Somatic hypermutation in variable heavy chain rearranged regions is abrogated in the absence of the 3′ regulatory region enhancer, whereas transcription rate in the Ig heavy chain is only partially reduced.
The IgH 3′ regulatory region controls somatic hypermutation in germinal center B cells
Pauline Rouaud,C. Vincent-Fabert,A. Saintamand,Rémi Fiancette,M. Marquet,I. Robert,B. Reina-San-Martin,E. Pinaud,M. Cogné,Y. Denizot
Published 2013 in Journal of Experimental Medicine
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- Publication year
2013
- Venue
Journal of Experimental Medicine
- Publication date
2013-07-29
- Fields of study
Biology, Medicine
- Identifiers
- External record
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Semantic Scholar, PubMed
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