The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Current Biology

• Publication date

  2005-05-24

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.CUB.2005.04.018PMID 15916949
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• TRP ion channels in the nervous system.

  2004cited by this paper
• Thermosensation and pain.

  2004cited by this paper
• Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin.

  2004cited by this paper
• Aversion of European starlings (Sturnus vulgaris) to garlic oil treated granules: garlic oil as an avian repellent. Garlic oil analysis by nuclear magnetic resonance spectroscopy.

  2004cited by this paper
• Anticarcinogenic Properties of Garlic: A Review

  2004cited by this paper
• Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1

  2004cited by this paper
• ThermoTRP channels and beyond: mechanisms of temperature sensation

  2003cited by this paper
• Antibacterial activity of vegetables and juices.

  2003cited by this paper
• ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures.

  2003cited by this paper
• Lessons from peppers and peppermint: the molecular logic of thermosensation.

  2003cited by this paper
• Comparative study of extraction techniques for determination of garlic flavor components by gas chromatography–mass spectrometry

  2003cited by this paper
• Molecular basis for species-specific sensitivity to "hot" chili peppers.

  2002cited by this paper
• Identification of a cold receptor reveals a general role for TRP channels in thermosensation

  2002cited by this paper
• A cold‐ and menthol‐activated current in rat dorsal root ganglion neurones: properties and role in cold transduction

  2002cited by this paper
• A TRP channel that senses cold stimuli and menthol.

  2002cited by this paper
• Effect of garlic on cardiovascular disorders: a review

  2002cited by this paper
• Intake of garlic and its bioactive components.

  2001cited by this paper
• Enhanced immunocompetence by garlic: role in bladder cancer and other malignancies.

  2001cited by this paper
• Impaired nociception and pain sensation in mice lacking the capsaicin receptor.

  2000cited by this paper
• Measurement of [Ca2+] using the Fluorometric Imaging Plate Reader (FLIPR).

  1999cited by this paper
• The cloned capsaicin receptor integrates multiple pain-producing stimuli.

  1998cited by this paper
• The capsaicin receptor: a heat-activated ion channel in the pain pathway

  1997cited by this paper
• The Organosulfur Chemistry of the Genus Allium – Implications for the Organic Chemistry of Sulfur

  1992cited by this paper
• February

  1988cited by this paper
• The chemistry of garlic and onions.

  1985influential reference
• Repellent property of oil fraction of garlic, Allium sativum Linn.

  1974cited by this paper

• TRPA1 as a Key Regulator of Keratinocyte Homeostasis and Inflammation in Human Skin

  2026cites this paper
• Transient Receptor Potential channels (TRP) in GtoPdb v.2025.4

  2025cites this paper
• TRP Channels from Sensory Coding to Physiology

  2025cites this paper
• Physiological functions and pharmacological targeting of transient receptor potential channels

  2025cites this paper
• Research Progress in Saltiness Perception and Salty Substitutes.

  2025cites this paper
• Antidiabetic potential of Allium sativum: A mini review

  2025cites this paper
• TRPV1 in Dorsal Root Ganglion Contributed to Chronic Pancreatitis Pain

  2025cites this paper
• Regulation of transient receptor potential ankyrin 1 by traditional Chinese medicine drugs and their active ingredients

  2025cites this paper
• Identification of Phialomustin‑B (PHL-B) as a Novel Natural TRPA1 Channel Inhibitor

  2025cites this paper
• The impact of enriching heat-stressed rabbit diets with flaxseed oil with/ without allicin, lycopene, or Punicalagin on antioxidative status, physiological response and meat omega-3

  2025cites this paper
• Differential modulation of polycystin-2 gain-of-function channels by cysteine-reactive compounds, amphiphilic substances, and S4-S5 linker mutations

  2025cites this paper
• Lacking TRPA1 cation channel impairs primary closure of a stromal incision injury in a mouse cornea.

  2025cites this paper
• New options for targeting TRPV1 receptors for cancer treatment: odorous Chinese herbal medicine

  2025cites this paper
• Identification of S-1-propenyl-L-cysteine as the catalytic product of AfGGT1 and a key intermediate in isoalliin biosynthesis in Allium fistulosum. L

  2025cites this paper
• Evolution of Temperature Receptors and Their Roles in Sensory Diversification and Adaptation

  2025cites this paper
• Antimicrobial effect of garlic-based mouthwash on dental caries-related oral microorganisms: A systematic review and meta-analysis.

  2025cites this paper
• Pharmacological manipulation of TRPC5 by kaempferol attenuates metastasis of gastrointestinal cancer via inhibiting calcium involved in the formation of filopodia

  2024cites this paper
• Functions of TRPs in retinal tissue in physiological and pathological conditions

  2024cites this paper
• Uncaria Rhynchophylla and hirsuteine as TRPV1 agonists inducing channel desensitization.

  2024cites this paper
• Visual analysis of global research on the transient receptor potential ankyrin 1 channel: A literature review from 2002 to 2022

  2024cites this paper
• Food drugs as drivers of therapeutic knowledge and the role of chemosensory qualities.

  2024cites this paper
• Nociceptive TRP channels function as molecular target for several antifungal drugs

  2024cites this paper
• Ligustilide covalently binds to Cys703 in the pre-S1 helix of TRPA1, blocking the opening of channel and relieving pain in rats with acute soft tissue injury.

  2024cites this paper
• The TRPA1 Ion Channel Mediates Oxidative Stress-Related Migraine Pathogenesis

  2024cites this paper
• Mechanosensitive channels in the mechanical component of the exercise pressor reflex.

  2023cites this paper
• Illuminating Airway Nerve Structure and Function in Chronic Cough

  2023cites this paper
• Garlic: Tracing its changing popularity in British cuisine

  2023cites this paper
• Counteract severe heat stress by including different forms of zinc in the rabbit bucks’ diet

  2023cites this paper
• Functional TRPA1 Channels Regulate CD56dimCD16+ NK Cell Cytotoxicity against Tumor Cells

  2023cites this paper
• Targeting temperature-sensitive transient receptor potential channels in hypertension: far beyond the perception of hot and cold

  2023cites this paper
• Reusable Electronic Tongue Based on Transient Receptor Potential Vanilloid 1 Nanodisc‐Conjugated Graphene Field‐Effect Transistor for a Spiciness‐Related Pain Evaluation

  2023cites this paper
• Allicin promotes functional recovery in ischemic stroke via glutathione peroxidase-1 activation of Src-Akt-Erk

  2023cites this paper
• Pungency Perception and the Interaction with Basic Taste Sensations: An Overview

  2023cites this paper
• Antimicrobial Efficacy of Phyto-L, Thiosulfonate from Allium spp. Containing Supplement, against Escherichia Coli Strains from Rabbits

  2023cites this paper
• Modulation of transient receptor potential (TRP) channels by plant derived substances used in over-the-counter cough and cold remedies

  2023cites this paper
• Inhaled Volatile Molecules-Responsive TRP Channels as Non-Olfactory Receptors

  2023cites this paper
• The expression of liver TNF-α gene, liver and small intestine histology of thermal stressed growing rabbits affected by allicin and lycopene.

  2023cites this paper
• TRP Channels in Cancer: Signaling Mechanisms and Translational Approaches

  2023cites this paper
• Thermogenic adipose tissue in energy regulation and metabolic health

  2023cites this paper
• Thermal illusions for thermal displays: a review

  2023cites this paper
• Natural Active Ingredients and TRPV1 Modulation: Focus on Key Chemical Moieties Involved in Ligand–Target Interaction

  2023cites this paper
• Ginger and Garlic Extracts Enhance Osteogenesis in 3D Printed Calcium Phosphate Bone Scaffolds with Bimodal Pore Distribution.

  2022cites this paper
• Lotus Seed Green Embryo Extract and a Purified Glycosyloxyflavone Constituent, Narcissoside, Activate TRPV1 Channels in Dorsal Root Ganglion Sensory Neurons.

  2022cites this paper
• Anti-myocardial Infarctus, Efficient Antipoison and Anti-prostate Mighty Spicy Miscellany

  2022cites this paper
• Are TRPA1 and TRPV1 Channel-mediated Signalling Cascades Involved in UVB Radiation-induced Sunburn?

  2022cites this paper
• Antinociceptive effect of garlic, garlic preparations and derivative compounds

  2022cites this paper
• Phytomicrobial Dietary Treatment Improves Growth Indices of Pigs

  2022cites this paper
• Slack Potassium Channels Modulate TRPA1-Mediated Nociception in Sensory Neurons

  2022cites this paper
• Agonistic/antagonistic properties of lactones in food flavors on the sensory ion channels TRPV1 and TRPA1.

  2022cites this paper
• Nociception and pain in humans lacking a functional TRPV1 channel

  2022cites this paper
• Species-specific activation of transient receptor potential ankyrin 1 by phthalic acid monoesters.

  2022cites this paper
• Flavor enhancement as a strategy to improve food liking in cancer patients with taste and smell alterations

  2022cites this paper
• Health benefits of bioactive components in pungent spices mediated via the involvement of TRPV1 channel

  2022cites this paper
• comprehensive ethnopharmacological review on onion, garlic and ginger

  2022cites this paper
• Lack of transient receptor potential ankyrin 1 (TRPA1) retards cutaneous wound healing in mice: A preliminary study

  2022cites this paper
• TRP channels: a journey towards a molecular understanding of pain

  2022cites this paper
• TRP channels in inflammatory bowel disease: potential therapeutic targets.

  2022cites this paper
• A Study of TRPA1 Activation via Covalent Electrophilic Modification of Cysteines

  2022cites this paper
• Identification of the NRF2 transcriptional network as a therapeutic target for trigeminal neuropathic pain

  2022cites this paper
• Extent of intrinsic disorder and NMR chemical shift assignments of the distal N-termini from human TRPV1, TRPV2 and TRPV3 ion channels

  2022cites this paper
• Allicin Facilitates Airway Surface Liquid Hydration by Activation of CFTR

  2022cites this paper
• Isolation of human TRPA1 channel from transfected HEK293 cells and identification of alkylation sites after sulfur mustard exposure

  2022cites this paper
• The Relationship of Adding Allicin Powder to Diet on Concentration of Glutathione Enzyme and Histological of Thymus Gland of Broiler

  2021cites this paper
• TRP Channels in Cancer Pain.

  2021cites this paper
• Transient Receptor Potential Channel Ankyrin 1: A Unique Regulator of Vascular Function

  2021cites this paper
• Analgesia for Sheep in Commercial Production: Where to Next?

  2021cites this paper
• Interactions between Chemesthesis and Taste: Role of TRPA1 and TRPV1

  2021influential citation
• Transient Receptor Potential Ankyrin 1 (TRPA1)—An Inflammation-Induced Factor in Human HaCaT Keratinocytes

  2021cites this paper
• The TRPA1 Agonist Cinnamaldehyde Induces the Secretion of HCO3− by the Porcine Colon

  2021cites this paper
• Allicin-rich garlic extract alleviates high-fat diet-induced complications in rats: A nutrigenomic study

  2021influential citation
• Allicin, the Odor of Freshly Crushed Garlic: A Review of Recent Progress in Understanding Allicin’s Effects on Cells

  2021cites this paper
• The Role of TRPA1 in Skin Physiology and Pathology

  2021cites this paper
• Allicin, a dietary trpa1 agonist, prevents high fat diet-induced dysregulation of gut hormones and associated complications.

  2021cites this paper
• Discoveries of receptors for temperature and touch

  2021cites this paper
• TRP Channels as Molecular Targets to Relieve Cancer Pain

  2021cites this paper
• The Calcium Signaling Mechanisms in Arterial Smooth Muscle and Endothelial Cells.

  2021cites this paper
• A Novel Quantitative Prediction Approach for Pungency Level of Chinese Liquor (Baijiu) Based on Infrared Thermal Imager

  2021cites this paper
• Capsaicinoids – Properties and Mechanisms of Pro-health Action

  2021cites this paper
• Chinese nutraceuticals and physical activity; their role in neurodegenerative tauopathies

  2021cites this paper
• The nutritional applications of garlic (Allium sativum) as natural feed additives in animals

  2021cites this paper
• Individual differences in responsiveness to oral sensations and odours with chemesthetic activity: Relationships between sensory modalities and impact on the hedonic response

  2021cites this paper
• Peripheral receptors and neuromediators involved in the antihyperalgesic effects of acupuncture: a state-of-the-art review

  2021cites this paper
• Potential of herbal medicines in cancer therapy

  2021cites this paper
• A combination of garlic oil and cooked chilli oil could be effective and efficient for pigeon production.

  2021cites this paper
• Analgesic Effects of Lipid Raft Disruption by Sphingomyelinase and Myriocin via Transient Receptor Potential Vanilloid 1 and Transient Receptor Potential Ankyrin 1 Ion Channel Modulation

  2021cites this paper
• A Comparative study on the effects of Yaji (Suya Meat sauce) and its spice constituents on the male reproductive profile of adult male Sprague Dawley rats

  2021cites this paper
• Redox-sensitive TRP channels: a promising pharmacological target in chemotherapy-induced peripheral neuropathy

  2021cites this paper
• Potential Interplay between Nrf2, TRPA1, and TRPV1 in Nutrients for the Control of COVID-19

  2021cites this paper
• Phytogenic Bioactive Compounds Shape Fish Mucosal Immunity

  2021cites this paper
• TRPA1: Pharmacology, natural activators and role in obesity prevention.

  2021cites this paper
• The Cough Reflex: The Janus of Respiratory Medicine

  2021cites this paper
• The Inflammatory Regulation of TRPA1 Expression in Human A549 Lung Epithelial Cells.

  2021cites this paper
• Triterpene glycosides isolated from the edible sea cucumber Bohadschia vitiensis and their antagonistic activity against transient receptor potential ankyrin 1.

  2020cites this paper
• Canonical Transient Receptor Potential (TRPC) Channels in Nociception and Pathological Pain

  2020cites this paper
• Ultrasound-assisted extraction for enhanced retention of physicochemical properties of garlic powder obtained by spray-drying

  2020cites this paper
• Putative antidiabetic herbal food ingredients: Nutra/functional properties, bioavailability and effect on metabolic pathways

  2020cites this paper
• Regulation of vascular tone by transient receptor potential ankyrin 1 channels.

  2020cites this paper
• Voltage-dependent modulation of TRPA1 currents by diphenhydramine.

  2020cites this paper
• TRPA1 as a Novel Factor and Drug Target in Osteoarthritis

  2020cites this paper
• Lifting the veil on the keratinocyte contribution to cutaneous nociception

  2020cites this paper