Hemodynamic and cellular response feedback in calcific aortic valve disease.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Circulation Research

• Publication date

  2013-07-05

• Fields of study

  Medicine

• Identifiers
  DOI 10.1161/CIRCRESAHA.112.300154PMID 23833293
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The progression of calcific aortic valve disease through injury, cell dysfunction, and disruptive biologic and physical force feedback loops.

  2013cited by this paper
• Microdevice array-based identification of distinct mechanobiological response profiles in layer-specific valve interstitial cells.

  2013cited by this paper
• Activation of vascular p38MAPK by mechanical stretch is independent of c-Src and NADPH oxidase: influence of hypertension and angiotensin II.

  2012cited by this paper
• Cyclic strain anisotropy regulates valvular interstitial cell phenotype and tissue remodeling in three-dimensional culture.

  2012cited by this paper
• In Vitro Characterization of Bicuspid Aortic Valve Hemodynamics Using Particle Image Velocimetry

  2012cited by this paper
• Experimental measurement of dynamic fluid shear stress on the ventricular surface of the aortic valve leaflet

  2012cited by this paper
• Experimental measurement of dynamic fluid shear stress on the aortic surface of the aortic valve leaflet

  2012cited by this paper
• Elevated cyclic stretch and serotonin result in altered aortic valve remodeling via a mechanosensitive 5-HT(2A) receptor-dependent pathway.

  2012cited by this paper
• A novel technique for quantifying mouse heart valve leaflet stiffness with atomic force microscopy.

  2012cited by this paper
• Small peptide functionalized thiol-ene hydrogels as culture substrates for understanding valvular interstitial cell activation and de novo tissue deposition.

  2012cited by this paper
• Effect of Geometry on the Leaflet Stresses in Simulated Models of Congenital Bicuspid Aortic Valves

  2011cited by this paper
• Progenitor Cells Confer Plasticity to Cardiac Valve Endothelium

  2011cited by this paper
• Preferential Activation of SMAD1/5/8 on the Fibrosa Endothelium in Calcified Human Aortic Valves - Association with Low BMP Antagonists and SMAD6

  2011cited by this paper
• Discovery of shear- and side-specific mRNAs and miRNAs in human aortic valvular endothelial cells.

  2011cited by this paper
• Recruitment of bone marrow-derived valve interstitial cells is a normal homeostatic process.

  2011cited by this paper
• Measurement of layer-specific mechanical properties in multilayered biomaterials by micropipette aspiration.

  2011cited by this paper
• The aortic valve microenvironment and its role in calcific aortic valve disease.

  2011cited by this paper
• The Effects of Combined Cyclic Stretch and Pressure on the Aortic Valve Interstitial Cell Phenotype

  2011cited by this paper
• Combining Dynamic Stretch and Tunable Stiffness to Probe Cell Mechanobiology In Vitro

  2011cited by this paper
• Cell–Matrix Interactions in the Pathobiology of Calcific Aortic Valve Disease: Critical Roles for Matricellular, Matricrine, and Matrix Mechanics Cues

  2011cited by this paper
• &bgr;-Catenin Mediates Mechanically Regulated, Transforming Growth Factor-&bgr;1–Induced Myofibroblast Differentiation of Aortic Valve Interstitial Cells

  2011cited by this paper
• Aortic valve cyclic stretch causes increased remodeling activity and enhanced serotonin receptor responsiveness.

  2011cited by this paper
• Inhibition of Pathological Differentiation of Valvular Interstitial Cells by C-Type Natriuretic Peptide

  2011cited by this paper
• Endothelial Heterogeneity Associated with Regional Athero-Susceptibility and Adaptation to Disturbed Blood Flow in Vivo

  2010cited by this paper
• Dynamic deformation characteristics of porcine aortic valve leaflet under normal and hypertensive conditions.

  2010cited by this paper
• Hypercholesterolemia Induces Side-Specific Phenotypic Changes and Peroxisome Proliferator–Activated Receptor-&ggr; Pathway Activation in Swine Aortic Valve Endothelium

  2010cited by this paper
• In situ elasticity modulation with dynamic substrates to direct cell phenotype.

  2010cited by this paper
• Regulation of valvular interstitial cell calcification by adhesive peptide sequences.

  2010cited by this paper
• Calcification by Valve Interstitial Cells Is Regulated by the Stiffness of the Extracellular Matrix

  2009cited by this paper
• Inhibition of calcifying nodule formation in cultured porcine aortic valve cells by nitric oxide donors.

  2009cited by this paper
• Elevated cyclic stretch alters matrix remodeling in aortic valve cusps: implications for degenerative aortic valve disease.

  2009cited by this paper
• Endothelium-dependent regulation of the mechanical properties of aortic valve cusps.

  2009cited by this paper
• On the biomechanics of heart valve function.

  2009cited by this paper
• Altered Shear Stress Stimulates Upregulation of Endothelial VCAM-1 and ICAM-1 in a BMP-4– and TGF-&bgr;1–Dependent Pathway

  2009cited by this paper
• Identification and characterization of aortic valve mesenchymal progenitor cells with robust osteogenic calcification potential.

  2009cited by this paper
• The effect of enzymatically degradable poly(ethylene glycol) hydrogels on smooth muscle cell phenotype.

  2008cited by this paper
• Aortic Valve: From Function to Tissue Engineering

  2008cited by this paper
• Substrate properties influence calcification in valvular interstitial cell culture.

  2008cited by this paper
• Evolving Concepts of Cardiac Valve Dynamics: The Continuum of Development, Functional Structure, Pathobiology, and Tissue Engineering

  2008cited by this paper
• Cofilin is a marker of myofibroblast differentiation in cells from porcine aortic cardiac valves.

  2008cited by this paper
• Mechanobiology of the aortic heart valve.

  2008cited by this paper
• Bone formation in cardiac valves: a histopathological study of 128 cases

  2007cited by this paper
• Molecular and functional characteristics of heart-valve interstitial cells

  2007influential reference
• Synergistic effects of cyclic tension and transforming growth factor-beta1 on the aortic valve myofibroblast.

  2007influential reference
• Valvular endothelial cells and the mechanoregulation of valvular pathology

  2007cited by this paper
• Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix

  2007cited by this paper
• Formation and function of the myofibroblast during tissue repair.

  2007cited by this paper
• Macromolecular transport in heart valves. I. Studies of rat valves with horseradish peroxidase.

  2007cited by this paper
• Matrix-dependent adhesion of vascular and valvular endothelial cells in microfluidic channels.

  2007cited by this paper
• In-situ deformation of the aortic valve interstitial cell nucleus under diastolic loading.

  2007cited by this paper
• Distinct Downregulation of C-Type Natriuretic Peptide System in Human Aortic Valve Stenosis

  2007cited by this paper
• Interstitial cells from the atrial and ventricular sides of the bovine mitral valve respond differently to denuding endocardial injury

  2007cited by this paper
• Analytical modeling of the instantaneous maximal transvalvular pressure gradient in aortic stenosis.

  2006cited by this paper
• An Ex Vivo Study of the Biological Properties of Porcine Aortic Valves in Response to Circumferential Cyclic Stretch

  2006cited by this paper
• Valvular Endothelial Cells Regulate the Phenotype of Interstitial Cells in Co-culture: Effects of Steady Shear Stress

  2006cited by this paper
• Natriuretic peptides, their receptors, and cyclic guanosine monophosphate-dependent signaling functions.

  2006cited by this paper
• Human Semilunar Cardiac Valve Remodeling by Activated Cells From Fetus to Adult: Implications for Postnatal Adaptation, Pathology, and Tissue Engineering

  2006cited by this paper
• Cyclic pressure and shear stress regulate matrix metalloproteinases and cathepsin activity in porcine aortic valves.

  2006cited by this paper
• Valvular aortic stenosis: disease severity and timing of intervention.

  2006influential reference
• Cellular mechanotransduction: putting all the pieces together again

  2006influential reference
• Transcriptional Profiles of Valvular and Vascular Endothelial Cells Reveal Phenotypic Differences: Influence of Shear Stress

  2006cited by this paper
• The flexural rigidity of the aortic valve leaflet in the commissural region.

  2006cited by this paper
• The effects of cellular contraction on aortic valve leaflet flexural stiffness.

  2006cited by this paper
• An In Vivo Analysis of Hematopoietic Stem Cell Potential: Hematopoietic Origin of Cardiac Valve Interstitial Cells

  2006cited by this paper
• Spatial Heterogeneity of Endothelial Phenotypes Correlates With Side-Specific Vulnerability to Calcification in Normal Porcine Aortic Valves

  2005cited by this paper
• Activation of valvular interstitial cells is mediated by transforming growth factor-beta1 interactions with matrix molecules.

  2005cited by this paper
• Serum deprivation improves seeding and repopulation of acellular matrices with valvular interstitial cells.

  2005cited by this paper
• Spectrum of Calcific Aortic Valve Disease: Pathogenesis, Disease Progression, and Treatment Strategies

  2005influential reference
• Crosslinked hyaluronan scaffolds as a biologically active carrier for valvular interstitial cells.

  2005cited by this paper
• On the biaxial mechanical properties of the layers of the aortic valve leaflet.

  2005cited by this paper
• Analytical modeling of the instantaneous pressure gradient across the aortic valve.

  2005cited by this paper
• Presence of a smooth muscle system in aortic valve leaflets

  2004cited by this paper
• Dynamic and reversible changes of interstitial cell phenotype during remodeling of cardiac valves.

  2004cited by this paper
• Valvular Myofibroblast Activation by Transforming Growth Factor-&bgr;: Implications for Pathological Extracellular Matrix Remodeling in Heart Valve Disease

  2004cited by this paper
• Native aortic valve thrombosis: a rare cause of acute ischemia of the lower limb.

  2004cited by this paper
• Unique Morphology and Focal Adhesion Development of Valvular Endothelial Cells in Static and Fluid Flow Environments

  2004cited by this paper
• Progression of aortic valve stenosis: TGF-beta1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis.

  2003cited by this paper
• Aortic valve sclerosis is associated with systemic endothelial dysfunction.

  2003cited by this paper
• Human Aortic Valve Calcification Is Associated With an Osteoblast Phenotype

  2003cited by this paper
• Computational analyses of mechanically induced collagen fiber remodeling in the aortic heart valve.

  2003cited by this paper
• Transcriptional profiling and growth kinetics of endothelium reveals differences between cells derived from porcine aorta versus aortic valve.

  2003cited by this paper
• Smoothelin-positive cells in human and porcine semilunar valves

  2003cited by this paper
• Flow, NO, and atherogenesis

  2003cited by this paper
• Myofibroblasts and mechano-regulation of connective tissue remodelling

  2002cited by this paper
• Bone Formation and Inflammation in Cardiac Valves

  2001cited by this paper
• Activated Interstitial Myofibroblasts Express Catabolic Enzymes and Mediate Matrix Remodeling in Myxomatous Heart Valves

  2001cited by this paper
• Evaluation and Management of Chronic Mitral Regurgitation

  2001cited by this paper
• Clinical practice. Evaluation and management of chronic mitral regurgitation.

  2001cited by this paper
• Fluid shear stress increases membrane fluidity in endothelial cells: a study with DCVJ fluorescence.

  2000cited by this paper
• Expression of endothelial cell adhesion molecules on heart valves: up‐regulation in degeneration as well as acute endocarditis

  2000cited by this paper
• Phenotypic and functional characterization of interstitial cells from human heart valves, pericardium and skin.

  2000cited by this paper
• Adhesion molecules in nonrheumatic aortic valve disease: endothelial expression, serum levels and effects of valve replacement.

  2000cited by this paper
• Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress.

  2000cited by this paper
• Transient and steady-state effects of shear stress on endothelial cell adherens junctions.

  1999cited by this paper
• Founder's Award, 25th Annual Meeting of the Society for Biomaterials, perspectives. Providence, RI, April 28-May 2, 1999. Tissue heart valves: current challenges and future research perspectives.

  1999cited by this paper
• Shear Stress Induction of C-type Natriuretic Peptide (CNP) in Endothelial Cells is Independent of NO Autocrine Signaling

  1999cited by this paper
• Endothelial-dependent dynamic and antithrombotic properties of porcine aortic and pulmonary valves.

  1998cited by this paper
• A small angle light scattering device for planar connective tissue microstructural analysis

  1997cited by this paper
• Heparin-binding domain of fibrin mediates its binding to endothelial cells.

  1996cited by this paper
• Nitric oxide release from porcine mitral valves.

  1993cited by this paper

• Evaluating caplacizumab's potential to mitigate thrombosis risk in aortic valve stenosis: a microfluidic and computational approach.

  2025cites this paper
• Intrinsic Phenotypic Differences, Not Hemodynamic Shear, Associate with Cusp-Specific Remodeling in Aortic Valve Disease

  2025cites this paper
• Relationship Between Aortic Valve and Mitral Annular Calcification With Coronary Artery Calcification in Asymptomatic Individuals: Cross-Sectional and Longitudinal Analyses

  2025cites this paper
• A Fluid-Structure Interaction Model of the Zebrafish Aortic Valve.

  2024cites this paper
• Correlation between staging classification of aortic stenosis based on the extent of cardiac damage and platelet indices

  2024cites this paper
• Physical properties of Korean normal aortic valves based on fluid–structure interactions

  2024cites this paper
• Low Intraocular Pressure Induces Fibrotic Changes in the Trabecular Meshwork and Schlemm's Canal of Sprague Dawley Rats

  2024cites this paper
• Current Management and Therapy of Severe Aortic Stenosis and Future Perspective

  2024cites this paper
• Beyond VICs: Shedding light on the overlooked VECs in calcific aortic valve disease.

  2024cites this paper
• Recent advances in targeted therapy for inflammatory vascular diseases.

  2024cites this paper
• Investigation of autophagy‑related genes and immune infiltration in calcific aortic valve disease: A bioinformatics analysis and experimental validation

  2024cites this paper
• Endothelial dysfunction and cardiovascular diseases: The role of human induced pluripotent stem cells and tissue engineering.

  2024cites this paper
• Albumin Thiolation and Oxidative Stress Status in Patients with Aortic Valve Stenosis

  2023cites this paper
• Rho A/ROCK1 signaling-mediated metabolic reprogramming of valvular interstitial cells toward Warburg effect accelerates aortic valve calcification via AMPK/RUNX2 axis

  2023cites this paper
• Oxidative stress and valvular endothelial cells in aortic valve calcification.

  2023cites this paper
• Influence of Aortic Valve Stenosis and Wall Shear Stress on Platelets Function

  2023cites this paper
• Predicting key gene related to immune infiltration and myofibroblast-like valve interstitial cells in patients with calcified aortic valve disease based on bioinformatics analysis

  2023cites this paper
• Lp(a) in the Pathogenesis of Aortic Stenosis and Approach to Therapy with Antisense Oligonucleotides or Short Interfering RNA

  2023cites this paper
• The Role of Endoplasmic Reticulum Stress in Calcific Aortic Valve Disease.

  2023cites this paper
• Variability in structure, morphology, and mechanical properties of the descending thoracic and infrarenal aorta around their circumference.

  2023cites this paper
• [Optimal time window for observation of calcific aortic valve disease in mice following catheter-induced valve injury].

  2022cites this paper
• Lipoprotein(a), a Lethal Player in Calcific Aortic Valve Disease

  2022cites this paper
• Prognosis and risk factors for cardiac valve calcification in Chinese end-stage kidney disease patients on combination therapy with hemodialysis and hemodiafiltration

  2022cites this paper
• Bioinformatics and Machine Learning Methods to Identify FN1 as a Novel Biomarker of Aortic Valve Calcification

  2022cites this paper
• Elevated N-terminal pro C-type natriuretic peptide is associated with mortality in patients undergoing transcatheter aortic valve replacement

  2022cites this paper
• Potential ferroptosis key genes in calcific aortic valve disease

  2022cites this paper
• Different calcification patterns of tricuspid and bicuspid aortic valves and their clinical impact

  2022cites this paper
• Heart Valve Bioengineering

  2021cites this paper
• New calcification model for intact murine aortic valves.

  2021cites this paper
• Aortic valve cell microenvironment: Considerations for developing a valve-on-chip.

  2021cites this paper
• Role of Runx2 in Calcific Aortic Valve Disease in Mouse Models

  2021cites this paper
• Tgfβ1-Cthrc1 Signaling Plays an Important Role in the Short-Term Reparative Response to Heart Valve Endothelial Injury

  2021cites this paper
• Computational Analysis of Wall Shear Stress Patterns on Calcified and Bicuspid Aortic Valves: Focus on Radial and Coaptation Patterns

  2021cites this paper
• Calcific Aortic Stenosis—A Review on Acquired Mechanisms of the Disease and Treatments

  2021cites this paper
• Micromechanical force promotes aortic valvular calcification.

  2021cites this paper
• Self-eating and Heart: The Emerging Roles of Autophagy in Calcific Aortic Valve Disease

  2021cites this paper
• Fluid Flow Characteristics of Healthy and Calcified Aortic Valves Using Three-Dimensional Lagrangian Coherent Structures Analysis

  2021cites this paper
• Superimposed Tissue Formation in Human Aortic Valve Disease: Differences between Regurgitant and Stenotic Valves

  2021cites this paper
• NOTCH Signaling in Aortic Valve Development and Calcific Aortic Valve Disease

  2021cites this paper
• Protective Effects of Fucoxanthin on Hydrogen Peroxide-Induced Calcification of Heart Valve Interstitial Cells

  2021cites this paper
• Predicting the Key Genes Involved in Aortic Valve Calcification Through Integrated Bioinformatics Analysis

  2021cites this paper
• Air pollution and human health risks: mechanisms and clinical manifestations of cardiovascular and respiratory diseases

  2021cites this paper
• Recent progress toward clinical translation of tissue engineered heart valves.

  2021cites this paper
• miR-214 Attenuates Aortic Valve Calcification by Regulating Osteogenic Differentiation of Valvular Interstitial Cells

  2020cites this paper
• Transcriptional Profiling of Normal, Stenotic, and Regurgitant Human Aortic Valves

  2020cites this paper
• Effect of Left and Right Coronary Flow Waveforms on Aortic Sinus Hemodynamics and Leaflet Shear Stress: Correlation with Calcification Locations

  2020cites this paper
• Prevalence and risk factors of aortic stenosis and aortic sclerosis: a 21-year follow-up of middle-aged men

  2020cites this paper
• Stembell Therapy Reduces Macrophages in Atherosclerotic Aortic Valves after Myocardial Infarction

  2020cites this paper
• Developmental Pathways and Aortic Valve Calcification

  2020cites this paper
• Dynamic changes in platelets caused by shear stress in aortic valve stenosis

  2020cites this paper
• Tissue engineered heart valves for transcatheter aortic valve implantation: current state, challenges, and future developments

  2020cites this paper
• Age related extracellular matrix and interstitial cell phenotype in pulmonary valves

  2020cites this paper
• Prognosis and risk factors of cardiac valve calcification in Chinese end-stage renal disease patients

  2020cites this paper
• Role of Interleukin 17A in Aortic Valve Inflammation in Apolipoprotein E-deficient Mice

  2020cites this paper
• Platelet Membrane-Coated Nanoparticles Target Sclerotic Aortic Valves in ApoE−/− Mice by Multiple Binding Mechanisms Under Pathological Shear Stress

  2020cites this paper
• Development of calcific aortic valve disease: Do we know enough for new clinical trials?

  2019cites this paper
• [Galectin-3 as a novel biotarget in cardiovascular alterations associated to development of severe aortic stenosis].

  2019cites this paper
• Inactivation of platelet-derived TGF-β1 attenuates aortic stenosis progression in a robust murine model.

  2019cites this paper
• From Biology to Clinical Management: An Update on Aortic Valve Disease

  2019cites this paper
• Tissue-engineered heart valves

  2019cites this paper
• Cellular Stretching Device 2019

  2019influential citation
• Spatial Regulation of Valve Interstitial Cell Phenotypes within Three-Dimensional Micropatterned Hydrogels.

  2019cites this paper
• Diagnostic and Therapeutic Targets for Aortic Valve and Ascending Aorta Pathologies: Challenges and Opportunities

  2019cites this paper
• Cardiovascular tissue engineering: From basic science to clinical application

  2019cites this paper
• miR-214 is Stretch-Sensitive in Aortic Valve and Inhibits Aortic Valve Calcification

  2019cites this paper
• New insights into mechanical regulation of valve disease and regeneration

  2018cites this paper
• Cardiovascular risk factors in aortic stenosis

  2018cites this paper
• Advances in Pathophysiology of Calcific Aortic Valve Disease Propose Novel Molecular Therapeutic Targets

  2018cites this paper
• TGF-β Signaling in Control of Cardiovascular Function.

  2018cites this paper
• The Roles of Matrix Stiffness and ß-Catenin Signaling in Endothelial-to-Mesenchymal Transition of Aortic Valve Endothelial Cells

  2018cites this paper
• Deletion of calponin 2 attenuates the development of calcific aortic valve disease in ApoE-/- mice.

  2018cites this paper
• Editorial: Special Issue on Heart Valve Mechanobiology

  2018cites this paper
• The Genetic Regulation of Aortic Valve Development and Calcific Disease

  2018cites this paper
• Utilizing Combinatorial Screening Platforms and Modelling Techniques to Predict Optimal Design Conditions for 3D Mesenchymal Stromal Cell Based Heart Valve Tissue Engineering

  2018cites this paper
• Endothelial to mesenchymal transformation is induced by altered extracellular matrix in aortic valve endothelial cells.

  2017cites this paper
• Application of a new procedure for liquid chromatography/mass spectrometry profiling of plasma amino acid-related metabolites and untargeted shotgun proteomics to identify mechanisms and biomarkers of calcific aortic stenosis.

  2017cites this paper
• Integrated Bioinformatics Analysis Predicts the Key Genes Involved in Aortic Valve Calcification: From Hemodynamic Changes to Extracellular Remodeling.

  2017cites this paper
• Beneficial Effects of Galectin-3 Blockade in Vascular and Aortic Valve Alterations in an Experimental Pressure Overload Model

  2017cites this paper
• A correlation between long-term in vitro dynamic calcification and abnormal flow patterns past bioprosthetic heart valves

  2017cites this paper
• Specific changes in circulating cytokines and growth factors induced by exercise stress testing in asymptomatic aortic valve stenosis

  2017cites this paper
• A strain-based finite element model for calcification progression in aortic valves.

  2017cites this paper
• Mécanismes physiopathologiques du rétrécissement aortique calcifié

  2017cites this paper
• Multiscale Systems Biology Model of Calcific Aortic Valve Disease Progression.

  2017cites this paper
• Pathology of aortic valve remodeling after continuous-flow left ventricular assist device support.

  2017cites this paper
• Association Between Cardiovascular Risk Factors and Aortic Stenosis: The CANHEART Aortic Stenosis Study.

  2017cites this paper
• A correlation between long-term in vitro dynamic calcification and abnormal flow patterns past bioprosthetic heart valves

  2017cites this paper
• Molecular and Cellular Mechanobiology

  2016cites this paper
• Valve interstitial cell contractile strength and metabolic state are dependent on its shape.

  2016cites this paper
• Valve interstitial cell shape modulates cell contractility independent of cell phenotype.

  2016cites this paper
• Heart valve regeneration: the need for systems approaches

  2016cites this paper
• Osteogenesis in calcified aortic valve disease: From histopathological observation towards molecular understanding.

  2016cites this paper
• Heart valve health, disease, replacement, and repair: a 25-year cardiovascular pathology perspective.

  2016cites this paper
• Myocardial blood flow reserve is impaired in patients with aortic valve calcification and unobstructed epicardial coronary arteries.

  2016cites this paper
• Sélection in vivo par phage display dans un modèle de sténose valvulaire aortique chez la souris pour la découverte de nouveaux peptides ciblant la valve aortique

  2016cites this paper
• Heart Valve Mechanobiology in Development and Disease

  2016cites this paper
• Translating calcified aortic valve disease to the bench - Use of 3D matrices in the development of future treatment strategies.

  2016cites this paper
• Biomechanical conditioning of tissue engineered heart valves: Too much of a good thing?

  2016cites this paper
• Integrated microRNA and messenger RNA analysis in aortic stenosis

  2016cites this paper
• Shear-Sensitive Genes in Aortic Valve Endothelium

  2016cites this paper
• Hemodynamics and Mechanobiology of Aortic Valve Calcification

  2016cites this paper