Molecular characterization of the mouse involuted thymus: aberrations in expression of transcription regulators in thymocyte and epithelial compartments.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  International Immunology

• Publication date

  2002-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/INTIMM/DXF042PMID 12096041
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation

  2002cited by this paper
• T cell receptor excision circle assessment of thymopoiesis in aging mice.

  2002cited by this paper
• Early Thymocyte Development Is Regulated by Modulation of E2a Protein Activity

  2001cited by this paper
• Laser capture microdissection‐based expression profiling identifies PD1‐ligand as a target of the nude locus gene product

  2001cited by this paper
• Mapping Precursor Movement through the Postnatal Thymus Reveals Specific Microenvironments Supporting Defined Stages of Early Lymphoid Development

  2001cited by this paper
• T cell senescence.

  2001cited by this paper
• Thymic atrophy in the mouse is a soluble problem of the thymic environment.

  2000cited by this paper
• Stepwise specification of lymphocyte developmental lineages.

  2000cited by this paper
• Definition of a T-Cell Receptor β Gene Core Enhancer of V(D)J Recombination by Transgenic Mapping

  2000cited by this paper
• Chemokines define distinct microenvironments in the developing thymus

  2000cited by this paper
• Leukemia Inhibitory Factor, Oncostatin M, IL-6, and Stem Cell Factor mRNA Expression in Human Thymus Increases with Age and Is Associated with Thymic Atrophy1

  2000cited by this paper
• Functions of E2A-HEB Heterodimers in T-Cell Development Revealed by a Dominant Negative Mutation of HEB

  2000cited by this paper
• Altered aging-related thymic involution in T cell receptor transgenic, MHC-deficient, and CD4-deficient mice.

  2000cited by this paper
• Facilitation of β Selection and Modification of Positive Selection in the Thymus of Pd-1–Deficient Mice

  2000cited by this paper
• Transgenic Expression of Cyclin D1 in Thymic Epithelial Precursors Promotes Epithelial and T Cell Development1

  2000cited by this paper
• SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-Tα chain expression

  2000cited by this paper
• Immunosenescence: potential causes and strategies for reversal.

  2000cited by this paper
• Murine CCR9, a Chemokine Receptor for Thymus-Expressed Chemokine That Is Up-Regulated Following Pre-TCR Signaling1

  2000cited by this paper
• Evidence for thymic function in the elderly.

  2000cited by this paper
• The human thymus during aging

  2000cited by this paper
• Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

  2000cited by this paper
• Exposing the human nude phenotype

  1999cited by this paper
• Transcription factors in hematopoiesis.

  1999cited by this paper
• Failure of rearranged TCR transgenes to prevent age-associated thymic involution.

  1999cited by this paper
• On the lifespan of virgin T lymphocytes.

  1999cited by this paper
• A novel role for HEB downstream or parallel to the pre-TCR signaling pathway during alpha beta thymopoiesis.

  1999cited by this paper
• Transcriptional regulation of lymphocyte lineage commitment

  1999cited by this paper
• Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor.

  1999cited by this paper
• The oncogenic T cell LIM‐protein Lmo2 forms part of a DNA‐binding complex specifically in immature T cells

  1998cited by this paper
• Thymic function in young/old chimeras: substantial thymic T cell regenerative capacity despite irreversible age‐associated thymic involution

  1998influential reference
• Changes in thymic function with age and during the treatment of HIV infection

  1998influential reference
• Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment.

  1998influential reference
• Induction of Early B Cell Factor (EBF) and Multiple B Lineage Genes by the Basic Helix-Loop-Helix Transcription Factor E12

  1998cited by this paper
• E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas

  1997cited by this paper
• Early αβ T cell development in the thymus of normal and genetically altered mice

  1997cited by this paper
• Age-associated thymic atrophy in the mouse is due to a deficiency affecting rearrangement of the TCR during intrathymic T cell development.

  1997cited by this paper
• E2A Deficiency Leads to Abnormalities in ab T-Cell Development and to Rapid Development of T-Cell Lymphomas

  1997cited by this paper
• Early alpha beta T cell development in the thymus of normal and genetically altered mice.

  1997cited by this paper
• Thymic aging and T‐cell regeneration

  1997cited by this paper
• Early T lymphocyte progenitors.

  1996cited by this paper
• Protein dimerization between Lmo2 (Rbtn2) and Tal1 alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice.

  1996cited by this paper
• The nu gene acts cell-autonomously and is required for differentiation of thymic epithelial progenitors.

  1996influential reference
• Two Genetically Separable Steps in the Differentiation of Thymic Epithelium

  1996cited by this paper
• Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

  1995cited by this paper
• Crucial role of the pre-T-cell receptor alpha gene in development of alpha beta but not gamma delta T cells.

  1995cited by this paper
• The pattern of T lymphocyte differentiation is altered during thymic involution.

  1995cited by this paper
• New member of the winged-helix protein family disrupted in mouse and rat nude mutations

  1994influential reference
• On a causal mechanism of chronic thymic involution in man.

  1994cited by this paper
• A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression.

  1993cited by this paper
• Regulation of basal and luminal cell-specific cytokeratin expression in rat accessory sex organs. Evidence for a new class of androgen-repressed genes and insight into their pairwise control.

  1992cited by this paper
• Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell line.

  1991cited by this paper
• Evolutionary comparison of murine and human delta T-cell receptor deleting elements.

  1989cited by this paper
• Reduced expression of Ia antigens by thymic epithelial cells of aged mice.

  1984cited by this paper
• Duration of thymic function.

  1974cited by this paper

• miR-194-5p-mediated suppression of protein tyrosine phosphatase non-receptor type 12 (PTPN12) expression in the thymus enhances immunologic functional restoration in aged mice

  2026cites this paper
• Age-related thymic involution: Mechanistic insights and rejuvenating approaches to restore immune function

  2026cites this paper
• Burning Down the House: Thymic Repair and Regeneration After Acute Damage

  2025cites this paper
• The cellular senescence–metabolism axis: emerging insights into T cell dynamics in the context of biological aging

  2025cites this paper
• Enhancing thymic function improves T-cell reconstitution and immune responses in aged mice

  2025cites this paper
• Age-Related Thymic Involution.

  2025cites this paper
• Premature thymic involution in young Foxn1lacz mutant mice causes peripheral T cell phenotypes similar to aging-induced immunosenescence

  2024cites this paper
• Primary and secondary defects of the thymus

  2024cites this paper
• The role of thymic epithelium in thymus development and age-related thymic involution.

  2024cites this paper
• Thymic microenvironment’s impact on immunosenescence

  2024cites this paper
• Mechanisms underlying the direct programming of mouse embryonic fibroblasts to thymic epithelial cells by FOXN1.

  2024cites this paper
• Physiological and Functional Effects of Dominant Active TCRα Expression in Transgenic Mice

  2023cites this paper
• What's the role of thymus in diabetes mellitus?

  2023cites this paper
• The potential role of the thymus in immunotherapies for acute myeloid leukemia

  2023cites this paper
• Role of thymus in health and disease

  2022cites this paper
• Thymic Rejuvenation by Adult Grafts in the Lymph Node

  2022cites this paper
• Thymic changes as a contributing factor in the increased susceptibility of old Albino Oxford rats to EAE development.

  2022cites this paper
• Age‐related thymic involution: Mechanisms and functional impact

  2022cites this paper
• Thymus Functionality Needs More Than a Few TECs

  2022cites this paper
• Mechanisms underlying the reprogramming of mouse embryonic fibroblasts to thymic epithelial cells

  2022cites this paper
• Immune System Effects of Insulin-Like Peptide 5 in a Mouse Model

  2021cites this paper
• Dynamics of thymus function and T cell receptor repertoire breadth in health and disease

  2021cites this paper
• A 2020 View of Thymus Stromal Cells in T Cell Development

  2021cites this paper
• Strategies for thymus regeneration and generating thymic organoids

  2021cites this paper
• Thymic rejuvenation via induced thymic epithelial cells (iTECs) from FOXN1-overexpressing fibroblasts to counteract inflammaging

  2020cites this paper
• Thymus and parathyroid organogenesis

  2020cites this paper
• Selective expression of claudin-5 in thymic endothelial cells regulates the blood–thymus barrier and T-cell export

  2020cites this paper
• When the Damage Is Done: Injury and Repair in Thymus Function

  2020cites this paper
• Conventional and Computational Flow Cytometry Analyses Reveal Sustained Human Intrathymic T Cell Development From Birth Until Puberty

  2020cites this paper
• Qualitative Changes in Cortical Thymic Epithelial Cells Drive Postpartum Thymic Regeneration

  2020cites this paper
• Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging

  2020cites this paper
• Thymus aging in mice deficient in either EphB2 or EphB3, two master regulators of thymic epithelium development

  2020cites this paper
• Postnatal Involution and Counter-Involution of the Thymus

  2020cites this paper
• Thymic rejuvenation via FOXN1-reprogrammed embryonic fibroblasts (FREFs) to counteract age-related inflammation

  2020cites this paper
• Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging.

  2019cites this paper
• A tímusz öregedésének molekuláris mechanizmusa: új intervenciós célpont azonosítása

  2019cites this paper
• Gallic acid attenuates thymic involution in the d-galactose induced accelerated aging mice.

  2019cites this paper
• The transcription factor Foxn1 regulates skin adipogenesis and affects susceptibility to diet-induced obesity.

  2019cites this paper
• Adding Insult to Injury: Improving the Regenerative Capacity of the Aged Thymus Following Clinically Induced Damage

  2019cites this paper
• Mouse Models and Genetics of Immunosenescence

  2019cites this paper
• Interleukin-7 and Immunorejuvenation

  2019cites this paper
• Age-Related Thymic Atrophy: Mechanisms and Outcomes

  2019cites this paper
• The Pivotal Role of Thymus in Atherosclerosis Mediated by Immune and Inflammatory Response

  2018cites this paper
• Profiling analysis of 17β-estradiol-regulated lncRNAs in mouse thymic epithelial cells.

  2018cites this paper
• Challenging the current model of early‐onset myasthenia gravis pathogenesis in the light of the MGTX trial and histological heterogeneity of thymectomy specimens

  2018cites this paper
• Defining novel stages in medullary thymic epithelial cell differentiation: Implications for tolerance induction

  2018cites this paper
• Thymus

  2018cites this paper
• Dynamic regulation of NOTCH1 activation and Notch ligand expression in human thymus development

  2018cites this paper
• A suboptimal maternal diet combined with accelerated postnatal growth results in an altered aging profile in the thymus of male rats

  2018cites this paper
• Mechanisms in hypertension and target organ damage: Is the role of the thymus key? (Review)

  2018cites this paper
• Compromised T cell Immunity in Elderly via Naïve T cell Anergy

  2018cites this paper
• Polymorphisms in the canine IL7R 3′UTR are associated with thymic output in Labrador retriever dogs and influence post‐transcriptional regulation by microRNA 185

  2018cites this paper
• Dysfunction of the thymus in mice with hypertension

  2017cites this paper
• Nab2 maintains thymus cellularity with aging and stress

  2017cites this paper
• Thymic stromal cells: Roles in atrophy and age‐associated dysfunction of the thymus

  2017cites this paper
• A novel Foxn1eGFP/+ mouse model identifies Bmp4‐induced maintenance of Foxn1 expression and thymic epithelial progenitor populations

  2017cites this paper
• Improving sex steroid ablation-induced thymic recovery for clinical application

  2017cites this paper
• Immune senescence: significance of the stromal microenvironment

  2017cites this paper
• Epigenetic Regulation of Cellular Senescence and Aging

  2017cites this paper
• Age-associated alterations in the levels of cytotoxic lipid molecular species and oxidative stress in the murine thymus are reduced by growth hormone treatment.

  2017cites this paper
• Development and developmental potential of cortical thymic epithelial cells

  2016cites this paper
• Development of Thymic Epithelial Cells

  2016cites this paper
• An overview of the necessary thymic contributions to tolerance in transplantation.

  2016cites this paper
• Synthetic Immunology

  2016cites this paper
• MicroRNA-195a-5p inhibits mouse medullary thymic epithelial cells proliferation by directly targeting Smad7.

  2016cites this paper
• Strategies for Thymic Regeneration: Recent Advances Towards Clinical Therapy

  2016cites this paper
• Thymus: the next (re)generation

  2016cites this paper
• The Immunoendocrine Thymus as a Pacemaker of Lifespan.

  2016cites this paper
• Medullary thymic epithelial stem cells: role in thymic epithelial cell maintenance and thymic involution

  2016cites this paper
• Foxn1 Is Dynamically Regulated in Thymic Epithelial Cells during Embryogenesis and at the Onset of Thymic Involution

  2016cites this paper
• Impacts of Aging and Inflammation on Mycobacterium tuberculosis Control

  2016cites this paper
• Role of Bone Marrow Maturity, Insulin‐Like Growth Factor 1 Receptor, and Forkhead Box Protein N1 in Thymic Involution and Rejuvenation

  2016cites this paper
• FOXN1 in thymus organogenesis and development

  2016cites this paper
• Preventing thymus involution in K5.Cyclin D1 transgenic mice sustains the naïve T cell compartment with age (LYM6P.716)

  2015influential citation
• Thymic Involution Perturbs Negative Selection Leading to Autoreactive T Cells That Induce Chronic Inflammation

  2015cites this paper
• That Induce Chronic Inflammation Selection Leading to Autoreactive T Cells Thymic Involution Perturbs Negative

  2015cites this paper
• Foxn1 Protein Expression in the Developing, Aging, and Regenerating Thymus

  2015cites this paper
• Adult thymic epithelial cell (TEC) progenitors and TEC stem cells: Models and mechanisms for TEC development and maintenance

  2015cites this paper
• Lipid-Laden Multilocular Cells in the Aging Thymus Are Phenotypically Heterogeneous

  2015cites this paper
• Decline of FOXN1 gene expression in human thymus correlates with age: possible epigenetic regulation

  2015cites this paper
• Long-Term Persistence of Functional Thymic Epithelial Progenitor Cells In Vivo under Conditions of Low FOXN1 Expression

  2014cites this paper
• Insights into the mechanisms of thymus involution and regeneration by modeling the glucocorticoid-induced perturbation of thymocyte populations dynamics.

  2014cites this paper
• Biological significance of FoxN1 gain-of-function mutations during T and B lymphopoiesis in juvenile mice

  2014influential citation
• Regeneration of the aged thymus by a single transcription factor

  2014cites this paper
• Long-Term Persistence of Functional Thymic Epithelial Progenitor Cells In Vivo under Conditions of Low FOXN 1 Expression

  2014cites this paper
• Cellular signalling pathways in immune aging and regeneration.

  2014cites this paper
• T Cell-Mediated Immunity in the Immunosenescence Process

  2014cites this paper
• Global transcriptional profiling reveals distinct functions of thymic stromal subsets and age-related changes during thymic involution.

  2014cites this paper
• FOXN1 in Organ Development and Human Diseases

  2014cites this paper
• The role of the transcription factor Foxn1 in Thymus organogenesis and maintenance

  2014cites this paper
• Structural and functional basis of accelerated involution of the thymus in OXYS rats

  2014cites this paper
• Severe influenza A(H1N1)pdm09 infection induces thymic atrophy through activating innate CD8+CD44hi T cells by upregulating IFN-γ

  2014cites this paper
• Immunosenescence is associated with altered gene expression and epigenetic regulation in primary and secondary immune organs

  2013influential citation
• Transcriptome analysis of murine thymic epithelial cells reveals age‑associated changes in microRNA expression.

  2013cites this paper
• The Effect of Age on Thymic Function

  2013cites this paper
• conjunction with overexpression of HOXA9 Conditional MN1-TEL knock-in mice develop acute myeloid leukemia in

  2013cites this paper
• Enhancing T Lineage Production in Aged Mice: A Novel Function of Foxn1 in the Bone Marrow Niche

  2013cites this paper
• Thymus and aging: morphological, radiological, and functional overview

  2013cites this paper
• Stability Analysis and its Impact on the Parameters Estimation for a Logistic Growth Model

  2013cites this paper
• Marrow Niche Mice: A Novel Function of Foxn1 in the Bone Enhancing T Lineage Production in Aged

  2013cites this paper