Plin3 protects against alcoholic liver injury by facilitating lipid export from the endoplasmic reticulum

Hepatic lipid accumulation is the most common pathological characteristic of alcoholic liver disease (ALD). In mammalian cells, excess neutral lipids are stored in lipid droplets (LDs). As a member of perilipin family proteins, Plin3 was recently found to regulate the LD biogenesis. However, the roles and mechanism of Plin3 in ALD progression remain unclear.

• Publication year

  2019

• Venue

  Journal of Cellular Biochemistry

• Publication date

  2019-09-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1002/jcb.28889PMID 31119787
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Perilipin 1 Mediates Lipid Metabolism Homeostasis and Inhibits Inflammatory Cytokine Synthesis in Bovine Adipocytes

  2018cited by this paper
• The collaborative work of droplet assembly.

  2017cited by this paper
• Endoplasmic Reticulum Stress, Unfolded Protein Response, and Cancer Cell Fate

  2017cited by this paper
• Perilipins: a diversity of intracellular lipid droplet proteins

  2017influential reference
• The constitutive lipid droplet protein PLIN2 regulates autophagy in liver

  2017cited by this paper
• Differential Roles of Cell Death-inducing DNA Fragmentation Factor-α-like Effector (CIDE) Proteins in Promoting Lipid Droplet Fusion and Growth in Subpopulations of Hepatocytes*♦

  2016cited by this paper
• The Perilipins: Major Cytosolic Lipid Droplet-Associated Proteins and Their Roles in Cellular Lipid Storage, Mobilization, and Systemic Homeostasis.

  2016influential reference
• Liver-specific loss of Perilipin 2 alleviates diet-induced hepatic steatosis, inflammation, and fibrosis.

  2016cited by this paper
• Perilipin 5 improves hepatic lipotoxicity by inhibiting lipolysis

  2015influential reference
• Lipid droplet-associated proteins in alcoholic liver disease: a potential linkage with hepatocellular damage.

  2015cited by this paper
• Tracking Movements of the Microtubule Motors Kinesin and Dynein Using Total Internal Reflection Fluorescence Microscopy.

  2015cited by this paper
• A conserved family of proteins facilitates nascent lipid droplet budding from the ER

  2015influential reference
• Perilipin discerns chronic from acute hepatocellular steatosis.

  2014cited by this paper
• Bidirectional cargo transport: moving beyond tug of war

  2014cited by this paper
• Absence of Perilipin 2 Prevents Hepatic Steatosis, Glucose Intolerance and Ceramide Accumulation in Alcohol-Fed Mice

  2014cited by this paper
• Cidea controls lipid droplet fusion and lipid storage in brown and white adipose tissue

  2013cited by this paper
• Alcohol Metabolism and Epigenetics Changes

  2013cited by this paper
• Alcoholic liver disease: pathogenesis and new therapeutic targets.

  2011cited by this paper
• Chronic ethanol consumption in mice alters hepatocyte lipid droplet properties.

  2011cited by this paper
• Docosahexaenoic acid supplementation decreases liver fat content in children with non-alcoholic fatty liver disease: double-blind randomised controlled clinical trial

  2011cited by this paper
• Genetic determinants of alcoholic liver disease

  2011cited by this paper
• ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1

  2011cited by this paper
• Alcohol consumption impairs hepatic protein trafficking: mechanisms and consequences

  2010cited by this paper
• Alcohol-induced alterations of the hepatocyte cytoskeleton.

  2010cited by this paper
• Cideb, an ER- and lipid droplet-associated protein, mediates VLDL lipidation and maturation by interacting with apolipoprotein B.

  2009cited by this paper
• Diacylglycerol Enrichment of Endoplasmic Reticulum or Lipid Droplets Recruits Perilipin 3/TIP47 during Lipid Storage and Mobilization*

  2009influential reference
• TIP47 functions in the biogenesis of lipid droplets

  2009influential reference
• Multiple functions encoded by the N-terminal PAT domain of adipophilin

  2008cited by this paper
• Adipose differentiation-related protein is a reliable lipid droplet marker in alcoholic fatty liver of rats.

  2008cited by this paper
• Hepatitis C Virus Core Protein Induces Lipid Droplet Redistribution in a Microtubule‐ and Dynein‐Dependent Manner

  2008cited by this paper
• Degradation of perilipin is mediated through ubiquitination-proteasome pathway.

  2006cited by this paper
• Functional Compensation for Adipose Differentiation-related Protein (ADFP) by Tip47 in an ADFP Null Embryonic Cell Line*

  2006cited by this paper
• Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model.

  2006cited by this paper
• Regulation of lipid-droplet transport by the perilipin homolog LSD2.

  2005cited by this paper
• Proteomic Analysis of Proteins Associated with Lipid Droplets of Basal and Lipolytically Stimulated 3T3-L1 Adipocytes*

  2004cited by this paper
• Alcohol and hepatocellular carcinoma.

  2004influential reference
• The Enzymes of Neutral Lipid Synthesis*

  2001cited by this paper
• TIP47 Associates with Lipid Droplets*

  2001cited by this paper
• Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein.

  1997cited by this paper
• Post-translational Regulation of Perilipin Expression

  1997cited by this paper

• Lipid Droplet‐Localized Spindle Apparatus Coiled‐Coil Protein 1 Regulates Lipid Droplet Distribution

  2026cites this paper
• The Myo2 adaptor Ldm1 and its receptor Ldo16 mediate actin-dependent lipid droplet motility

  2025cites this paper
• PLIN3: a multifaceted regulator of lipid droplet dynamics and disease pathogenesis

  2025cites this paper
• Lipid droplet on the move: remodeling, trafficking and interaction with other organelles.

  2025cites this paper
• Lipid Droplet - Organelle Crosstalk and its Implication in Cancer.

  2025cites this paper
• The Role of PLIN3 in Prognosis and Tumor-Associated Macrophage Infiltration: A Pan-Cancer Analysis

  2025cites this paper
• Mechanisms of Tripterygium wilfordii Hook F on treating rheumatoid arthritis explored by network pharmacology analysis and molecular docking

  2024cites this paper
• Neuroinvasive virus utilizes a lipid droplet surface protein, perilipin2, to restrict apoptosis by decreasing Bcl-2 ubiquitination

  2024cites this paper
• Lipid droplets-related Perilipin-3: potential immune checkpoint and oncogene in oral squamous cell carcinoma

  2024cites this paper
• Hepatoprotective Effect of Albumin Peptide Fractions from Corn Germ Meal against Alcohol-Induced Acute Liver Injury in Mice

  2023cites this paper
• Milk Fat Globule Membrane Relieves Fatigue via Regulation of Oxidative Stress and Gut Microbiota in BALB/c Mice

  2023cites this paper
• Tapping lipid droplets: A rich fat diet of intracellular bacterial pathogens

  2023cites this paper
• Silencing of Perilipin 3 Inhibits Lung Adenocarcinoma Cell Immune Resistance by Regulating the Transcription of PD-L1 Through c-Myc

  2023cites this paper
• Mechanisms of Lipid Droplet Accumulation in Steatotic Liver Diseases

  2023cites this paper
• Perilipins at a glance.

  2022cites this paper
• Microtubule motor driven interactions of lipid droplets: Specificities and opportunities

  2022cites this paper
• Touch and Go: Membrane Contact Sites Between Lipid Droplets and Other Organelles

  2022influential citation
• Motility Plays an Important Role in the Lifetime of Mammalian Lipid Droplets

  2021cites this paper
• Lipid Storage and Interferon Response Determine the Phenotype of Ground Glass Hepatocytes in Mice and Humans

  2021cites this paper
• Schisantherin A improves learning and memory abilities partly through regulating the Nrf2/Keap1/ARE signaling pathway in chronic fatigue mice

  2021cites this paper
• DGAT1 inhibitors protect pancreatic β-cells from palmitic acid-induced apoptosis

  2020cites this paper
• Lipid droplets throughout the evolutionary tree.

  2020cites this paper
• Suppression of IRE1α Attenuated the Fatty Degeneration in Parenteral Nutrition-Related Liver Disease (PNALD) Cell Model

  2020cites this paper
• Alcohol effects on hepatic lipid metabolism

  2020cites this paper
• RalA and PLD1 promote lipid droplet growth in response to nutrient withdrawal

  2020cites this paper
• DGAT1 inhibitors protect pancreatic β-cells from palmitic acid-induced apoptosis

  2020cites this paper
• Lipid Droplet Motility and Organelle Contacts

  2019cites this paper