Endotoxin-induced systemic inflammation activates microglia: [11C]PBR28 positron emission tomography in nonhuman primates

No abstract is available for this paper.

• Publication year

  2012

• Venue

  NeuroImage

• Publication date

  2012-10-15

• Fields of study

  Medicine, Computer Science

• Identifiers
  DOI 10.1016/j.neuroimage.2012.06.055PMID 22776451PMCID PMC3699786
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Glucose Metabolism in the Insula and Cingulate Is Affected by Systemic Inflammation in Humans

  2012cited by this paper
• Citalopram reduces endotoxin-induced fatigue.

  2011influential reference
• An 18-kDa Translocator Protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28

  2011cited by this paper
• Systemic inflammation and delirium: important co-factors in the progression of dementia.

  2011influential reference
• MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α–PU.1 pathway

  2011cited by this paper
• A meta-analysis of cytokines in major depression.

  2010cited by this paper
• Long-term cognitive impairment and functional disability among survivors of severe sepsis.

  2010cited by this paper
• Chronic Systemic Infection Exacerbates Ischemic Brain Damage via a CCL5 (Regulated on Activation, Normal T-Cell Expressed and Secreted)-Mediated Proinflammatory Response in Mice

  2010cited by this paper
• A critical review of human endotoxin administration as an experimental paradigm of depression.

  2010cited by this paper
• Systemic infection and delirium: when cytokines and acetylcholine collide.

  2010cited by this paper
• Endotoxemia-induced inflammation and the effect on the human brain

  2010influential reference
• Toll-like Receptor 4 Modulation as a Strategy to Treat Sepsis

  2010cited by this paper
• Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states.

  2010influential reference
• Delirium as a predictor of long-term cognitive impairment in survivors of critical illness

  2010cited by this paper
• Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders

  2010cited by this paper
• Hematopoietic origin of pathological grooming in Hoxb8 mutant mice.

  2010cited by this paper
• Microglia: gatekeepers of central nervous system immunology

  2009cited by this paper
• Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain

  2009cited by this paper
• Delayed Treatment with Isoflurane Attenuates Lipopolysaccharide and Interferon &ggr;–induced Activation and Injury of Mouse Microglial Cells

  2009cited by this paper
• Systemic infection and inflammation in acute CNS injury and chronic neurodegeneration: underlying mechanisms.

  2009influential reference
• Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment

  2008cited by this paper
• Sepsis causes neuroinflammation and concomitant decrease of cerebral metabolism

  2008influential reference
• MyD88 signaling in brain endothelial cells is essential for the neuronal activity and glucocorticoid release during systemic inflammation

  2008cited by this paper
• Brain and whole-body imaging in nonhuman primates of [11C]PBR28, a promising PET radioligand for peripheral benzodiazepine receptors

  2008influential reference
• Isoflurane preconditioning reduces mouse microglial activation and injury induced by lipopolysaccharide and interferon-gamma.

  2008cited by this paper
• Inflammation, Glutamate, and Glia in Depression: A Literature Review

  2008cited by this paper
• Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration

  2007cited by this paper
• The origin and cell lineage of microglia: new concepts.

  2007cited by this paper
• Cancer-related fatigue: links with inflammation in cancer patients and survivors.

  2007cited by this paper
• Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

  2007cited by this paper
• Lipopolysaccharide signaling in endothelial cells

  2006cited by this paper
• The peripheral benzodiazepine receptor (Translocator protein 18kDa) in microglia: from pathology to imaging.

  2006cited by this paper
• Infection–associated encephalopathies—their investigation, diagnosis, and treatment

  2006cited by this paper
• CD163‐positive perivascular macrophages in the human CNS express molecules for antigen recognition and presentation

  2005cited by this paper
• Toll-Like Receptor 4 on Nonhematopoietic Cells Sustains CNS Inflammation during Endotoxemia, Independent of Systemic Cytokines

  2005cited by this paper
• LARGE ANIMAL MODELS: BABOONS FOR TRAUMA, SHOCK, AND SEPSIS STUDIES

  2005cited by this paper
• Lipopolysaccharide Dose Response in Baboons

  2003influential reference
• Proinflammatory cytokines increase in sepsis after anti-adhesion molecule therapy.

  2000cited by this paper
• Intercomparison of four reconstruction techniques for positron volume imaging with rotating planar detectors.

  1998cited by this paper
• Progressive activation of adult microglial cells in vitro

  1996cited by this paper
• Guide for the Care and Use of Laboratory Animals

  1996cited by this paper
• Phenotypic Differences between Human Monocytes/Macrophages and Microglial Cells Studied In Situ and In Vitro

  1994cited by this paper
• MRI‐PET Registration with Automated Algorithm

  1993cited by this paper
• Ketamine: a review of its pharmacologic properties and use in ambulatory anesthesia.

  1992cited by this paper
• Characterisation of ramified microglial cells: detailed morphology, morphological plasticity and proliferative capability.

  1992cited by this paper
• Journal of Neuroinflammation Microglia Activation in Sepsis: a Case-control Study

  year unknowncited by this paper

• Network-Based Analysis for the Quantification of Brain and Body Immune Axes with Total-Body PET Imaging.

  2026cites this paper
• Greater neuroimmune system deficit in women than men with alcohol use disorder.

  2025cites this paper
• PET Imaging of Sphingosine-1-Phosphate Receptor 1 with [18F]TZ4877 in Nonhuman Primates

  2025cites this paper
• Inflammatory Exposure and Depression in Older Adults With Insomnia

  2025cites this paper
• Updates of nuclear medicine imaging in neurodegenerative disorders.

  2025cites this paper
• The (neuro)inflammatory system in anxiety disorders and PTSD: Potential treatment targets.

  2025cites this paper
• Post-mortem validation of in vivo TSPO PET as a microglial biomarker

  2025cites this paper
• Evaluation of microglia activation related markers following a clinical course of TBS: A non-human primate study

  2024cites this paper
• Neural and immune interactions linking early life stress and anhedonia

  2024cites this paper
• PET Imaging of Sphingosine-1-Phosphate Receptor 1 with [18F]TZ4877 in Nonhuman Primates

  2024cites this paper
• Brain inflammaging in the pathogenesis of late-life depression

  2024cites this paper
• Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia

  2024cites this paper
• Reversal of cerebral ischaemia and hypoxia and of sickness behaviour by megadose sodium ascorbate in ovine Gram-negative sepsis.

  2024cites this paper
• Neuroimmune and Neuroinflammation Response for Traumatic Brain Injury.

  2024cites this paper
• Post-Mortem validation of in vivo 18kDa Translocator Protein (TSPO) PET as a microglial biomarker

  2024cites this paper
• Navitoclax safety, tolerability, and effect on biomarkers of senescence and neurodegeneration in aged nonhuman primates

  2024cites this paper
• Diffusion magnetic resonance spectroscopy captures microglial reactivity related to gut-derived systemic lipopolysaccharide: A preliminary study.

  2024cites this paper
• Physically informed deep neural networks for metabolite-corrected plasma input function estimation in dynamic PET imaging

  2024cites this paper
• Increased Inflammation and Treatment of Depression: From Resistance to Reuse, Repurposing, and Redesign.

  2023cites this paper
• Stress to Inflammation and Anhedonia: Mechanistic Insights from Preclinical and Clinical Models.

  2023cites this paper
• The glial perspective of autism spectrum disorder convergent evidence from postmortem brain and PET studies.

  2023cites this paper
• Inflammation-induced reorientation of reward versus punishment sensitivity is attenuated by Minocycline.

  2023cites this paper
• Neuropathologic changes associated with systemic bacterial infection in 28 dogs

  2022cites this paper
• Reactive Microgliosis in Sepsis-Associated and Acute Hepatic Encephalopathies: An Ultrastructural Study

  2022cites this paper
• Systemic inflammation enhances stimulant-induced striatal dopamine elevation in tobacco smokers

  2022influential citation
• The Effects of Peripheral Inflammation on the Brain—A Neuroimaging Perspective

  2022cites this paper
• Is the Neuroimmune System a Therapeutic Target for Opioid Use Disorder? A Systematic Review

  2022cites this paper
• Brain temperature as an indicator of neuroinflammation induced by typhoid vaccine: Assessment using whole-brain magnetic resonance spectroscopy in a randomised crossover study

  2022cites this paper
• A dual tracer [11C]PBR28 and [18F]FDG microPET evaluation of neuroinflammation and brain energy metabolism in murine endotoxemia

  2022cites this paper
• Quantification of the purinergic P2X7 receptor with [11C]SMW139 improves through correction for brain-penetrating radiometabolites

  2022cites this paper
• Comparative Risk of Alzheimer Disease and Related Dementia Among Medicare Beneficiaries With Rheumatoid Arthritis Treated With Targeted Disease-Modifying Antirheumatic Agents

  2022cites this paper
• Radiopharmaceuticals for PET and SPECT Imaging: A Literature Review over the Last Decade

  2022cites this paper
• Nicotinic Acetylcholine Receptors and Microglia as Therapeutic and Imaging Targets in Alzheimer’s Disease

  2022cites this paper
• TSPO imaging in animal models of brain diseases

  2021cites this paper
• Postmortem Evidence of Brain Inflammatory Markers and Injury in Septic Patients: A Systematic Review

  2021cites this paper
• Neuroinflammation as a Common Denominator of Complex Diseases (Cancer, Diabetes Type 2, and Neuropsychiatric Disorders)

  2021cites this paper
• Acute systemic inflammation exacerbates neuroinflammation in Alzheimer's disease: IL‐1β drives amplified responses in primed astrocytes and neuronal network dysfunction

  2021cites this paper
• Systemic inflammation alters the neuroinflammatory response: a prospective clinical trial in traumatic brain injury

  2021cites this paper
• Rapid and Persistent Decrease in Brain Tissue Oxygenation in Ovine Gram-negative Sepsis.

  2021cites this paper
• The TSPO-specific Ligand PK11195 Protects Against LPS-Induced Cognitive Dysfunction by Inhibiting Cellular Autophagy

  2021cites this paper
• What value can TSPO PET bring for epilepsy treatment?

  2021cites this paper
• A primer Sjögren-szindróma pszichológiai vonatkozásai

  2021cites this paper
• Effects of acute glial cell activation on memory performance - implications for treatment of cognitive symptoms in neurological and psychiatric disorders.

  2021cites this paper
• A double-blind placebo-controlled trial of minocycline on translocator protein distribution volume in treatment-resistant major depressive disorder

  2021cites this paper
• Recent Developments in Diagnosis of Epilepsy: Scope of MicroRNA and Technological Advancements

  2021cites this paper
• Microglia and Psychiatric Disorders

  2021cites this paper
• Imaging the influence of red blood cell docosahexaenoic acid status on the expression of the 18KDa translocator protein in the brain: a [11C]PBR28 PET study in young healthy males.

  2021cites this paper
• Systemic In ammation Alters The Neuroin ammatory Response: A Prospective Clinical Trial In Traumatic Brain Injury

  2021cites this paper
• Microglia as therapeutic targets after neurological injury: strategy for cell therapy

  2021cites this paper
• Resolving the cellular specificity of TSPO imaging in a rat model of peripherally-induced neuroinflammation

  2021cites this paper
• Diffusion-weighted MR Spectroscopy (DW-MRS) is sensitive to LPS-induced changes in human glial morphometry: A preliminary study.

  2021influential citation
• Psychological features of primary Sjögren syndrome

  2021cites this paper
• Comparison of Invasive and Non-invasive Estimation of [11C]PBR28 Binding in Non-human Primates

  2021influential citation
• How environmental enrichment balances out neuroinflammation in chronic pain and comorbid depression and anxiety disorders

  2021cites this paper
• [18F]FEPPA PET imaging for monitoring CD68-positive microglia/macrophage neuroinflammation in nonhuman primates

  2020cites this paper
• Sick for science: experimental endotoxemia as a translational tool to develop and test new therapies for inflammation-associated depression

  2020cites this paper
• [ 18 f]Feppa Pet Imaging For Monitoring Neuroinflammation In Nonhuman Primates CURRENT STATUS: UNDER REVIEW

  2020cites this paper
• Neuroinflammation is able to downregulate cytochrome P450 epoxygenases 2J3 and 2C11 in the rat brain.

  2020cites this paper
• Experimental infection by Aeromonas hydrophila in Piaractus mesopotamicus: DL50, neurological disturbances, and mortality

  2020cites this paper
• The Role of Inflammation after Surgery for Elders (RISE) study: Examination of [11C]PBR28 binding and exploration of its link to post-operative delirium

  2020cites this paper
• Nalmefene alleviates the neuroimmune response to repeated binge‐like ethanol exposure: A TSPO PET imaging study in adolescent rats

  2020cites this paper
• Meta-analysis of the Glial Marker TSPO in Psychosis Revisited: Reconciling Inconclusive Findings of Patient-Control Differences.

  2020cites this paper
• PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies

  2020cites this paper
• Neuronal activity increases translocator protein (TSPO) levels

  2020cites this paper
• PET Imaging of the Endocannabinoid System

  2020cites this paper
• Is there neuroinflammation in depression? Understanding the link between the brain and the peripheral immune system in depression.

  2020cites this paper
• Interleukin-10 Prevents Pathological Microglia Hyperactivation following Peripheral Endotoxin Challenge.

  2020cites this paper
• Peripheral benzodiazepine receptor/18 kDa translocator protein positron emission tomography imaging in a rat model of acute brain injury

  2020cites this paper
• North American Prodrome Longitudinal Study (NAPLS 3): Methods and baseline description.

  2020cites this paper
• Acute neuroimmune stimulation impairs verbal memory in adults: A PET brain imaging study.

  2020cites this paper
• Microbiome and substances of abuse.

  2020cites this paper
• Tobacco Smoking in People Is Not Associated with Altered 18-kDa Translocator Protein Levels: A PET Study

  2020cites this paper
• Microglial translocator protein and stressor-related disorder.

  2020cites this paper
• PET imaging shows no changes in TSPO brain density after IFN-α immune challenge in healthy human volunteers

  2020cites this paper
• Vasopressor Therapy and the Brain: Dark Side of the Moon

  2020cites this paper
• Assessment of simplified methods for quantification of [18F]-DPA-714 using 3D whole-brain TSPO immunohistochemistry in a non-human primate

  2020cites this paper
• Quantification of [11C]PBR28 data after systemic lipopolysaccharide challenge

  2020cites this paper
• Fluorescence-activated cell sorting to reveal the cell origin of radioligand binding

  2020cites this paper
• Sepsis-associated Encephalopathy

  2020cites this paper
• Evidence of diffuse cerebellar neuroinflammation in multiple sclerosis by 11C-PBR28 MR-PET

  2020cites this paper
• Perspective: Solving the Heterogeneity Conundrum of TSPO PET Imaging in Psychosis

  2020cites this paper
• Effects of Antipsychotic Drugs: Cross Talk Between the Nervous and Innate Immune System

  2020cites this paper
• Increased risk of non-multiple sclerosis demyelinating syndromes in patients with preexisting septicaemia: a nationwide retrospective cohort study

  2019cites this paper
• Human Positron Emission Tomography Neuroimaging.

  2019cites this paper
• Kinetic modelling and quantification bias in small animal PET studies with [18F]AB5186, a novel 18 kDa translocator protein radiotracer

  2019cites this paper
• Micro-PET imaging of [18F]fluoroacetate combined with [18F]FDG to differentiate chronic Mycobacterium tuberculosis infection from an acute bacterial infection in a mouse model: a preliminary study

  2019cites this paper
• Assessing the interactions between radiotherapy and antitumour immunity

  2019cites this paper
• Neuroimaging Advance in Depressive Disorder.

  2019cites this paper
• Imaging of neuroinflammation in migraine with aura

  2019cites this paper
• Imaging Biomarkers of the Neuroimmune System among Substance Use Disorders: A Systematic Review

  2019cites this paper
• Microglial activation in early Alzheimer trajectory is associated with higher gray matter volume

  2019cites this paper
• Detecting neuroinflammation in the brain following chronic alcohol exposure in rats: A comparison between in vivo and in vitro TSPO radioligand binding

  2019cites this paper
• Altered brain diagnostic techniques in obesity and related metabolic complications

  2019cites this paper
• PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R)

  2019cites this paper
• Role of Inflammation in Depression and Treatment Implications.

  2019cites this paper
• GABA levels and TSPO expression in people at clinical high risk for psychosis and healthy volunteers: a PET-MRS study.

  2019cites this paper
• TSPO in diverse CNS pathologies and psychiatric disease: A critical review and a way forward.

  2019influential citation
• Identification of AV-1451 as a Weak, Nonselective Inhibitor of Monoamine Oxidase.

  2019cites this paper
• The Role of Depressive Subtypes within the Neuroinflammation Hypothesis of Major Depressive Disorder.

  2019cites this paper
• Stress: A Public Health Concern for Progression of Neurodegeneration and Cognitive Decline in Pakistani Population

  2019cites this paper