Striatal Excitatory Amino Acid Transporter Transcript Expression in Schizophrenia, Bipolar Disorder, and Major Depressive Disorder

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Neuropsychopharmacology

• Publication date

  2002-03-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/S0893-133X(01)00370-0PMID 11850151
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• (3H]MK-801 binding sites in postmortem brain regions of schizophrenic patients

  2005cited by this paper
• Expression of excitatory amino acid transporter transcripts in the thalamus of subjects with schizophrenia.

  2001influential reference
• The expression of glutamate transporter GLT-1 in the rat cerebral cortex is down-regulated by the antipsychotic drug clozapine

  2001cited by this paper
• Striatal ionotropic glutamate receptor expression in schizophrenia, bipolar disorder, and major depressive disorder.

  2001cited by this paper
• Reduced glutamate in the anterior cingulate cortex in depression: an in vivo proton magnetic resonance spectroscopy study.

  2000cited by this paper
• Antidepressant effects of ketamine in depressed patients.

  2000cited by this paper
• Increased cerebrospinal fluid glutamine levels in depressed patients.

  2000cited by this paper
• Proton MR spectroscopy in children with bipolar affective disorder: preliminary observations.

  2000cited by this paper
• Ionotropic glutamate receptor binding and subunit mRNA expression in thalamic nuclei in schizophrenia.

  2000influential reference
• The stanley foundation brain collection and neuropathology consortium.

  2000cited by this paper
• Glutamate receptor expression in schizophrenic brain.

  2000cited by this paper
• Chronic haloperidol treatment impairs glutamate transport in the rat striatum.

  1999cited by this paper
• NR2B-containing NMDA receptors are up-regulated in temporal cortex in schizophrenia.

  1999cited by this paper
• Expression patterns and regulation of glutamate transporters in the developing and adult nervous system.

  1999cited by this paper
• Characterization of the human glutamate receptor subunit 3 gene (GRIA3), a candidate for bipolar disorder and nonspecific X-linked mental retardation.

  1999cited by this paper
• The RNA of the glutamate transporter EAAT2 is variably spliced in amyotrophic lateral sclerosis and normal individuals.

  1999cited by this paper
• The EAAT2 (GLT-1) gene in motor neuron disease: absence of mutations in amyotrophic lateral sclerosis and a point mutation in patients with hereditary spastic paraplegia

  1998cited by this paper
• Increased density of glutamate/N-methyl-D-aspartate receptors in putamen from schizophrenic patients.

  1998cited by this paper
• Chronic neuroleptic treatment alters expression of glial glutamate transporter GLT‐1 mRNA in the striatum

  1998cited by this paper
• Glycine site antagonists and partial agonists inhibit N-methyl-D-aspartate receptor-mediated [3H]arachidonic acid release in cerebellar granule cells.

  1998cited by this paper
• Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice

  1998cited by this paper
• AMPA Receptor Binding and Subunit mRNA Expression in Prefrontal Cortex and Striatum of Elderly Schizophrenics

  1998cited by this paper
• Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis.

  1998cited by this paper
• Lithium acutely inhibits and chronically up-regulates and stabilizes glutamate uptake by presynaptic nerve endings in mouse cerebral cortex.

  1998cited by this paper
• Expression of the human excitatory amino acid transporter 2 and metabotropic glutamate receptors 3 and 5 in the prefrontal cortex from normal individuals and patients with schizophrenia.

  1998influential reference
• The expression of the glial glutamate transporter protein EAAT2 in motor neuron disease: an immunohistochemical study

  1998cited by this paper
• Expression of NMDAR1, GluR1, GluR7, and KA1 Glutamate Receptor mRNAs Is Decreased in Frontal Cortex of “Neuroleptic‐Free” Schizophrenics: Evidence on Reversible Up‐Regulation by Typical Neuroleptics

  1998cited by this paper
• Cellular and synaptic localization of the neuronal glutamate transporters excitatory amino acid transporter 3 and 4.

  1997cited by this paper
• Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance.

  1997cited by this paper
• GluR2 glutamate receptor subunit flip and flop isoforms are decreased in the hippocampal formation in schizophrenia: a reverse transcriptase-polymerase chain reaction (RT-PCR) study.

  1997cited by this paper
• Distribution of kainate receptor subunit mRNAs in human hippocampus, neocortex and cerebellum, and bilateral reduction of hippocampal GluR6 and KA2 transcripts in schizophrenia.

  1997cited by this paper
• Expression of the glial glutamate transporter EAAT2 in the human CNS: an immunohistochemical study.

  1997influential reference
• Immunoautoradiographic evidence for a loss of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate-preferring non-N-methyl-D-aspartate glutamate receptors within the medial temporal lobe in schizophrenia

  1997cited by this paper
• Changes of NMDA Receptor Subunit (NR1, NR2B) and Glutamate Transporter (GLT1) mRNA Expression in Huntington's Disease—An In Situ Hybridization Study

  1997cited by this paper
• Immunoautoradiographic evidence for a loss of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate-preferring non-N-methyl-D-aspartate glutamate receptors within the medial temporal lobe in schizophrenia.

  1997cited by this paper
• Distribution of Glutamate Transporter Subtypes During Human Brain Development

  1997influential reference
• Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1.

  1997cited by this paper
• Changes in expression and distribution of the glutamate transporter EAAT4 in developing mouse Purkinje cells.

  1997cited by this paper
• The antibipolar drug valproate mimics lithium in stimulating glutamate release and inositol 1,4,5-trisphosphate accumulation in brain cortex slices but not accumulation of inositol monophosphates and bisphosphates.

  1997cited by this paper
• Glutamate receptors in the postmortem striatum of schizophrenic, suicide, and control brains

  1997influential reference
• NMDA receptor mRNA correlation with antemortem cognitive impairment in schizophrenia.

  1996cited by this paper
• Adaptation of N-methyl-D-aspartate (NMDA) receptors following antidepressant treatment: implications for the pharmacotherapy of depression.

  1996cited by this paper
• EAAT4 is a post-synaptic glutamate transporter at Purkinje cell synapses.

  1996cited by this paper
• Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate.

  1996cited by this paper
• Cloning and Functional Characterization of a System ASC-like Na+-dependent Neutral Amino Acid Transporter*

  1996cited by this paper
• Selective alterations in gene expression for NMDA receptor subunits in prefrontal cortex of schizophrenics

  1996cited by this paper
• Decreased expression of mRNAs encoding non-NMDA glutamate receptors GluR1 and GluR2 in medial temporal lobe neurons in schizophrenia.

  1995cited by this paper
• Differential expression of two glial glutamate transporters in the rat brain: quantitative and immunocytochemical observations

  1995influential reference
• Glutamate transporters in glial plasma membranes: highly differentiated localizations revealed by quantitative ultrastructural immunocytochemistry.

  1995influential reference
• Localization of neuronal and glial glutamate transporters.

  1994influential reference
• Dopamine Receptor Gene Expression in the Human Medial Temporal Lobe

  1994cited by this paper
• Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family.

  1993cited by this paper
• Effects of cocaine on dopamine receptor gene expression: a study in the postmortem human brain.

  1993cited by this paper
• Adaptive changes in the N-methyl-D-aspartate receptor complex after chronic treatment with imipramine and 1-aminocyclopropanecarboxylic acid.

  1993cited by this paper
• 1-aminocyclopropanecarboxylates exhibit antidepressant and anxiolytic actions in animal models.

  1991cited by this paper
• Decreased Hippocampal Expression of a Glutamate Receptor Gene in Schizophrenia

  1991cited by this paper
• Decreased hippocampal expression of a glutamate receptor gene in schizophrenia.

  1991cited by this paper
• Rat pup isolation calls are reduced by functional antagonists of the NMDA receptor complex.

  1990cited by this paper
• Functional antagonists at the NMDA receptor complex exhibit antidepressant actions.

  1990cited by this paper
• Quantitative autoradiographic analysis of glutamate binding sites in the hippocampal formation in normal and schizophrenic brain post mortem.

  1990cited by this paper
• Frontal Cortical and Left Temporal Glutamatergic Dysfunction in Schizophrenia

  1989cited by this paper
• Asymmetrical loss of glutamate receptor subtype in left hippocampus in schizophrenia.

  1988cited by this paper
• Increased [3H]kainic acid binding in the prefrontal cortex in schizophrenia.

  1983cited by this paper

• Excitatory Amino Acid Transporters as Therapeutic Targets in the Treatment of Neurological Disorders: Their Roles and Therapeutic Prospects

  2025cites this paper
• Neurophysiological profiles of patients with bipolar disorders as probed with transcranial magnetic stimulation: A systematic review

  2024cites this paper
• The Impacts of Adolescent Cannabinoid Exposure on Striatal Anxiety- and Depressive-Like Pathophysiology Are Prevented by the Antioxidant N-Acetylcysteine

  2024cites this paper
• Neurocognition and NMDAR co-agonists pathways in individuals with treatment resistant first-episode psychosis: a 3-year follow-up longitudinal study

  2024cites this paper
• Chronic Stress in a Rat Model of Depression Disturbs the Glutamine–Glutamate–GABA Cycle in the Striatum, Hippocampus, and Cerebellum [Letter]

  2024cites this paper
• The Importance of α-Klotho in Depression and Cognitive Impairment and Its Connection to Glutamate Neurotransmission—An Up-to-Date Review

  2023cites this paper
• Dysfunction of EAAT3 Aggravates LPS-Induced Post-Operative Cognitive Dysfunction

  2022cites this paper
• Cyanidin Chloride Improves LPS-Induced Depression-Like Behavior in Mice by Ameliorating Hippocampal Inflammation and Excitotoxicity.

  2022cites this paper
• The neuroprotective and neuroplastic potential of glutamatergic therapeutic drugs in bipolar disorder.

  2022cites this paper
• Machine Learning algorithm unveils glutamatergic alterations in the post-mortem schizophrenia brain

  2022cites this paper
• Glutamate Transporters: Critical components of glutamatergic transmission.

  2021cites this paper
• Transcriptional profile of pyramidal neurons in chronic schizophrenia reveals lamina-specific dysfunction of neuronal immunity

  2021cites this paper
• Role of Astrocytes in Major Neuropsychiatric Disorders

  2021cites this paper
• Low-Level Brain Somatic Mutations Are Implicated in Schizophrenia.

  2021cites this paper
• Cryo-EM structures of excitatory amino acid transporter 3 visualize coupled substrate, sodium, and proton binding and transport

  2021cites this paper
• Dysfunction of EAAT3 enhances LPS-induced Postoperative Cognitive Dysfunction

  2021cites this paper
• Astrocytes in Bipolar Disorder.

  2021cites this paper
• Astrocytes in Neuropsychiatric Disorders: A Review of Postmortem Evidence.

  2021cites this paper
• The link between neurology and behavior in veterinary medicine: a review

  2021cites this paper
• Early-life stress induces EAAC1 expression reduction and attention-deficit and depressive behaviors in adolescent rats

  2020cites this paper
• Solute Carrier Family 1 (SLC1A1) Contributes to Susceptibility and Psychopathology Symptoms of Schizophrenia in the Han Chinese Population

  2020cites this paper
• Glutamatergic dysregulation in mood disorders: opportunities for the discovery of novel drug targets

  2020cites this paper
• Transport mechanism of the neuronal excitatory amino acid transporter

  2020cites this paper
• Transcriptional profile of pyramidal neurons in chronic schizophrenia reveals lamina-specific dysfunction of neuronal immunity

  2020cites this paper
• Dysregulation of the Glutamatergic System in Major Depressive Disorder

  2020cites this paper
• L-Carnosine combination therapy for major depressive disorder: A randomized, double-blind, placebo-controlled trial.

  2020cites this paper
• Neurobiologic properties of mood disorders may have an impact on epilepsy: Should this motivate neurologists to screen for this psychiatric comorbidity in these patients?

  2019cites this paper
• EAAT2 as a Research Target in Bipolar Disorder and Unipolar Depression: A Systematic Review

  2019cites this paper
• Glutamate transporters: Gene expression regulation and signaling properties.

  2019cites this paper
• Integration of GWAS and brain eQTL identifies FLOT1 as a risk gene for major depressive disorder

  2019cites this paper
• Emerging Role of Glutamate Receptors in Pathophysiology of Depression

  2018cites this paper
• Genes associated with anhedonia: a new analysis in a large clinical trial (GENDEP)

  2018cites this paper
• Regulation of Glutamate Transporter Expression in Glial Cells.

  2017cites this paper
• The role of zinc deficiency-induced changes in the phospholipid-protein balance of blood serum in animal depression model by Raman, FTIR and UV-vis spectroscopy.

  2017cites this paper
• Evaluation of logistic regression models and effect of covariates for case–control study in RNA-Seq analysis

  2017cites this paper
• Can Neurochemical Changes of Mood Disorders Explain the Increase Risk of Epilepsy or its Worse Seizure Control?

  2017cites this paper
• Glutamate Transport: A New Bench to Bedside Mechanism for Treating Drug Abuse

  2017cites this paper
• The systemic effects of glutamatergic dysfunction in schizophrenia: from receptors to networks

  2017cites this paper
• Neuropathology of mood disorders: do we see the stigmata of inflammation?

  2016cites this paper
• Quantitative mass spectrometry reveals changes in SNAP-25 isoforms in schizophrenia.

  2016cites this paper
• Up-Regulation of Excitatory Amino Acid Transporters EAAT3 and EAAT4 by Lithium Sensitive Glycogen Synthase Kinase GSK3ß

  2016cites this paper
• The importance of the excitatory amino acid transporter 3 (EAAT3).

  2016cites this paper
• Ketamine’s Mechanisms of Rapid Antidepressant Activity: Evidence from Preclinical Studies

  2016cites this paper
• Glutamate transporter splice variant expression in an enriched pyramidal cell population in schizophrenia

  2015cites this paper
• SPAK and OSR1 Sensitivity of Excitatory Amino Acid Transporter EAAT3

  2015cites this paper
• Doxepin and imipramine but not fluoxetine reduce the activity of the rat glutamate transporter EAAT3 expressed in Xenopus oocytes

  2015cites this paper
• Genetic analysis of bipolar disorder and alcohol use disorder

  2015cites this paper
• Partial effects of the AMPAkine CX717 in a strain specific battery of tests for manic-like behavior in black Swiss mice

  2015cites this paper
• Neuregulin 1 Controls Glutamate Uptake by Up-regulating Excitatory Amino Acid Carrier 1 (EAAC1)*

  2015cites this paper
• Characterization of a Novel Mutation in SLC1A1 Associated with Schizophrenia

  2015cites this paper
• Neural correlates of rapid antidepressant response to ketamine in bipolar disorder

  2014cites this paper
• Evidence of Glutamatergic Dysfunction in the Pathophysiology of Schizophrenia

  2014cites this paper
• Astroglia and Severe Mental Illness: A Role for Glutamate Microdomains

  2014cites this paper
• Antipsychotic treatment modulates glutamate transport and NMDA receptor expression

  2014cites this paper
• The role of NMDA receptors in the pathophysiology and treatment of mood disorders.

  2014cites this paper
• Postmortem Brain: An Underutilized Substrate for Studying Severe Mental Illness

  2014cites this paper
• Abnormal partitioning of hexokinase 1 suggests disruption of a glutamate transport protein complex in schizophrenia.

  2014cites this paper
• Synergistic association of PI4KA and GRM3 genetic polymorphisms with poor antipsychotic response in south Indian schizophrenia patients with low severity of illness

  2014cites this paper
• MIR137 variants identified in psychiatric patients affect synaptogenesis and neuronal transmission gene sets

  2014cites this paper
• Brain biopsy findings link major depressive disorder to neuroinflammation, oxidative stress, and neurovascular dysfunction: a case report.

  2014cites this paper
• Using Our Understanding of Stress-Related Effects on Glutamate Neurotransmission to Guide the Development of Novel Treatment Strategies

  2014cites this paper
• Is depression associated with an increased risk of treatment-resistant epilepsy? Research strategies to investigate this question.

  2014cites this paper
• Changes in the expression of the glutamate transporter EAAT3/EAAC1 in health and disease

  2013cites this paper
• Involvement of pGluR1, EAAT2 and EAAT3 in offspring depression induced by prenatal stress.

  2013cites this paper
• Cognitive Manic Symptoms in Bipolar Disorder Associated with Polymorphisms in the DAOA and COMT Genes

  2013cites this paper
• Glutamate system as target for development of novel antidepressants

  2013cites this paper
• Neuroinflammation and psychiatric illness

  2013cites this paper
• Abnormal expression of glutamate transporters in temporal lobe areas in elderly patients with schizophrenia.

  2013cites this paper
• Lack of association of SLC1A1 variants with schizophrenia in Chinese Han population.

  2013cites this paper
• Klotho Sensitivity of the Neuronal Excitatory Amino Acid Transporters EAAT3 and EAAT4

  2013cites this paper
• Deletion at the SLC1A1 glutamate transporter gene co‐segregates with schizophrenia and bipolar schizoaffective disorder in a 5‐generation family

  2013cites this paper
• Gene expression of glutamate transporters SLC1A1, SLC1A3 and SLC1A6 in the cerebellar subregions of elderly schizophrenia patients and effects of antipsychotic treatment

  2013cites this paper
• Glycine site N-methyl-D-aspartate receptor antagonist 7-CTKA produces rapid antidepressant-like effects in male rats.

  2013cites this paper
• Parasynaptic NMDA Receptor Signaling Couples Neuronal Glutamate Transporter Function to AMPA Receptor Synaptic Distribution and Stability

  2012cites this paper
• Pathophysiology of mood disorders in temporal lobe epilepsy.

  2012cites this paper
• Platelet uptake of GABA and glutamate in patients with bipolar disorder.

  2012cites this paper
• Overview of glutamatergic neurotransmission in the nervous system.

  2012cites this paper
• Novel glutamatergic agents for major depressive disorder and bipolar disorder.

  2012cites this paper
• Update on the neurobiology of schizophrenia: a role for extracellular microdomains.

  2012cites this paper
• Depression and epilepsy: epidemiologic and neurobiologic perspectives that may explain their high comorbid occurrence.

  2012cites this paper
• Can neurobiological pathogenic mechanisms of depression facilitate the development of seizure disorders?

  2012cites this paper
• Regulation of the glutamate transporter EAAT3 by mammalian target of rapamycin mTOR.

  2012cites this paper
• Association of SNPs linked to increased expression of SLC1A1 with schizophrenia

  2012cites this paper
• Neurotransmitters and neuropeptides in depression.

  2012cites this paper
• Research Review: altered reward function in adolescent depression: what, when and how?

  2012cites this paper
• Stress-induced deficits in cognition and emotionality: a role of glutamate.

  2012cites this paper
• Mediators of synaptic activity in anxiety- and depression-related behaviors

  2012cites this paper
• Motor Symptoms and Schizophrenia

  2012cites this paper
• Subchronic treatment with aldosterone induces depression-like behaviours and gene expression changes relevant to major depressive disorder.

  2012cites this paper
• Development of Brain Monoaminergic Systems

  2011cites this paper
• RT-qPCR study on post-mortem brain samples from patients with major psychiatric disorders: reference genes and specimen characteristics.

  2011cites this paper
• A Copy Number Variation Morbidity Map of Developmental Delay

  2011cites this paper
• Hippocampal glutamate transporter 1 (GLT-1) complex levels are paralleling memory training in the Multiple T-Maze in C57BL/6J mice

  2011cites this paper
• Discovering imaging endophenotypes for major depression

  2011cites this paper
• Schizoaffective disorder–an ongoing challenge for psychiatric nosology

  2011cites this paper
• Corticotropin-Releasing Hormone, Glutamate, and γ-Aminobutyric Acid in Depression

  2011cites this paper
• Fluoxetine treatment induces EAAT2 expression in rat brain

  2011influential citation
• Expression, distribution and glutamate uptake activity of high affinity-excitatory aminoacid transporters in in vitro cultures of embryonic rat dorsal root ganglia.

  2011influential citation
• Expression, distribution and glutamate uptake activityof excitatory aminoacid transporters in vitro cultures of embryonic rat dorsal root ganglia cells

  2011cites this paper
• Role of the Transcription Factor CREB in the NMDA Receptor Antagonist-Induced Attention Deficits

  2011cites this paper