Reversible Oxidative Modification: A Key Mechanism of Na+-K+ Pump Regulation

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Circulation Research

• Publication date

  2009-07-17

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1161/CIRCRESAHA.109.199547PMID 19542013
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Angiotensin II inhibits the Na+-K+ pump via PKC-dependent activation of NADPH oxidase.

  2009cited by this paper
• Crystal structure of the sodium–potassium pump at 2.4 Å resolution

  2009cited by this paper
• Opposing effects of coupled and uncoupled NOS activity on the Na+-K+ pump in cardiac myocytes.

  2008cited by this paper
• Thiol chemistry and specificity in redox signaling.

  2008cited by this paper
• Tackling heart failure in the twenty-first century

  2008cited by this paper
• Signalling by NO-induced protein S-nitrosylation and S-glutathionylation: convergences and divergences.

  2007cited by this paper
• Mechanisms of reversible protein glutathionylation in redox signaling and oxidative stress.

  2007cited by this paper
• Janus model of the Na,K-ATPase beta-subunit transmembrane domain: distinct faces mediate alpha/beta assembly and beta-beta homo-oligomerization.

  2007cited by this paper
• Glutathionylation of beta-actin via a cysteinyl sulfenic acid intermediary

  2007cited by this paper
• Crystal structure of the sodium–potassium pump

  2007cited by this paper
• Functional analysis of Na+/K+-ATPase isoform distribution in rat ventricular myocytes.

  2007cited by this paper
• Janus Model of The Na,K-ATPase β-subunit Transmembrane Domain: Distinct Faces Mediate α /β Assembly and β-β Homo- Oligomerization

  2007cited by this paper
• S-glutathionylation in protein redox regulation.

  2007cited by this paper
• Fluorometric measurements of intermolecular distances between the alpha- and beta-subunits of the Na+/K+-ATPase.

  2006cited by this paper
• Nitric-oxide-induced vasodilatation: regulation by physiologic s-glutathiolation and pathologic oxidation of the sarcoplasmic endoplasmic reticulum calcium ATPase.

  2006cited by this paper
• Fluorometric Measurements of Intermolecular Distances between the α- and β-Subunits of the Na+/K+-ATPase*

  2006cited by this paper
• Phospholemman Phosphorylation Mediates the Protein Kinase C–Dependent Effects on Na+/K+ Pump Function in Cardiac Myocytes

  2006cited by this paper
• Functional significance of the shark Na,K-ATPase N-terminal domain. Is the structurally variable N-Terminus involved in tissue-specific regulation by FXYD proteins?

  2005cited by this paper
• The nitric oxide donor sodium nitroprusside stimulates the Na+–K+ pump in isolated rabbit cardiac myocytes

  2005cited by this paper
• Phospholemman-Phosphorylation Mediates the β-Adrenergic Effects on Na/K Pump Function in Cardiac Myocytes

  2005cited by this paper
• S-Glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide

  2004cited by this paper
• Identification of potential regulatory sites of the Na+,K+-ATPase by kinetic analysis.

  2004cited by this paper
• Modulation of Na,K-ATPase by phospholipids and cholesterol. II. Steady-state and presteady-state kinetics.

  2003cited by this paper
• [Na+]i handling in the failing human heart.

  2003cited by this paper
• Coupling of Cell Energetics with Membrane Metabolic Sensing

  2002cited by this paper
• The functional role of beta subunits in oligomeric P-type ATPases.

  2001cited by this paper
• Structural and Functional Features of the Transmembrane Domain of the Na,K-ATPase β Subunit Revealed by Tryptophan Scanning*

  2001cited by this paper
• Rate limitation of the Na(+),K(+)-ATPase pump cycle.

  2001cited by this paper
• Role of paraquat in the uncoupling of nitric oxide synthase.

  2000cited by this paper
• Identification of Oxidant-Sensitive Proteins: TNF-α Induces Protein Glutathiolation

  2000cited by this paper
• Identification of oxidant-sensitive proteins: TNF-alpha induces protein glutathiolation.

  2000cited by this paper
• Transport and Pharmacological Properties of Nine Different Human Na,K-ATPase Isozymes*

  2000cited by this paper
• Packing of the transmembrane helices of Na,K-ATPase: direct contact between beta-subunit and H8 segment of alpha-subunit revealed by oxidative cross-linking.

  2000cited by this paper
• K(+)/Na(+) antagonism at cytoplasmic sites of Na(+)-K(+)-ATPase: a tissue-specific mechanism of sodium pump regulation.

  1999cited by this paper
• K+/Na+antagonism at cytoplasmic sites of Na+-K+-ATPase: a tissue-specific mechanism of sodium pump regulation.

  1999cited by this paper
• Changes in Steady-state Conformational Equilibrium Resulting from Cytoplasmic Mutations of the Na,K-ATPase α-Subunit*

  1998cited by this paper
• Oligomerization and maturation of Na,K-ATPase: functional interaction of the cytoplasmic NH2 terminus of the beta subunit with the alpha subunit

  1996cited by this paper
• An endogenous ATP-sensitive glutathione S-conjugate efflux mechanism in Xenopus laevis oocytes.

  1996cited by this paper
• Angiotensin-converting enzyme inhibition, intracellular Na+, and Na(+)-K+ pumping in cardiac myocytes.

  1995cited by this paper
• Fluorescent styryl dyes as probes for Na,K-ATPase reaction mechanism: significance of the charge of the hydrophilic moiety of RH dyes.

  1995cited by this paper
• Modulation of the Na,K-pump function by beta subunit isoforms

  1994cited by this paper
• Gastric H(+)-K(+)-ATPase activity is inhibited by reduction of disulfide bonds in beta-subunit.

  1992cited by this paper
• Primary sequence of Xenopus laevis Na+-K+-ATPase and its localization in A6 kidney cells.

  1989cited by this paper
• Transvesicular Reactions of Thiols with Ellman′s Reagent.

  1989cited by this paper
• Transvesicular reactions of thiols with Ellman's reagent

  1988cited by this paper
• Membrane insertion of alpha- and beta-subunits of Na+,K+-ATPase.

  1985cited by this paper
• A simplification of the protein assay method of Lowry et al. which is more generally applicable.

  1977cited by this paper
• Purification and characterization of (Na+ plus K+ )-ATPase. 3. Purification from the outer medulla of mammalian kidney after selective removal of membrane components by sodium dodecylsulphate.

  1974cited by this paper
• Microdetermination of inorganic phosphate, phospholipids, and total phosphate in biologic materials.

  1967cited by this paper
• A new member of the ATPase family.

  1967cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• Na,K-ATPase mediated and cardiotonic induced signaling in health and disease

  2025cites this paper
• Glycolytic activation of β-cell Na+/K+-ATPases containing β1-subunits accelerates Na+ extrusion, prolonging the duration of Ca2+ oscillations but decreasing insulin secretion

  2025cites this paper
• Oxidative Stress in the Regulation of Autosis-Related Proteins

  2025cites this paper
• The significance of glutaredoxins for diabetes mellitus and its complications

  2024cites this paper
• β3-adrenergic agonist counters oxidative stress and Na+-K+ pump inhibitory S-glutathionylation of placental cells: Implications for preeclampsia.

  2024cites this paper
• Interplay between the Redox System and Renal Tubular Transport

  2024cites this paper
• Transcriptome Analysis of Myocardial Ischemic‐Hypoxic Injury in Rats and Hypoxic H9C2 Cells

  2024cites this paper
• Hypoxia and HIF-1α Regulate the Activity and Expression of Na,K-ATPase Subunits in H9c2 Cardiomyoblasts

  2023cites this paper
• Hypoxic Stress-Dependent Regulation of Na,K-ATPase in Ischemic Heart Disease

  2023influential citation
• The Na+/K+-ATPase: A potential therapeutic target in cardiometabolic diseases

  2023cites this paper
• The FXYD1 protein plays a protective role against pulmonary hypertension and arterial remodelling via redox and inflammatory mechanisms.

  2023cites this paper
• Displacement of Native FXYD Protein From Na+/K+-ATPase With Novel FXYD Peptide Derivatives: Effects on Doxorubicin Cytotoxicity

  2022cites this paper
• Self-Sustained Regulation or Self-Perpetuating Dysregulation: ROS-dependent HIF-YAP-Notch Signaling as a Double-Edged Sword on Stem Cell Physiology and Tumorigenesis

  2022cites this paper
• FXYD3 facilitates Na+ and liquid absorption across human airway epithelia by increasing the transport capacity of the Na/K ATPase

  2022cites this paper
• Short term deuterium depletion in drinking water reduced tumor induced oxidative stress in mice liver.

  2022cites this paper
• "Evaluation of Enzymes Involved in the Production of Endogenous Reactive Oxygen Species and Role of Long-term Oxidative Stress in Pathobiology of Atherosclerosis with Common Oxidative Stress Markers"

  2021cites this paper
• Reactive species driven oxidative modifications of peptides—Tracing physical plasma liquid chemistry

  2021cites this paper
• FXYD proteins and sodium pump regulatory mechanisms

  2021cites this paper
• The role of AMPK in regulation of Na+,K+-ATPase in skeletal muscle: does the gauge always plug the sink?

  2021cites this paper
• FXYD1 Is Protective Against Vascular Dysfunction

  2021cites this paper
• Muscle Ionic Shifts During Exercise: Implications for Fatigue and Exercise Performance.

  2021cites this paper
• Role of Na+/K+-ATPase in ischemic stroke: in-depth perspectives from physiology to pharmacology

  2021cites this paper
• The Na/K-ATPase Signaling Regulates Natriuresis in Renal Proximal Tubule

  2020cites this paper
• S-glutathionylation of the Na +-K + pump: a novel redox mechanism in preeclampsia.

  2020cites this paper
• Molecular Mechanisms of the Redox Regulation of the Na,K-ATPase

  2020cites this paper
• The Redox-Sensitive Na/K-ATPase Signaling in Uremic Cardiomyopathy

  2020influential citation
• The Na/K-ATPase α1 and c-Src form signaling complex under native condition: A crosslinking approach

  2020cites this paper
• Long-noncoding RNA MALAT1 sponges microRNA-92a-3p to inhibit doxorubicin-induced cardiac senescence by targeting ATG4a

  2020cites this paper
• Molecular mechanisms by which iNOS uncoupling can induce cardiovascular dysfunction during sepsis: Role of posttranslational modifications (PTMs).

  2020cites this paper
• Oxidized Glutathione Increases Delta-Subunit Expressing Epithelial Sodium Channel Activity in Xenopus laevis Oocytes

  2020cites this paper
• Na+/K+-ATPase-associated FXYD3 Protein As An Intracellular Therapeutic Target in Cancer

  2020cites this paper
• Apical periodontitis induces changes on oxidative stress parameters and increases Na+/K+-ATPase activity in adult rats.

  2020cites this paper
• Protective role of zinc in liver damage in experimental diabetes demonstrated via different biochemical parameters

  2020cites this paper
• S-glutathionylation, friend or foe in cardiovascular health and disease

  2020cites this paper
• Phospholemman: a novel cardiac stress protein

  2020cites this paper
• Hormonal regulation of Na+-K+-ATPase from the evolutionary perspective.

  2019cites this paper
• Control of cardiac contraction by sodium: Promises, reckonings, and new beginnings.

  2019cites this paper
• Effect of untreated pharmaceutical plant effluent on cardiac Na+-K+- ATPase and Ca2+-Mg2+-ATPase activities in mice (Mus Musculus)

  2019cites this paper
• Na,K-ATPase α-subunit conformation determines glutathionylation efficiency.

  2019cites this paper
• NaKtide Targeted to Adipocytes Ameliorates Western Diet Induced Obesity

  2019influential citation
• Sodium pyruvate ameliorates in vitro oxidative damage resulting from lethal methemoglobinemia

  2018cites this paper
• Hypokalemia-Induced Arrhythmias and Heart Failure: New Insights and Implications for Therapy

  2018cites this paper
• Molecular stressors underlying exercise training‐induced improvements in K+ regulation during exercise and Na+,K+‐ATPase adaptation in human skeletal muscle

  2018cites this paper
• The Na/K-ATPase Signaling: From Specific Ligands to General Reactive Oxygen Species

  2018cites this paper
• Assessment of S-Glutathionylated Rac1 in Cells Using Biotin-Labeled Glutathione.

  2018cites this paper
• Targeting Na/K-ATPase Signaling: A New Approach to Control Oxidative Stress.

  2018cites this paper
• Neuroglobin mediates neuroprotection of hypoxic postconditioning against transient global cerebral ischemia in rats through preserving the activity of Na+/K+ ATPases

  2018cites this paper
• Festschrift for Professor Stephen Hunyor - Celebrating his Clinical and Scientific Contribution and the Legacy he has Left at Royal North Shore Hospital, and the Broader Cardiovascular Research Community.

  2017cites this paper
• Regulation of Na+/K+-ATPase by Estradiol and IGF-1 in Cardio-Metabolic Diseases.

  2017cites this paper
• How widespread is stable protein S‐nitrosylation as an end‐effector of protein regulation?

  2017cites this paper
• Redox modification of caveolar proteins in the cardiovascular system‐ role in cellular signalling and disease

  2017cites this paper
• Cysteine residues 244 and 458–459 within the catalytic subunit of Na,K-ATPase control the enzyme's hydrolytic and signaling function under hypoxic conditions

  2017cites this paper
• The NRF2 activator DH404 attenuates adverse ventricular remodeling post‐myocardial infarction by modifying redox signalling

  2017cites this paper
• Effect of Reduction of Redox Modifications of Cys-Residues in the Na,K-ATPase α1-Subunit on Its Activity

  2017cites this paper
• Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans

  2017cites this paper
• Cytotoxic effect of zinc oxide nanoparticles on murine photoreceptor cells via potassium channel block and Na+/K+‐ATPase inhibition

  2017cites this paper
• Sodium potassium adenosine triphosphatase (Na/K-ATPase) as a therapeutic target for uremic cardiomyopathy

  2017cites this paper
• Stallion spermatozoa surviving freezing and thawing experience membrane depolarization and increased intracellular Na+

  2017influential citation
• L30A Mutation of Phospholemman Mimics Effects of Cardiac Glycosides in Isolated Cardiomyocytes.

  2016cites this paper
• NO turns on Na,K‐ATPase in skeletal muscle

  2016cites this paper
• Regulation of the Cardiac Na+/K+-ATPase by Phospholemman

  2016cites this paper
• Targeted Antioxidant Interventions for Vascular Pathologies

  2016cites this paper
• Mixed results with mixed disulfides.

  2016cites this paper
• β3 Adrenergic Stimulation Restores Nitric Oxide/Redox Balance and Enhances Endothelial Function in Hyperglycemia

  2016cites this paper
• Evaluating the Oxidative Stress in Renal Diseases: What Is the Role for S-Glutathionylation?

  2016cites this paper
• Na,K-ATPase regulation in skeletal muscle.

  2016cites this paper
• Carbonylation Modification Regulates Na/K-ATPase Signaling and Salt Sensitivity: A Review and a Hypothesis

  2016cites this paper
• Exercise-Induced Regulation of the Na, K-Pump in Skeletal Muscles

  2016cites this paper
• “Oxygen Sensing” by Na,K-ATPase: These Miraculous Thiols

  2016influential citation
• The Role of Na/K-ATPase Signaling in Oxidative Stress Related to Obesity and Cardiovascular Disease

  2016cites this paper
• Redox Regulation of the Na+-K+ ATPase in the Cardiovascular System

  2016cites this paper
• Pivotal role of α2 Na+ pumps and their high affinity ouabain binding site in cardiovascular health and disease

  2016influential citation
• Enhancement in cellular Na+K+ATPase activity by low doses of peroxynitrite in mouse renal tissue and in cultured HK2 cells

  2016influential citation
• The influence of heavy metal ions, spermine and sodium nitroprusside on ATP-hydrolases of cell membranes of rat colon smooth muscle.

  2016cites this paper
• Glutathionylation-Dependence of Na(+)-K(+)-Pump Currents Can Mimic Reduced Subsarcolemmal Na(+) Diffusion.

  2016cites this paper
• Selective Assembly of Na,K-ATPase α2β2 Heterodimers in the Heart

  2016cites this paper
• Oxidative and nitrosative signalling in pulmonary arterial hypertension - Implications for development of novel therapies.

  2016cites this paper
• Changes in Intracellular Na+ following Enhancement of Late Na+ Current in Virtual Human Ventricular Myocytes

  2016cites this paper
• Protein Carbonylation of an Amino Acid Residue of the Na/K‐ATPase α1 Subunit Determines Na/K‐ATPase Signaling and Sodium Transport in Renal Proximal Tubular Cells

  2016cites this paper
• Silencing overexpression of FXYD3 protein in breast cancer cells amplifies effects of doxorubicin and γ-radiation on Na+/K+-ATPase and cell survival

  2016cites this paper
• Redox biomarkers in cardiovascular medicine.

  2015cites this paper
• Cell Signaling : Proteins , Pathways and Mechanisms 3-Adrenoceptor activation relieves oxidative inhibition of the cardiac Na-K pump in hyperglycemia induced by insulin receptor blockade

  2015influential citation
• Stimulation of the cardiac myocyte Na+-K+ pump due to reversal of its constitutive oxidative inhibition.

  2015influential citation
• Na+/Ca2+ exchange and Na+/K+-ATPase in the heart

  2015cites this paper
• CALL FOR PAPERS Cell Signaling: Proteins, Pathways and Mechanisms 3-Adrenoceptor activation relieves oxidative inhibition of the cardiac Na -K pump in hyperglycemia induced by insulin receptor blockade

  2015influential citation
• Redox control of cardiac remodeling in atrial fibrillation.

  2015cites this paper
• Ca2+ signaling in the myocardium by (redox) regulation of PKA/CaMKII

  2015cites this paper
• Chronic unpredictable mild stress decreases BDNF and NGF levels and Na(+),K(+)-ATPase activity in the hippocampus and prefrontal cortex of mice: antidepressant effect of chrysin.

  2015cites this paper
• Fall 10-11-2013 Involvement of Reactive Oxygen Species in a Feed-Forward Mechanism of Na / K-ATPase Mediated Signaling

  2015cites this paper
• β3-Adrenoceptor activation relieves oxidative inhibition of the cardiac Na+-K+ pump in hyperglycemia induced by insulin receptor blockade.

  2015cites this paper
• Membrane accessibility of glutathione.

  2015cites this paper
• The effect of exercise and beta2-adrenergic stimulation on glutathionylation and function of the Na,K-ATPase in human skeletal muscle

  2015cites this paper
• Bis(phenylimidazoselenazolyl) diselenide as an antioxidant compound: An in vitro and in vivo study.

  2015cites this paper
• β2‐Adrenergic stimulation enhances Ca2+ release and contractile properties of skeletal muscles, and counteracts exercise‐induced reductions in Na+–K+‐ATPase Vmax in trained men

  2014cites this paper
• Cardiotonic steroids in adaptation to dietary salt intake.

  2014cites this paper
• Oxidative Stress (Glutathionylation) and Na,K-ATPase Activity in Rat Skeletal Muscle

  2014cites this paper
• Glutathionylation Mediates Angiotensin II–Induced eNOS Uncoupling, Amplifying NADPH Oxidase‐Dependent Endothelial Dysfunction

  2014cites this paper
• S-Glutathionylation of an Auxiliary Subunit Confers Redox Sensitivity to Kv4 Channel Inactivation

  2014cites this paper
• Glutathionylation of the alpha-subunit of Na,K-ATPase from rat heart by oxidized glutathione inhibits the enzyme

  2014cites this paper
• The H(+)-ATP synthase: a gate to ROS-mediated cell death or cell survival.

  2014cites this paper