Sequential activation and distinct functions for distal and proximal modules within the IgH 3′ regulatory region

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2016-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/pnas.1514090113PMID 26831080PMCID PMC4760834
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Elucidation of IgH 3′ region regulatory role during class switch recombination via germline deletion

  2015cited by this paper
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• RNA exosome-regulated long non-coding RNA transcription controls super-enhancer activity.

  2015cited by this paper
• CTCF-binding elements 1 and 2 in the Igh intergenic control region cooperatively regulate V(D)J recombination

  2015cited by this paper
• Epigenetic Regulation of Individual Modules of the immunoglobulin heavy chain locus 3′ Regulatory Region

  2014cited by this paper
• The Eμ Enhancer Region Influences H Chain Expression and B Cell Fate without Impacting IgVH Repertoire and Immune Response In Vivo

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• CTCF and ncRNA Regulate the Three-Dimensional Structure of Antigen Receptor Loci to Facilitate V(D)J Recombination

  2014cited by this paper
• Spt5 accumulation at variable genes distinguishes somatic hypermutation in germinal center B cells from ex vivo–activated cells

  2014cited by this paper
• Transgenes of the Mouse Immunoglobulin Heavy Chain Locus, Lacking Distal Elements in the 3′ Regulatory Region, Are Impaired for Class Switch Recombination

  2013cited by this paper
• 4C-ing the Igh Landscape.

  2013cited by this paper
• The IgH 3′ regulatory region controls somatic hypermutation in germinal center B cells

  2013cited by this paper
• Flexible long-range loops in the VH gene region of the Igh locus facilitate the generation of a diverse antibody repertoire.

  2013cited by this paper
• AID-Driven Deletion Causes Immunoglobulin Heavy Chain Locus Suicide Recombination in B Cells

  2012cited by this paper
• Preparing Targets for V(D)J Recombinase: Transcription Paves the Way

  2012cited by this paper
• Germline Deletion of Igh 3′ Regulatory Region Elements hs 5, 6, 7 (hs5–7) Affects B Cell-Specific Regulation, Rearrangement, and Insulation of the Igh Locus

  2012cited by this paper
• Enhancers Located in Heavy Chain Regulatory Region (hs3a, hs1,2, hs3b, and hs4) Are Dispensable for Diversity of VDJ Recombination*

  2012cited by this paper
• CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells

  2011cited by this paper
• CTCF Binding Elements Mediate Control of V(D)J Recombination

  2011cited by this paper
• Homologous Elements hs3a and hs3b in the 3′ Regulatory Region of the Murine Immunoglobulin Heavy Chain (Igh) Locus Are Both Dispensable for Class-switch Recombination*

  2011cited by this paper
• Enhancement of Antibody Class-Switch Recombination by the Cumulative Activity of Four Separate Elements

  2011cited by this paper
• Position and sequence conservation in Amniota of polymorphic enhancer HS1.2 within the palindrome of IgH 3'Regulatory Region

  2011cited by this paper
• The IgH locus 3' regulatory region: pulling the strings from behind.

  2011cited by this paper
• In Vivo Redundant Function of the 3′ IgH Regulatory Element HS3b in the Mouse

  2010cited by this paper
• The Mouse Immunoglobulin Heavy Chain V-D Intergenic Sequence Contains Insulators That May Regulate Ordered V(D)J Recombination

  2010cited by this paper
• Genomic deletion of the whole IgH 3' regulatory region (hs3a, hs1,2, hs3b, and hs4) dramatically affects class switch recombination and Ig secretion to all isotypes.

  2010cited by this paper
• Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination

  2010cited by this paper
• Faculty Opinions recommendation of Cutting edge: developmental stage-specific recruitment of cohesin to CTCF sites throughout immunoglobulin loci during B lymphocyte development.

  2009cited by this paper
• Switch recombination and somatic hypermutation are controlled by the heavy chain 3′ enhancer region

  2009influential reference
• Ikaros controls isotype selection during immunoglobulin class switch recombination

  2009cited by this paper
• Cutting Edge: Developmental Stage-Specific Recruitment of Cohesin to CTCF Sites throughout Immunoglobulin Loci during B Lymphocyte Development1

  2009cited by this paper
• A role for the IgH intronic enhancer Eμ in enforcing allelic exclusion

  2009cited by this paper
• Ig Synthesis and Class Switching Do Not Require the Presence of the hs4 Enhancer in the 3′ IgH Regulatory Region1

  2009cited by this paper
• HoxC4 binds to the Aicda promoter to induce AID expression, class switch DNA recombination and somatic hypermutation

  2009cited by this paper
• The 3D structure of the immunoglobulin heavy-chain locus: implications for long-range genomic interactions.

  2008cited by this paper
• Cis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus.

  2008cited by this paper
• Antibody class switching differs among SJL, C57BL/6 and 129 mice.

  2007cited by this paper
• Antisense Intergenic Transcription Precedes Igh D-to-J Recombination and Is Controlled by the Intronic Enhancer Eμ

  2007cited by this paper
• Regulation of IgH Gene Assembly: Role of the Intronic Enhancer and 5′DQ52 Region in Targeting DHJH Recombination1

  2006cited by this paper
• Analysis of transforming growth factor‐β1‐induced Ig germ‐line γ2b transcription and its implication for IgA isotype switching

  2005cited by this paper
• Chromatin Architecture near a Potential 3′ End of the Igh Locus Involves Modular Regulation of Histone Modifications during B-Cell Development and In Vivo Occupancy at CTCF Sites

  2005cited by this paper
• Comparative analysis of human and mouse 3' Igh regulatory regions identifies distinctive structural features.

  2005cited by this paper
• Elucidation of IgH intronic enhancer functions via germ-line deletion.

  2005cited by this paper
• The immunoglobulin heavy-chain locus hs3b and hs4 3' enhancers are dispensable for VDJ assembly and somatic hypermutation.

  2003cited by this paper
• The human genome browser at UCSC.

  2002cited by this paper
• Localization of the 3' IgH locus elements that effect long-distance regulation of class switch recombination.

  2001cited by this paper
• Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions.

  1999cited by this paper
• Class Switching in B Cells Lacking 3′ Immunoglobulin Heavy Chain Enhancers

  1998cited by this paper
• Dyad symmetry within the mouse 3' IgH regulatory region includes two virtually identical enhancers (C alpha3'E and hs3).

  1997cited by this paper
• In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death.

  1997cited by this paper
• Palindromic structure of the IgH 3′locus control region

  1996cited by this paper

• Core regions in immunoglobulin heavy chain enhancers essential for survival of non-Hodgkin lymphoma cells are identified by a CRISPR interference screen

  2024cites this paper
• Core enhancers of the 3′RR optimize IgH nuclear position and loop conformation for successful oriented class switch recombination

  2024cites this paper
• Variation of the 3’RR1 HS1.2 Enhancer and Its Genomic Context

  2024cites this paper
• Roles of G4-DNA and G4-RNA in Class Switch Recombination and Additional Regulations in B-Lymphocytes

  2023cites this paper
• Core enhancers of the 3’RR optimize IgH nuclear position and loop conformation for oriented CSR

  2023cites this paper
• How Estrogen, Testosterone, and Sex Differences Influence Serum Immunoglobulin Isotype Patterns in Mice and Humans

  2023cites this paper
• New insight of human-IgH 3'Regulatory Regions in immunoglobulins switch.

  2023cites this paper
• A dual function for the chromatin organizer Special A-T rich Binding Protein 1 in B-lineage cells

  2022cites this paper
• Contribution of Immunoglobulin Enhancers to B Cell Nuclear Organization

  2022cites this paper
• Enhancing B-Cell Malignancies—On Repurposing Enhancer Activity towards Cancer

  2021cites this paper
• Long-Range Control of Class Switch Recombination by Transcriptional Regulatory Elements

  2021influential citation
• Panorama of stepwise involvement of the IgH 3' regulatory region in murine B cells.

  2021cites this paper
• Concerted variation of the 3' regulatory region of Ig heavy chain and Gm haplotypes across human continental populations.

  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018influential citation
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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