The IgH 3′ regulatory region controls somatic hypermutation in germinal center B cells

Pauline Rouaud,C. Vincent-Fabert,A. Saintamand,Rémi Fiancette,M. Marquet,I. Robert,B. Reina-San-Martin,E. Pinaud,M. Cogné,Y. Denizot

Published 2013 in Journal of Experimental Medicine

ABSTRACT

Somatic hypermutation in variable heavy chain rearranged regions is abrogated in the absence of the 3′ regulatory region enhancer, whereas transcription rate in the Ig heavy chain is only partially reduced.

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