizes β-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid β-peptide biogenesis

  2003cited by this paper
• Mechanisms of cancer drug resistance.

  2002cited by this paper
• The therapeutic potential of modulating the ceramide/sphingomyelin pathway.

  2002cited by this paper
• The Ceramide-centric Universe of Lipid-mediated Cell Regulation: Stress Encounters of the Lipid Kind*

  2002cited by this paper
• Protein phosphatase 2A is the main phosphatase involved in the regulation of protein kinase B in rat adipocytes.

  2002cited by this paper
• Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress–induced death of motor neurons in amyotrophic lateral sclerosis

  2002cited by this paper
• Elevation of glucosylceramide in multidrug‐resistant cancer cells and accumulation in cytoplasmic droplets

  2001cited by this paper
• Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer.

  2001cited by this paper
• The organizing potential of sphingolipids in intracellular membrane transport.

  2001cited by this paper
• Alzheimer's disease: genes, proteins, and therapy.

  2001cited by this paper
• Sphingolipids in mammalian cell signalling

  2001cited by this paper
• The Endosomal-Lysosomal System of Neurons in Alzheimer's Disease Pathogenesis: A Review

  2000cited by this paper
• Ceramide Generation Is Sufficient to Account for the Inhibition of the Insulin-stimulated PKB Pathway in C2C12 Skeletal Muscle Cells Pretreated with Palmitate*

  1999cited by this paper
• Regulation of Insulin-Stimulated Glucose Transporter GLUT4 Translocation and Akt Kinase Activity by Ceramide

  1998cited by this paper
• Tumor Necrosis Factor-α-induced Insulin Resistance in 3T3-L1 Adipocytes Is Accompanied by a Loss of Insulin Receptor Substrate-1 and GLUT4 Expression without a Loss of Insulin Receptor-mediated Signal Transduction*

  1997cited by this paper
• Mitochondrial Free Radical Signal in Ceramide‐Dependent Apoptosis: A Putative Mechanism for Neuronal Death in Parkinson's Disease

  1997cited by this paper
• Tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction.

  1997cited by this paper
• Accumulation of Glucosylceramides in Multidrug-resistant Cancer Cells*

  1996cited by this paper
• Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling.

  1994cited by this paper
• Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance.

  1994cited by this paper
• Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.

  1993cited by this paper
• Tumor necrosis factor-alpha activates the sphingomyelin signal transduction pathway in a cell-free system.

  1992cited by this paper
• 1,2-Diacylglycerol and ceramide levels in insulin-resistant tissues of the rat in vivo.

  1990cited by this paper
• Plasma long chain fatty acids and esterified lipids in cirrhosis and hepatic encephalopathy

  1978cited by this paper

• Metabolic effects following initiation of single-inhaler triple therapy in COPD: a prospective observational study.

  2026cites this paper
• Discovery of IID432 for Chagas Disease: A Cyanotriazole Inhibitor of Trypanosoma cruzi Topoisomerase II Achieves Sterile Cure After Short-Term Treatment in a Chronic Infection Model

  2026cites this paper
• Targeting ceramide metabolism to restore hypoxia-induced apoptosis in p53-deficient colon cancer cells

  2026cites this paper
• Plasma biomarkers in drug-naïve schizophrenia with severe cognitive impairment via targeted metabolomics.

  2025cites this paper
• Sphingolipid and methionine metabolism in aging.

  2025cites this paper
• Sphingosine kinase SPHK-1 maintains sphingolipid metabolism to protect lysosome membrane integrity in C. elegans.

  2025cites this paper
• Noncovalent crown ether–assisted separation of stereoisomeric glycosphingosines using cyclic ion mobility spectrometry

  2025cites this paper
• Comprehensive characterization and comparison of polar lipids in bovine and donkey Milk based on Lipidomics.

  2025cites this paper
• Advancing Clinical and Pathophysiological Insights into Pancreatitis Using Lipidomics and Metabolomics

  2025cites this paper
• Selective Knockdown of Ceramide Synthases Reveals Opposite Roles of Different Ceramide Species in Cardiac Homeostasis

  2025cites this paper
• Neurite outgrowth inhibitor-B (Nogo-B) in physiology and disease.

  2025cites this paper
• An integrated research strategy based on "compound exogenous chemical substances-endogenous metabolites in disease": To explore the scientific basis of Modified Bazhen Yimu Gao in the treatment of primary dysmenorrhea.

  2025cites this paper
• Genome-Scale Metabolic Modeling Predicts Per- and Polyfluoroalkyl Substance-Mediated Early Perturbations in Liver Metabolism

  2025cites this paper
• Metabolomic stratification of shock: pathophysiological insights for personalized critical care

  2025cites this paper
• Exploratory Metabolomic and Lipidomic Profiling in a Manganese-Exposed Parkinsonism-Affected Population in Northern Italy

  2025cites this paper
• Exploring the Cardiotoxic Potential of Fumonisin B1 through Inflammatory Pathways and Epigenetic Modifications: A Mini Review.

  2025cites this paper
• hsa-miR-330-5p regulates serine palmitoyltransferase long chain base subunit 1 and augments host protective immune response against Leishmania donovani infection

  2025cites this paper
• Drug Resistance: The Role of Sphingolipid Metabolism

  2025cites this paper
• Serum sphingomyelin levels define oxyhemoglobin desaturation-related metabolic threshold in symptomatic obstructive sleep apnea

  2025influential citation
• Machine learning identified promising markers for cervical cancer prognosis and immune response from sphingolipid metabolism

  2025cites this paper
• Sphingolipids in Cancer: Metabolism, Signaling, and Clinical Implications.

  2025cites this paper
• Differential Metabolomics Profiling of Dead and Halal-Slaughtered Poultry Meat Using Liquid Chromatography Coupled with Electrospray Ionization Quadrupole Time-of-Flight Mass Spectrometry

  2025cites this paper
• Sparstolonin B Suppresses Proliferation and Modulates Toll-like Receptor Signaling and Inflammatory Pathways in Human Colorectal Cancer Cells

  2025cites this paper
• The role of oxidative stress in the pathogenesis of endometriosis

  2025cites this paper
• Metabolic needs and capabilities among Cryptosporidium species.

  2025cites this paper
• Structural Damage and Organelle Destruction: Mechanisms of Pseudolaric Acid B Against S. parasitica.

  2024cites this paper
• Bwa, an ortholog of alkaline ceramidase-ACER2, promotes intestinal stem cell proliferation through pro-inflammatory cytokine signaling in Drosophila melanogaster

  2024cites this paper
• Dysregulation of sphingolipid metabolism in liver fibrosis

  2024cites this paper
• Metabolomic and Lipidomic Analysis of Manganese-Associated Parkinsonism: a Case-Control Study in Brescia, Italy

  2024cites this paper
• Deciphering sphingolipid biosynthesis dynamics in Arabidopsis thaliana cell cultures: Quantitative analysis amid data variability

  2024cites this paper
• Serum metabolism distribution in individuals exposed to dioxins: A case study of residents near the municipal solid waste incinerators in China.

  2024cites this paper
• Follicular Fluid and Blood Monitorization of Infertility Biomarkers in Women with Endometriosis

  2024cites this paper
• Sphingolipid-Induced Bone Regulation and Its Emerging Role in Dysfunction Due to Disease and Infection

  2024cites this paper
• Critical Roles of the Sphingolipid Metabolic Pathway in Liver Regeneration, Hepatocellular Carcinoma Progression and Therapy

  2024cites this paper
• Metabolomic associations of impaired awareness of hypoglycaemia in type 1 diabetes

  2024influential citation
• Molecular docking as a tool for the discovery of novel insight about the role of acid sphingomyelinase inhibitors in SARS- CoV-2 infectivity

  2024cites this paper
• Mysterious sphingolipids: metabolic interrelationships at the center of pathophysiology

  2024cites this paper
• Alzheimer’s disease and neuroinflammation: will new drugs in clinical trials pave the way to a multi-target therapy?

  2023cites this paper
• Prospective Association Between Plasma Concentrations of Fatty Acids and Other Lipids, and Multimorbidity in Older Adults.

  2023cites this paper
• The Ying and Yang of Sphingosine-1-Phosphate Signalling within the Bone

  2023cites this paper
• Abnormalities of Sphingolipids Metabolic Pathways in the Pathogenesis of Psoriasis

  2023cites this paper
• Host metabolome and faecal microbiome shows potential interactions impacted by age and weaning times in calves

  2023cites this paper
• PFO5DoDA disrupts hepatic homeostasis primarily through glucocorticoid signaling inhibition.

  2023cites this paper
• Effective carrier-free gene-silencing activity of sphingosine-modified siRNAs.

  2023cites this paper
• SGMS2 in primary osteoporosis with facial nerve palsy

  2023cites this paper
• Combined quercetin and simvastatin attenuate hepatic fibrosis in rats by modulating SphK1/NLRP3 pathways.

  2023cites this paper
• Defining the glucosylceramide population of C. elegans

  2023cites this paper
• Astrocyte metabolism and signaling pathways in the CNS

  2023cites this paper
• Metabolite profiling of Trichinella spiralis adult worms and muscle larvae identifies their excretory and secretory products

  2023cites this paper
• The SIRT1-c-Myc axis in regulation of stem cells

  2023cites this paper
• Sterigmatocystin induced cytotoxicity and disturbed lipid metabolism

  2023cites this paper
• The Role of Obesity, Inflammation and Sphingolipids in the Development of an Abdominal Aortic Aneurysm

  2022cites this paper
• CSF sphingomyelin metabolites in Alzheimer's disease, neurodegeneration, and neuroinflammation

  2022cites this paper
• Metabolites Associated with Memory and Gait: A Systematic Review

  2022cites this paper
• Hydroxychloroquine Causes Early Inner Retinal Toxicity and Affects Autophagosome–Lysosomal Pathway and Sphingolipid Metabolism in the Retina

  2022cites this paper
• DDDT_A_357061 931..950

  2022cites this paper
• Involvement of Huanglian Jiedu Decoction on Microglia with Abnormal Sphingolipid Metabolism in Alzheimer’s Disease

  2022cites this paper
• Serine Palmitoyltransferase Gene Silencing Prevents Ceramide Accumulation and Insulin Resistance in Muscles in Mice Fed a High-Fat Diet

  2022cites this paper
• Two different phospholipases C, Isc1 and Pgc1, cooperate to regulate mitochondrial function

  2022cites this paper
• The Role of Lipids in CRAC Channel Function

  2022cites this paper
• Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy

  2022cites this paper
• Novel Insight into the Serum Sphingolipid Fingerprint Characterizing Longevity

  2022cites this paper
• Cerebrospinal Fluid Sphingomyelins in Alzheimer’s Disease, Neurodegeneration, and Neuroinflammation

  2022cites this paper
• CSF sphingomyelins in Alzheimer’s disease, neurodegeneration, and neuroinflammation

  2022cites this paper
• Comprehensive metabolomics and lipidomics profiling uncovering neuroprotective effects of Ginkgo biloba L. leaf extract on Alzheimer’s disease

  2022cites this paper
• Machine learning to construct sphingolipid metabolism genes signature to characterize the immune landscape and prognosis of patients with uveal melanoma

  2022cites this paper
• Metabolomic Analysis of Renal Cell Carcinoma in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

  2022cites this paper
• Two Different Phospholipases C, Isc1 and Pgc1, Cooperate To Regulate Mitochondrial Function

  2022cites this paper
• Lipid Profiles Obtained from MALDI Mass Spectrometric Imaging in Liver Cancer Metastasis Model

  2022cites this paper
• Large 22q13.3 deletions perturb peripheral transcriptomic and metabolomic profiles in Phelan-McDermid syndrome

  2022cites this paper
• Prenatal transcript levels and metabolomics analyses reveal metabolic changes associated with intrauterine growth restriction and sex

  2022cites this paper
• MicroRNA‐520c‐3p impacts sphingolipid metabolism mediating PI3K/AKT signaling in NSCLC: Systems perspective

  2022cites this paper
• Diverse Roles of Ceramide in the Progression and Pathogenesis of Alzheimer’s Disease

  2022cites this paper
• Dietary bile acids supplementation mainly regulates the amino acid metabolic pathways without decreasing bile acids levels in the liver of farmed European eel (Anguilla anguilla) juveniles

  2022cites this paper
• Large deletions perturb peripheral transcriptomic and metabolomic profiles in Phelan-McDermid syndrome

  2022cites this paper
• Co-expression analysis identifies neuro-inflammation as a driver of sensory neuron aging in Aplysia californica

  2021cites this paper
• Physiological and molecular responses of lobe coral indicate nearshore adaptations to anthropogenic stressors

  2021cites this paper
• Metabolomic signatures of the long-term exposure to air pollution and temperature

  2021cites this paper
• Oxidative stress increases 1-deoxysphingolipid levels in chronic kidney disease.

  2021cites this paper
• Ambient PM2.5 species and ultrafine particle exposure and their differential metabolomic signatures.

  2021cites this paper
• SIRT1 regulates sphingolipid metabolism and neural differentiation of mouse embryonic stem cells through c-Myc- SMPDL3B

  2021cites this paper
• Biochemical characterization of proliferative and differentiated SH-SY5Y cell line as a model for Parkinson's disease.

  2021cites this paper
• Neutral sphingomyelinase‐2 and cardiometabolic diseases

  2021cites this paper
• REP1 deficiency causes systemic dysfunction of lipid metabolism and oxidative stress in choroideremia

  2021cites this paper
• Targeting the Sphingosine Kinase/Sphingosine-1-Phosphate Signaling Axis in Drug Discovery for Cancer Therapy

  2021cites this paper
• Sphingolipid lysosomal storage diseases: from bench to bedside

  2021cites this paper
• Physiological functions and therapeutic applications of neutral sphingomyelinase and acid sphingomyelinase.

  2021cites this paper
• SIRT1 regulates sphingolipid metabolism and neural differentiation of mouse embryonic stem cells through c-Myc-SMPDL3B

  2021cites this paper
• Spirulina liquid extract prevents metabolic disturbances and improves liver sphingolipids profile in hamster fed a high-fat diet

  2021cites this paper
• Vitamin K2 as a New Modulator of the Ceramide De Novo Synthesis Pathway

  2021cites this paper
• Metabolomic signatures of the short-term exposure to air pollution and temperature.

  2021cites this paper
• The study of the anti-inflammatory properties of carotenoid liquid extracts on the model of adjuvant-induced inflammation

  2021cites this paper
• Overview of concepts of the sphingolipid metabolism

  2021cites this paper
• Bioinformatic Exploration for Prognostic Significance of Sphingolipid Metabolism-Related Genes in Invasive Ductal Carcinoma Using the Cancer Genome Atlas Cohort

  2021cites this paper
• Perturbed transcriptional profiles after chronic low dose rate radiation in mice

  2021cites this paper
• Therapeutic effect of Moringa oleifera leaves on constipation mice based on pharmacodynamics and serum metabonomics.

  2021cites this paper
• Ocular surface sphingolipids associate with the refractory nature of vernal keratoconjunctivitis: newer insights in VKC pathogenesis

  2021cites this paper
• Hydroxylated Fatty Acids: The Role of the Sphingomyelin Synthase and the Origin of Selectivity

  2021cites this paper
• Alterations in β-Cell Sphingolipid Profile Associated with ER Stress and iPLA2β: Another Contributor to β-Cell Apoptosis in Type 1 Diabetes

  2021cites this paper
• Inhibition of acid ceramidase elicits mitochondrial dysfunction and oxidative stress in pancreatic cancer cells

  2021cites this paper