Renal phosphaturia during metabolic acidosis revisited: molecular mechanisms for decreased renal phosphate reabsorption

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Pflügers Archiv: European Journal of Physiology

• Publication date

  2008-06-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00424-008-0530-5PMID 18535837
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Genome-wide gene expression profiling reveals renal genes regulated during metabolic acidosis.

  2008cited by this paper
• Isolation of renal proximal tubular brush-border membranes

  2007cited by this paper
• SLC34A3 mutations in patients with hereditary hypophosphatemic rickets with hypercalciuria predict a key role for the sodium-phosphate cotransporter NaPi-IIc in maintaining phosphate homeostasis.

  2006cited by this paper
• Hereditary hypophosphatemic rickets with hypercalciuria is caused by mutations in the sodium-phosphate cotransporter gene SLC34A3.

  2006cited by this paper
• Internalization of renal type IIc Na-Pi cotransporter in response to a high-phosphate diet.

  2005cited by this paper
• Inhibition of Intestinal Sodium‐dependent Inorganic Phosphate Transport by Fibroblast Growth Factor 23

  2005cited by this paper
• Regulation of intestinal phosphate transport. II. Metabolic acidosis stimulates Na(+)-dependent phosphate absorption and expression of the Na(+)-P(i) cotransporter NaPi-IIb in small intestine.

  2005cited by this paper
• Regulation of intestinal phosphate transport. I. Segmental expression and adaptation to low-P(i) diet of the type IIb Na(+)-P(i) cotransporter in mouse small intestine.

  2005cited by this paper
• Substrate interactions in the human type IIa sodium-phosphate cotransporter (NaPi-IIa).

  2005cited by this paper
• The sodium phosphate cotransporter family SLC34

  2004cited by this paper
• Segment-specific expression of sodium-phosphate cotransporters NaPi-IIa and -IIc and interacting proteins in mouse renal proximal tubules

  2004cited by this paper
• Regulation of Na/Pi transporter in the proximal tubule.

  2003cited by this paper
• Differential effects of Npt2a gene ablation and X-linked Hyp mutation on renal expression of Npt2c.

  2003cited by this paper
• Cloning, gene structure and dietary regulation of the type-IIc Na/Pi cotransporter in the mouse kidney

  2003influential reference
• Effect of hydrolysis-resistant FGF23-R179Q on dietary phosphate regulation of the renal type-II Na/Pi transporter

  2003cited by this paper
• Bone buffering of acid and base in humans.

  2003cited by this paper
• Growth-related Renal Type II Na/Pi Cotransporter*

  2002influential reference
• Differential effects of 19-nor-1,25-dihydroxyvitamin D(2) and 1,25-dihydroxyvitamin D(3) on intestinal calcium and phosphate transport.

  2002cited by this paper
• Identification of the type II Na(+)-Pi cotransporter (Npt2) in the osteoclast and the skeletal phenotype of Npt2-/- mice.

  2001cited by this paper
• Glycosphingolipids modulate renal phosphate transport in potassium deficiency.

  2001cited by this paper
• Proximal tubular phosphate reabsorption: molecular mechanisms.

  2000cited by this paper
• Regulation of small intestinal Na-Pi type IIb cotransporter by dietary phosphate intake.

  1999cited by this paper
• Differential expression, abundance, and regulation of Na+-phosphate cotransporter genes in murine kidney.

  1998cited by this paper
• Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities.

  1998cited by this paper
• p38 Mitogen-activated protein kinase expression and activation in smooth muscle.

  1998cited by this paper
• p38 mitogen-activated protein kinase expression and activation in smooth muscle.

  1998cited by this paper
• Regulation of renal phosphate transport by acute and chronic metabolic acidosis in the rat.

  1998cited by this paper
• Differential expression, abundance, and regulation of Na+-phosphate cotransporter genes in murine kidney.

  1998cited by this paper
• Identification and characterization of a widely expressed phosphate transporter/retrovirus receptor family.

  1996cited by this paper
• Properties of electrogenic Pi transport by a human renal brush border Na+/Pi transporter.

  1995cited by this paper
• Cellular mechanisms of acute and chronic adaptation of rat renal P(i) transporter to alterations in dietary P(i).

  1994cited by this paper
• The cellular receptor for gibbon ape leukemia virus is a novel high affinity sodium-dependent phosphate transporter.

  1994cited by this paper
• Expression of Na-P(i) cotransport in rat kidney: localization by RT-PCR and immunohistochemistry.

  1994cited by this paper
• Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters.

  1994cited by this paper
• Ecto-5'-nucleotidase: localization in rat kidney by light microscopic histochemical and immunohistochemical methods.

  1989cited by this paper
• Effect of pH on phosphate transport in rat renal brush border membrane vesicles.

  1985cited by this paper
• Simplified manual high performance clinical chemistry methods for developing countries.

  1984cited by this paper
• Effect of pH on phosphate transport into intestinal brush-border membrane vesicles

  1984cited by this paper
• Mechanism for the phosphaturia of NH4Cl: dependence on acidemia but not on diet PO4 or PTH.

  1982cited by this paper
• A high yield preparation for rat kidney brush border membranes. Different behaviour of lysosomal markers.

  1981cited by this paper

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• Beyond SGLT2: proximal tubule transporters as potential drug targets for chronic kidney disease

  2025cites this paper
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  2024cites this paper
• Young adults’ circulating FGF23 and α-klotho and their relationship with habitual dietary acid load and phosphorus intake during growth

  2024cites this paper
• The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal Tubular Function

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• The Effects of Acid on Calcium and Phosphate Metabolism

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• Diuretic Use and Serum Phosphate: Rotterdam Study and UK Biobank

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• A novel mouse model for familial hypocalciuric hypercalcemia (FHH1) reveals PTH-dependent and independent CaSR defects

  2024cites this paper
• The Calcium-sensing receptor (CaSR) has only a PTH-dependent role in the acute response of renal phosphatetransporters to phosphate intake.

  2024cites this paper
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• Clinical and Functional Assessment of Digenicity in Renal Phosphate Wasting

  2023cites this paper
• The basics of phosphate metabolism

  2023cites this paper
• Intestinal and Renal Adaptations to Changes of Dietary Phosphate Concentrations in Rat

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• Acute adaptation of renal phosphate transporters in the murine kidney to oral phosphate intake requires multiple signals

  2022cites this paper
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  2022cites this paper
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  2022cites this paper
• Phosphate Homeostasis and Disorders of Phosphate metabolism.

  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2020cites this paper
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  2020cites this paper
• Intestinal epithelial ablation of Pit‐2/Slc20a2 in mice leads to sustained elevation of vitamin D3 upon dietary restriction of phosphate

  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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  2016cites this paper
• Apelin: A novel inhibitor of vascular calcification in chronic kidney disease.

  2016cites this paper
• The Effects of Lithium on FGF 23 Die Wirkung von Lithium auf FGF 23 Inaugural

  2016cites this paper
• Renal control of calcium, phosphate, and magnesium homeostasis.

  2015cites this paper
• Regulation of hormone-sensitive renal phosphate transport.

  2015cites this paper
• Impaired expression of key molecules of ammoniagenesis underlies renal acidosis in a rat model of chronic kidney disease.

  2015influential citation
• Fibroblast growth factor 23 and dietary factors in renal disease

  2015cites this paper
• Sodium-Dependent Phosphate Transporters in Osteoclast Differentiation and Function

  2015cites this paper
• Phosphate and FGF-23 homeostasis after kidney transplantation

  2015cites this paper
• Intestinal Depletion of NaPi‐IIb/Slc34a2 in Mice: Renal and Hormonal Adaptation

  2015cites this paper
• Effect of Mineralocorticoids on Acid-Base Balance

  2014cites this paper
• Proximal tubule function and response to acidosis.

  2014cites this paper
• Renal handling of phosphate and sulfate.

  2014cites this paper
• Genetic diseases of renal phosphate handling.

  2014cites this paper
• Everything you need to know about distal renal tubular acidosis in autoimmune disease

  2014cites this paper
• The Murine Cl-/HCO3- Exchanger Ae3 (Slc4a3) is Not Required for Acid-Base Balance but is Involved in Magnesium Handling by the Kidney

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• Upregulation of the Na+-Coupled Phosphate Cotransporters NaPi-IIa and NaPi-IIb by B-RAF

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• Hyperphosphatemic familial tumoral calcinosis: Response to acetazolamide and postulated mechanisms

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• Renal-specific and inducible depletion of NaPi-IIc/Slc34a3, the cotransporter mutated in HHRH, does not affect phosphate or calcium homeostasis in mice.

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  2014cites this paper
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  2014cites this paper
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  2013cites this paper
• Stimulation of Na(+) coupled phosphate transporter NaPiIIa by janus kinase JAK2.

  2013cites this paper
• Dietary phosphorus sources and their acute effects on mineral metabolism in healthy women

  2013influential citation
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  2013influential citation
• Roux-en-Y gastric bypass surgery reduces bone mineral density and induces metabolic acidosis in rats.

  2013cites this paper
• The Proton-Activated Receptor GPR4 Modulates Glucose Homeostasis by Increasing Insulin Sensitivity

  2013cites this paper
• The SLC34 family of sodium-dependent phosphate transporters

  2013cites this paper
• Significance of the anti-aging protein Klotho

  2013influential citation
• Vascular calcification--is aldosterone a culprit?

  2013cites this paper
• Proximal Tubular Handling of Phosphate

  2013cites this paper
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  2013cites this paper
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  2013cites this paper
• Spironolactone ameliorates PIT1-dependent vascular osteoinduction in klotho-hypomorphic mice.

  2013cites this paper
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  2012cites this paper
• Sirolimus Induced Phosphaturia is Not Caused by Inhibition of Renal Apical Sodium Phosphate Cotransporters

  2012cites this paper
• Enhanced FGF23 Serum Concentrations and Phosphaturia in Gene Targeted Mice Expressing WNK-Resistant Spak

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  2012cites this paper
• Altered Regulation of Renal Acid Base Transporters in Response to Ammonium Chloride Loading in Rats

  2012cites this paper
• The normal acid-base status of mice.

  2012cites this paper
• Decreased bone density and increased phosphaturia in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase 3.

  2011cites this paper
• The regulation of renal phosphate transport.

  2011cites this paper
• Effects of a reduced calcium, phosphorus and protein intake and of benzoic acid on calcium and phosp

  2011cites this paper
• Regulation of pathways involved in intestinal phosphate transport

  2011cites this paper
• PKB/SGK-resistant GSK3 enhances phosphaturia and calciuria.

  2011cites this paper
• Toxicity and toxicokinetics of metformin in rats.

  2010cites this paper
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  2010cites this paper
• Renal function during metabolic acidosis

  2010cites this paper
• Both FGF23 and extracellular phosphate activate Raf/MEK/ERK pathway via FGF receptors in HEK293 cells

  2010cites this paper
• Acute parathyroid hormone differentially regulates renal brush border membrane phosphate cotransporters

  2010influential citation
• Phosphate transport in the kidney.

  2010cites this paper
• Akt2/PKBβ‐sensitive regulation of renal phosphate transport

  2010cites this paper